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1. 发明申请

US20100238398A1 Extended Wear Ophthalmic Lens 失效
标题翻译：延长佩戴眼科镜片
公开(公告)号：US20100238398A1
公开(公告)日：2010-09-23
申请号：US12794333
申请日：2010-06-04
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。

2. 发明授权

US06951894B1 Extended wear ophthalmic lens 失效
标题翻译：延长佩戴眼科镜片
公开(公告)号：US06951894B1
公开(公告)日：2005-10-04
申请号：US09640526
申请日：2000-08-17
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Höpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jürgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Höpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jürgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有很大的佩戴者不适。透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含氧大分子单体和离子单体单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

3. 发明授权

US06923978B2 Multilayer materials 失效
标题翻译：多层材料
公开(公告)号：US06923978B2
公开(公告)日：2005-08-02
申请号：US10368693
申请日：2003-02-19
申请人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
发明人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
IPC分类号： A61L27/00 , A61L27/34 , C08L101/16 , G02B1/04 , G02C7/04 , A61F2/00 , C08F8/00
CPC分类号： G02B1/043 , A61L27/34 , C08L5/00
摘要： The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continuous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.
摘要翻译：本发明涉及复合材料，特别是生物医学装置，例如，眼科装置，优选隐形眼镜，具有能够在其上容纳水性流体的连续层的一个或多个可润湿表面，所述复合材料包括本体材料和亲水涂层，其特征在于，所述亲水性涂层由共价连接到反应性的碳水化合物在本体材料表面的基团，直接地或通过低官能化合物的官能团，所述低官能化合物又具有能够与本体材料的表面与碳水化合物的所述反应性基团反应的官能团，其中所述反应性基团本质上（先验地）存在于本体材料中，或者其中所述反应性基团已经通过等离子体表面制备被附着到散装材料的表面，以及制造这种复合材料的方法。

4. 发明授权

US06623747B1 Multilayer materials 失效
公开(公告)号：US06623747B1
公开(公告)日：2003-09-23
申请号：US08601420
申请日：1996-02-14
申请人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
发明人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
IPC分类号： A61F200
CPC分类号： G02B1/043 , A61L27/34 , C08L5/00
摘要： The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.

5. 发明授权

US06582754B1 Coating process 失效
标题翻译：涂层工艺
公开(公告)号：US06582754B1
公开(公告)日：2003-06-24
申请号：US09697861
申请日：2000-10-27
申请人： Paul Pasic , Hans Jörg Griesser , Peter Kambouris , Peter Chabrecek
发明人： Paul Pasic , Hans Jörg Griesser , Peter Kambouris , Peter Chabrecek
IPC分类号： B05D138
CPC分类号： B82Y30/00 , A61L27/34 , B05D1/185 , B05D7/00 , B82Y40/00 , C08J7/16 , G02B1/043
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface; (b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups, (c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and (d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）将包含烯键式不饱和双键的化合物共价结合到所述材料表面;（b）在表面上聚合包含反应性或可交联基团的单体从而提供包含反应性或可交联基团的初级聚合物涂层，（c）在步骤（b）中包含反应性基团的单体的情况下，使初级涂层的反应性基团与包含烯属不饱和双键的另外的化合物和接枝在步骤（b）或（c）中存在可交联基团的情况下，将亲水性单体和任选的具有可交联基团的共聚单体聚合到根据步骤（b）和（d）获得的初级涂层上，引发所述团体通过本发明的方法可获得的涂覆制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的所需特性，因此可用于制造生物医学制品如眼科装置。

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