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2. 发明授权

US07288659B2 Acylaminothiazole derivatives, their preparation and therapeutic use 有权
标题翻译：酰氨基噻唑衍生物，其制备和治疗用途
公开(公告)号：US07288659B2
公开(公告)日：2007-10-30
申请号：US10485837
申请日：2002-08-05
申请人： Paul De Cointet , Pierre Despeyroux , Daniel Frehel , Chantal Guenet , Corinne Heckel , Jean-Pierre Maffrand , Rebecca Pruss
发明人： Paul De Cointet , Pierre Despeyroux , Daniel Frehel , Chantal Guenet , Corinne Heckel , Jean-Pierre Maffrand , Rebecca Pruss
IPC分类号： C07D277/46
CPC分类号： C07D417/12 , C07D277/40 , C07D277/42 , C07D277/46
摘要： The invention concerns a compound of general formula (I), wherein: X represents an oxygen or sulphur atom; R1 represents, independently of each other when n=2 or 3, a halogen atom, a hydroxy, a C1-C3 alkyl, a C1-C3 alkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy; R2 represents a C1-C6 alkyl group optionally substituted, a C3-C7 cycloalkyl, piperidinyl or phenyl group, the C3-C7 cycloalkyl, piperidinyl or phenyl groups being optionally substituted; R3 represents a hydrogen atom or a C1-C6 alkyl group optionally substituted; R4 represents a hydrogen atom or a C1-C4 alkyl group; and R5 and R5′ represent, independently of each other, a hydrogen atom, a hydroxy, a halogen atom, a C1-C3 alkyl group, or R5 and R5′ form together an oxo group; R6 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl, a C1-C3 alkoxy, a trifluoromethyl, or a trifluoromethoxy; in the form of a base, addition to an acid, hydrate or solvate. The invention is applicable in therapy
摘要翻译：本发明涉及通式（I）的化合物，其中：X表示氧或硫原子; R 1表示n = 2或3时彼此独立地表示卤素原子，羟基，C 1 -C 3烷基 C 1 -C 3烷氧基，三氟甲基，三氟甲氧基或亚甲二氧基; R 2表示任选取代的C 1 -C 6烷基，C 3 -C 6烷基， 7个环烷基，哌啶基或苯基，C 3 -C 7环烷基，哌啶基或苯基任选被取代; R 3表示任选取代的氢原子或C 1 -C 6 -C 6烷基; R 4表示氢原子或C 1 -C 4烷基; R 5和R 5'彼此独立地表示氢原子，羟基，卤素原子，C 1〜 C 3烷基或R 5和R 5'一起形成氧代基; R 6表示氢原子，卤素原子，C 1 -C 3烷基，C 1〜 -C 3烷氧基，三氟甲基或三氟甲氧基; 以碱的形式加入酸，水合物或溶剂化物。本发明适用于治疗

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