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1. 发明授权

US06254829B1 Optochemical sensor 有权
标题翻译：光化学传感器
公开(公告)号：US06254829B1
公开(公告)日：2001-07-03
申请号：US09161841
申请日：1998-09-28
申请人： Paul Hartmann , Marco Jean Pierre Leiner
发明人： Paul Hartmann , Marco Jean Pierre Leiner
IPC分类号： G01N2101
CPC分类号： G01N21/6408 , G01N21/6428 , G01N2021/6432 , G01N2021/773 , G01N2021/7786 , Y10T436/20 , Y10T436/207497
摘要： There is disclosed an optical sensor including a matrix containing a luminescence indicator whose luminescence may be quenched by oxygen. The optical sensor contains at least one agent capable of deactivating singlet oxygen and has an enhanced stability relative to oxygen.
摘要翻译：公开了一种光学传感器，其包括含有其发光可被氧淬灭的发光指示器的基体。光学传感器包含至少一种能够使单线态氧失活并且相对于氧具有增强的稳定性的试剂。

2. 发明授权

US6124135A Method of determining an alkali ion 失效
标题翻译：碱离子的测定方法
公开(公告)号：US6124135A
公开(公告)日：2000-09-26
申请号：US85807
申请日：1998-05-27
申请人： Marco Jean Pierre Leiner , Huarui He , Andrei Boila-Gockel
发明人： Marco Jean Pierre Leiner , Huarui He , Andrei Boila-Gockel
IPC分类号： G01N21/76 , C07D273/00 , C07D413/10 , C07D498/08 , C09K11/07 , G01N31/22 , G01N33/20
CPC分类号： C07D413/10 , G01N31/22
摘要： The invention relates to a method of determining an alkali ion in a sample, wherein the alkali ion is contacted with a compound having a luminophoric moiety and an ionophoric moiety, which ionophoric moiety reacts with the alkali ion present in the sample, wherein the luminophoric moiety changes its luminescence properties, after which the luminescence is measured and the alkali ion determined utilizing the test reading, which method is characterized in that the compound utilized is a diaza-cryptand of the general Formula I: ##STR1## in which X is the luminophoric moiety, m is the number 0, 1 or 2, and o and p independently mean the numbers 0, 1 or 2.
摘要翻译：本发明涉及一种测定样品中的碱离子的方法，其中碱离子与具有发光部分和离子部分的化合物接触，离子部分与存在于样品中的碱离子反应，其中发光部分改变其发光特性，之后测量发光，并且使用测试读数确定碱离子，该方法的特征在于所用的化合物是通式I的二氮基 - 穴状物：其中X是发光部分，m 是数字0，1或2，o和p独立地表示数字0,1或2。

3. 发明授权

US5952491A Method of determining an alkali ion 失效
标题翻译：碱离子的测定方法
公开(公告)号：US5952491A
公开(公告)日：1999-09-14
申请号：US085218
申请日：1998-05-27
申请人： Marco Jean Pierre Leiner , Huarui He , Andrei Boila-Gockel
发明人： Marco Jean Pierre Leiner , Huarui He , Andrei Boila-Gockel
IPC分类号： G01N21/76 , C07D273/00 , C07D413/10 , C07D498/08 , C09K11/07 , G01N31/22 , C07D419/02 , G01N21/64
CPC分类号： C07D413/10 , G01N31/22
摘要： The invention relates to a method of determining an alkali ion in a sample, wherein the alkali ion is contacted with a compound having a luminophoric moiety and an ionophoric moiety, which ionophoric moiety reacts with the alkali ion present in the sample, wherein the luminophoric moiety changes its luminescence properties, after which the luminescence is measured and the alkali ion determined utilizing the test reading,which method is characterized in that the compound utilized is a monoaza-crown ether of the general Formula I ##STR1## in which X is the luminophoric moiety, m is the number 0, 1 or 2, and r and s independently mean the numbers 0, 1 or 2.
摘要翻译：本发明涉及一种测定样品中的碱离子的方法，其中碱离子与具有发光部分和离子部分的化合物接触，离子部分与存在于样品中的碱离子反应，其中发光部分改变其发光性能，之后测量发光，并且使用测试读数确定碱离子，该方法的特征在于所用的化合物是通式I的单加冠 - 冠醚，其中X是发光部分，m 是数字0,1或2，r和s独立地表示数字0,1或2。

4. 发明申请

US20100271213A1 Process and Device for Determining Recommendations for Active Ingredient Dosages on the Basis of Series of Measurements of at Least One Physiological Parameter of a Patient 审中-公开
标题翻译：用于确定基于患者的至少一个生理参数的一系列测量的活性成分剂量的建议的方法和装置
公开(公告)号：US20100271213A1
公开(公告)日：2010-10-28
申请号：US12766455
申请日：2010-04-23
申请人： Michael Krainz , Marco Jean Pierre Leiner
发明人： Michael Krainz , Marco Jean Pierre Leiner
IPC分类号： G08B23/00 , G06F19/00 , G01N33/50
CPC分类号： A61B5/4839 , A61B5/14532 , A61M5/1723 , A61M2205/18 , G06F19/3456
摘要： A process comprises performing a series of measurements of at least one physiological parameter, in particular a blood value, such as, e.g., blood sugar, on a patient, wherein samples are taken from the patient at discrete measuring times, with the measurements being performed on those samples. A recommendation for a dosage of an active ingredient to be administered to the patient until the next measuring time is determined from the measurements, for which purpose a dosage proposal algorithm incorporating the at least one measured physiological parameter is applied. As a result, it is possible to adjust at least one physiological parameter of the patient to a target range or keep it in the target range, respectively. The dosage proposal algorithm is configured such that the next measuring time is determined in consideration of measurement exclusion time windows and is optionally reported to the person in charge.
摘要翻译：一种方法包括对患者进行至少一个生理参数，特别是血糖值（例如血糖）的一系列测量，其中以离散的测量时间从患者身上取出样本，并进行测量在这些样品上。根据测量确定要向患者施用的活性成分的剂量直到下一个测量时间的建议，为此应用包含至少一个测量的生理参数的剂量提议算法。结果，可以将患者的至少一个生理参数调整到目标范围或将其保持在目标范围内。剂量提议算法被配置为使得下一个测量时间考虑到测量排除时间窗口来确定，并且可选地向负责人报告。

5. 发明授权

US06211359B1 Triaza-cryptand and method of determining an alkali ion 有权
标题翻译： Triaza-cryptand和测定碱离子的方法
公开(公告)号：US06211359B1
公开(公告)日：2001-04-03
申请号：US09375366
申请日：1999-08-17
申请人： Huarui He , Mark Alan Mortellaro , Marco Jean Pierre Leiner
发明人： Huarui He , Mark Alan Mortellaro , Marco Jean Pierre Leiner
IPC分类号： C07D41914
CPC分类号： C07D498/08 , C07F5/022 , G01N31/22 , G01N33/84
摘要： The invention relates to a triaza-cryptand of the general Formula I wherein a is selected from the group consisting of 0 and 1, b and c independently are selected from the group consisting of 0 and 1, with the proviso that not both of b and c are 0, d is selected from the group consisting of 1, 2 and 3, e and f independently are selected from the group consisting of 0 and 1, with the proviso that not both of e and f are 0, R1 and R2 are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1C4) benzene ring together with C1 and C2, wherein C2 is the para position, R3 and R2 are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1-C4) benzene ring together with C3 and C4, wherein C3 is the para position, R5 and R6 are either hydrogen or form a benzene ring or a naphtalene ring together with C5 and C6, R7 and R8 are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1-C4) benzene ring together with C7 and C8, wherein C8 is the para position, R9 and R10 are either hydrogen or form an alkyl(C1-C4) benzene ring or an alkoxy(C1-C4) benzene ring together with C9 and C10, wherein C9 is the para position, X is a luminophoric moiety in ortho, para or meta position with respect to the nitrogen and m is selected from the group consisting of 0, 1 and 2. The triaza-cryptand of the invention is useful as a luminescence indicator for alkali ions.
摘要翻译：本发明涉及通式I的三氮杂穴，其中选自0和1，b和c独立地选自0和1，条件是b和c两者不是 0，d选自1,2和3，e和f独立地选自0和1，条件是e和f都不是0，R1和R2是氢或与C 1和C 2一起形成烷基（C 1 -C 4）苯环或烷氧基（C 1 -C 4）苯环，其中C 2为对位，R 3和R 2为氢或形成烷基（C 1 -C 4）苯环或烷氧基（C 1 -C 4）苯环与C 3和C 4一起，其中C 3为对位，R 5和R 6为氢或与C 5和C 6一起形成苯环或萘环，R 7和R 8为氢或与C 7和C 8一起形成烷基（C 1 -C 4）苯环或烷氧基（C 1 -C 4）苯环，其中C 8为对位，R 9和R 10 是氢或与C9和C10一起形成烷基（C1-C4）苯环或烷氧基（C1-C4）苯环，其中C9是对位，X是邻位，对位或间位的发光部分，相对于氮，m选自0,1和2.本发明的三氮cry穴可用作碱离子的发光指示剂。

6. 发明授权

US08262992B2 Modular sensor cassette 有权
标题翻译：模块化传感器盒
公开(公告)号：US08262992B2
公开(公告)日：2012-09-11
申请号：US12269280
申请日：2008-11-12
申请人： Heinz Kontschieder , Marco Jean Pierre Leiner , Wolfgang Huber , Franz-Josef Krysl , Christoph Ritter , Helmut Offenbacher , Bernhard Schaffar , Marie-Luise Schinnerl , Johann Harer
发明人： Heinz Kontschieder , Marco Jean Pierre Leiner , Wolfgang Huber , Franz-Josef Krysl , Christoph Ritter , Helmut Offenbacher , Bernhard Schaffar , Marie-Luise Schinnerl , Johann Harer
IPC分类号： G01N21/00
CPC分类号： G01N33/48771 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2300/021 , B01L2300/022 , B01L2300/0627 , B01L2300/0645 , B01L2300/1805 , B01L2300/1883 , B01L2400/0481 , B01L2400/0655
摘要： The invention concerns a sensor cassette that can be inserted into an analyzer comprising a continuous measuring channel for receiving fluidic media and sensory elements for determining chemical and/or physical parameters of the fluidic media. According to the invention the sensor cassette consists of at least two permanently connected but separately manufactured modules which each have a housing and a measuring channel section wherein the measuring channel sections of adjacent modules are connected to the continuous measuring channel by a fluidic coupling and wherein at least one of the connected modules is designed as a sensor module and has a sensor array comprising at least two sensory elements. Furthermore, a memory element is allocated to the sensor cassette on which specific information for the sensor cassette in particular with regard to its construction from the respective modules is stored.
摘要翻译：本发明涉及一种可插入分析器中的传感器盒，该分析器包括用于接收流体介质的连续测量通道和用于确定流体介质的化学和/或物理参数的感官元件。根据本发明，传感器盒由至少两个永久连接但单独制造的模块组成，每个模块具有壳体和测量通道部分，其中相邻模块的测量通道部分通过流体耦合连接到连续测量通道，并且其中连接的模块中的至少一个被设计为传感器模块，并且具有包括至少两个感觉元件的传感器阵列。此外，将存储元件分配给传感器盒，在该传感器盒上存储有关于其各个模块的结构的特别是传感器盒的特定信息。

7. 发明申请

US20090156966A1 MODULAR SENSOR CASSETTE 有权
标题翻译：模块式传感器CASSETTE
公开(公告)号：US20090156966A1
公开(公告)日：2009-06-18
申请号：US12269280
申请日：2008-11-12
申请人： Heinz Kontschieder , Marco Jean Pierre Leiner , Wolfgang Huber , Franz-Josef Krysl , Christoph Ritter , Helmut Offenbacher , Bernhard Schaffar , Marie-Luise Schinnerl , Johann Harer
发明人： Heinz Kontschieder , Marco Jean Pierre Leiner , Wolfgang Huber , Franz-Josef Krysl , Christoph Ritter , Helmut Offenbacher , Bernhard Schaffar , Marie-Luise Schinnerl , Johann Harer
IPC分类号： A61B5/00
CPC分类号： G01N33/48771 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2300/021 , B01L2300/022 , B01L2300/0627 , B01L2300/0645 , B01L2300/1805 , B01L2300/1883 , B01L2400/0481 , B01L2400/0655
摘要： The invention concerns a sensor cassette that can be inserted into an analyzer comprising a continuous measuring channel for receiving fluidic media and sensory elements for determining chemical and/or physical parameters of the fluidic media. According to the invention the sensor cassette consists of at least two permanently connected but separately manufactured modules which each have a housing and a measuring channel section wherein the measuring channel sections of adjacent modules are connected to the continuous measuring channel by a fluidic coupling and wherein at least one of the connected modules is designed as a sensor module and has a sensor array comprising at least two sensory elements. Furthermore, a memory element is allocated to the sensor cassette on which specific information for the sensor cassette in particular with regard to its construction from the respective modules is stored.
摘要翻译：本发明涉及一种可插入分析器中的传感器盒，该分析器包括用于接收流体介质的连续测量通道和用于确定流体介质的化学和/或物理参数的感官元件。根据本发明，传感器盒由至少两个永久连接但单独制造的模块组成，每个模块具有壳体和测量通道部分，其中相邻模块的测量通道部分通过流体耦合连接到连续测量通道，并且其中连接的模块中的至少一个被设计为传感器模块，并且具有包括至少两个感觉元件的传感器阵列。此外，将存储元件分配给传感器盒，在该传感器盒上存储有关于其各个模块的结构的特别是传感器盒的特定信息。

8. 发明授权

US6001999A Luminescence indicator including ionophoric moiety 失效
标题翻译：发光指示剂包括离子部分
公开(公告)号：US6001999A
公开(公告)日：1999-12-14
申请号：US85812
申请日：1998-05-27
申请人： Otto S. Wolfbeis , Jorg Daub , Thomas Gareis , Matthias Kollmannsberger , Stefan Heinl , Tobias Werner , Christian Huber , Andrei Boila-Gockel , Marco Jean Pierre Leiner
发明人： Otto S. Wolfbeis , Jorg Daub , Thomas Gareis , Matthias Kollmannsberger , Stefan Heinl , Tobias Werner , Christian Huber , Andrei Boila-Gockel , Marco Jean Pierre Leiner
IPC分类号： G01N21/80 , C07D519/00 , C07F5/02 , C09K11/07 , G01N21/78 , G01N31/00 , G01N31/22 , C07D419/02 , C07D209/56
CPC分类号： C07F5/022 , G01N31/22
摘要： The invention relates to a compound having the general Formula I in which one of the groups R.sub.1,R.sub.2,R.sub.3,R.sub.4,R.sub.5,R.sub.6 and R.sub.7 represents an ionophoric moiety and the remaining groups each independently are hydrogen, a lipophilic or hydrophilic group or a reactive group for coupling to a polymer or a biomolecule, or R.sub.2 forms an aromatic ring system together with R.sub.3 and R.sub.5 forms an aromatic ring system together with R.sub.6.the compound of the invention is useful as a luminescence indicator for cations.
摘要翻译：本发明涉及具有通式I的化合物，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7中的一个表示离子部分，其余基团各自独立地为氢，亲脂基或亲水基团用于偶联到聚合物或生物分子的反应性基团，或者R 2与R 3和R 5一起形成芳环体系与R6一起形成芳族环系统。本发明的化合物可用作阳离子的发光指示剂。

9. 发明授权

US5981746A Luminescence indicator 失效
标题翻译：发光指标
公开(公告)号：US5981746A
公开(公告)日：1999-11-09
申请号：US85219
申请日：1998-05-27
申请人： Otto S. Wolfbeis , Jorg Daub , Thomas Gareis , Matthias Kollmannsberger , Stefan Heinl , Tobias Werner , Christian Huber , Andrei Boila-Gockel , Marco Jean Pierre Leiner
发明人： Otto S. Wolfbeis , Jorg Daub , Thomas Gareis , Matthias Kollmannsberger , Stefan Heinl , Tobias Werner , Christian Huber , Andrei Boila-Gockel , Marco Jean Pierre Leiner
IPC分类号： G01N21/80 , C07D519/00 , C07F5/02 , C09K11/07 , G01N21/78 , G01N31/00 , G01N31/22 , C07D267/00 , C07D209/00 , C07D209/56
CPC分类号： C07F5/022 , G01N31/22
摘要： The invention relates to a compound having the general Formula I ##STR1## in which one of the groups R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 represents an ionophoric moiety and the remaining groups each independently are hydrogen, a lipophilic or hydrophilic group or a reactive group for coupling to a polymer or a biomolecule, or R.sub.2 forms an aromatic ring system together with R.sub.3 and R.sub.5 forms an aromatic ring system together with R.sub.6.The compound of the invention is useful as a luminescence indicator for alkali ions.
摘要翻译：本发明涉及具有通式I的化合物，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7中的一个表示离子部分，其余基团各自独立地为氢，亲脂基或亲水基团用于偶联到聚合物或生物分子的反应性基团，或者R 2与R 3和R 5一起形成芳环体系与R6一起形成芳族环系统。本发明的化合物可用作碱离子的发光指示剂。

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