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1. 发明授权

US11672866B2 Osteotropic nanoparticles for prevention or treatment of bone metastases 有权
公开(公告)号：US11672866B2
公开(公告)日：2023-06-13
申请号：US16068235
申请日：2017-01-06
申请人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-Shen Lin , Hon Leong
发明人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-Shen Lin , Hon Leong
IPC分类号： A61K47/54 , A61K9/51 , A61P35/00 , A61K9/16 , B82Y5/00 , A61K47/69 , C12N15/88 , A61K47/10 , A61K45/06
CPC分类号： A61K47/548 , A61K9/16 , A61K9/5115 , A61K9/5123 , A61K9/5192 , A61K47/10 , A61K47/6923 , A61P35/00 , C12N15/88 , A61K45/06 , A61K2300/00 , B82Y5/00
摘要： The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

2. 发明申请

US20190022235A1 OSTEOTROPIC NANOPARTICLES FOR PREVENTION OR TREATMENT OF BONE METASTASES 审中-公开
公开(公告)号：US20190022235A1
公开(公告)日：2019-01-24
申请号：US16068235
申请日：2017-01-06
申请人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-shen Lin , Hon Leong
发明人： Paul N. Durfee , Charles Jeffrey Brinker , Yu-shen Lin , Hon Leong
IPC分类号： A61K47/54 , A61K47/69 , A61K47/10 , A61K9/16 , A61P35/00
摘要： The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

3. 发明申请

US20200009264A1 ACTIVE TARGETING OF CELLS BY MONOSIZED PROTOCELLS 审中-公开
公开(公告)号：US20200009264A1
公开(公告)日：2020-01-09
申请号：US16490280
申请日：2018-03-01
申请人： Charles Jeffrey Brinker , Kimberly Butler , Paul N. Durfee
发明人： Charles Jeffrey Brinker , Kimberly Butler , Paul N. Durfee
IPC分类号： A61K47/69 , C07K16/30 , A61P35/02 , C07K16/28
摘要： In one aspect, the disclosure provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit cell binding specificity. For example, MSNPs and protocells of the disclosure may be used to target specific delivery of therapeutic agents to CD19 or EGFR expressing cancer cells, or target specific delivery of therapeutic agents to other cell types. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

4. 发明授权

US11344629B2 Active targeting of cells by monosized protocells 有权
公开(公告)号：US11344629B2
公开(公告)日：2022-05-31
申请号：US16490280
申请日：2018-03-01
申请人： Charles Jeffrey Brinker , Kimberly Butler , Paul N. Durfee
发明人： Charles Jeffrey Brinker , Kimberly Butler , Paul N. Durfee
IPC分类号： C12N5/00 , A61P35/00 , A61K39/395 , A61K47/69 , A61P35/02 , C07K16/28 , C07K16/30 , A61K39/00
摘要： In one aspect, the disclosure provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit cell binding specificity. For example, MSNPs and protocells of the disclosure may be used to target specific delivery of therapeutic agents to CD19 or EGFR expressing cancer cells, or target specific delivery of therapeutic agents to other cell types. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

5. 发明申请

US20110206925A1 DURABLE POLYMER-AEROGEL BASED SUPERHYDROPHOBIC COATINGS, A COMPOSITE MATERIAL 有权
标题翻译：耐用聚合物 - 空气基超级涂料，复合材料
公开(公告)号：US20110206925A1
公开(公告)日：2011-08-25
申请号：US13121150
申请日：2009-06-30
申请人： David J. Kissel , Charles Jeffrey Brinker
发明人： David J. Kissel , Charles Jeffrey Brinker
IPC分类号： B32B3/26 , C08J9/36 , C09K3/18 , C09K3/00 , C09D183/02 , C09D133/12 , B05D1/18 , B05D1/28 , B05D1/02 , B05D3/02
CPC分类号： C09D7/1225 , A01N55/00 , C08K3/36 , C08K9/06 , C09D5/006 , C09D5/14 , C09D5/165 , C09D5/1681 , C09D7/62 , C09D133/12 , D06N3/0043 , D06N3/0063 , D10B2401/10 , D10B2401/13 , Y10T428/249953 , Y10T428/249972 , Y10T428/24999 , Y10T428/249991 , Y10T442/20
摘要： Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140° and a contact angle hysteresis of less than about 1°. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.
摘要翻译：提供聚合物 - 气凝胶复合涂层，装置和制品，包括聚合物 - 气凝胶复合涂层，以及制备聚合物 - 气凝胶复合材料的方法。示例性制品可以包括表面，其中表面包括至少一个区域和设置在至少一个区域上的聚合物 - 气凝胶复合涂层，其中聚合物 - 气凝胶复合涂层具有至少约140°的水接触角和接触角滞后小于约1°。聚合物 - 气凝胶复合涂层可以包括聚合物和超高含水量催化的聚硅酸盐气凝胶，所述聚硅酸盐气凝胶包括具有由甲硅烷基化剂衍生的表面官能团和多个孔的二氧化硅颗粒的三维网络。

6. 发明授权

US07744673B2 Hollow sphere metal oxides 有权
标题翻译：中空球体金属氧化物
公开(公告)号：US07744673B2
公开(公告)日：2010-06-29
申请号：US11876338
申请日：2007-10-22
申请人： Xingmao Jiang , Charles Jeffrey Brinker
发明人： Xingmao Jiang , Charles Jeffrey Brinker
IPC分类号： B22F9/24
CPC分类号： B01J13/0095 , B01J13/02 , B22F3/1112 , B22F2001/0029 , B22F2998/00 , B22F2999/00 , B22F1/0018 , B22F9/22 , B22F2201/013
摘要： In accordance with invention, there are methods for fabricating hollow spheres and nanofoams. The method for making hollow spheres can include providing a homogeneous precursor solution including a first solvent and one or more anhydrous precursor species and forming aerosol droplets having a first size distribution using the homogeneous precursor solution in an anhydrous carrier gas. The method can also include transporting the aerosol droplets through an aerosol reactor including a reactant to form a plurality of hollow spheres, wherein each of the plurality of hollow spheres can be formed by one or more chemical reactions occurring at a surface of the aerosol droplet. The method can further include controlling size and thickness of the hollow spheres by one or more of the precursor solution concentration, aerosol droplet size, temperature, residence time of the aerosol droplets in the aerosol reactor, and the reactant distribution in the aerosol reactor.
摘要翻译：根据本发明，存在制造中空球体和纳米烟雾的方法。制备中空球体的方法可以包括提供包含第一溶剂和一种或多种无水前体物质的均匀前体溶液，并使用均匀的前体溶液在无水载气中形成具有第一尺寸分布的气雾剂液滴。该方法还可以包括通过包括反应物的气溶胶反应器运送气溶胶液滴以形成多个中空球体，其中多个中空球体中的每一个可以通过在气溶胶液滴的表面处发生的一个或多个化学反应形成。该方法还可以包括通过前体溶液浓度，气溶胶液滴尺寸，温度，气溶胶微滴在气溶胶反应器中的停留时间以及气溶胶反应器中的反应物分布中的一种或多种来控制中空球的尺寸和厚度。

7. 发明申请

US20080210053A1 HOLLOW SPHERE METAL OXIDES 有权
标题翻译：中空球状金属氧化物
公开(公告)号：US20080210053A1
公开(公告)日：2008-09-04
申请号：US11876338
申请日：2007-10-22
申请人： Xingmao Jiang , Charles Jeffrey Brinker
发明人： Xingmao Jiang , Charles Jeffrey Brinker
IPC分类号： B22F9/16 , B01J2/04
CPC分类号： B01J13/0095 , B01J13/02 , B22F3/1112 , B22F2001/0029 , B22F2998/00 , B22F2999/00 , B22F1/0018 , B22F9/22 , B22F2201/013
摘要： In accordance with invention, there are methods for fabricating hollow spheres and nanofoams. The method for making hollow spheres can include providing a homogeneous precursor solution including a first solvent and one or more anhydrous precursor species and forming aerosol droplets having a first size distribution using the homogeneous precursor solution in an anhydrous carrier gas. The method can also include transporting the aerosol droplets through an aerosol reactor including a reactant to form a plurality of hollow spheres, wherein each of the plurality of hollow spheres can be formed by one or more chemical reactions occurring at a surface of the aerosol droplet. The method can further include controlling size and thickness of the hollow spheres by one or more of the precursor solution concentration, aerosol droplet size, temperature, residence time of the aerosol droplets in the aerosol reactor, and the reactant distribution in the aerosol reactor.
摘要翻译：根据本发明，存在制造中空球体和纳米烟雾的方法。制备中空球体的方法可以包括提供包含第一溶剂和一种或多种无水前体物质的均匀前体溶液，并使用均匀的前体溶液在无水载气中形成具有第一尺寸分布的气雾剂液滴。该方法还可以包括通过包括反应物的气溶胶反应器运送气雾剂液滴以形成多个中空球体，其中多个中空球体中的每一个可以通过在气溶胶液滴的表面处发生的一个或多个化学反应形成。该方法还可以包括通过前体溶液浓度，气溶胶液滴尺寸，温度，气溶胶微滴在气溶胶反应器中的停留时间以及气溶胶反应器中的反应物分布中的一种或多种来控制中空球的尺寸和厚度。

8. 发明申请

US20180049984A1 Carriers for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States 审中-公开
公开(公告)号：US20180049984A1
公开(公告)日：2018-02-22
申请号：US15474810
申请日：2017-03-30
申请人： Charles Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Joshua Santarpia , Adrienne Celeste Greene , Oscar Negrete , Steven Branda , Ayse Muniz , Jacob Ongundi Agola , Kimberly Butler
发明人： Charles Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Joshua Santarpia , Adrienne Celeste Greene , Oscar Negrete , Steven Branda , Ayse Muniz , Jacob Ongundi Agola , Kimberly Butler
IPC分类号： A61K9/127 , C12N9/22 , A61K9/51 , A61K49/00
CPC分类号： A61K9/1274 , A61K9/501 , A61K9/5115 , A61K9/5123 , A61K31/7088 , A61K45/06 , A61K48/005 , A61K49/005 , C12N9/22 , C12N15/8206 , C12N2310/11 , C12N2310/20
摘要： The present disclosure relates to the delivery of polynucleotides and/or oligonucleotides using silica delivery platforms, e.g., silica carriers or protocells. In particular, in the present disclosure, polynucleotides in the form of plasmids expressing siRNA may be administered as cargo in the silica delivery platform to a patient or subject to inhibit and/or treat cancer in a patient. In one aspect, the silica delivery platform that have been charged with cargo comprising plasmid DNA (in particular, CRISPR ds plasmid DNA) which expresses siRNA, shRNA, mRNA and other RNA which may be used to administer these plasmids to patients in order to effect inhibition of cancer cells (especially including apoptosis of those cancer cells) and effective and/or prophylaxis of cancer, as well as numerous pathogens, including viruses, bacteria, fungi, and/or other disease states and/or conditions. In another aspect, the silica delivery platform comprises a biological package (e.g., plasmid nucleic acid, such as a for a CRISPR/Cas system) that interacts with a genomic sequence to either activate or inhibit gene expression. Such vehicles can be employed to control gene activation and repression in a host (e.g., a patient) and/or a pathogen.

9. 发明申请

US20180028686A1 Protocells for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States 审中-公开
公开(公告)号：US20180028686A1
公开(公告)日：2018-02-01
申请号：US15474800
申请日：2017-03-30
申请人： Charles Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Joshua Santarpia , Adrienne Celeste Greene , Oscar Negrete , Steven Branda , Ayse Muniz , Jacob Ongundi Agola , Kimberly Butler
发明人： Charles Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Joshua Santarpia , Adrienne Celeste Greene , Oscar Negrete , Steven Branda , Ayse Muniz , Jacob Ongundi Agola , Kimberly Butler
IPC分类号： A61K48/00 , A61K9/50 , A61K31/7088 , A61K45/06
CPC分类号： A61K9/1274 , A61K9/501 , A61K9/5115 , A61K9/5123 , A61K31/7088 , A61K45/06 , A61K48/005 , A61K49/005 , C12N9/22 , C12N15/8206 , C12N2310/11 , C12N2310/20
摘要： The present disclosure relates to the delivery of polynucleotides and/or oligonucleotides using silica delivery platforms, e.g., silica carriers or protocells. In particular, in the present disclosure, polynucleotides in the form of plasmids expressing siRNA may be administered as cargo in the silica delivery platform to a patient or subject to inhibit and/or treat cancer in a patient. In one aspect, the silica delivery platform that have been charged with cargo comprising plasmid DNA (in particular, CRISPR ds plasmid DNA) which expresses siRNA, shRNA, mRNA and other RNA which may be used to administer these plasmids to patients in order to effect inhibition of cancer cells (especially including apoptosis of those cancer cells) and effective and/or prophylaxis of cancer, as well as numerous pathogens, including viruses, bacteria, fungi, and/or other disease states and/or conditions. In another aspect, the silica delivery platform comprises a biological package (e.g., plasmid nucleic acid, such as a for a CRISPR/Cas system) that interacts with a genomic sequence to either activate or inhibit gene expression. Such vehicles can be employed to control gene activation and repression in a host (e.g., a patient) and/or a pathogen.

10. 发明授权

US06808867B2 Photo-definable self-assembled materials 有权
标题翻译：可自定义的自组装材料
公开(公告)号：US06808867B2
公开(公告)日：2004-10-26
申请号：US10100108
申请日：2002-03-19
申请人： Dhaval Doshi , Hongyou Fan , Nicola Huesing , Alan Hurd , Charles Jeffrey Brinker
发明人： Dhaval Doshi , Hongyou Fan , Nicola Huesing , Alan Hurd , Charles Jeffrey Brinker
IPC分类号： G03F700
CPC分类号： G03F7/0048 , G03F7/0047 , G03F7/038 , G03F7/075
摘要： The present invention provides a mesoporous material comprising at least one region of mesoporous material patterned at a lithographic scale. The present invention also provides a a method for forming a patterned mesoporous material comprising: coating a sol on a substrate to form a film, the sol comprising: a templating molecule, a photoactivator generator, a material capable of being sol-gel processed, water, and a solvent; and exposing the film to light to form a patterned mesoporous material.
摘要翻译：本发明提供一种介孔材料，其包括在光刻尺度上图案化的介孔材料的至少一个区域。本发明还提供了一种用于形成图案化介孔材料的方法，包括：在基底上涂覆溶胶以形成膜，所述溶胶包括：模板分子，光活化剂发生剂，能够进行溶胶 - 凝胶加工的材料，水，和溶剂; 并将该膜曝光以形成图案化的介孔材料。

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