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1. 发明授权

US5126433A Soluble forms of the T cell surface protein CD4 失效
标题翻译： T细胞表面蛋白CD4的可溶形式
公开(公告)号：US5126433A
公开(公告)日：1992-06-30
申请号：US114244
申请日：1987-10-23
申请人： Paul J. Maddon , Leonard Chess , Richard Axel , Robin Weiss , Dan R. Littman , J. Steven McDougal
发明人： Paul J. Maddon , Leonard Chess , Richard Axel , Robin Weiss , Dan R. Littman , J. Steven McDougal
IPC分类号： A61K38/00 , C07K14/725 , C07K14/73 , C12Q1/70
CPC分类号： C12Q1/703 , C07K14/70514 , A61K38/00
摘要： A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
摘要翻译：提供编码包含至少一部分T4糖蛋白的氨基酸序列的单链核酸分子。此外，提供了包含T4糖蛋白的至少一部分并且可用作预防用于治疗获得性免疫缺陷综合征的受试者的氨基酸序列。这些氨基酸序列能够与人免疫缺陷病毒包膜糖蛋白特异性形成复合物，并且其可溶于水溶液。可以使用针对本发明的水溶性氨基酸序列的单克隆抗体作为用于免疫受试者免疫获得性免疫缺陷综合征的疫苗。

2. 发明授权

US6093539A DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS 失效
标题翻译：编码T细胞表面蛋白T4的DNA和使用T4片段治疗艾滋病
公开(公告)号：US6093539A
公开(公告)日：2000-07-25
申请号：US466368
申请日：1995-06-06
申请人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss , J. Steven McDougal
发明人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss , J. Steven McDougal
IPC分类号： A61K38/00 , C07K14/725 , C07K14/73 , C12N15/12 , C12Q1/68 , C12N5/10 , C12N15/63
CPC分类号： C07K14/70514 , A61K38/00
摘要： This invention provides an isolated single-stranded nucleic acid which encodes an aqueous-soluble polypeptide comprising at least a portion of a human T4 glycoprotein, which portion specifically forms a complex with a human immunodeficiency virus envelope glycoprotein.
摘要翻译：本发明提供了分离的单链核酸，其编码包含至少一部分人T4糖蛋白的水溶性多肽，该部分与人免疫缺陷病毒包膜糖蛋白特异性形成复合物。

3. 发明授权

US5871913A DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS 失效
标题翻译：编码T细胞表面蛋白T4的DNA和使用T4片段治疗艾滋病
公开(公告)号：US5871913A
公开(公告)日：1999-02-16
申请号：US462138
申请日：1995-06-05
申请人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss , J. Steven McDougal
发明人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss , J. Steven McDougal
IPC分类号： C12N15/09 , A61K38/00 , A61P31/12 , C07H21/04 , C07K14/00 , C07K14/73 , C12N1/21 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/91 , G01N33/569 , G01N33/577
CPC分类号： C12Q1/703 , C07K14/70514 , A61K38/00
摘要： A single-stranded nucleic acid molecule which encodes the amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4 cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
摘要翻译：提供编码包含至少一部分T4糖蛋白的氨基酸序列的单链核酸分子。此外，提供了包含T4糖蛋白的至少一部分并且可用作预防用于治疗获得性免疫缺陷综合征的受试者的氨基酸序列。能够与人免疫缺陷病毒糖蛋白特异性形成复合物并且可溶于水溶液的这些氨基酸序列可以施用于感染人免疫缺陷病毒的受试者，以阻止人类免疫缺陷病毒结合 T4细胞。可以使用针对本发明的水溶性氨基酸序列的单克隆抗体作为用于免疫受试者免疫获得性免疫缺陷综合征的疫苗。

4. 发明授权

US5958678A DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS 失效
标题翻译：编码T细胞表面蛋白T4的DNA和使用T4片段治疗艾滋病
公开(公告)号：US5958678A
公开(公告)日：1999-09-28
申请号：US354452
申请日：1994-12-12
申请人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss , J. Steven McDougal
发明人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss , J. Steven McDougal
IPC分类号： A61K38/00 , C07K14/725 , C07K14/73 , C12N15/12 , C12Q1/68 , C07K1/00 , A61K45/05 , A61K39/38
CPC分类号： C07K14/70514 , A61K38/00
摘要： A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4.sup.+ cells.Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
摘要翻译：提供编码包含至少一部分T4糖蛋白的氨基酸序列的单链核酸分子。此外，提供了包含T4糖蛋白的至少一部分并且可用作预防用于治疗获得性免疫缺陷综合征的受试者的氨基酸序列。能够与人免疫缺陷病毒包膜糖蛋白特异性形成复合物并且可溶于水溶液的这些氨基酸序列可以施用于感染人免疫缺陷病毒的受试者，以阻止人免疫缺陷病毒结合到T4 +细胞。可以使用针对本发明的水溶性氨基酸序列的单克隆抗体作为用于免疫受试者免疫获得性免疫缺陷综合征的疫苗。

5. 发明授权

US06570000B1 DNA encoding the T cell surface protein CD4 and use of fragments of CD4 in the treatment of AIDS 失效
标题翻译：编码T细胞表面蛋白的DNA和使用CD4的片段来治疗艾滋病
公开(公告)号：US06570000B1
公开(公告)日：2003-05-27
申请号：US08470998
申请日：1995-06-06
申请人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss
发明人： Paul J. Maddon , Dan R. Littman , Leonard Chess , Richard Axel , Robin Weiss
IPC分类号： C07H2104
CPC分类号： C12Q1/703 , A61K38/00 , C07K14/70514
摘要： A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4+ cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
摘要翻译：提供编码包含至少一部分T4糖蛋白的氨基酸序列的单链核酸分子。此外，提供了包含T4糖蛋白的至少一部分并且可用作预防用于治疗获得性免疫缺陷综合征的受试者的氨基酸序列。能够与人免疫缺陷病毒包膜糖蛋白特异性形成复合物并且可溶于水溶液的这些氨基酸序列可以施用于感染人免疫缺陷病毒的受试者，以阻止人免疫缺陷病毒结合可以使用针对本发明的水溶性氨基酸序列的单克隆抗体作为用于免疫受试者免疫获得性免疫缺陷综合征的疫苗。

6. 发明授权

US5110906A Derivatives of soluble T-4 失效
标题翻译：可溶性T-4的衍生物
公开(公告)号：US5110906A
公开(公告)日：1992-05-05
申请号：US160348
申请日：1988-02-24
申请人： Paul J. Maddon , Richard Axel , Raymond W. Sweet , James Arthos
发明人： Paul J. Maddon , Richard Axel , Raymond W. Sweet , James Arthos
IPC分类号： C12N15/09 , A61K38/00 , A61P31/12 , C07K14/00 , C07K14/725 , C07K14/73 , C07K16/28 , C12N5/10 , C12P21/02 , C12Q1/70 , C12R1/91
CPC分类号： C12Q1/703 , C07K14/70514 , C07K16/2812 , A61K38/00 , Y10S435/974 , Y10S530/821 , Y10S930/221
摘要： This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185.This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供能够特异性形成与包含多肽的人免疫缺陷病毒包膜糖蛋白复合物的治疗剂。在本发明的一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。约1 + 1至约+ 18 5的氨基酸序列与约+353至约+ 371融合。在本发明的另一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。与约+353至约+ 371的氨基酸序列融合的约1 + 1至约+ 10 6。在本发明的另一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。 6从约+1到约+185。本发明还提供了治疗感染人免疫缺陷病毒的受试者的方法。该方法包括向受试者施用有效量的包含有效量的本发明治疗剂和药学上可接受的载体的药物组合物。

7. 发明授权

US5422274A Internal deletion mutants of soluble T4(CD4) 失效
标题翻译：可溶性T4（CD4）的内部缺失突变体
公开(公告)号：US5422274A
公开(公告)日：1995-06-06
申请号：US830489
申请日：1992-02-05
申请人： Paul J. Maddon , Richard Axel , Raymond W. Sweet , James Arthos
发明人： Paul J. Maddon , Richard Axel , Raymond W. Sweet , James Arthos
IPC分类号： C12N15/09 , A61K38/00 , A61P31/12 , C07K14/00 , C07K14/725 , C07K14/73 , C07K16/28 , C12N5/10 , C12P21/02 , C12Q1/70 , C12R1/91 , C12N15/00 , A61K39/00 , C07K1/00
CPC分类号： C12Q1/703 , C07K14/70514 , C07K16/2812 , A61K38/00 , Y10S435/974 , Y10S530/821 , Y10S930/221
摘要： This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185.This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method treats the subject with an effective amount of a pharmaceutical composition having an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供能够特异性形成与包含多肽的人免疫缺陷病毒包膜糖蛋白复合物的治疗剂。在本发明的一个实施方案中，多肽的氨基酸序列具有图1所示的氨基酸序列。约1 + 1至约+ 18 5的氨基酸序列与约+353至约+ 371融合。在本发明的另一个实施方案中，多肽的氨基酸序列具有图1所示的氨基酸序列。与约+353至约+ 371的氨基酸序列融合的约1 + 1至约+ 10 6。在本发明的又一个实施方案中，多肽的氨基酸序列具有图1所示的氨基酸序列。 6从约+1到约+185。本发明还提供了治疗感染人免疫缺陷病毒的受试者的方法。该方法用有效量的具有有效量的本发明的治疗剂和药学上可接受的载体的药物组合物治疗受试者。

8. 发明授权

US06673896B1 Derivatives of soluble T-4 失效
标题翻译：可溶性T-4的衍生物
公开(公告)号：US06673896B1
公开(公告)日：2004-01-06
申请号：US08328500
申请日：1994-10-25
申请人： Paul J. Maddon , Richard Axel
发明人： Paul J. Maddon , Richard Axel
IPC分类号： C07K100
CPC分类号： C12Q1/703 , A61K38/00 , C07K14/70514 , C07K16/2812
摘要： This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185. This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供能够特异性形成与包含多肽的人免疫缺陷病毒包膜糖蛋白复合物的治疗剂。在本发明的一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。约1 + 1至约+ 18 5的氨基酸序列与约+353至约+ 371融合。在本发明的另一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。与约+353至约+ 371的氨基酸序列融合的约1 + 1至约+ 10 6。在本发明的另一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。 6为约+1至约+ 185.本发明还提供了一种治疗感染人类免疫缺陷病毒的受试者的方法。该方法包括向受试者施用有效量的包含有效量的本发明治疗剂和药学上可接受的载体的药物组合物。

9. 发明申请

US20190261597A1 RAIL SYSTEM, AND APPARTUS AND METHOD FOR VIRTUAL BURROW ASSAY FOR A DIVERSITY OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS 审中-公开
公开(公告)号：US20190261597A1
公开(公告)日：2019-08-29
申请号：US16392767
申请日：2019-04-24
申请人： Tanya Tabachnik , Andrew J.P. Fink , Carl E. Schoonover , Richard Axel
发明人： Tanya Tabachnik , Andrew J.P. Fink , Carl E. Schoonover , Richard Axel
IPC分类号： A01K1/03 , A01K29/00 , G05B19/4155
摘要： Methods and apparatuses are provided for a virtual burrow assay for a diversity of neurological and psychiatric disorders. For example, a virtual burrow assay device including a virtual burrow (or enclosure), a linear actuator and one or more sensors is provided. A novel rail system is configured to have a lightweight configuration which, when coupled to the virtual burrow or enclosure, reduces inertia of the virtual burrow or enclosure and can facilitate nearly-frictionless motion of the virtual burrow or enclosure.

10. 发明申请

US20190133521A1 VIRTUAL BURROW ASSAY FOR A DIVERSITY OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS 审中-公开
公开(公告)号：US20190133521A1
公开(公告)日：2019-05-09
申请号：US16149310
申请日：2018-10-02
申请人： Carl E. Schoonover , Andrew J.P. Fink , Richard Axel
发明人： Carl E. Schoonover , Andrew J.P. Fink , Richard Axel
IPC分类号： A61B5/00 , A61K49/00 , A61D3/00 , A61B5/11 , A61B5/16
CPC分类号： A61B5/4884 , A61B5/11 , A61B5/1105 , A61B5/16 , A61B2503/40 , A61B2503/42 , A61D3/00 , A61D2003/003 , A61K49/0008
摘要： Methods and apparatuses are provided for a virtual burrow assay for a diversity of neurological and psychiatric disorders. For example, a virtual burrow array device including a virtual, burrow, a linear actuator and one or more sensors is provided.

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