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1. 发明申请

US20090082265A1 COMPOSITIONS AND METHODS FOR TREATING DISEASES 审中-公开
公开(公告)号：US20090082265A1
公开(公告)日：2009-03-26
申请号：US11865591
申请日：2007-10-01
申请人： Paul Bartel , Daniel Cimbora , Janice Sugiyama , Daniel A. Wettstein , Karen Heichman
发明人： Paul Bartel , Daniel Cimbora , Janice Sugiyama , Daniel A. Wettstein , Karen Heichman
IPC分类号： A61K38/16 , C07K14/00 , G01N33/68 , G01N33/53 , C12Q1/68 , A61P9/00 , A61P31/12 , A61P25/00 , A61P35/00 , A61K31/7052 , C12N1/00 , C40B40/10
CPC分类号： C07K14/775 , A61K31/7052 , A61K38/00 , C07K2319/00 , C07K2319/70 , G01N33/6893 , G01N2500/02
摘要： Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.

2. 发明申请

US20050222029A1 Compositions and methods for treating diseases 审中-公开
标题翻译：治疗疾病的组合物和方法
公开(公告)号：US20050222029A1
公开(公告)日：2005-10-06
申请号：US11075234
申请日：2005-03-07
申请人： Paul Bartel , Daniel Cimbora , Janice Sugiyama , Daniel Wettstein , Karen Heichman
发明人： Paul Bartel , Daniel Cimbora , Janice Sugiyama , Daniel Wettstein , Karen Heichman
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/775 , G01N33/68
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/775 , C07K2319/00 , C07K2319/70 , G01N2333/775 , G01N2500/00
摘要： Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.
摘要翻译：提供包含至少一个相互作用的蛋白质对的蛋白质复合物。蛋白质复合物可用于鉴定化合物，用于鉴定有效调节蛋白质复合物的化合物，以及治疗和/或预防与蛋白质复合物和/或其组成相互作用成员相关的疾病和病症。

3. 发明申请

US20050112118A1 Compositions and methods for treating inflammatory disorders 审中-公开
标题翻译：用于治疗炎性疾病的组合物和方法
公开(公告)号：US20050112118A1
公开(公告)日：2005-05-26
申请号：US10690276
申请日：2003-10-20
申请人： Daniel Cimbora , Karen Heichman , Paul Bartel , Kimberly Mauck , Angie Bush
发明人： Daniel Cimbora , Karen Heichman , Paul Bartel , Kimberly Mauck , Angie Bush
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/52 , C07K16/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/90 , C12N15/10 , C12Q1/68 , G01N33/574 , A61K39/395 , A61K38/17
CPC分类号： C12N9/0083 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4702 , C07K14/4711 , C07K14/4716 , C07K14/4747 , C07K14/52 , C07K16/00 , C07K2319/00 , C12N9/1085 , C12N9/1205 , C12N9/14 , C12N9/90 , C12N15/1055 , C12Q1/6883 , C12Y114/99001 , C12Y205/01029 , C12Y207/01037 , G01N33/57407 , G01N33/57415 , G01N2500/02 , Y02A50/401
摘要： Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.
摘要翻译：提供包含至少一个相互作用的蛋白质对的蛋白质复合物。蛋白质复合物可用于鉴定化合物，用于鉴定有效调节蛋白质复合物的化合物，以及治疗和/或预防与蛋白质复合物和/或其组成相互作用成员相关的疾病和病症。

4. 发明申请

US20070254300A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的组合物和方法
公开(公告)号：US20070254300A1
公开(公告)日：2007-11-01
申请号：US11741617
申请日：2007-04-27
申请人： Daniel Cimbora , Karen Heichman , Paul Bartel , Kimberly Mauck , Angie Bush
发明人： Daniel Cimbora , Karen Heichman , Paul Bartel , Kimberly Mauck , Angie Bush
IPC分类号： C07K14/00 , C12P21/04 , C12Q1/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/6893 , G01N33/564 , G01N2500/02 , G01N2800/24 , Y02A50/57
摘要： Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.
摘要翻译：提供包含至少一个相互作用的蛋白质对的蛋白质复合物。蛋白质复合物可用于鉴定化合物，用于鉴定有效调节蛋白质复合物的化合物，以及治疗和/或预防与蛋白质复合物和/或其组成相互作用成员相关的疾病和病症。

5. 发明申请

US20070225209A1 COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS AND DISEASES 审中-公开
标题翻译：用于治疗神经疾病和疾病的组合物和方法
公开(公告)号：US20070225209A1
公开(公告)日：2007-09-27
申请号：US11669939
申请日：2007-01-31
申请人： Jean-Marc Roch , Paul Bartel , Karen Heichman
发明人： Jean-Marc Roch , Paul Bartel , Karen Heichman
IPC分类号： A61K38/04 , C07K4/12 , G01N33/53
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/4711 , G01N2500/00
摘要： The present invention generally relates to methods and compositions for treating neurological disorders and diseases. In addition, methods for selecting therapeutic agents useful for treating neurological disorders and diseases are provided.
摘要翻译：本发明一般涉及用于治疗神经障碍和疾病的方法和组合物。此外，提供了用于治疗神经障碍和疾病的治疗剂的选择方法。

6. 发明申请

US20070087363A1 Therapeutic methods, compounds and compositions 审中-公开
标题翻译：治疗方法，化合物和组合物
公开(公告)号：US20070087363A1
公开(公告)日：2007-04-19
申请号：US11523767
申请日：2006-09-18
申请人： Paul Bartel , Jean-Marc Roch , Janice Sugiyama
发明人： Paul Bartel , Jean-Marc Roch , Janice Sugiyama
IPC分类号： A61K48/00 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/496 , C12Q1/68 , C12Q1/26
CPC分类号： G01N33/6896 , C12N15/1137 , C12N2310/14 , C12Y114/19001 , G01N2333/90241
摘要： The invention provides methods of treating, preventing, delaying the onset, slowing the progression, or reversing the symptoms of Alzheimer's disease and other neurodegenerative diseases characterized by the accumulation of amyloid plaques comprising the Aβ42 peptide. The invention also provides compounds that reduce the production or secretion of the Aβ42-peptide by cells, and pharmaceutical compositions comprising such compounds, for the treatment of neurodegenerative diseases characterized by the accumulation of amyloid plaques comprising the Aβ42 peptide.
摘要翻译：本发明提供了治疗，预防，延缓发作，减缓进展或逆转阿尔茨海默病症状的其他方法，其它特征在于包含Abeta42肽的淀粉样蛋白斑块的积累的其他神经变性疾病。本发明还提供了减少细胞产生或分泌Aβ42-肽的化合物，以及包含这些化合物的药物组合物，用于治疗特征在于包含Aβ42肽的淀粉样蛋白斑块积聚的神经变性疾病。

7. 发明授权

US06831154B1 Membrane-associated protein 17KD (MAP17)-interacting protein and use thereof 失效
标题翻译：膜相关蛋白17KD（MAP17） - 相互作用蛋白及其用途
公开(公告)号：US06831154B1
公开(公告)日：2004-12-14
申请号：US10146710
申请日：2002-05-14
申请人： Paul Bartel
发明人： Paul Bartel
IPC分类号： C07K1400
CPC分类号： C07K14/705
摘要： Protein complexes are provided comprising MAP17 and SCAMP2. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and disorders associated with MAP17 and SCAMP2. In addition, methods for detecting the protein complexes and modulating the functions and activities of the protein complexes or interacting members thereof are also provided.
摘要翻译：提供蛋白质复合物包括MAP17和SCAMP2。蛋白质复合物可用于鉴定化合物中有效调节蛋白质复合物和治疗和/或预防与MAP17和SCAMP2相关的疾病和病症的筛选测定。此外，还提供了用于检测蛋白质复合物和调节蛋白质复合物或其相互作用构件的功能和活性的方法。

8. 发明授权

US07067312B1 PN7718 nucleic acids and use thereof 失效
标题翻译： PN7718核酸及其用途
公开(公告)号：US07067312B1
公开(公告)日：2006-06-27
申请号：US10247146
申请日：2002-09-19
申请人： Paul Bartel , Kimberly Ann Mauck
发明人： Paul Bartel , Kimberly Ann Mauck
IPC分类号： C12N5/00 , C12P21/06 , C07H21/02
CPC分类号： C07K14/47
摘要： Novel PN7718 protein and nucleic acids encoding PN7718 are provided. PN7718-containing protein complexes formed by PN7718 and a PN7718-interacting protein (e.g., cyclophilin C) are also provided. Cyclophilin C and PN7718 may be involved in common biological processes such as intracellular calcium signaling, beta-amyloid formation, T-cell receptor and IgE receptor signaling pathways, and protein folding and degradation. Thus, the protein complexes as well as PN7718 can be used in screening assays to select modulators of PN7718 and the protein complexes formed by PN7718 and cyclophilin C. The identified modulators can be useful in modulating the functions and activities of PN7718 and protein complexes containing PN7718, and in treating and preventing autoimmune diseases, neurological diseases and cardiovascular disorders.
摘要翻译：提供新型PN7718蛋白质和编码PN7718的核酸。还提供了由PN7718和PN7718相互作用的蛋白质（例如亲环蛋白C）形成的含PN7718的蛋白质复合物。 Cyclophilin C和PN7718可能参与常见的生物过程，如细胞内钙信号传导，β-淀粉样蛋白形成，T细胞受体和IgE受体信号通路，以及蛋白质折叠和降解。因此，蛋白质复合物以及PN7718可以用于选择PN7718的调节剂和由PN7718和亲环蛋白C形成的蛋白质复合物的筛选试验。鉴定的调节剂可用于调节PN7718和含有PN7718的蛋白复合物的功能和活性，以及治疗和预防自身免疫性疾病，神经系统疾病和心血管疾病。

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