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1. 发明申请

US20050131528A1 Biodegradable drug delivery vascular stent 有权
公开(公告)号：US20050131528A1
公开(公告)日：2005-06-16
申请号：US11041027
申请日：2005-01-21
申请人： Paul Buscemi , Elizabeth Stejskal , Donald Palme , Lixiao Wang
发明人： Paul Buscemi , Elizabeth Stejskal , Donald Palme , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.

2. 发明授权

US5795318A Method for delivering drugs to a vascular site 失效
标题翻译：将药物输送到血管部位的方法
公开(公告)号：US5795318A
公开(公告)日：1998-08-18
申请号：US802521
申请日：1997-02-20
申请人： Lixiao Wang , Roger Hastings , Paul Buscemi , Sew-Wah Tay
发明人： Lixiao Wang , Roger Hastings , Paul Buscemi , Sew-Wah Tay
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/88 , A61M25/10 , A61M5/00
CPC分类号： A61M25/1027 , A61F2/88 , A61F2/958 , A61F2210/0033 , A61F2230/0017 , A61M2025/0058 , A61M2025/1004
摘要： A temporary stent comprises a coil of tubular thermoplastic material and a heating element inside the tubular material, or a film with a metal film resistive heating element coated thereon. A method of temporarily supporting the wall of a vessel comprises the steps of inserting a thermoplastic body having a first outer dimension less than the inside dimension of the vessel into the vessel to the desired support position; heating the thermoplastic above its softening transition temperature and expanding it to a second outer dimension larger than its first outer dimension; cooling the thermoplastic body to below its softening transition temperature while at its second outer dimension; allowing the cooled thermoplastic body to temporarily support the vessel; heating the thermoplastic above its softening transition temperature to soften the thermoplastic; and removing the softened thermoplastic body from the vessel.
摘要翻译：临时支架包括管状热塑性材料的线圈和管状材料内的加热元件，或者涂覆有金属膜电阻加热元件的膜。临时支撑容器壁的方法包括以下步骤：将具有小于容器的内部尺寸的第一外部尺寸的热塑性主体插入容器中至所需的支撑位置; 将热塑性塑料高于其软化转变温度并将其膨胀至大于其第一外部尺寸的第二外部尺寸; 在其第二外部尺寸下将热塑性体冷却至其软化转变温度以下; 允许冷却的热塑性体暂时支撑容器; 将热塑性塑料加热到其软化转变温度以软化热塑性塑料; 以及从容器中去除软化的热塑性体。

3. 发明授权

US5716410A Temporary stent and method of use 失效
标题翻译：临床支架及使用方法
公开(公告)号：US5716410A
公开(公告)日：1998-02-10
申请号：US577089
申请日：1995-12-22
申请人： Lixiao Wang , Roger Hastings , Paul Buscemi , Sew-Wah Tay
发明人： Lixiao Wang , Roger Hastings , Paul Buscemi , Sew-Wah Tay
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/88 , A61M25/10 , A61F2/04 , A61M25/00
CPC分类号： A61M25/1027 , A61F2/88 , A61F2/958 , A61F2210/0033 , A61F2230/0017 , A61M2025/0058 , A61M2025/1004
摘要： A temporary stent comprises a coil of tubular thermoplastic material and a heating element inside the tubular material, or a film with a metal film resistive heating element coated thereon. A method of temporarily supporting the wall of a vessel comprises the steps of inserting a thermoplastic body having a first outer dimension less than the inside dimension of the vessel into the vessel to the desired support position; heating the thermoplastic above its softening transition temperature and expanding it to a second outer dimension larger than its first outer dimension; cooling the thermoplastic body to below its softening transition temperature while at its second outer dimension; allowing the cooled thermoplastic body to temporarily support the vessel; heating the thermoplastic above its softening transition temperature to soften the thermoplastic; and removing the softened thermoplastic body from the vessel.
摘要翻译：临时支架包括管状热塑性材料的线圈和管状材料内的加热元件，或者涂覆有金属膜电阻加热元件的膜。临时支撑容器壁的方法包括以下步骤：将具有小于容器的内部尺寸的第一外部尺寸的热塑性主体插入容器中至所需的支撑位置; 将热塑性塑料高于其软化转变温度并将其膨胀至大于其第一外部尺寸的第二外部尺寸; 在其第二外部尺寸下将热塑性体冷却至其软化转变温度以下; 允许冷却的热塑性体暂时支撑容器; 将热塑性塑料加热到其软化转变温度以软化热塑性塑料; 以及从容器中去除软化的热塑性体。

4. 发明申请

US20150273117A1 Drug Coated Balloon Catheters for Nonvascular Strictures 审中-公开
标题翻译：用于非血管狭窄的药物涂层气球导管
公开(公告)号：US20150273117A1
公开(公告)日：2015-10-01
申请号：US14438327
申请日：2013-10-14
申请人： Lixiao WANG , Urotronic, Inc.
发明人： Lixiao Wang
IPC分类号： A61L29/16 , A61L29/08
摘要： Embodiments of the present invention provide a method for treatment of nonvascular body lumen strictures such as benign prostatic hyperplasia (BPH), urethral strictures, ureteral strictures, prostate cancer, esophageal strictures, sinus strictures, biliary tract strictures, asthma and chronic obstructive pulmonary disease (COPD). The method involves delivering, preferably via drug coated balloon catheters, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and one or more additives.
摘要翻译：本发明的实施方案提供了一种用于治疗诸如良性前列腺增生（BPH），尿道狭窄，输尿管狭窄，前列腺癌，食管狭窄，窦狭窄，胆道狭窄，哮喘和慢性阻塞性肺病的非血管性体腔狭窄的方法 COPD）。该方法优选通过药物涂覆的气囊导管递送抗炎和抗增殖药物（雷帕霉素或紫杉醇及其类似物）和一种或多种添加剂。

5. 发明授权

US08425459B2 Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent 有权
公开(公告)号：US08425459B2
公开(公告)日：2013-04-23
申请号：US12123956
申请日：2008-05-20
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61M25/10 , A61F2/82 , A61K31/337 , A61K31/4433 , A61K51/02
CPC分类号： A61L29/08 , A61B17/320725 , A61B18/24 , A61B18/245 , A61B2018/00327 , A61B2018/00345 , A61B2018/00446 , A61B2018/00488 , A61B2018/00505 , A61F2/07 , A61F2/24 , A61F2/82 , A61K31/337 , A61K31/436 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/08 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2420/06 , A61L2420/08 , A61L2430/20 , A61M5/007 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M31/005 , A61M37/00 , A61M2025/105 , A61K2300/00
摘要： The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.

6. 发明授权

US08403910B2 Drug releasing coatings for medical devices 有权
公开(公告)号：US08403910B2
公开(公告)日：2013-03-26
申请号：US13042213
申请日：2011-03-07
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61K31/337 , A61K31/4353 , A61K31/59 , A61F2/01 , A61P35/00 , A61P9/00 , A61P7/02 , A61L29/16
CPC分类号： A61L29/16 , A61K31/337 , A61K31/436 , A61K45/06 , A61L29/08 , A61L29/085 , A61L29/18 , A61L31/16 , A61L31/18 , A61L2300/216 , A61L2300/416 , A61L2300/428 , A61L2300/608 , A61L2300/802 , A61L2420/06 , A61L2420/08 , A61M25/10 , A61M2025/105 , A61M2210/1025 , A61K2300/00
摘要： The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

7. 发明授权

US08366660B2 Drug releasing coatings for medical devices 有权
公开(公告)号：US08366660B2
公开(公告)日：2013-02-05
申请号：US13042207
申请日：2011-03-07
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61M29/00
CPC分类号： A61L29/16 , A61K31/337 , A61K31/436 , A61K45/06 , A61L29/08 , A61L29/085 , A61L29/18 , A61L31/16 , A61L31/18 , A61L2300/216 , A61L2300/416 , A61L2300/428 , A61L2300/608 , A61L2300/802 , A61L2420/06 , A61L2420/08 , A61M25/10 , A61M2025/105 , A61M2210/1025 , A61K2300/00
摘要： The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

8. 发明授权

US08244344B2 Drug releasing coatings for medical devices 有权
公开(公告)号：US08244344B2
公开(公告)日：2012-08-14
申请号：US13272432
申请日：2011-10-13
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61M37/00 , A61M25/10 , A61B18/20
CPC分类号： A61L31/16 , A61K31/337 , A61K31/436 , A61L29/16 , A61L31/08 , A61L2300/416 , A61L2300/80 , A61L2300/802 , A61K2300/00
摘要： The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.

9. 发明授权

US07914486B2 Catheter having an improved balloon-to-catheter bond 有权
标题翻译：导管具有改善的气球与导管接合
公开(公告)号：US07914486B2
公开(公告)日：2011-03-29
申请号：US10764405
申请日：2004-01-23
申请人： John Chen , Nie Tang , Ed Parsonage , Paul Miller , Lixiao Wang
发明人： John Chen , Nie Tang , Ed Parsonage , Paul Miller , Lixiao Wang
IPC分类号： A61M29/00
CPC分类号： A61L29/04 , A61L29/06 , A61M25/10 , A61M25/1034 , C08L77/00 , C08L67/02
摘要： A balloon catheter assembly includes a first tubular member with a proximal portion and a distal portion and a lumen extending between the proximal portion and the distal portion. A balloon has a proximal waist length, a distal waist length and an expandable region therebetween disposed about the distal portion. A tie layer is disposed between the proximal waist length or distal waist length and the first tubular member. The tie layer comprises a polyester polymer and a polyamide polymer.
摘要翻译：球囊导管组件包括具有近端部分和远端部分的第一管状部件和在近端部分和远端部分之间延伸的内腔。气球具有近端腰部长度，远端腰围长度和围绕远侧部分设置的可扩张区域。连接层设置在近端腰部长度或远端腰部长度与第一管状部件之间。连结层包含聚酯聚合物和聚酰胺聚合物。

10. 发明授权

US07682553B2 Balloon structure with PTFE component 有权
标题翻译：气球结构采用PTFE组分
公开(公告)号：US07682553B2
公开(公告)日：2010-03-23
申请号：US10797996
申请日：2004-03-11
申请人： Lixiao Wang , John Jianhua Chen
发明人： Lixiao Wang , John Jianhua Chen
IPC分类号： B29C49/22 , A61M25/10
CPC分类号： A61M25/1029 , A61L29/041 , A61L29/12 , A61M25/10 , A61M2025/1075 , Y10T428/1334 , Y10T428/139 , Y10T428/1393 , C08L27/18
摘要： A medical balloon having a high burst strength and the ability to return to its preinflation diameter following repeated inflation may be prepared from a first inner layer of material, a second intermediate layer of expanded PTFE and a third outer layer of material.
摘要翻译：可以从第一内层材料，膨胀PTFE的第二中间层和第三外层材料制备具有高爆裂强度和在反复充气之后恢复到其预充气直径的能力的医用气囊。

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