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1. 发明申请

US20060241125A1 Compounds useful in therapy 失效
标题翻译：化合物可用于治疗
公开(公告)号：US20060241125A1
公开(公告)日：2006-10-26
申请号：US11408286
申请日：2006-04-18
申请人： Paul Bradley , Kevin Dack , Ian Marsh
发明人： Paul Bradley , Kevin Dack , Ian Marsh
IPC分类号： A61K31/506 , A61K31/4152 , C07D403/02
CPC分类号： C07D231/28 , C07D231/18 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/06 , C07D417/06
摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substituted by CN), or Het; R3 represents OH, CN, Het, —R4—C1-6alkyl, or CONR5R6; R4 represents —CO2—, or —O—; R5 and R6 independently represent H, C1-6alkyl (optionally substituted by OR7) or C3-8cycloalkyl; R7 represents H or C1-6alkyl; Het represents a five or six membered aromatic heterocyclic group containing (i) from one to four nitrogen heteroatom(s) or (ii) one or two nitrogen heteroatom(s) and one oxygen or one sulphur heteroatom or (iii) one or two oxygen or sulphur heteroatom(s), said heterocyclic group being optionally substituted by one or more groups selected from CN and C1-6 alkyl; R8 represents C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R9 and R10 independently represent H, C1-6alkyl, C1-6alkyloxy, CN, CF3 or halo; may be useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中：R 1表示H，C 1-6烷基，C 1-6烷基，烷氧基，C 3-8环烷基或卤素; R 2表示H，C 1-6烷基（任选被R 3 O 3取代），苯基（任选被CN取代）或Het; R 3表示OH，CN，Het，-R 4 -C 1-6烷基或CONR 5 R 6; R 4表示-CO 2 - 或-O-; R 5和R 6独立地表示H，C 1-6烷基（任选被OR 7取代）或 C 3-8环烷基; R 7表示H或C 1-6烷基; Het表示含有（i）1-4个氮杂原子或（ii）一个或两个氮杂原子和一个氧或一个硫杂原子的五元或六元芳族杂环基，或（iii）一个或两个氧或硫杂原子，所述杂环基团任选被一个或多个选自CN和C 1-6烷基的基团取代; R 8表示C 1-6烷基，C 1-6烷氧基，C 3-8环烷基，或光环; R 9和R 10独立地代表H，C 1-6烷基，C 1-6烷氧基，CN CF 3或卤素; 可能有助于治疗子宫内膜异位症，子宫肌瘤（平滑肌瘤），月经过多，子宫腺肌症，原发性和继发性痛经（包括性交疼痛，dyschexia和慢性盆腔疼痛症状）或慢性盆腔疼痛综合征。

2. 发明申请

US20070105909A1 Compounds useful in therapy 失效
标题翻译：化合物可用于治疗
公开(公告)号：US20070105909A1
公开(公告)日：2007-05-10
申请号：US11592574
申请日：2006-11-03
申请人： Paul Bradley , Kevin Dack , Patrick Johnson , Sarah Skerratt
发明人： Paul Bradley , Kevin Dack , Patrick Johnson , Sarah Skerratt
IPC分类号： A61K31/4439 , A61K31/4152 , C07D403/02 , C07D231/12
CPC分类号： C07D231/18 , C07D401/12
摘要： Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R1 and R3 independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; R2 represents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R4, R5, R7 and R8 independently represent H, C1-6alkyl, C1-6alkyloxy, CN or halogen, or R4 and R5, or R7 and R8, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH2 or O; R6 represents H, CN or halo provided that, when X represents N, R6 is absent. The compounds are useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1和R 3独立代表H，C 1-6烷基 C 3-8环烷基或卤素; R 2表示C 1-6烷基，CF 3或芳基; a代表1或2; R 4，R 5，R 7和R 8独立地表示H，C 1-6 C 1-6烷基，C 1-6烷氧基，CN或卤素，或R 4和R 5或R 7 和它们所连接的环连接形成芳基或杂环稠环体系; X表示C或N; Y表示CH 2或O; R 6表示H，CN或卤素，条件是当X表示N时，R 6不存在。这些化合物可用于治疗子宫内膜异位症，子宫肌瘤（平滑肌瘤），月经过多，子宫腺肌症，原发性和继发性痛经（包括性交疼痛，dyschexia和慢性盆腔疼痛症状）或慢性盆腔疼痛综合征。

3. 发明申请

US20080085919A1 1H-Pyrazoles Useful In Therapy 失效
标题翻译： 1H-吡唑有用的治疗
公开(公告)号：US20080085919A1
公开(公告)日：2008-04-10
申请号：US11870451
申请日：2007-10-11
申请人： Paul Bradley , Kevin Dack , Patrick Johnson , Sarah Skerratt
发明人： Paul Bradley , Kevin Dack , Patrick Johnson , Sarah Skerratt
IPC分类号： A61K31/415 , A61K31/4152 , A61K31/4709 , A61P43/00 , A61P7/00
CPC分类号： C07D231/18 , C07D401/12
摘要： Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R1 and R3 independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; R2 represents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R4, R5, R7 and R8 independently represent H, C1-6alkyl, C1-6alkyloxy, CN or halogen, or R4 and R5, or R7 and R8, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH2 or O; R6 represents H, CN or halo provided that, when X represents N, R6 is absent. The compounds are useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1和R 3独立代表H，C 1-6烷基 C 3-8环烷基或卤素; R 2表示C 1-6烷基，CF 3或芳基; a代表1或2; R 4，R 5，R 7和R 8独立地表示H，C 1-6 C 1-6烷基，C 1-6烷氧基，CN或卤素，或R 4和R 5或R 7 和它们所连接的环连接形成芳基或杂环稠环体系; X表示C或N; Y表示CH 2或O; R 6表示H，CN或卤素，条件是当X表示N时，R 6不存在。这些化合物可用于治疗子宫内膜异位症，子宫肌瘤（平滑肌瘤），月经过多，子宫腺肌症，原发性和继发性痛经（包括性交疼痛，dyschexia和慢性盆腔疼痛症状）或慢性盆腔疼痛综合征。

4. 发明申请

US20140118913A1 USER INTERCHANGEABLE ORNAMENTAL PORTIONS OF ELECTRONIC DEVICES 审中-公开
公开(公告)号：US20140118913A1
公开(公告)日：2014-05-01
申请号：US14145767
申请日：2013-12-31
申请人： Antonio T. Latto , Isaac A. Simpson , Markus Diebel , Paul Bradley
发明人： Antonio T. Latto , Isaac A. Simpson , Markus Diebel , Paul Bradley
IPC分类号： H05K5/02
CPC分类号： H05K5/0243 , G03B17/568 , H04M1/0283 , H04M1/72544 , H05K5/03 , Y10T29/53
摘要： A method and apparatus is disclosed for the customization of electronic equipment of which portable audio players, portable disc players, portable digital games and laptop computers are representative. The electronic equipment may be fitted with a substantially transparent faceplate that may cover removable inserts. These inserts may be customizable to provide unique decorative appearances to the electronic equipment upon which they may be fitted. Decorative designs may either be preprinted on the inserts or a user may produce a customized design.

5. 发明申请

US20120190354A1 UICCs EMBEDDED IN TERMINALS OR REMOVABLE THERE FROM 有权
标题翻译：嵌入终端的UICC或可从其中移除
公开(公告)号：US20120190354A1
公开(公告)日：2012-07-26
申请号：US13312309
申请日：2011-12-06
申请人： Lionel MERRIEN , Nicolas Mathian , Nicolas Roussel , Xavier Berard , Denis Gachon , Pierre Girard , Philippe Proust , Fabrice Vergnes , Frédéric Faria , Franck Imoucha , Paul Bradley
发明人： Lionel MERRIEN , Nicolas Mathian , Nicolas Roussel , Xavier Berard , Denis Gachon , Pierre Girard , Philippe Proust , Fabrice Vergnes , Frédéric Faria , Franck Imoucha , Paul Bradley
IPC分类号： H04W4/00 , H04B5/00
CPC分类号： G06F21/6218 , G06F8/61 , H04B1/3816 , H04L9/0825 , H04L63/0428 , H04L63/08 , H04L63/083 , H04L63/123 , H04L67/34 , H04W4/50 , H04W4/60 , H04W4/70 , H04W8/18 , H04W8/183 , H04W8/205 , H04W8/22 , H04W8/245 , H04W12/04 , H04W12/06 , H04W12/08 , H04W12/10 , H04W84/04
摘要： The invention proposes several improvements related to the management of secure elements, like UICCs embedding Sim applications, these secure elements being installed, fixedly or not, in terminals, like for example mobile phones. In some cases, the terminals are constituted by machines that communicate with other machines for M2M (Machine to Machine) applications.
摘要翻译：本发明提出了与安全元件的管理相关的若干改进，例如嵌入SIM应用的UICC，这些安全元件被固定地或不固定地安装在诸如移动电话的终端中。在某些情况下，终端由与M2M（机器到机器）应用的其他机器通信的机器构成。

6. 发明授权

US07603458B1 System and methods for processing and displaying aggregate status events for remote nodes 有权
标题翻译：用于处理和显示远程节点聚合状态事件的系统和方法
公开(公告)号：US07603458B1
公开(公告)日：2009-10-13
申请号：US10674322
申请日：2003-09-30
申请人： John C. Sexton , Paul Bradley , Hanna Yehuda , David Barta
发明人： John C. Sexton , Paul Bradley , Hanna Yehuda , David Barta
IPC分类号： G06F15/173
CPC分类号： H04L41/065 , H04L41/0213 , H04L41/046 , H04L41/0681 , H04L41/142 , H04L41/22 , H04L43/0817
摘要： A status monitoring and reporting mechanism which distinguishes more significant events and prominently displays events pertaining to nodes, interconnections, and other network entities which may present problems, and to suppresses benign messages which may not require immediate attention, provides an “at a glance” view of overall system health. By processing and displaying aggregate status events from a plurality of agent components to highlight the most severe and critical events from among a large volume of general status events allows an operator to quickly diagnose potential problems before detrimental results occur, and helps maintain a general efficient system health by isolating less efficient areas to allow for timely remedial action prior to failure. Various agents disseminated in a storage area network determine and report status events back to a central server. The server receives, aggregates, and processes the status events to display a status array indicative of overall system health.
摘要翻译：区分更重要事件并显着地显示有关可能存在问题的节点，互连和其他网络实体的事件以及抑制可能不需要立即注意的良性消息的状态监视和报告机制提供了“一目了然”视图的整体系统健康。通过处理和显示来自多个代理组件的聚合状态事件以突显来自大量一般状态事件中的最严重和关键的事件，允许操作者在有害的结果发生之前快速诊断潜在问题，并且有助于维持一般的有效系统通过隔离效率较低的领域，以便在失败之前及时采取补救措施来保护健康。在存储区域网络中传播的各种代理确定并将状态事件报告回中央服务器。服务器接收，聚合和处理状态事件以显示指示整个系统运行状况的状态数组。

7. 发明授权

US07375215B2 Compounds for PDT 失效
标题翻译： PDT化合物
公开(公告)号：US07375215B2
公开(公告)日：2008-05-20
申请号：US10221218
申请日：2001-03-08
申请人： Paul Bradley , Mehar Manku
发明人： Paul Bradley , Mehar Manku
IPC分类号： C07D487/22 , C07D47/00 , C08G18/08 , A01N55/02 , A61K31/409 , A61K31/555
CPC分类号： C07D487/22 , A61K41/0071
摘要： A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the other isocyanate or isothiocyanate group being itself derivatised by addition reaction with the hydroxy group of an w-alkylated or acylated poly(alkylene oxide) or to a hydroxy group of a link residue itself carrying a residue of such poly(alkylene oxide).
摘要翻译：通过与二异氰酸酯，二异硫氰酸酯或异氰酸酯 - 异硫氰酸酯在一个异氰酸酯或异硫氰酸酯基团的加成反应，在一个或多个羟基衍生的四（羟基苯基）二氢卟酚，细菌二氢卟酚或异细菌素，其它异氰酸酯或异硫氰酸酯基团本身由与w-烷基化或酰化的聚（环氧烷）的羟基或本身携带这种聚（环氧烷）的残基的连接残基的羟基的加成反应。

8. 发明申请

US20080042778A1 General matching network for acoustic wave filters and acoustic resonators 有权
标题翻译：声波滤波器和声谐振器的通用匹配网络
公开(公告)号：US20080042778A1
公开(公告)日：2008-02-21
申请号：US11505453
申请日：2006-08-17
申请人： Tiberiu Jamneala , Paul Bradley , Michael Frank
发明人： Tiberiu Jamneala , Paul Bradley , Michael Frank
IPC分类号： H03H9/70
CPC分类号： H03H9/706 , H03H9/0004
摘要： A method and circuit matches a device to n filters, wherein each filter is a SAW filter, BAW filter, or FBAR filter. The method and system: (a) provide an inductor or transmission line connected between a common terminal and ground; (b) provide a plurality of capacitance values (C1m, C2m, . . . , Cnm) each corresponding to one of the n filters; and (c) for each of the n filters, directly connect a first terminal of the filter to either: (1) the common terminal, or (2) a first terminal of a corresponding capacitor having the correspondence capacitance value calculated in step (b), where a second terminal of the corresponding capacitor is directly connected to the common terminal.
摘要翻译：方法和电路将器件与n个滤波器相匹配，其中每个滤波器是SAW滤波器，BAW滤波器或FBAR滤波器。方法和系统：（a）提供连接在公共端子和地之间的电感器或传输线; （b）提供多个电容值（C 1m 2，C 2 m，...，C nm），每个对应于 n过滤器和（c）对于n个滤波器中的每一个，直接将滤波器的第一端连接到：（1）公共端子，或者（2）具有在步骤（b）中计算的对应电容值的相应电容器的第一端子），其中相应电容器的第二端子直接连接到公共端子。

9. 外观设计

USD533857S1 Television set 有权
公开(公告)号：USD533857S1
公开(公告)日：2006-12-19
申请号：US29244316
申请日：2005-12-07
申请人： Paul Bradley
设计人： Paul Bradley

10. 发明申请

US20060232361A1 Acoustically coupled resonators and method of making the same 有权
标题翻译：声耦合谐振器及其制作方法
公开(公告)号：US20060232361A1
公开(公告)日：2006-10-19
申请号：US11109596
申请日：2005-04-18
申请人： Kun Wang , Paul Bradley , Richard Ruby
发明人： Kun Wang , Paul Bradley , Richard Ruby
IPC分类号： H03H9/72 , H03H9/56
CPC分类号： H03H9/587 , H03H3/02 , H03H7/1708 , H03H9/0095 , H03H9/0571 , H03H9/583 , H03H9/584 , H03H9/706 , H03H2003/0428 , Y10T29/49002
摘要： An apparatus includes a substrate with a cavity and a two-stage resonator filter fabricated over the cavity. The two-stage resonator filter includes a first stage and a second stage. The first stage includes a first resonator and a second resonator, the second resonator acoustically coupled to the first resonator. The second stage includes a third resonator and a fourth resonator, the fourth resonator acoustically coupled to the third resonator. The second resonator and the third resonators are electrically coupled. A decoupling layer couples the first resonator and the second resonator. The decoupling layer extends between the third resonator and the fourth resonator. The first resonator and the fourth resonator are above the substrate. The decoupling layer is above the first resonator and the fourth resonator. The second resonator and the third resonators are above the decoupling layer.
摘要翻译：一种装置包括具有空腔的衬底和在空腔上制造的两级谐振器滤波器。两级谐振滤波器包括第一级和第二级。第一级包括第一谐振器和第二谐振器，第二谐振器声耦合到第一谐振器。第二级包括第三谐振器和第四谐振器，第四谐振器声耦合到第三谐振器。第二谐振器和第三谐振器电耦合。去耦层耦合第一谐振器和第二谐振器。解耦层在第三谐振器和第四谐振器之间延伸。第一谐振器和第四谐振器在衬底之上。去耦层位于第一谐振器和第四谐振器之上。第二谐振器和第三谐振器在去耦层之上。

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