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1. 发明授权

US4087436A Methylation of de-A steroids 失效
标题翻译： de-A类固醇的甲基化
公开(公告)号：US4087436A
公开(公告)日：1978-05-02
申请号：US589650
申请日：1975-06-23
申请人： Paul Buchschacher , Andor Furst , Ludwig Labler , Werner Meier , John William Scott
发明人： Paul Buchschacher , Andor Furst , Ludwig Labler , Werner Meier , John William Scott
IPC分类号： C07C49/417 , C07D261/08 , C07J1/00 , C07J7/00 , C07J17/00 , C07J43/00 , C07D261/06 , C07C49/54 , C07C49/60 , C07D317/08
CPC分类号： C07D261/08 , C07C49/417 , C07J1/00 , C07J17/00 , C07J43/00 , C07J7/00 , C07C2103/16 , C07C2103/26
摘要： Treatment of de-A steroids with a methylation agent at extremely low temperatures, i.e., below -50.degree. C. produces corresponding 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids with a high 10.beta. to 10.alpha. isomer ratio. A number of the product 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids are novel compounds. They are useful as intermediates in the synthesis of known medicinally valuable steroids.
摘要翻译：用非常低的温度（即低于-50℃）用甲基化剂处理de-A类固醇，产生相应的具有高10β-10α异构体比例的10个β-甲基-DETTA 9（11）-deA类固醇。一些产品10β-甲基-DTATA 9（11）-deA类固醇是新化合物。它们可用作合成已知药用有价值类固醇的中间体。

2. 发明授权

US4312812A Process for the manufacture of cholesterol derivatives 失效
标题翻译：制备胆固醇衍生物的方法
公开(公告)号：US4312812A
公开(公告)日：1982-01-26
申请号：US226293
申请日：1981-01-19
申请人： Andor Furst , Ludwig Labler , Werner Meier
发明人： Andor Furst , Ludwig Labler , Werner Meier
IPC分类号： C07C43/15 , C07J9/00 , C07J17/00 , C07J31/00 , C07J7/00
CPC分类号： C07C43/15 , C07J17/00 , C07J31/006 , C07J9/00
摘要： The present disclosure is directed to a process for the preparation of cholesterol derivatives from corresponding 21-hydroxymethyl steroidal compounds.
摘要翻译：本公开涉及从相应的21-羟甲基甾体化合物制备胆固醇衍生物的方法。

3. 发明授权

US4568491A Process for the preparation of cholesterol derivatives and novel intermediates therefor 失效
标题翻译：制备胆固醇衍生物及其新型中间体的方法
公开(公告)号：US4568491A
公开(公告)日：1986-02-04
申请号：US584200
申请日：1984-02-27
申请人： Andor Furst , Ludwig Labler , Werner Meier
发明人： Andor Furst , Ludwig Labler , Werner Meier
IPC分类号： C07C29/10 , C07C29/14 , C07C43/178 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/26 , C07J9/00 , C07J17/00 , C07J31/00 , C07J53/00 , C07J5/00
CPC分类号： C07C43/1782 , C07C29/10 , C07C29/14 , C07C43/1785 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/26 , C07J17/00 , C07J31/006 , C07J53/00 , C07J9/00 , C07B2200/09
摘要： The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1.alpha., 24,25-trihydroxycholecalciferol.
摘要翻译：本发明涉及制备1氢或羟基胆固醇衍生物及其中间体的方法。本发明的化合物可用作制备24,25-二羟基和1α，24,25-三羟基胆钙化甾醇的中间体。

4. 发明授权

US4305881A Process for 1.alpha.,3.beta.-dihydroxy-.DELTA..sup.5 -steroids 失效
标题翻译： 1α，3β-二羟基-DTATA 5-类固醇的方法
公开(公告)号：US4305881A
公开(公告)日：1981-12-15
申请号：US93209
申请日：1979-11-13
申请人： Andor Furst , Ludwig Labler , Werner Meier
发明人： Andor Furst , Ludwig Labler , Werner Meier
IPC分类号： C07J1/00 , A61K31/59 , A61P3/02 , C07C67/00 , C07C401/00 , C07J7/00 , C07J9/00 , C07J17/00 , C07J21/00 , C07J71/00 , C07J75/00
CPC分类号： C07J17/00 , C07J21/008 , C07J7/007 , C07J71/001 , C07J9/00
摘要： A process for the synthesis of 1.alpha.,3.beta.-dihydroxy-.DELTA..sup.5 -steroids from steroids such as 1.alpha.,2.alpha.-epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and subsequently reduced by repeated alternative additions of a proton donator, said additions being followed in each case by an equivalent amount of lithium. The final product, a 1.alpha.,3.beta.-dihydorxy-.DELTA..sup.5 -steroid, is useful in the synthesis of derivatives of cholecalciferol.
摘要翻译：从类固醇如1α，2α-环氧 - 胆甾烯-4,6-二烯-3-酮合成1α，3β-二羟基-TATA5-类固醇的方法，其与液体氨中的锂反应在不存在质子供体的情况下，随后通过反复添加质子给体而减少，所述添加物在每种情况下都遵循等量的锂。最终产物1α，3β-二羟基-D-DELTA5-类固醇可用于合成胆钙化甾醇的衍生物。

5. 发明授权

US4691032A Process for the preparation of cholesterol derivatives and novel intermediates therefor 失效
标题翻译：制备胆固醇衍生物及其新型中间体的方法
公开(公告)号：US4691032A
公开(公告)日：1987-09-01
申请号：US793928
申请日：1985-11-01
申请人： Andor Furst , Ludwig Labler , Werner Meier
发明人： Andor Furst , Ludwig Labler , Werner Meier
IPC分类号： C07C29/10 , C07C29/14 , C07C43/178 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/26 , C07J9/00 , C07J17/00 , C07J31/00 , C07J53/00
CPC分类号： C07C43/1782 , C07C29/10 , C07C29/14 , C07C43/1785 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/26 , C07J17/00 , C07J31/006 , C07J53/00 , C07J9/00 , C07B2200/09
摘要： The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1.alpha.,24,25-trihydroxycholecalciferol.
摘要翻译：本发明涉及制备1氢或羟基胆固醇衍生物及其中间体的方法。本发明的化合物可用作制备24,25-二羟基和1α，24,25-三羟基胆钙化甾醇的中间体。

6. 发明授权

US4193921A Pregnane derivatives 失效
标题翻译：孕烯衍生物
公开(公告)号：US4193921A
公开(公告)日：1980-03-18
申请号：US841430
申请日：1977-10-12
申请人： Andor Furst , Ludwig Labler , Werner Meier
发明人： Andor Furst , Ludwig Labler , Werner Meier
IPC分类号： C07J5/00 , C07J9/00 , C07J17/00 , C07J31/00 , C07J71/00
CPC分类号： C07J31/006 , C07J17/00 , C07J71/001 , C07J9/00 , C07J9/005
摘要： The present invention relates to pregnane derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.3 are hydroxyl groups or readily cleavable etherified or esterified hydroxyl groups and R.sup.20 is hydroxymethyl or readily cleavable etherified or esterified hydroxy methyl, formyl, carboxyl or carbalkoxy useful as intermediates for the preparation of 1.alpha.-hydroxycholecalciferols. The present invention also relates to processes for the preparation of the pregnane derivatives and the intermediates thereof.
摘要翻译：本发明涉及式IMAGE的孕烷衍生物，其中R 1和R 3是羟基或易于切割的醚化或酯化的羟基，R 20是羟甲基或易裂解的醚化或酯化的羟甲基，甲酰基，羧基或烷氧羰基，可用作中间体制备1α-羟基胆钙化醇。本发明还涉及制备孕烷衍生物及其中间体的方法。

7. 发明授权

US4045490A 9,10-Seco-steroid preparation 失效
标题翻译： 9,10-类固醇制剂
公开(公告)号：US4045490A
公开(公告)日：1977-08-30
申请号：US651764
申请日：1976-01-23
申请人： Jean-Marie Cassal , Andor Furst , Werner Meier
发明人： Jean-Marie Cassal , Andor Furst , Werner Meier
IPC分类号： C07C401/00 , C07C49/76 , C07C49/82 , C07C49/84
CPC分类号： C07C201/12 , C07C49/753 , C07C2102/24
摘要： A process for the preparation of 9,10-seco-steroids of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy - lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.
摘要翻译：其中R1和R2独立地是氢，氨基，OR5，OCOR6或NHCOR5，其中R5是氢或低级烷基，R6是低级烷基或苯基; R3是低级烷基; R4是氧代，其中R13是低级烷基，低级烷氧基 - 低级亚烷基，四氢吡喃基或四氢呋喃基，R14是低级烷基或芳基，R15和R16是低级烷基或一起形成低级亚烷基或亚芳基，n是1或 2。本发明的9,10-秒类固醇是制备类固醇的有用中间体。

8. 发明授权

US4064173A 9,10-Seco-steroids 失效
标题翻译： 9,10-类固醇
公开(公告)号：US4064173A
公开(公告)日：1977-12-20
申请号：US651763
申请日：1976-01-23
申请人： Jean-Marie Cassal , Andor Furst , Werner Meier
发明人： Jean-Marie Cassal , Andor Furst , Werner Meier
IPC分类号： C07C401/00 , C07C49/27
CPC分类号： C07C205/45 , C07C2102/24
摘要： A process for the preparation of 9,10-seco-steroids of the formula ##STR1## WHEREIN R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy -- lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.
摘要翻译：其中R 1和R 2独立地为氢，氨基，OR 5，OCOR 6或NHCOR 5，其中R 5为氢或低级烷基且R 6为低级烷基或苯基; R3是低级烷基; R4是氧代，其中R13是低级烷基，低级烷氧基 - 低级亚烷基，四氢吡喃基或四氢呋喃基，R14是低级烷基或芳基，R15和R16是低级烷基或一起形成低级亚烷基或亚芳基，n是1或 2。本发明的9,10-秒类固醇是制备类固醇的有用中间体。

9. 发明授权

US08669345B2 Nogo receptor antagonists 有权
标题翻译： Nogo受体拮抗剂
公开(公告)号：US08669345B2
公开(公告)日：2014-03-11
申请号：US12162256
申请日：2007-01-26
申请人： Daniel H. S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
发明人： Daniel H. S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K51/00
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。还公开了Nogo受体拮抗剂多核苷酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的核苷酸和拮抗剂多核苷酸的制备和使用方法。

10. 发明申请

US20140064428A1 LOWER NOZZLE FOR USE IN NUCLEAR FUEL ASSEMBLY 有权
标题翻译：用于核燃料组件的低喷嘴
公开(公告)号：US20140064428A1
公开(公告)日：2014-03-06
申请号：US13822516
申请日：2012-05-11
申请人： Dirk Blavius , Erhard Friedrich , Werner Meier
发明人： Dirk Blavius , Erhard Friedrich , Werner Meier
IPC分类号： G21C3/32
CPC分类号： G21C3/3206 , G21C3/322 , G21C3/3305 , Y02E30/40
摘要： A lower nozzle for use in a nuclear fuel assembly provided. The lower nozzle is of the type having an axis and comprising a transverse lower tie plate for channelling the coolant through the lower tie plate and a tubular skirt extending axially from the periphery of the lower tie plate, the skirt delimiting an axial housing closed at one end by the lower tie plate and open at the opposite end, a debris filter configured for axial insertion in the housing and snap-fit springs for retaining the debris filter in the housing after insertion. The springs are configured to shift the debris filter axially towards the lower tie plate.
摘要翻译：用于核燃料组件的下喷嘴。下喷嘴是具有轴线的类型，并且包括用于将冷却剂引导通过下连接板的横向下连接板和从下连接板的周边轴向延伸的管状裙部，裙部限定在一个闭合的轴向壳体通过下连接板结束并在相对端开口，构造成用于轴向插入壳体中的碎屑过滤器和用于在插入之后将碎屑过滤器保持在壳体中的卡合弹簧。弹簧构造成将碎屑过滤器轴向移向下连接板。

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