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1. 发明申请

US20110294167A1 NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：核酸放大
公开(公告)号：US20110294167A1
公开(公告)日：2011-12-01
申请号：US13132305
申请日：2009-12-02
申请人： Paul McEwan , Bjarne Faurholm , Eric Van Der Walt
发明人： Paul McEwan , Bjarne Faurholm , Eric Van Der Walt
IPC分类号： C12P19/34 , C12N9/12
CPC分类号： C12Q1/6844 , C12Q2527/125
摘要： The present invention provides improved systems and methods for amplifying nucleic acids. Among other things the present invention provides a system for amplifying nucleic acids through use of a primase and a polymerase with strand-displacement ability without, for example, exogenously-added primers. The present invention is particularly useful for whole genome amplification.
摘要翻译：本发明提供了用于扩增核酸的改进的系统和方法。其中本发明提供了一种通过使用引物酶和具有链置换能力的聚合酶来扩增核酸的系统，而不需要例如外源性加入的引物。本发明对于全基因组扩增特别有用。

2. 发明申请

US20120115188A1 CHIMERIC DNA POLYMERASES 有权
公开(公告)号：US20120115188A1
公开(公告)日：2012-05-10
申请号：US13127420
申请日：2009-11-03
申请人： Bjarne Faurholm , Paul McEwan , William Bourn , Gavin Rush
发明人： Bjarne Faurholm , Paul McEwan , William Bourn , Gavin Rush
IPC分类号： C12P19/34 , C12N1/21 , C07H21/00 , C12N9/10 , C12N15/63
CPC分类号： C12N9/1252 , C12N9/1241 , C12P19/34
摘要： The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same. In some embodiments, the present invention can combine desired functional characteristics (e.g., high processivity; high elongation rate; thermostability; resistance to salt, PCR additives (e.g., PCR enhancers) and other impurities; and high fidelity) of different DNA polymerases in a chimeric polymerase.
摘要翻译：本发明尤其提供了含有异源结构域的嵌合DNA聚合酶，所述异源结构域具有源自至少两种DNA聚合酶的序列，其具有至少一个不同的功能特征（例如伸长率，持续性，错误率或保真度，耐盐性或抗性）以及制作和使用它们的方法。在一些实施方案中，本发明可以将不同DNA聚合酶的所需功能特征（例如，高延展率，高延伸率，耐热性，耐盐性，PCR添加剂（例如PCR增强剂）以及其他杂质以及高保真度）结合在一起嵌合聚合酶。

3. 发明授权

US09023633B2 Chimeric DNA polymerases 有权
标题翻译：嵌合DNA聚合酶
公开(公告)号：US09023633B2
公开(公告)日：2015-05-05
申请号：US13127420
申请日：2009-11-03
申请人： Bjarne Faurholm , Paul McEwan , William Bourn , Gavin Rush
发明人： Bjarne Faurholm , Paul McEwan , William Bourn , Gavin Rush
IPC分类号： C12N9/00 , C12N9/12 , C12P19/34
CPC分类号： C12N9/1252 , C12N9/1241 , C12P19/34
摘要： The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same. In some embodiments, the present invention can combine desired functional characteristics (e.g., high processivity; high elongation rate; thermostability; resistance to salt, PCR additives (e.g., PCR enhancers) and other impurities; and high fidelity) of different DNA polymerases in a chimeric polymerase.
摘要翻译：本发明尤其提供了含有异源结构域的嵌合DNA聚合酶，所述异源结构域具有源自至少两种DNA聚合酶的序列，其具有至少一个不同的功能特征（例如伸长率，持续性，错误率或保真度，耐盐性或抗性）以及制作和使用它们的方法。在一些实施方案中，本发明可以将不同DNA聚合酶的所需功能特征（例如，高延展率，高延伸率，耐热性，耐盐性，PCR添加剂（例如PCR增强剂）以及其他杂质以及高保真度）结合在一起嵌合聚合酶。

4. 发明申请

US20110129415A1 NOVEL ANTIBODY AND USE IN DIAGNOSIS AND THERAPY OF ARTHROPATHIES 有权
标题翻译：新型抗体和用于诊断和治疗ARTHROPATHIES
公开(公告)号：US20110129415A1
公开(公告)日：2011-06-02
申请号：US12598671
申请日：2008-05-02
申请人： Ahuva Nissim , Yuti Chernajovsky , Bjarne Faurholm , David Perrett , Paul Winyard , Christopher Hughes , Stephen Mather , Francesco Dell'Accio
发明人： Ahuva Nissim , Yuti Chernajovsky , Bjarne Faurholm , David Perrett , Paul Winyard , Christopher Hughes , Stephen Mather , Francesco Dell'Accio
IPC分类号： A61K51/10 , C07K16/00 , C07K14/565 , C07K14/52 , A61K39/395 , A61K38/19 , A61K38/21 , A61K49/00 , C07K14/555 , A61P19/02
CPC分类号： A61K47/6851 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6843 , A61K47/6849 , A61K51/1096 , C07K16/18 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/76
摘要： The present invention provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidised Collagen II (Gil) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.
摘要翻译：本发明提供包含抗体或其片段的抗体或其片段与抗体或其片段与药学活性部分缀合的氧化胶原II（CII）的组合物。本发明还提供包含抗氧化胶原II（Gil）和可检测标记的抗体或其片段的组合物。本发明进一步提供了这种组合物在药物中的用途，特别是用于治疗关节病以及诊断方法。

5. 发明授权

US09844602B2 Antibody and use in diagnosis and therapy of arthropathies 有权
公开(公告)号：US09844602B2
公开(公告)日：2017-12-19
申请号：US12598671
申请日：2008-05-02
申请人： Ahuva Nissim , Yuti Chernajovsky , Bjarne Faurholm , David Perrett , Paul Winyard , Christopher Hughes , Stephen Mather , Francesco Dell'Accio
发明人： Ahuva Nissim , Yuti Chernajovsky , Bjarne Faurholm , David Perrett , Paul Winyard , Christopher Hughes , Stephen Mather , Francesco Dell'Accio
IPC分类号： A61K47/48 , A61K51/10 , C07K16/18
CPC分类号： A61K47/6851 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6843 , A61K47/6849 , A61K51/1096 , C07K16/18 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/76
摘要： The present invention provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (Gil) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.

6. 发明授权

US08481685B2 Modified DNA polymerases 有权
标题翻译：修饰的DNA聚合酶
公开(公告)号：US08481685B2
公开(公告)日：2013-07-09
申请号：US13127425
申请日：2009-11-03
申请人： William Bourn , Bjarne Faurholm , John Foskett
发明人： William Bourn , Bjarne Faurholm , John Foskett
IPC分类号： C12P21/08 , C12N9/00 , C12N9/10 , C12N9/12
CPC分类号： C12N9/1252
摘要： The present invention provides, among other things, modified DNA polymerases containing amino acid alterations based on mutations identified in directed evolution experiments designed to select enzymes that are better suited for applications in recombinant DNA technologies.
摘要翻译：本发明尤其提供了包含基于设计用于选择更适合于重组DNA技术应用的酶的定向进化实验中鉴定的突变的氨基酸改变的修饰的DNA聚合酶。

7. 发明申请

US20110269211A1 MODIFIED DNA POLYMERASES 有权
标题翻译：改性DNA聚合酶
公开(公告)号：US20110269211A1
公开(公告)日：2011-11-03
申请号：US13127425
申请日：2009-11-03
申请人： William Bourn , Bjarne Faurholm , John Foskett
发明人： William Bourn , Bjarne Faurholm , John Foskett
IPC分类号： C12N9/12 , C12N1/21 , C07H21/00 , C12N15/63
CPC分类号： C12N9/1252
摘要： The present invention provides, among other things, modified DNA polymerases containing amino acid alterations based on mutations identified in directed evolution experiments designed to select enzymes that are better suited for applications in recombinant DNA technologies.
摘要翻译：本发明尤其提供了包含基于设计用于选择更适合于重组DNA技术应用的酶的定向进化实验中鉴定的突变的氨基酸改变的修饰的DNA聚合酶。

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