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1. 发明授权

US6159725A Transformed yeast strains 失效
标题翻译：转化酵母菌株
公开(公告)号：US6159725A
公开(公告)日：2000-12-12
申请号：US783045
申请日：1997-01-16
申请人： Paul Klaassen , Rutger Jan Van Rooijen
发明人： Paul Klaassen , Rutger Jan Van Rooijen
IPC分类号： C12G1/00 , A21D8/04 , C07K14/395 , C12C11/00 , C12C11/02 , C12G1/022 , C12N1/19 , C12N15/09 , C12N15/81 , C12P7/06 , C12R1/865 , C12N1/16 , C12P21/06
CPC分类号： C12C12/006 , A21D8/047 , C07K14/395 , C12C12/004 , C12G1/0203 , C12N15/81 , Y02E50/17
摘要： Transformed yeasts are provided which constitutively express a hexose transporter gene. The transformed yeast can be used in the beer, bread, wine and whisky production.
摘要翻译：提供了组成型表达己糖转运蛋白基因的转化酵母。转化酵母可用于啤酒，面包，葡萄酒和威士忌生产。

2. 发明申请

US20140162312A1 PENTOSE SUGAR FERMENTING CELL 有权
标题翻译：戊香糖发酵细胞
公开(公告)号：US20140162312A1
公开(公告)日：2014-06-12
申请号：US14236191
申请日：2012-08-02
申请人： Paul Klaassen , Gijsberdina Pieternella Van Suylekom , Rene Marcel De Jong
发明人： Paul Klaassen , Gijsberdina Pieternella Van Suylekom , Rene Marcel De Jong
IPC分类号： C12N15/81 , C12P7/16 , C12P7/56 , C12P7/42 , C12P7/40 , C12P35/00 , C12P7/46 , C12P7/48 , C12P7/18 , C12P5/02 , C12P7/20 , C12P7/06 , C12P7/54
CPC分类号： C12N15/81 , C12N9/92 , C12N15/815 , C12P5/026 , C12P7/06 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P35/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
摘要翻译：本发明涉及包含编码木糖异构酶的核苷酸序列的细胞，其中所述木糖异构酶的氨基酸序列与SEQ ID NO：2所示的氨基酸序列具有至少75％的序列同一性，并且其中所述核苷酸序列与宿主异源。本发明的细胞可用于生产发酵产物如乙醇的方法中。这样的方法可以包括用本发明的细胞发酵含有木糖来源的培养基，使得细胞向发酵产物发酵木糖。

3. 发明申请

US20120034648A1 PENTOSE SUGAR FERMENTING CELL 有权
标题翻译：戊香糖发酵细胞
公开(公告)号：US20120034648A1
公开(公告)日：2012-02-09
申请号：US12867927
申请日：2009-03-05
申请人： Paul Klaassen , Jan Metske Van Der Laan , Bianca Elisabeth Maria Gielesen , Gijsberdina Pieternella Van Suylekom
发明人： Paul Klaassen , Jan Metske Van Der Laan , Bianca Elisabeth Maria Gielesen , Gijsberdina Pieternella Van Suylekom
IPC分类号： C12P37/00 , C12N1/14 , C12N1/15 , C12N1/19 , C12P1/00 , C12P7/06 , C12P7/16 , C12P7/56 , C12P7/52 , C12P7/54 , C12P7/48 , C12P7/46 , C12P7/44 , C12P13/04 , C12P7/18 , C12P7/20 , C12P35/00 , C12N1/16
CPC分类号： C12N9/92 , C12P7/10 , Y02E50/16
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
摘要翻译：本发明涉及包含编码木糖异构酶的核苷酸序列的细胞，其中木糖异构酶的氨基酸序列与SEQ ID NO：3所示的氨基酸序列具有至少约70％的序列同一性，其中所述核苷酸序列与宿主异源。本发明的细胞可用于生产发酵产物如乙醇的方法中。这样的方法可以包括用本发明的细胞发酵含有木糖来源的培养基，使得细胞向发酵产物发酵木糖。

4. 发明申请

US20100009404A1 PRODUCTION OF BETA-LACTAM ANTIBIOTICS 有权
标题翻译：生产β-LACTAM抗生素
公开(公告)号：US20100009404A1
公开(公告)日：2010-01-14
申请号：US12444108
申请日：2007-10-02
申请人： Marcus Hans , Roelof Ary Lans Bovenberg , Paul Klaassen , Rémon Boer , Jan Metske Van Der Laan
发明人： Marcus Hans , Roelof Ary Lans Bovenberg , Paul Klaassen , Rémon Boer , Jan Metske Van Der Laan
IPC分类号： C12P37/00 , C12N9/00 , C12N15/52 , C12N1/21 , C12P35/00
CPC分类号： C12N9/0004
摘要： The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl-valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N-hydroxyphenylglycyl or the N-phenylglycyl β-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides. Also a host cell is provided capable of fermentatively producing β-lactam antibiotics with N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl side chains.
摘要翻译：本发明描述了制备N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯基乙酰基β-内酰胺抗生素的方法，其包括前体三肽羟基苯基甘氨酰 - 半胱氨酰 - 缬氨酸（HpgCV）或苯基甘氨酰 - 半胱氨酰缬氨酸（PgCV）分别分别与N-羟基苯基甘氨酰或N-苯基甘氨酰β-内酰胺抗生素。三肽HpgCV或三肽PgCV可以通过使氨基酸羟基苯基甘氨酸（Hpg）或苯基甘氨酸（Pg），半胱氨酸（C）和缬氨酸（V）与非核糖体肽合成酶（NRPS）接触来进一步制备，以形成三肽HpgCV或三肽PgCV，NRPS包括特定于Hpg或Pg的第一模块M1，特定于C的第二模块M2和特定于V An IPNS的第三模块M3，还具有在该转换中具有改进的活性作为催化三肽形成的NRPS。还提供了能够用N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯乙酰侧链发酵生产β-内酰胺抗生素的宿主细胞。

5. 发明授权

US09701972B2 Pentose sugar fermenting cell 有权
公开(公告)号：US09701972B2
公开(公告)日：2017-07-11
申请号：US14236191
申请日：2012-08-02
申请人： Paul Klaassen , Gijsberdina Pieternella Van Suylekom , Rene Marcel De Jong
发明人： Paul Klaassen , Gijsberdina Pieternella Van Suylekom , Rene Marcel De Jong
IPC分类号： C12N15/81 , C12N9/92 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P5/02 , C12P7/06 , C12P35/00
CPC分类号： C12N15/81 , C12N9/92 , C12N15/815 , C12P5/026 , C12P7/06 , C12P7/10 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P35/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

6. 发明授权

US09034608B2 Polypeptides with permease activity 有权
标题翻译：具有通透酶活性的多肽
公开(公告)号：US09034608B2
公开(公告)日：2015-05-19
申请号：US13822288
申请日：2011-10-11
申请人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
发明人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
IPC分类号： C12P19/18 , C12P7/56 , C12P7/16 , C12P7/06 , C12P7/14 , C12N9/12 , C12N1/00 , C12P21/06 , C12P19/34 , C12N15/00 , C07H21/04 , C07K1/00 , C12N15/81 , C07K14/395 , C12P7/10
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译：本发明涉及在一个或多个对应于SEQ ID NO：55的T219的位置具有突变的多肽，其中多肽与SEQ ID NO：55具有至少50％的序列同一性，并且其中多肽具有通透酶活性。

7. 发明授权

US09096675B2 Cell suitable for fermentation of a mixed sugar composition 有权
标题翻译：适合发酵混合糖组合物的细胞
公开(公告)号：US09096675B2
公开(公告)日：2015-08-04
申请号：US13642114
申请日：2011-04-19
申请人： Paul Klaassen , Bianca Elisabeth Maria Gielesen , Gijsberdina Pieternella Van Suylekom , Wilbert Herman Marie Heijne
发明人： Paul Klaassen , Bianca Elisabeth Maria Gielesen , Gijsberdina Pieternella Van Suylekom , Wilbert Herman Marie Heijne
IPC分类号： C12P7/06 , C12N1/20 , C12N9/00 , C07K14/395 , C12N1/36
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/0004 , C12N9/0006 , C12N9/10 , C12N9/1205 , C12N9/16 , C12N9/2405 , C12N9/2411 , C12N9/2437 , C12N9/2468 , C12N9/248 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/026 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/005 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/227 , C12P17/10 , C12P35/00 , C12Y101/01 , C12Y207/01016 , C12Y501/03004 , C12Y503/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.
摘要翻译：本发明涉及适用于从包含葡萄糖，半乳糖，阿拉伯糖和木糖的糖组合物生产一种或多种发酵产物的细胞，其中所述细胞包含两至十五份一种或多种木糖异构酶基因或两至十五份一种或多种木糖还原酶和木糖醇脱氢酶，以及两到十个拷贝的araA，araB和araD基因，其中这些基因整合到细胞基因组中。

8. 发明申请

US20140141473A1 YEAST CELL CAPABLE OF CONVERTING SUGARS INCLUDING ARABINOSE AND XLOSE 审中-公开
标题翻译： YEAST细胞能转化糖，包括阿拉伯胶和XLOSE
公开(公告)号：US20140141473A1
公开(公告)日：2014-05-22
申请号：US14112713
申请日：2012-04-20
申请人： Paul Klaassen , Bianca Elisabeth Maria Gielesen , Gijsberdina Pieternella Van Suylekom , Panagiotis Sarantinopoulos , Wilbert Herman Marie Heijne , Aldo Greeve
发明人： Paul Klaassen , Bianca Elisabeth Maria Gielesen , Gijsberdina Pieternella Van Suylekom , Panagiotis Sarantinopoulos , Wilbert Herman Marie Heijne , Aldo Greeve
IPC分类号： C12P7/10
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/1205 , C12N9/90 , C12N9/92 , C12P2203/00 , C12R1/865 , C12Y207/01016 , C12Y503/01 , C12Y503/01003 , C12Y503/01005 , Y02E50/16
摘要： Yeast cell belonging to the genus Saccharomyces having introduced into its genome at least one xylA gene and at least one of each of araA, araB and araD genes and that is capable of consuming a mixed sugar mixture comprising glucose, xylose and arabinose, wherein the cell co-consumes glucose and arabinose, has genetic variations obtained during adaptive evolution and has a specific xylose consumption rate in the presence of glucose that is 0.25 g xylose/h, g DM or more.
摘要翻译：属于酵母属的酵母细胞已经在其基因组中引入了至少一种xylA基因和araA，araB和araD基因中的至少一种，并且能够消耗包含葡萄糖，木糖和阿拉伯糖的混合糖混合物，其中细胞共同消耗葡萄糖和阿拉伯糖，在适应性进化过程中获得遗传变异，并且在葡萄糖存在下具有特异性的木糖消耗率，其为0.25g木糖/ h，g DM或更多。

9. 发明申请

US20130236932A1 POLYPEPTIDES WITH PERMEASE ACTIVITY 有权
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：US20130236932A1
公开(公告)日：2013-09-12
申请号：US13822288
申请日：2011-10-11
申请人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
发明人： Hendrik Wouter Wisselink , Antonius Jeroen Adriaan Van Maris , Jacobus Thomas Pronk , Paul Klaassen , Rene Marcel De Jong
IPC分类号： C12N9/12
CPC分类号： C12N15/81 , C07K14/395 , C12N9/1205 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.
摘要翻译：本发明涉及在一个或多个对应于SEQ ID NO：55的T219的位置具有突变的多肽，其中多肽与SEQ ID NO：55具有至少50％的序列同一性，并且其中多肽具有通透酶活性。

10. 发明授权

US08293511B2 Production of β-Lactam antibiotics 有权
标题翻译：生产＆bgr - 内酰胺抗生素
公开(公告)号：US08293511B2
公开(公告)日：2012-10-23
申请号：US12444108
申请日：2007-10-02
申请人： Marcus Hans , Roelof Ary Lans Bovenberg , Paul Klaassen , Rémon Boer , Jan Metske Van Der Laan
发明人： Marcus Hans , Roelof Ary Lans Bovenberg , Paul Klaassen , Rémon Boer , Jan Metske Van Der Laan
IPC分类号： C12N9/00 , C12P37/00
CPC分类号： C12N9/0004
摘要： The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl-valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N-hydroxyphenylglycyl or the N-phenylglycyl β-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides. Also a host cell is provided capable of fermentatively producing β-lactam antibiotics with N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl side chains.
摘要翻译：本发明描述了一种制备N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯基乙酰基 - 内酰胺抗生素的方法，其包括前体三肽羟基苯基甘氨酰 - 半胱氨酰 - 缬氨酸（HpgCV）或苯基甘氨酰 - 半胱氨酰缬氨酸（PgCV）分别转化为N-羟基苯基甘氨酰或N-苯基甘氨酰和β-内酰胺抗生素。三肽HpgCV或三肽PgCV可以通过使氨基酸羟基苯基甘氨酸（Hpg）或苯基甘氨酸（Pg），半胱氨酸（C）和缬氨酸（V）与非核糖体肽合成酶（NRPS）接触来进一步制备，以形成三肽HpgCV或三肽PgCV，NRPS包括特定于Hpg或Pg的第一模块M1，特定于C的第二模块M2和特定于V An IPNS的第三模块M3，还具有在该转换中具有改进的活性作为催化三肽形成的NRPS。还提供了能够用N-α-氨基 - 羟基苯基乙酰基或N-α-氨基苯乙酰侧链发酵生产β-内酰胺抗生素的宿主细胞。

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