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1. 发明申请

US20110268710A1 METHODS OF TREATING STROKE USING STEM CELL-LIKE MENSTRUAL BLOOD CELLS 有权
标题翻译：使用干细胞样淋巴细胞治疗小肠的方法
公开(公告)号：US20110268710A1
公开(公告)日：2011-11-03
申请号：US13107391
申请日：2011-05-13
申请人： Paul R. Sanberg , Cesario V. Borlongan , Julie Allickson
发明人： Paul R. Sanberg , Cesario V. Borlongan , Julie Allickson
IPC分类号： A61K35/14 , A61P9/10 , A61K38/18
CPC分类号： A61K35/14 , A61K35/30 , A61K38/185 , A61K38/1866
摘要： A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good source of stem cells for cell therapy. Menstrual blood is found to be another important source of stem cells. Assays of cultured menstrual blood reveal that they express embryonic like-stem cell phenotypic markers and neuronal phenotypic markers under appropriate conditioned media. Oxygen glucose deprivation stroke models show that OGD-exposed primary rat neurons, co-cultured with menstrual blood-derived stem cells or exposed to the media from cultured menstrual blood, exhibited significantly reduced cell death. Transplantation of menstrual blood-derived stem cells, either intracerebrally or intravenously, after experimentally induced ischemic stroke in adult rats also significantly reduced behavioral and histological impairments compared to vehicle-infused rats.
摘要翻译：与移植受体完全匹配的细胞类型似乎是最佳方案，以最小的并发症向大量患者群体开放治疗选择。已经提出使用自体骨髓或脐带血作为细胞治疗的干细胞的良好来源。月经血被认为是干细胞的另一个重要来源。培养的月经血液的测定显示它们在合适的条件培养基下表达胚胎样干细胞表型标记物和神经元表型标记物。氧葡萄糖剥夺中风模型显示，OGD暴露的原代大鼠神经元，与月经血源干细胞共培养或暴露于来自培养的月经血液的培养基，显示出显着降低的细胞死亡。在实验性诱导的成年大鼠缺血性卒中后，月经血液或静脉内移植月经血源性干细胞也显着降低与载体输注大鼠相比的行为和组织学损伤。

2. 发明授权

US09044431B2 Methods of treating stroke using stem cell-like menstrual blood cells 有权
标题翻译：使用干细胞样月经血细胞治疗中风的方法
公开(公告)号：US09044431B2
公开(公告)日：2015-06-02
申请号：US13107391
申请日：2011-05-13
申请人： Paul R. Sanberg , Cesario V. Borlongan , Julie Allickson
发明人： Paul R. Sanberg , Cesario V. Borlongan , Julie Allickson
IPC分类号： A61K35/30 , A61K35/14 , A61K38/18
CPC分类号： A61K35/14 , A61K35/30 , A61K38/185 , A61K38/1866
摘要： A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good source of stem cells for cell therapy. Menstrual blood is found to be another important source of stem cells. Assays of cultured menstrual blood reveal that they express embryonic like-stem cell phenotypic markers and neuronal phenotypic markers under appropriate conditioned media. Oxygen glucose deprivation stroke models show that OGD-exposed primary rat neurons, co-cultured with menstrual blood-derived stem cells or exposed to the media from cultured menstrual blood, exhibited significantly reduced cell death. Transplantation of menstrual blood-derived stem cells, either intracerebrally or intravenously, after experimentally induced ischemic stroke in adult rats also significantly reduced behavioral and histological impairments compared to vehicle-infused rats.
摘要翻译：与移植受体完全匹配的细胞类型似乎是最佳方案，以最小的并发症向大量患者群体开放治疗选择。已经提出使用自体骨髓或脐带血作为细胞治疗的干细胞的良好来源。月经血被认为是干细胞的另一个重要来源。培养的月经血液的测定显示它们在合适的条件培养基下表达胚胎样干细胞表型标记物和神经元表型标记物。氧葡萄糖剥夺中风模型显示，OGD暴露的原代大鼠神经元，与月经血源干细胞共培养或暴露于来自培养的月经血液的培养基，显示出显着降低的细胞死亡。在实验性诱导的成年大鼠缺血性卒中后，月经血液或静脉内移植月经血源性干细胞也显着降低与载体输注大鼠相比的行为和组织学损伤。

3. 发明授权

US06649160B1 Sertoli cells as transplantation facilitator for cell transplantation 失效
标题翻译： Sertoli细胞作为细胞移植的移植促进剂
公开(公告)号：US06649160B1
公开(公告)日：2003-11-18
申请号：US09661352
申请日：2000-09-14
申请人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
发明人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
IPC分类号： A01N6300
CPC分类号： C12N5/0683 , A61K35/12 , A61K35/30 , A61K35/48 , A61K2035/122 , C12N5/0618 , C12N2502/246
摘要： A method of producing a sustained localized immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the tissue.
摘要翻译：通过移植靠近组织的Sertoli细胞来实现在局部组织中产生持续的局部免疫抑制作用的方法。

4. 发明申请

US20100221233A1 COMPOSITIONS AND METHODS FOR ENHANCING NEUROPROTECTION VIA ADMINISTRATION OF STEM CELLS AND BLOOD BRAIN BARRIER PERMEABILIZERS 审中-公开
标题翻译：用于通过干细胞和血液脑膜阻滞剂的施用来增强神经保护的组合物和方法
公开(公告)号：US20100221233A1
公开(公告)日：2010-09-02
申请号：US12719565
申请日：2010-03-08
申请人： Cesario V. Borlongan , Paul R. Sanberg
发明人： Cesario V. Borlongan , Paul R. Sanberg
IPC分类号： A61K35/14 , A61K35/44 , A61P9/00 , A61P25/16 , A61P25/28
CPC分类号： A61K35/44 , A61K9/0019 , A61K38/08 , A61K47/26 , A61K2300/00
摘要： The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating neurodegenerative disorders by administering umbilical cord blood cells and a substance capable of permeabilizing the blood brain barrier. In one embodiment, the blood brain barrier permeabilizer is mannitol. In another embodiment, the blood brain barrier permeabilizer is Cereport.
摘要翻译：本发明提供了增强脐带血细胞神经保护作用的组合物和方法。更具体地，本发明提供了通过施用脐带血细胞和能够渗透血脑屏障的物质来治疗神经变性疾病的方法。在一个实施方案中，血脑屏障渗透剂是甘露糖醇。在另一个实施方案中，血脑屏障渗透剂是Cereport。

5. 发明授权

US6036951A Sertoli cells as neurorecovery inducing cells for neurodegenerative disorders 失效
标题翻译： Sertoli细胞作为神经复发诱导细胞用于神经退行性疾病
公开(公告)号：US6036951A
公开(公告)日：2000-03-14
申请号：US913865
申请日：1997-09-12
申请人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
发明人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
IPC分类号： A01K67/027 , A61K35/12 , C12N5/071 , C12N5/0793 , A61K48/00 , A61K35/00 , C12N15/85
CPC分类号： C12N5/0683 , A01K67/0271 , C12N5/0619 , A61K2035/122 , A61K35/12 , C12N2502/246
摘要： A method of generating in situ trophic factor production by transplanting Sertoli cells into a tissue in need of trophic factors of a mammal, the cells creating trophic factors in situ.
摘要翻译： PCT No.PCT / US96 / 03335 Sec。 371日期：1997年9月12日 102（e）1997年9月12日PCT PCT 1996年3月12日PCT公布。公开号WO96 / 28030 日期1996年9月19日一种通过将Sertoli细胞移植到需要哺乳动物营养因子的组织中的原位营养因子产生的方法，该细胞原位产生营养因子。

6. 发明授权

US5830460A Sertoli cells as transplantation facilitator for cell transplantation 失效
标题翻译： Sertoli细胞作为细胞移植的移植促进剂
公开(公告)号：US5830460A
公开(公告)日：1998-11-03
申请号：US402387
申请日：1995-03-13
申请人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan , Richard Heller
发明人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan , Richard Heller
IPC分类号： A61K35/12 , A61K35/30 , A61K35/48 , A61P25/00 , C12N5/071 , C12N5/00
CPC分类号： C12N5/0683 , A61K35/30 , A61K35/48 , C12N5/0618 , A61K2035/122 , A61K35/12 , C12N2502/246
摘要： A method of producing a sustained localized brain immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the brain tissue.
摘要翻译：通过移植靠近脑组织的Sertoli细胞来实现在局部组织中产生持续的局部脑免疫抑制作用的方法。

7. 发明授权

US6037175A Method and media for enhancing cryopreservation of cells 失效
标题翻译：用于增强细胞冷冻保存的方法和培养基
公开(公告)号：US6037175A
公开(公告)日：2000-03-14
申请号：US615039
申请日：1996-03-12
申请人： Don F. Cameron , Paul R. Sanberg , Cesario V. Borlongan , Samuel Saporta
发明人： Don F. Cameron , Paul R. Sanberg , Cesario V. Borlongan , Samuel Saporta
IPC分类号： A01N1/02 , A61K35/12 , C12N5/071 , C12N5/0793
CPC分类号： C12N5/0683 , A01N1/0226 , C12N5/0619 , A61K2035/122 , A61K35/12 , C12N2502/246
摘要： A method of enhancing the viability of cryopreserved cells is culturing Sertoli cells in media to produce preconditioned media and adding the preconditioned media to the cells to be cryopreserved. The cells are then cryopreserved. Alternatively, a method of enhancing the viability of cryopreserved cells is co-culturing Sertoli cells and cells to be cryopreserved in media and cryopreserving both.
摘要翻译：提高冷冻保存细胞活力的方法是在培养基中培养Sertoli细胞以产生预处理的培养基，并将预处理的培养基加入待冷冻保存的细胞中。然后将细胞冷冻保存。或者，提高冷冻保存细胞的存活力的方法是共培养Sertoli细胞和细胞以在培养基中冷冻保存并冷冻保存两者。

8. 发明授权

US5942437A Method and media for enhancing viability maturation, and cryopreservation of cells 失效
标题翻译：用于增强活力成熟和细胞冷冻保存的方法和培养基
公开(公告)号：US5942437A
公开(公告)日：1999-08-24
申请号：US799108
申请日：1997-02-11
申请人： Paul R. Sanberg , Agneta Othberg , Don F. Cameron , Samuel Saporta , Cesario V. Borlongan
发明人： Paul R. Sanberg , Agneta Othberg , Don F. Cameron , Samuel Saporta , Cesario V. Borlongan
IPC分类号： A01N1/02 , A61K35/12 , C12N5/071 , C12N5/0793 , A01N63/00
CPC分类号： C12N5/0683 , A01N1/0226 , C12N5/0619 , A61K2035/122 , A61K35/12 , C12N2502/246
摘要： A method to increase viability, number, survival and maturation of cells for transplantation or cryopreservation by culturing the cells with Sertoli cells or with sertoli-cell conditioned media (SCM) prior to transplantation (pre-culturing) or cryopreservation.
摘要翻译：在移植（预培养）或低温保存之前通过用Sertoli细胞或sertoli细胞条件培养基（SCM）培养细胞来增加用于移植或冷冻保存的细胞的活力，数量，存活和成熟的方法。

9. 发明授权

US5702700A Sertoli cells as neurorecovery inducing cells for Parkinson's disease 失效
标题翻译： Sertoli细胞作为神经复发诱导的帕金森病细胞
公开(公告)号：US5702700A
公开(公告)日：1997-12-30
申请号：US402389
申请日：1995-03-13
申请人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
发明人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
IPC分类号： A61K35/48 , A01N63/00 , A61K35/52 , A61K38/22
CPC分类号： A61K35/48
摘要： A method of generating in situ trophic factor production by transplanting Sertoli cells into the central nervous system of a mammal, the cells creating trophic factors in situ.
摘要翻译：通过将Sertoli细胞移植到哺乳动物的中枢神经系统中产生原位营养因子产生的方法，该细胞原位产生营养因子。

10. 发明授权

US08618167B2 Methods of attenuating cognitive deficits with sulfonyl fluorides 有权
公开(公告)号：US08618167B2
公开(公告)日：2013-12-31
申请号：US10218893
申请日：2002-08-14
申请人： Cesario V. Borlongan , Donald E. Moss , Isabel C. Sumaya
发明人： Cesario V. Borlongan , Donald E. Moss , Isabel C. Sumaya
IPC分类号： A01N37/00 , A61K31/185
CPC分类号： A61K31/185
摘要： The present invention provides for methods of treating cognitive deficits resulting from interruption of blood supply and/or oxygen deficit by administering a therapeutically effective dose of a sulfonyl fluoride, such as methanesulfonyl fluoride and ethanesulfonyl fluoride. The underlying cause of the or oxygen deficit can be from stroke, trauma, carbon monoxide poisoning, and other poisonings. This method also includes co-administering with sulfonyl fluoride with a therapeutically effective dose of a second agent.

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