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1. 发明授权

US08775095B2 Methods and apparatus for decentralized diabetes monitoring 失效
标题翻译：分散糖尿病监测的方法和装置
公开(公告)号：US08775095B2
公开(公告)日：2014-07-08
申请号：US12818781
申请日：2010-06-18
申请人： Paul Douglas Walling , Nigel Surridge
发明人： Paul Douglas Walling , Nigel Surridge
IPC分类号： G01N33/50 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/4842
摘要： Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy.
摘要翻译：用于分散监测患者糖尿病状态进展的方法包括同时获得一组初始静脉血样本和在集中式设置中来自患者的标准化代谢攻击之后的初始毛细血管样本组，其中所述糖尿病状态为使用初始静脉血样本进行诊断并通过将初始毛细血管样本集与初始静脉血样品集合相关联来实现，实施治疗，在达到目标事件之后进行分散测试，其中状态在随后的标准化代谢攻击之后，从患者获得的毛细血管血样的状态集获得测试，并将状态测试与第一测试基线进行比较以确定治疗的有效性。

2. 发明申请

US20090020502A1 BIOSENSOR AND METHOD OF MAKING 有权
标题翻译：生物传感器和制造方法
公开(公告)号：US20090020502A1
公开(公告)日：2009-01-22
申请号：US12238023
申请日：2008-09-25
申请人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
发明人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
IPC分类号： H01B13/008
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译：具有电极元件的电化学生物传感器具有光滑，高质量的边缘。这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量形成它们

3. 发明授权

US08287703B2 Biosensor and method of making 有权
标题翻译：生物传感器和制作方法
公开(公告)号：US08287703B2
公开(公告)日：2012-10-16
申请号：US12238023
申请日：2008-09-25
申请人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
发明人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
IPC分类号： C12M1/00 , C12N11/00 , C12N9/00 , C25B9/00 , C25B11/00 , C25B13/00 , G01N1/00
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译：具有电极元件的电化学生物传感器具有光滑，高质量的边缘。这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量形成它们

4. 发明授权

US08222044B2 Test strip with flared sample receiving chamber 有权
标题翻译：带有扩口样品接收室的测试条
公开(公告)号：US08222044B2
公开(公告)日：2012-07-17
申请号：US13297501
申请日：2011-11-16
申请人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
发明人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
IPC分类号： G01N21/75
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译：具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。本发明提供的更宽的开口更容易用样品流体“目标”。在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里流体样品接触。

5. 发明授权

US08071030B2 Test strip with flared sample receiving chamber 有权
标题翻译：带有扩口样品接收室的测试条
公开(公告)号：US08071030B2
公开(公告)日：2011-12-06
申请号：US10872027
申请日：2004-06-18
申请人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
发明人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
IPC分类号： G01N33/48
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译：具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。本发明提供的更宽的开口更容易用样品流体“目标”。在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里流体样品接触。

6. 发明授权

US08551308B2 Biosensor and method of making 有权
标题翻译：生物传感器和制作方法
公开(公告)号：US08551308B2
公开(公告)日：2013-10-08
申请号：US12238101
申请日：2008-09-25
申请人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
发明人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
IPC分类号： G01N27/327 , C12Q1/25 , H05K3/00
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译：具有电极元件的电化学生物传感器具有光滑，高质量的边缘。这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量形成它们

7. 发明申请

US20120055626A1 TEST STRIP WITH FLARED SAMPLE RECEIVING CHAMBER 有权
标题翻译：带有采样样品的测试条
公开(公告)号：US20120055626A1
公开(公告)日：2012-03-08
申请号：US13297501
申请日：2011-11-16
申请人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
发明人： Raghbir S. Bhullar , Nigel Surridge , Tom Funke , Paul Douglas Walling , Randall K. Riggles
IPC分类号： B32B37/02 , B32B38/04 , B32B37/14
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译：具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。本发明提供的更宽的开口更容易用样品流体“目标”。在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里流体样品接触。

8. 发明申请

US20110313673A1 METHODS AND APPARATUS FOR DECENTRALIZED DIABETES MONITORING 失效
标题翻译：用于分散式糖尿病监测的方法和装置
公开(公告)号：US20110313673A1
公开(公告)日：2011-12-22
申请号：US12818781
申请日：2010-06-18
申请人： Paul Douglas Walling , Nigel Surridge
发明人： Paul Douglas Walling , Nigel Surridge
IPC分类号： G01N33/50 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/4842
摘要： Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy.
摘要翻译：用于分散监测患者糖尿病状态进展的方法包括同时获得一组初始静脉血样本和在集中式设置中来自患者的标准化代谢攻击之后的初始毛细血管样本组，其中所述糖尿病状态为使用初始静脉血样本进行诊断并通过将初始毛细血管样本集与初始静脉血样品集合相关联来实现，实施治疗，在达到目标事件之后进行分散测试，其中状态在随后的标准化代谢攻击之后，从患者获得的毛细血管血样的状态集获得测试，并将状态测试与第一测试基线进行比较以确定治疗的有效性。

9. 发明申请

US20090056120A1 BIOSENSOR AND METHOD OF MAKING 有权
公开(公告)号：US20090056120A1
公开(公告)日：2009-03-05
申请号：US12238101
申请日：2008-09-25
申请人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
发明人： Raghbir S. Bhullar , Eric R. Diebold , Brian S. Hill , Nigel Surridge , Paul Douglas Walling
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.

10. 发明授权

US08506775B2 Devices and methods relating to electrochemical biosensors 有权
标题翻译：与电化学生物传感器有关的设备和方法
公开(公告)号：US08506775B2
公开(公告)日：2013-08-13
申请号：US10872008
申请日：2004-06-18
申请人： Nigel Anthony Surridge , Paul Douglas Walling , Melani Sullivan , Vladimir Svetnik , Brian S. Hill
发明人： Nigel Anthony Surridge , Paul Douglas Walling , Melani Sullivan , Vladimir Svetnik , Brian S. Hill
IPC分类号： C12M1/00
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A system for testing for analytes in a sample of biological fluid includes a test strip that defines a cavity for receiving the sample. At least two sets of electrodes are adjacent the sample cavity, including one for measuring one property of the sample, and another for measuring one or more other properties of the sample, such as temperature and/or the presence or magnitude of confounding variables. The measurements are combined to yield the desired result. At least one set of working and counter electrodes each have a plurality of elongated “fingers” interdigitated with those of the other electrode in the set. The gaps between fingers can be quite small, so that the two electrode sets together can operate in a small measurement volume of sample. Additional electrodes can be included that measure the presence or sufficiency of the sample, and additional traces on the strip can act as configuration identifiers.
摘要翻译：用于测试生物流体样品中分析物的系统包括限定用于接收样品的空腔的测试条。至少两组电极与样品腔相邻，包括一个用于测量样品的一个性质，另一组用于测量样品的一个或多个其他性质，如温度和/或混杂变量的存在或大小。将测量结合以产生期望的结果。至少一组工作电极和对电极各自具有与组中的另一电极的那些相互指向的多个细长“指状物”。手指之间的间隙可以相当小，使得两个电极组合在一起可以在小的测量体积的样品中操作。可以包括测量样品的存在或充分性的附加电极，并且条带上的附加痕迹可以用作配置标识符。

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