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1. 发明授权

US07744583B2 Systems and methods of de-endothelialization 有权
标题翻译：去内皮细胞的系统和方法
公开(公告)号：US07744583B2
公开(公告)日：2010-06-29
申请号：US10357572
申请日：2003-02-03
申请人： Paul S. Seifert , Elaine Lee , Michael P. Wallace , Stephen C. Porter
发明人： Paul S. Seifert , Elaine Lee , Michael P. Wallace , Stephen C. Porter
IPC分类号： A61M31/00
CPC分类号： A61M29/02 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12113 , A61B17/12118 , A61B17/12136 , A61B17/12145 , A61B17/1215 , A61B17/12159 , A61B17/12186 , A61B17/1219 , A61B2017/1205 , A61B2017/12063 , A61B2017/22068 , A61B2017/22069 , A61F2/82
摘要： Apparatus and methods for treating a wall of an aneurysm formed in a vessel includes introducing a tubular member into the body lumen until a distal end of the tubular member is located within the aneurysm. A fluid is delivered via a lumen of the tubular member into the aneurysm to at least partially de-endothelialize the wall of the aneurysm, thereby causing an endothelium of the wall to generate fibrous tissue to strengthen the wall of the aneurysm.
摘要翻译：用于治疗在血管中形成的动脉瘤壁的装置和方法包括将管状构件引入体腔，直到管状构件的远端位于动脉瘤内。流体通过管状构件的内腔被输送到动脉瘤中以至少部分地去动脉瘤内壁，从而导致壁的内皮产生纤维组织以加强动脉瘤壁。

2. 发明申请

US20100222803A1 SYSTEMS AND METHODS OF DE-ENDOTHELIALIZATION 审中-公开
标题翻译： DE-ENDOTHELIZIZATION的系统和方法
公开(公告)号：US20100222803A1
公开(公告)日：2010-09-02
申请号：US12780638
申请日：2010-05-14
申请人： Paul S. Seifert , Elaine Lee , Michael P. Wallace , Stephen C. Porter
发明人： Paul S. Seifert , Elaine Lee , Michael P. Wallace , Stephen C. Porter
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12113 , A61B17/12118 , A61B17/12136 , A61B17/12145 , A61B17/1215 , A61B17/12159 , A61B17/12186 , A61B17/1219 , A61B2017/1205 , A61B2017/12063 , A61B2017/22068 , A61B2017/22069 , A61F2/82
摘要： Apparatus and methods for treating a wall of an aneurysm formed in a vessel includes introducing a tubular member into the body lumen until a distal end of the tubular member is located within the aneurysm. A fluid is delivered via a lumen of the tubular member into the aneurysm to at least partially de-endothelialize the wall of the aneurysm, thereby causing an endothelium of the wall to generate fibrous tissue to strengthen the wall of the aneurysm.
摘要翻译：用于治疗在血管中形成的动脉瘤壁的装置和方法包括将管状构件引入体腔，直到管状构件的远端位于动脉瘤内。流体通过管状构件的内腔被输送到动脉瘤中以至少部分地去动脉瘤内壁，从而导致壁的内皮产生纤维组织以加强动脉瘤壁。

3. 发明授权

US08968352B2 Expandable body cavity liner device 有权
标题翻译：可扩展体腔衬垫装置
公开(公告)号：US08968352B2
公开(公告)日：2015-03-03
申请号：US10631928
申请日：2003-07-31
申请人： Clifford Teoh , Joseph C. Eder , Michael P. Wallace , Stephen C. Porter , David C. Barry , Amol Parkar
发明人： Clifford Teoh , Joseph C. Eder , Michael P. Wallace , Stephen C. Porter , David C. Barry , Amol Parkar
IPC分类号： A61M29/00 , A61B17/12
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12172
摘要： The present invention is a method for treating aneurysms of various shapes and sizes.
摘要翻译：本发明是一种治疗各种形状和大小的动脉瘤的方法。

4. 发明申请

US20110054504A1 RECANALIZATION DEVICE WITH EXPANDABLE CAGE 审中-公开
标题翻译：具有可扩展笼的再现装置
公开(公告)号：US20110054504A1
公开(公告)日：2011-03-03
申请号：US12870485
申请日：2010-08-27
申请人： Stephen C. Porter
发明人： Stephen C. Porter
IPC分类号： A61B17/22
CPC分类号： A61M29/02 , A61B17/221 , A61B2017/2212 , A61M25/0068
摘要： A vascular recanalization device for re-establishing blood flow through a vessel lumen. The vascular recanalization device includes an elongate wire and an expandable cage slidably coupled to the elongate wire. The expandable cage includes a proximal collar slidably disposed on the elongate wire and a distal collar slidably disposed on the elongate wire. A central stop is secured to the elongate wire intermediate the proximal collar and the distal collar. A proximal stop is located proximal of the proximal collar of the expandable cage, and a distal stop is located distal of the distal collar of the expandable cage. The proximal collar is slidable along the elongate wire between the proximal stop and the central stop, and the distal collar is slidable along the elongate wire between the central stop and the distal stop.
摘要翻译：用于重建血流通过血管腔的血管再通装置。血管再通装置包括细长线和可滑动地联接到细长线的可扩展笼。可伸缩保持架包括可滑动地设置在细长丝线上的近侧颈圈和可滑动地设置在细长丝线上的远侧颈圈。中心止动件固定到细长丝线的中间位于近端领和远端领。近端止动件位于可膨胀笼的近侧套环的近侧，远端止动件位于可膨胀笼的远侧套环的远侧。近端套环可沿着细长线在近端止动件和中心止动件之间滑动，并且远端套环可沿中心止动件和远端止动件之间的细长线滑动。

5. 发明授权

US07687053B2 Embolic compositions with non-cyanoacrylate rheology modifying agents 有权
标题翻译：具有非氰基丙烯酸酯流变改性剂的栓塞组合物
公开(公告)号：US07687053B2
公开(公告)日：2010-03-30
申请号：US09933316
申请日：2001-08-20
申请人： Stephen C. Porter
发明人： Stephen C. Porter
IPC分类号： A61K49/04
CPC分类号： C08F20/32 , A61L24/06 , A61L2430/36 , C08L35/04
摘要： Compositions for embolization are disclosed herein. The compositions disclosed can have a matrix-forming component, a solid-aggregate material, and a rheology modifying agent, wherein the matrix-forming component includes at least alkyl cyanoacrylate monomers, a stabilizer, and a plasticizer, and the solid-aggregate material includes at least a radiopacifier. The composition and a method of administering the composition are useful for treating vasculature abnormalities, particularly when the composition solidifies upon contact with an ionic environment, such as blood.
摘要翻译：本文公开了用于栓塞的组合物。所公开的组合物可以具有基质形成组分，固体骨料材料和流变改性剂，其中基质形成组分至少包括氰基丙烯酸烷基酯单体，稳定剂和增塑剂，并且所述固体骨料材料包括至少一个无线电传感器。组合物和施用组合物的方法可用于治疗脉管系统异常，特别是当组合物在与离子环境例如血液接触时固化。

6. 发明授权

US07651513B2 Flexible embolic device delivery system 有权
标题翻译：柔性栓塞装置输送系统
公开(公告)号：US07651513B2
公开(公告)日：2010-01-26
申请号：US10407295
申请日：2003-04-03
申请人： Clifford Teoh , Stephen C. Porter , Kevin M. Jaeger , Michael Wallace
发明人： Clifford Teoh , Stephen C. Porter , Kevin M. Jaeger , Michael Wallace
IPC分类号： A61M25/01
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00862 , A61B2017/00867 , A61B2017/1205 , A61B2017/12063
摘要： The present invention provides an embolic assembly delivery apparatus having superior flexibility characteristics at its distal end, that is, at the point of attachment of the embolic assembly to the delivery apparatus. It also provides a method of using the apparatus to deliver an embolic assembly to a target site in a patient's body.
摘要翻译：本发明提供一种栓塞组件输送装置，其在其远端具有优异的柔性特性，即在栓塞组件与输送装置的连接点处。它还提供了一种使用该装置将栓塞组件递送到患者身体中的目标部位的方法。

7. 发明申请

US20120265135A1 BALLOON CATHETER 有权
标题翻译：气球导管
公开(公告)号：US20120265135A1
公开(公告)日：2012-10-18
申请号：US13436378
申请日：2012-03-30
申请人： Stephen C. Porter
发明人： Stephen C. Porter
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61M25/09 , A61M25/104 , A61M2025/0079 , A61M2025/1052 , A61M2025/1063 , A61M2025/1093
摘要： A balloon catheter includes a balloon support member having a hollow axial lumen and open distal end for allowing passage of a guidewire therethrough, a balloon disposed around the balloon support member, and an annular balloon seal disposed proximate to a distal end of the balloon catheter. The seal defines a central passageway for allowing passage therethrough of a guidewire extending out the distal end of the balloon support member, and is configured to form a substantially fluid tight seal around each of a plurality of guidewires having different outer diameters.
摘要翻译：球囊导管包括球囊支撑构件，其具有中空的轴向内腔和用于允许导丝通过的敞开的远端，围绕球囊支撑构件设置的球囊以及靠近气囊导管的远端设置的环形气囊密封件。密封件限定了一个中心通道，用于允许从气球支撑构件的远端延伸的导丝通过，并且构造成围绕具有不同外径的多根导线的每一个形成基本上流体密封的密封。

8. 发明授权

US07485123B2 Complex vaso-occlusive coils 有权
标题翻译：复杂血管闭塞线圈
公开(公告)号：US07485123B2
公开(公告)日：2009-02-03
申请号：US10790982
申请日：2004-03-01
申请人： Stephen C. Porter
发明人： Stephen C. Porter
IPC分类号： A61B17/24
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/12054
摘要： A vaso-occlusive device includes a member that forms a series of at least four successive loops, each loop of the series having a different axis than, and lying in a separate plane from, any other loop of the series. Each plane in which a loop lies forms an angle greater than 30 degrees with any immediately proceeding, and any immediately succeeding, plane.
摘要翻译：血管闭塞装置包括形成一系列至少四个连续环的构件，该系列的每个环具有与该系列的任何其它环相比不同的轴，并且位于与该系列的任何其它环相离的独立平面中。循环所在的每个平面与立即进行任何立即进行的任何平面的任何立即成立的角度形成大于30度的角度。

9. 发明授权

US07341716B2 Occlusive composition 有权
标题翻译：闭塞组成
公开(公告)号：US07341716B2
公开(公告)日：2008-03-11
申请号：US10121634
申请日：2002-04-12
申请人： Stephen C. Porter
发明人： Stephen C. Porter
IPC分类号： A61K31/785 , A61F13/00
CPC分类号： C07C255/23 , A61L24/06 , A61L2430/36 , C08L35/04
摘要： The present invention provides an occlusive composition comprising: a) a poly(2-cyanoacrylate) monomer of the following formula (I): wherein n≧2 and R is an organic moiety; and b) a visualization agent. The present invention also provides a method for creating a solid mass in an ionic fluid-containing bodily cavity within a living organism, comprising delivering into the bodily cavity a clinically sufficient amount of an occlusive composition comprising a poly(2-cyanoacrylate) monomer of formula (I) and a visualization agent.
摘要翻译：本发明提供封闭组合物，其包含：a）下式（I）的聚（2-氰基丙烯酸酯）单体：其中n≥2且R是有机部分; 和b）可视化代理。本发明还提供了一种用于在活生物体内的含离子流体的体液中产生固体物质的方法，包括向身体腔内递送临床上足量的包含式（I）的聚（2-氰基丙烯酸酯）单体的封闭组合物（I）和可视化代理。

10. 发明授权

US07338511B2 Solid embolic material with variable expansion 失效
标题翻译：固体栓塞材料，膨胀可变
公开(公告)号：US07338511B2
公开(公告)日：2008-03-04
申请号：US10155563
申请日：2002-05-24
申请人： Gregory E. Mirigian , Huey Quoc Chan , Thomas Yung-Hui Chien , Stephen C. Porter , Robert P. Eury
发明人： Gregory E. Mirigian , Huey Quoc Chan , Thomas Yung-Hui Chien , Stephen C. Porter , Robert P. Eury
IPC分类号： A61M29/00
CPC分类号： A61B17/12195 , A61B17/12022 , A61B17/12113 , A61B17/12136 , A61B17/12186 , A61B2017/1205 , A61B2017/12063
摘要： A solid embolic material that is capable of filling irregularly shaped and asymmetrical vascular defects in a controlled and predictable manner, without the difficulties associated with delivery of the embolic material through a microcatheter and containment of the embolic material in a defect. A detachable embolic balloon with optional check valve for maintaining liquid in the balloon prior to curing and optional multi-leaflet covering to prevent the balloon from expanding into the native vascular lumen.
摘要翻译：一种固体栓塞材料，其能够以受控和可预测的方式填充不规则形状和不对称的血管缺陷，而不需要通过微导管输送栓塞材料并将栓塞材料容纳在缺陷中。一种可拆卸的栓塞气囊，其具有可选的止回阀，用于在固化之前保持气囊中的液体，并且可选的多叶片覆盖物以防止气囊扩张到天然血管腔中。

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