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1. 发明申请

US20080292596A1 METHODS OF PRODUCING EDIBLE FUNGI CONTAINING ACTIVATED FOLATES AND NUTRITIONAL SUPPLEMENTS CONTAINING ACTIVATED FOLATES 有权
标题翻译：生产含有活性成分的食用真菌的方法和含有活性脂肪的营养补充剂
公开(公告)号：US20080292596A1
公开(公告)日：2008-11-27
申请号：US12061791
申请日：2008-04-03
申请人： Siddharth Shastri , Peilin Guo , Jarrow L. Rogovin
发明人： Siddharth Shastri , Peilin Guo , Jarrow L. Rogovin
IPC分类号： A61K35/00 , A61P9/00
CPC分类号： C12N1/14 , A23L7/00 , A23L31/00 , A23L33/125 , A23L33/15 , A23V2002/00 , A61K36/07 , A61K36/074 , A23V2250/7058
摘要： Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate. Edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate) into edible portions of the plants. The mushroom-producing fungi reduce and methylate the pteroylmonoglutamates into activated folates. The cultivated mycelia or mushrooms of the mushroom-producing fungi are harvested, and may be consumed directly or processed into oral dosage formats (capsules, tablets, softgels, powders, gel packets, liquids, nutritional bars, beverages) for use as functional foods or nutritional supplements.
摘要翻译：描述了用于生产还原的，甲基化的，生物活性形式的叶酸的方法，包括5-甲基四氢叶酸（即5-甲基四氢丙酰基谷氨酸），5-甲酰基四氢叶酸，10-甲酰四氢叶酸和四氢叶酸。栽培可食用的蘑菇生产真菌以增强叶酸甲羟丁酸（合成叶酸）摄入植物的可食用部分。生产蘑菇的真菌减少并甲基化蝶呤单谷氨酸成为活化的叶酸。收获产生蘑菇的真菌的培养的菌丝体或蘑菇，并且可以直接消毒或加工成用作功能食品的口服剂型（胶囊，片剂，软胶囊，粉末，凝胶包，液体，营养棒，饮料）或营养补充剂。

2. 发明授权

US07682606B2 Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates 有权
标题翻译：生产含活性叶酸的食用真菌和含活性叶酸的营养补充剂的方法
公开(公告)号：US07682606B2
公开(公告)日：2010-03-23
申请号：US12061791
申请日：2008-04-03
申请人： Siddharth Shastri , Peilin Guo , Jarrow L. Rogovin
发明人： Siddharth Shastri , Peilin Guo , Jarrow L. Rogovin
IPC分类号： A01N65/00 , A61K9/00 , A61K47/00
CPC分类号： C12N1/14 , A23L7/00 , A23L31/00 , A23L33/125 , A23L33/15 , A23V2002/00 , A61K36/07 , A61K36/074 , A23V2250/7058
摘要： Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate. Edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate) into edible portions of the plants. The mushroom-producing fungi reduce and methylate the pteroylmonoglutamates into activated folates. The cultivated mycelia or mushrooms of the mushroom-producing fungi are harvested, and may be consumed directly or processed into oral dosage formats (capsules, tablets, softgels, powders, gel packets, liquids, nutritional bars, beverages) for use as functional foods or nutritional supplements.
摘要翻译：描述了用于生产还原的，甲基化的，生物活性形式的叶酸的方法，包括5-甲基四氢叶酸（即5-甲基四氢丙酰基谷氨酸），5-甲酰四氢叶酸，10-甲酰四氢叶酸和四氢叶酸。栽培可食用的蘑菇生产真菌以增强叶酸甲羟丁酸（合成叶酸）摄入植物的可食用部分。生产蘑菇的真菌减少并甲基化蝶呤单谷氨酸成为活化的叶酸。收获产生蘑菇的真菌的培养的菌丝体或蘑菇，并且可以直接消毒或加工成用作功能食品的口服剂型（胶囊，片剂，软胶囊，粉末，凝胶包，液体，营养棒，饮料）或营养补充剂。

3. 发明授权

US07354590B2 Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates 有权
标题翻译：生产含活性叶酸的食用真菌和含活性叶酸的营养补充剂的方法
公开(公告)号：US07354590B2
公开(公告)日：2008-04-08
申请号：US10821609
申请日：2004-04-09
申请人： Siddharth Shastri , Peilin Guo , Jarrow L. Rogovin
发明人： Siddharth Shastri , Peilin Guo , Jarrow L. Rogovin
IPC分类号： A01N65/00 , A01N43/60
CPC分类号： C12N1/14 , A23L7/00 , A23L31/00 , A23L33/125 , A23L33/15 , A23V2002/00 , A61K36/07 , A61K36/074 , A23V2250/7058
摘要： Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate. Edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate) into edible portions of the plants. The mushroom-producing fungi reduce and methylate the pteroylmonoglutamates into activated folates. The cultivated mycelia or mushrooms of the mushroom-producing fungi are harvested, and may be consumed directly or processed into oral dosage formats (capsules, tablets, softgels, powders, gel packets, liquids, nutritional bars, beverages) for use as functional foods or nutritional supplements.
摘要翻译：描述了用于生产还原的，甲基化的，生物活性形式的叶酸的方法，包括5-甲基四氢叶酸（即5-甲基四氢丙酰基谷氨酸），5-甲酰四氢叶酸，10-甲酰四氢叶酸和四氢叶酸。栽培可食用的蘑菇生产真菌以增强叶酸甲羟丁酸（合成叶酸）摄入植物的可食用部分。生产蘑菇的真菌减少并甲基化蝶呤单谷氨酸成为活化的叶酸。收获产生蘑菇的真菌的培养的菌丝体或蘑菇，并且可以直接消毒或加工成用作功能食品的口服剂型（胶囊，片剂，软胶囊，粉末，凝胶包，液体，营养棒，饮料）或营养补充剂。

4. 发明申请

US20050186188A1 Compositions containing probiotics and polysaccharides and methods of use 审中-公开
标题翻译：含有益生菌和多糖的组合物及其使用方法
公开(公告)号：US20050186188A1
公开(公告)日：2005-08-25
申请号：US10782482
申请日：2004-02-19
申请人： Peilin Guo
发明人： Peilin Guo
IPC分类号： A23L1/30 , A61K31/702 , A61K31/715 , A61K35/74 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/00 , A61K45/06
CPC分类号： A61K45/06 , A23L33/135 , A23V2002/00 , A23Y2220/73 , A23Y2240/75 , A23Y2300/55 , A61K31/702 , A61K35/744 , A61K35/745 , A61K35/747 , A23V2200/32 , A23V2200/3204 , A23V2250/28 , A61K2300/00
摘要： Compositions and methods are provided for improving GI tract health by reducing the level of pathogenic bacteria present. The compositions comprise probiotic microorganisms, such as a lactic acid producing bacteria or a yeast and mannanoligosaccharide. Optionally, the compositions may further comprise fructooligosaccharide. Methods for administering the composition to improve GI tract health are also provided.
摘要翻译：提供了通过降低存在的病原菌的水平来改善胃肠道健康的组合物和方法。组合物包含益生菌微生物，例如产生乳酸的细菌或酵母和甘露寡糖。任选地，组合物还可以包含低聚果糖。还提供了用于施用组合物以改善胃肠道健康的方法。

5. 发明申请

US20070104730A1 Methods and compositions employing pomegranate extracts and fementation products of statin-producing fungi 审中-公开
标题翻译：使用石榴提取物和他汀类生产菌的发酵产物的方法和组合物
公开(公告)号：US20070104730A1
公开(公告)日：2007-05-10
申请号：US11270564
申请日：2005-11-10
申请人： Peilin Guo , Jarrow Rogovin , Ephraim Lansky
发明人： Peilin Guo , Jarrow Rogovin , Ephraim Lansky
IPC分类号： A61K36/06 , A61K36/185
CPC分类号： A61K36/06 , A61K36/185 , A61K2300/00
摘要： Dietary supplements useful for treating or preventing cardiac disease are disclosed According to some embodiments, the presently disclosed supplement includes a pomegranate product fermented with a statin-producing fungus such one or more of Monascus, Aspergillus, Penicillium, Pleurotus, Pythium, Hypomyces, Paelicilomyces, Eupenicillium, and Doratomyces. Alternatively or additionally, the presently disclosed supplement includes a pomegranate product in combination with a plant product, such as a grain product and a legume, fermented with the statin-producing fungus. Optionally, the supplement includes at least one of coenzymeQ10 and a tocopherol. The presently disclosed dietary supplements include both a COX-2 inhibitor and a HMG-CoA reductase inhibitor, and in some embodiments, the supplement is useful for reducing or controlling blood cholesterol for managing atherosclerotic disease, and/or for managing blood pressure. Methods of preparing the presently disclosed dietary supplement are also provided.
摘要翻译：公开了用于治疗或预防心脏病的膳食补充剂。根据一些实施方案，本发明公开的补充剂包括与产生他汀类似物的真菌发酵的石榴产品，例如红曲霉，曲霉属，青霉菌，白头翁属，腐霉属，嗜酸性粒细胞霉，青花梨和多解剖。或者或另外，本公开的补充物包括与植物产品（例如谷物产品和豆类）组合的石榴产品，与产生他汀类的真菌发酵。任选地，补充剂包括辅酶Q10和生育酚中的至少一种。目前公开的膳食补充剂包括COX-2抑制剂和HMG-CoA还原酶抑制剂，并且在一些实施方案中，补充物可用于降低或控制用于管理动脉粥样硬化疾病和/或用于管理血压的血液胆固醇。还提供了制备本公开的膳食补充剂的方法。

6. 发明授权

US6086886A Composition for promoting intestinal health 失效
标题翻译：促进肠道健康的组合物
公开(公告)号：US6086886A
公开(公告)日：2000-07-11
申请号：US177230
申请日：1998-10-22
申请人： Peilin Guo
发明人： Peilin Guo
IPC分类号： A61K36/05 , A61K36/185 , A61K36/235 , A61K36/288 , A61K36/534 , A61K36/55 , A61K36/68 , A61K36/708 , A61K36/9068 , A61K38/00 , A61K38/16 , A01N65/00
CPC分类号： A61K38/164 , A61K35/74 , A61K35/747 , A61K36/05 , A61K36/185 , A61K36/235 , A61K36/288 , A61K36/534 , A61K36/55 , A61K36/68 , A61K36/708 , A61K36/9068
摘要： The present invention provides a composition for promoting intestinal health. The composition includes metabolites of lactic acid and propionic acid bacteria, chlorella, natural dietary fibers and botanicals. The composition suppresses the reproduction and proliferation of intestinal pathogens and is effective in removing toxic and chemotactic substances from the intestines. The composition also promotes improved bowel function.
摘要翻译：本发明提供一种促进肠道健康的组合物。该组合物包括乳酸和丙酸细菌的代谢物，小球藻，天然膳食纤维和植物药。该组合物抑制肠道病原体的繁殖和增殖，并且有效地从肠中去除有毒和趋化性物质。该组合物还促进肠功能改善。

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