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1. 发明申请

US20090042774A1 Parathyroid hormone analogues and methods of use 审中-公开
标题翻译：甲状旁腺激素类似物和使用方法
公开(公告)号：US20090042774A1
公开(公告)日：2009-02-12
申请号：US11799816
申请日：2007-05-02
申请人： Paul Morley , Martin Stogniew , Brian MacDonald , Gene Scott Merutka , Nagesh Palepu
发明人： Paul Morley , Martin Stogniew , Brian MacDonald , Gene Scott Merutka , Nagesh Palepu
IPC分类号： A61K38/29 , A61P19/00
CPC分类号： A61K38/29
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以导致有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

2. 发明申请

US20090010940A1 Parathyroid Hormone Analogues and Methods of Use 审中-公开
标题翻译：甲状旁腺激素类似物和使用方法
公开(公告)号：US20090010940A1
公开(公告)日：2009-01-08
申请号：US12210818
申请日：2008-09-15
申请人： Paul Morley , Martin Stogniew , Brian MacDonald , Gene Scott Merutka , Nagesh Palepu
发明人： Paul Morley , Martin Stogniew , Brian MacDonald , Gene Scott Merutka , Nagesh Palepu
IPC分类号： A61K39/395 , A61K38/17 , A61P19/00 , A61P19/10 , A61K38/29
CPC分类号： A61K38/29
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以导致有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

3. 发明申请

US20080176787A1 Parathyroid hormone analogues and methods of use 审中-公开
标题翻译：甲状旁腺激素类似物和使用方法
公开(公告)号：US20080176787A1
公开(公告)日：2008-07-24
申请号：US11890248
申请日：2007-08-02
申请人： Paul Morley , Martin Stogniew , Brian MacDonald , Gene Scott Merutka , Nagesh Palepu
发明人： Paul Morley , Martin Stogniew , Brian MacDonald , Gene Scott Merutka , Nagesh Palepu
IPC分类号： A61K38/16 , A61P19/00 , A61P19/10
CPC分类号： A61K38/29
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以导致有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

4. 发明申请

US20070270341A1 Parathyroid hormone analogues and methods of use 审中-公开
标题翻译：甲状旁腺激素类似物和使用方法
公开(公告)号：US20070270341A1
公开(公告)日：2007-11-22
申请号：US11650918
申请日：2007-01-05
申请人： Paul Morley , Martin Stogniew , Brian MacDonald
发明人： Paul Morley , Martin Stogniew , Brian MacDonald
IPC分类号： A61K38/29 , A61P19/10
CPC分类号： A61K38/29
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose sufficient to result in an effective pharmacokinetic profile and maintained adenylate cyclase activity, while simultaneously reducing undesirable side effects.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲状旁腺激素（PTH）肽类似物的药学上可接受的制剂，其日剂量足以导致有效的药代动力学特征并维持腺苷酸环化酶活性，同时减少不期望的副作用。

5. 发明授权

US6110892A Parathyroid hormone analogues for the treatment of osteoporosis 失效
标题翻译：甲状旁腺素类似物用于治疗骨质疏松症
公开(公告)号：US6110892A
公开(公告)日：2000-08-29
申请号：US904760
申请日：1997-08-01
申请人： Jean-Rene Barbier , Paul Morley , Witold Neugebauer , Virginia J. S. Ross , James F. Whitfield , Gordon E. Willick
发明人： Jean-Rene Barbier , Paul Morley , Witold Neugebauer , Virginia J. S. Ross , James F. Whitfield , Gordon E. Willick
IPC分类号： A61K38/00 , C07K14/635 , A61K38/29
CPC分类号： A61K38/29 , C07K14/635
摘要： This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailabilities. The peptides described are derivatives of hPTH-(1-31) which are cyclized for example, by formation of lactams between either Glu.sup.22 and Lys.sup.26 or Lys.sup.26 and Asp.sup.30. In addition, the natural Lys.sup.27 may be substituted by either a Leu or other hydrophobic residues, such as Ile, norleucine, Met, Val, Ala, Trp, or Phe. Typically, these analogues have enhanced abilities to stimulate adenylyl cyclase in rat osteosarcoma cells, and show increased activities in bone restoration, using the ovariectomized rat model. The analogues also show enhanced activities and bioavailabilities, as demonstrated by their hypotensive effects in the rat. An assay which correlates hypotensive activity with osteogenic activity is also described.
摘要翻译：本发明描述了人甲状旁腺激素的类似物，其具有增加的骨修复活性和增加的生物利用度。所描述的肽是hPTH-（1-31）的衍生物，其被环化，例如通过在Glu22和Lys26或Lys26和Asp30之间形成内酰胺。此外，天然Lys27可以被Leu或其它疏水性残基例如Ile，正亮氨酸，Met，Val，Ala，Trp或Phe取代。通常，这些类似物具有增强的能力来刺激大鼠骨肉瘤细胞中的腺苷酸环化酶，并且使用卵巢切除的大鼠模型显示增加的骨修复活动。类似物还显示出增强的活性和生物利用度，如其在大鼠中的降血压作用所证明的。还描述了将降血压活性与成骨活性相关联的测定法。

6. 发明申请

US20050065071A1 Cyclic analogs of human parathyroid hormone for the treatment of conditions characterized by hyperproliferative skin cells 审中-公开
标题翻译：人类甲状旁腺激素的循环类似物用于治疗以过度增殖性皮肤细胞为特征的病症
公开(公告)号：US20050065071A1
公开(公告)日：2005-03-24
申请号：US10892025
申请日：2004-07-15
申请人： Paul Morley , James Whitfield
发明人： Paul Morley , James Whitfield
IPC分类号： A61K38/29 , A61P17/06
CPC分类号： A61K38/29
摘要： The present invention provides methods for treating conditions characterized by hyperproliferation of skin cells, by administering to an individual in need thereof a cyclic analog of human parathyroid hormone.
摘要翻译：本发明提供了治疗特征为皮肤细胞过度增生的病症的方法，通过向有需要的个体施用人甲状旁腺激素的环状类似物。

7. 发明申请

US20090022684A1 Methods for hematopoietic stimulation 审中-公开
标题翻译：造血刺激方法
公开(公告)号：US20090022684A1
公开(公告)日：2009-01-22
申请号：US11800991
申请日：2007-05-07
申请人： Paul Morley
发明人： Paul Morley
IPC分类号： A61K38/18 , A61K38/17 , A61K38/20 , A61P35/02
CPC分类号： A61K38/29 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/204 , A61K2300/00
摘要： The present invention is directed to new methods for treating a subject in need of hematopoietic stimulation. The present invention is also directed to new methods of neutrophil stimulation in a subject in need thereof. The present invention is also directed to new methods of platelet stimulation in a subject in need thereof. The methods comprise administering to the subject an effective amount of a peptide optionally in combination of a hematopoietic growth factor, wherein the peptide is: (i) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH2 (SEQ ID NO: 1), where Xaa=Lys, Leu, Ile, Nle or Met, preferably Xaa=Lys; or (ii) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y (SEQ ID NO: 2), cyclized in the form of a lactam between Glu22 and Lys26, Xaa=Leu, Ile, Nle or Met, Y=NH2 or OH. Preferably, Xaa is Leu and Y is NH2.
摘要翻译：本发明涉及用于治疗需要造血刺激的受试者的新方法。本发明还涉及有需要的受试者中嗜中性粒细胞刺激的新方法。本发明还涉及有需要的受试者中血小板刺激的新方法。所述方法包括向受试者施用有效量的任选地与造血生长因子组合的肽，其中所述肽是：（i）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn- Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-NH2（SEQ ID NO：1）其中Xaa = Lys，Leu，Ile，Nle或Met，优选Xaa = Lys; 或（ii）Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp- Leu-Arg-Lys-Xaa-Leu-Gln-Asp-Val-Y（SEQ ID NO：2），在Glu22和Lys26之间以内酰胺的形式环化，Xaa = Leu，Ile，Nle或Met，Y = NH 2 或OH。优选地，Xaa是Leu，Y是NH 2。

8. 发明申请

US20070099831A1 Parathyroid hormone analogues and methods of use 审中-公开
标题翻译：甲状旁腺激素类似物和使用方法
公开(公告)号：US20070099831A1
公开(公告)日：2007-05-03
申请号：US11517146
申请日：2006-09-06
申请人： Paul Morley
发明人： Paul Morley
IPC分类号： A61K38/29 , A61K31/59 , A61K33/06
CPC分类号： A61K31/59 , A61K33/06 , A61K38/29 , A61K2300/00
摘要： The present invention is directed to novel methods of treating a subject with a bone deficit disorder. The methods generally include administering to a subject in need thereof a pharmaceutically acceptable formulation comprising a parathyroid hormone (PTH) peptide analogue in a daily dose of 2 μg to 60 μg, wherein said PTH peptide analogue has a reduced phospholipase-C activity and maintains adenylate cyclase activity.
摘要翻译：本发明涉及用骨缺损障碍治疗受试者的新方法。所述方法通常包括向有需要的受试者施用包含甲亢激素（PTH）肽类似物的药学上可接受的制剂，日剂量为2杯至60杯，其中所述PTH肽类似物具有降低的磷脂酶C活性并维持腺苷酸环化酶活性。

9. 发明申请

US20090278316A1 ILLUMINATED GAME 审中-公开
标题翻译：照明游戏
公开(公告)号：US20090278316A1
公开(公告)日：2009-11-12
申请号：US12116979
申请日：2008-05-08
申请人： Randy LaMarte , Paul Morley
发明人： Randy LaMarte , Paul Morley
IPC分类号： A63B43/00
CPC分类号： A63B63/00 , A63B67/06 , A63B69/0079 , A63B2207/00 , A63B2207/02 , A63B2210/50
摘要： On aspect of the present invention comprises an illuminated game having a base having a receiving member; a first member removably received within a receiving member; a third member removably received within a different receiving member. The third member oriented substantially perpendicular to the first member. A second member secured to the first member and the third member. A fourth member secured to the first member and the third member. The fourth member disposed downwardly from the third member. A fifth member secured to the first member and the third member. The fifth member disposed downwardly from the fourth member, each member being transparent. An illumination device disposed within at least one the members.
摘要翻译：本发明的一个方面包括具有底座的照明游戏，该底座具有接收构件; 第一构件，其可移除地容纳在接收构件内; 第三构件，其可移除地容纳在不同的接收构件内。第三构件基本上垂直于第一构件定向。固定到第一个构件和第三个构件的第二个构件。固定到第一个成员和第三个成员的第四个成员。第四构件从第三构件向下设置。固定到第一个成员和第三个成员的第五个成员。第五构件从第四构件向下设置，每个构件是透明的。设置在至少一个构件内的照明装置。

10. 发明申请

US20060068444A1 Compositions and methods for detecting cyclic analogs of hPTH 审中-公开
标题翻译：用于检测hPTH的循环类似物的组合物和方法
公开(公告)号：US20060068444A1
公开(公告)日：2006-03-30
申请号：US11083063
申请日：2005-03-17
申请人： Paul Morley , Ping Gao , Gordon Willick
发明人： Paul Morley , Ping Gao , Gordon Willick
IPC分类号： C07K16/26 , G01N33/53
CPC分类号： C07K14/635 , C07K16/26 , C07K2317/34 , G01N33/74 , G01N33/78 , G01N2333/635
摘要： The present invention is directed to novel antigens, antibodies and antigen binding fragments thereof, and to immunoassays and kits using these antigens and antibodies. The compositions and methods are useful in the determination of levels of cyclic analogs of hPTH in sample fluids, such as serum or plasma. The antibodies and methods of the invention have the particular advantage of possessing binding specificity for cyclic analogs of hPTH.
摘要翻译：本发明涉及新型抗原，抗体及其抗原结合片段，以及使用这些抗原和抗体的免疫测定和试剂盒。组合物和方法可用于测定样品流体如血清或血浆中hPTH的环状类似物的水平。本发明的抗体和方法具有对hPTH的环状类似物具有结合特异性的特别优点。

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