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    • 5. 发明授权
    • Silicon photonic wire waveguide biosensor
    • 硅光子线波导生物传感器
    • US07778499B2
    • 2010-08-17
    • US11898660
    • 2007-09-13
    • Siegfried JanzPavel ChebenAndre DelageAdam DensmoreDan-Xia Xu
    • Siegfried JanzPavel ChebenAndre DelageAdam DensmoreDan-Xia Xu
    • G02B6/00
    • G02B6/12007G01N21/7703G01N21/7746G01N2021/7779G01N2021/7783G02B6/2813
    • Methods and devices relating to a sensor for use in detecting and monitoring molecular interactions. A silicon waveguide sensing element is provided along with a layer of silicon. A silicon oxide layer is also provided between the waveguide element and the layer of silicon. The sensing element is adjacent to an aqueous solution in which the molecular interactions are occurring. A light beam travelling in the silicon waveguide creates an evanescent optical field on the surface of the sensing element adjacent to the boundary between the sensing element and the aqueous medium. Molecular interactions occurring on this surface affect the intensity or the phase of the light beam travelling through the waveguide by changing the effective refractive index of the medium. By measuring the effect on the intensity, phase, or speed of the light beam, the molecular interactions can be detected and monitored in real time.
    • 与用于检测和监测分子相互作用的传感器相关的方法和装置。 硅波导传感元件与硅层一起提供。 在波导元件和硅层之间还提供氧化硅层。 传感元件与发生分子相互作用的水溶液相邻。 在硅波导中行进的光束在感测元件的表面上邻近感测元件和水性介质之间的边界产生消逝的光场。 通过改变介质的有效折射率,在该表面上发生的分子相互作用影响穿过波导的光束的强度或相位。 通过测量对光束的强度,相位或速度的影响,可以实时检测和监测分子相互作用。