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1. 发明申请

US20130052177A1 MONOMERIC FORMS OF HUMAN AMINOACYL-t-RNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 有权
标题翻译：具有非经济生物活性的人类氨基酸-T-RNA合成的单体形式
公开(公告)号：US20130052177A1
公开(公告)日：2013-02-28
申请号：US13577090
申请日：2011-02-04
申请人： Paul Schimmel , Xiang-Lei Yang , Bonnie Slike , Xiaoling Xu , Min Guo
发明人： Paul Schimmel , Xiang-Lei Yang , Bonnie Slike , Xiaoling Xu , Min Guo
IPC分类号： A61K38/45 , A61P29/00
CPC分类号： C12N9/93 , A61K38/45 , C07K16/1045 , C07K16/40 , C12Y601/01 , C12Y601/01001 , C12Y601/01002 , C12Y601/01006 , Y02A50/473
摘要： Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
摘要翻译：提供了分离的单体氨酰-tRNA合成酶多肽和具有非规范生物活性的多核苷酸，以及与其相关的组合物和方法。

2. 发明授权

US08828685B2 Monomeric forms of human aminoacyl-t-RNA synthetases having non-canonical biological activities 有权
标题翻译：具有非规范生物活性的人氨酰-tRNA合成酶的单体形式
公开(公告)号：US08828685B2
公开(公告)日：2014-09-09
申请号：US13577090
申请日：2011-02-04
申请人： Paul Schimmel , Xiang-Lei Yang , Bonnie Slike
发明人： Paul Schimmel , Xiang-Lei Yang , Bonnie Slike
IPC分类号： C07K14/47 , C07K1/107 , A61K38/00 , A61K38/45 , C12P21/00 , C12P21/02
CPC分类号： C12N9/93 , A61K38/45 , C07K16/1045 , C07K16/40 , C12Y601/01 , C12Y601/01001 , C12Y601/01002 , C12Y601/01006 , Y02A50/473
摘要： Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
摘要翻译：提供了分离的单体氨酰-tRNA合成酶多肽和具有非规范生物活性的多核苷酸，以及与其相关的组合物和方法。

3. 发明申请

US20160144003A1 COMPOSITIONS AND METHODS FOR TREATING CHARCOT-MARIE-TOOTH DISEASES AND RELATED NEURONAL DISEASES 审中-公开
标题翻译：治疗精神病虫害及相关神经疾病的组合物和方法
公开(公告)号：US20160144003A1
公开(公告)日：2016-05-26
申请号：US14781563
申请日：2012-05-17
申请人： Xiang-lei Yang , Paul Schimmel , Weiwei He
发明人： Xiang-lei Yang , Paul Schimmel , Weiwei He
IPC分类号： A61K38/53
CPC分类号： A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/76 , C12N9/93
摘要： Provided are compositions and methods for the treatment of mutant glycyl-tRNA synthetase (GlyRS)-associated diseases, such as Charcot-Marie-Tooth (CMT) diseases, and related compositions and methods for diagnostic, drug discovery, and research applications. Also provided are mutant glycyl-tRNA synthetases and uses thereof.
摘要翻译：提供了用于治疗突变型糖基-tRNA合成酶（GlyRS）相关疾病如Charcot-Marie-Tooth（CMT）疾病的组合物和方法以及用于诊断，药物发现和研究应用的相关组合物和方法。还提供突变体甘氨酰-tRNA合成酶及其用途。

4. 发明授权

US08148125B2 Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis 有权
标题翻译：用于调节血管生成的人氨基-tRNA合成酶多肽
公开(公告)号：US08148125B2
公开(公告)日：2012-04-03
申请号：US13007714
申请日：2011-01-17
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
IPC分类号： C12N15/00 , C12N9/14 , C12N1/20 , C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521
摘要： Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
摘要翻译：描述了包含用于调节血管生成的截短的色氨酰-tRNA合成酶多肽的组合物，以及编码这种tRNA合成酶多肽的核酸。还公开了制备和使用这些组合物的方法。

5. 发明申请

US20100158883A1 Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis 有权
标题翻译：用于调节血管生成的人氨基-tRNA合成酶多肽
公开(公告)号：US20100158883A1
公开(公告)日：2010-06-24
申请号：US12655717
申请日：2010-01-06
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
IPC分类号： A61K38/43 , A61K31/7088
CPC分类号： C12N9/93 , A61K38/00
摘要： A method of suppressing angiogenesis in a mammal (e.g., for treating tumors, tumor metastasis or a condition that would benefit from decreased angiogenesis) comprises the step of administering to the mammal an angiostatically effective amount of a pharmaceutical composition comprising an isolated antiangiogenic truncated tryptophanyl-tRNA synthetase (TrpRS) polypeptide or an isolated nucleic acid that comprises a polynucleotide sequence that encodes the truncated TrpRS polypeptide. The truncated TrpRS polypeptide comprises residues 71-471 of SEQ ID NO: 10, residues 48-471 of SEQ ID NO: 10, or a polypeptide of approximately 47 kD molecular weight produced by cleavage of the polypeptide of SEQ ID NO: 10 with polymorphonuclear leucocyte elastase.
摘要翻译：抑制哺乳动物血管发生的方法（例如，用于治疗肿瘤，肿瘤转移或有益于血管生成减少的病症）包括向哺乳动物施用血管生成有效量的药物组合物的步骤，其包含分离的抗血管生成截短的色氨酸 - tRNA合成酶（TrpRS）多肽或分离的核酸，其包含编码截短的TrpRS多肽的多核苷酸序列。截短的TrpRS多肽包含SEQ ID NO：10的残基71-471，SEQ ID NO：10的残基48-471或通过用多核型切割SEQ ID NO：10的多肽产生的约47kD分子量的多肽白细胞弹性蛋白酶。

6. 发明授权

US07524646B2 Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases 失效
标题翻译：通过遗传上禁用其氨基tRNA合成酶的编辑功能使体内产生的蛋白质的化学成分多样化的方法
公开(公告)号：US07524646B2
公开(公告)日：2009-04-28
申请号：US11054192
申请日：2005-02-08
申请人： Volker Doring , Leslie A. Nangle , Tamara L. Hendrickson , Valerie De Crecy-Lagard , Paul Schimmel , Philippe Marliere
发明人： Volker Doring , Leslie A. Nangle , Tamara L. Hendrickson , Valerie De Crecy-Lagard , Paul Schimmel , Philippe Marliere
IPC分类号： C12P21/06 , C12N9/10 , C12N9/12
CPC分类号： C12N15/10 , C12N9/93 , C12N15/67 , C12P21/02 , C12R1/19
摘要： The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.
摘要翻译：本发明涉及使体内产生的蛋白质的化学组成多样化的方法，其包括特别是通过诱变使其氨酰tRNA合成酶之一的编辑功能失活的步骤。本发明还涉及编码这种突变的氨基酰基tRNA合成酶的核酸序列，其具有突变的编辑位点并且能够与非科学氨基酸对其同源tRNA进行错配。本文还描述了一种用于获得能够合成体内蛋白质的转化细胞的改进方法，其包含至少一种非科学氨基酸及其用于产生这种蛋白质的用途。

7. 发明授权

US07521215B2 Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis 有权
公开(公告)号：US07521215B2
公开(公告)日：2009-04-21
申请号：US11444924
申请日：2006-06-01
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
IPC分类号： C12N9/14 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521
摘要： Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.

8. 发明授权

US08562977B2 Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis 有权
标题翻译：用于调节血管生成的人氨基-tRNA合成酶多肽
公开(公告)号：US08562977B2
公开(公告)日：2013-10-22
申请号：US13434933
申请日：2012-03-30
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
IPC分类号： A61K38/51 , C12N9/10
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521
摘要： Pharmaceutical compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis an nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
摘要翻译：描述了包含用于调节血管生成的截短的色氨酰-tRNA合成酶多肽的药物组合物，其编码这种tRNA合成酶多肽的核酸。还公开了制备和使用这些组合物的方法。

9. 发明申请

US20120238620A1 TRYPTOPHANYL-tRNA SYNTHETASE-DERIVED POLYPEPTIDES USEFUL FOR THE REGULATION OF ANGIOGENESIS 有权
标题翻译：用于调节血管生成的TRYPTOPHANYL-tRNA合成酶衍生的多肽
公开(公告)号：US20120238620A1
公开(公告)日：2012-09-20
申请号：US13229866
申请日：2011-09-12
申请人： Paul Schimmel , Keisuke Wakasugi , Martin Friedlander
发明人： Paul Schimmel , Keisuke Wakasugi , Martin Friedlander
IPC分类号： A61K31/713 , C12N15/861 , C12N15/869 , C12N15/863 , A61P9/00 , C12N5/10 , C12N1/19 , C12N1/15 , C12N1/21 , C12N15/52 , C12N15/85 , C12N15/867
CPC分类号： C12N9/93 , A61K38/00 , C07H21/04 , C07K14/515 , C07K14/521 , C12Y601/01002 , Y10S435/975
摘要： The invention provides an isolated nucleic acid encoding a polypeptide capable of inhibiting angiogenesis or neovascularization, wherein the nucleic acid comprises a first polynucleotide sequence comprising a coding sequence at least 95 percent identical to a sequence selected from the group consisting of a polynucleotide SEQ ID NO:6, a polynucleotide that encodes a polypeptide of SEQ ID NO:12, and a polynucleotide that encodes a fragment of the polypeptide of SEQ ID NO:12; and wherein the nucleic acid does not encode for the amino acid sequence of amino acids 71-93 of SEQ ID NO:1. Pharmaceutical compositions, vectors, and methods for inhibiting neovascularization or angiogenesis comprising or utilizing the nucleic acids also are provided.
摘要翻译：本发明提供了编码能够抑制血管生成或新生血管形成的多肽的分离的核酸，其中所述核酸包含第一多核苷酸序列，所述第一多核苷酸序列包含与选自多核苷酸SEQ ID NO： 6，编码SEQ ID NO：12的多肽的多核苷酸和编码SEQ ID NO：12的多肽的片段的多核苷酸; 并且其中所述核酸不编码SEQ ID NO：1的氨基酸71-93的氨基酸序列。还提供了用于抑制新生血管形成或血管发生的药物组合物，载体和方法，其包含或利用核酸。

10. 发明申请

US20120122178A1 Human Aminoacyl-tRNA Synthetase Polypeptides Useful for the Regulation of Angiogenesis 审中-公开
标题翻译：人氨基酰基-tRNA合成酶多肽可用于调节血管发生
公开(公告)号：US20120122178A1
公开(公告)日：2012-05-17
申请号：US13356055
申请日：2012-01-23
申请人： Paul Schimmel , Keisuke Wakasugi
发明人： Paul Schimmel , Keisuke Wakasugi
IPC分类号： C12N9/00 , C12N15/63 , C12N15/52
CPC分类号： C12N9/93 , A61K38/00
摘要： The present invention provides an isolated polypeptide comprising residues 94-471 of SEQ ID NO: 10, wherein the isolated polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO: 10. Nucleic acids and expression vectors encoding the peptide also are provided.
摘要翻译：本发明提供了包含SEQ ID NO：10的残基94-471的分离的多肽，其中分离的多肽不包含SEQ ID NO：10的氨基酸残基1-47。还提供了编码该肽的核酸和表达载体。

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