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1. 发明授权

US08905932B2 Non-invasive characterization of human vasculature 有权
标题翻译：人类脉管系统的非侵入性表征
公开(公告)号：US08905932B2
公开(公告)日：2014-12-09
申请号：US11894052
申请日：2007-08-17
申请人： Paul A. Lovoi , Kieran Murphy , Jeff Jarvela , Pete Neild , John Thomas , Ray Schumacher
发明人： Paul A. Lovoi , Kieran Murphy , Jeff Jarvela , Pete Neild , John Thomas , Ray Schumacher
IPC分类号： A61B8/00 , A61B5/02 , A61B7/04 , A61B5/00 , G06F19/00
CPC分类号： A61B7/04 , A61B5/02007 , A61B5/4076 , A61B5/6814 , A61B5/7267 , G06F19/00 , G06F19/324 , G16H50/20 , G16H50/50
摘要： Vascular conditions are detected non-invasively in the human body using a collection of information from small local regions of the vasculature. An array of accelerometers or other sensors are attached to the head or other points of interest of a patient and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a library for further processing. The signature library is used to localize the origin of the recognized vascular feature, and the localized feature is presented to the physician in a clinically relevant manner.
摘要翻译：使用脉管系统的小的局部区域的信息收集在人体内非侵入性地检测血管病变。一组加速度计或其他传感器附着在患者的头部或其他感兴趣点上，并记录血流声音。使用随机，周期，带限或瞬态分析的血管结构如分支，动脉瘤，狭窄等的振动特征提供了进一步处理的文库。签名库用于定位识别的血管特征的起源，并且以临床相关的方式向局部特征提供局部特征。

2. 发明申请

US20090012430A1 Non-invasive characterization of human vasculature 有权
标题翻译：人类脉管系统的非侵入性表征
公开(公告)号：US20090012430A1
公开(公告)日：2009-01-08
申请号：US11894052
申请日：2007-08-17
申请人： Paul A. Lovoi , Kieran Murphy , Jeff Jarvela , Pete Neild , John Thomas , Ray Schumacher
发明人： Paul A. Lovoi , Kieran Murphy , Jeff Jarvela , Pete Neild , John Thomas , Ray Schumacher
IPC分类号： A61B7/00 , G06K9/00
CPC分类号： A61B7/04 , A61B5/02007 , A61B5/4076 , A61B5/6814 , A61B5/7267 , G06F19/00 , G06F19/324 , G16H50/20 , G16H50/50
摘要： Vascular conditions are detected non-invasively in the human body using a collection of acoustic information from small local regions of the vasculature. An array of accelerometers or other sensors are attached to the head or other points of interest of a patient and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a library for further processing. The signature library is used to localize the origin of the recognized vascular feature, and the localized feature is presented to the physician in a clinically relevant manner.
摘要翻译：使用从脉管系统的小的局部区域的声学信息的集合，在人体内非侵入性地检测血管状态。一组加速度计或其他传感器附着在患者的头部或其他感兴趣点上，并记录血流声音。使用随机，周期，带限或瞬态分析的血管结构如分支，动脉瘤，狭窄等的振动特征提供了进一步处理的文库。签名库用于定位识别的血管特征的起源，并且以临床相关的方式向局部特征提供局部特征。

3. 发明授权

US07914435B2 Everting gynecological brachytherapy applicator and method 失效
标题翻译：永乐妇科近距离放射治疗仪及方法
公开(公告)号：US07914435B2
公开(公告)日：2011-03-29
申请号：US11811295
申请日：2007-06-07
申请人： James E. Jervis , Paul A. Lovoi
发明人： James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
摘要翻译：用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管，套筒和心轴都具有内腔。柔性套管在其远端具有分叉的开口，优选为钟形或锥形，使得当开口端被推靠在阴道口时，套筒将自身退回，逐渐展开到内侧配置，其中，完全插入，套筒完全退回到心轴的外表面上。然后将辐射源，同位素或电子插入到心轴腔中，以开始阴道组织的治疗辐射程序。

4. 发明授权

US07812725B2 System for powering and reading RFID tags 失效
标题翻译： RFID标签的供电和读取系统
公开(公告)号：US07812725B2
公开(公告)日：2010-10-12
申请号：US11644075
申请日：2006-12-21
申请人： Jarie G. Bolander , Paul A. Lovoi , Geoff A. Zawolkow
发明人： Jarie G. Bolander , Paul A. Lovoi , Geoff A. Zawolkow
IPC分类号： G08B13/14
CPC分类号： H04B5/0037 , H02J17/00 , H02J50/20
摘要： A system for tracking items using passive RFID tags utilizes separate data and power frequencies. Within an area in which the items are located, one or more data readers are provided but many more separate power modules are distributed through the space, for powering up the tags. With the power nodes distributed, the tags are powered from a relatively short distance, enabling the tags to transmit through a greater distance. One or more of the readers can include a power-node control which sends an RF signal to control on/off status of specific power nodes within the area, so that power nodes can be activated zone by zone, to thereby permit the reader to determine location by zone of products as their RFID tags are read.
摘要翻译：使用无源RFID标签跟踪物品的系统使用单独的数据和电源频率。在项目所在的区域内，提供了一个或多个数据读取器，但是通过该空间分配了更多的分开的电源模块，以便为标签加电。在功率节点分布的情况下，标签从相对较短的距离供电，使标签能够通过更大的距离进行传输。一个或多个读取器可以包括发送RF信号以控制区域内的特定功率节点的开/关状态的功率节点控制，使得功率节点可以逐区激活，从而允许读取器确定读取产品的区域作为RFID标签。

5. 发明申请

US20100127181A1 Radiation sensor arrays for use with brachytherapy 审中-公开
标题翻译：用于近距离放射治疗的辐射传感器阵列
公开(公告)号：US20100127181A1
公开(公告)日：2010-05-27
申请号：US12321593
申请日：2009-01-21
申请人： Paul A. Lovoi , Steve Axelrod
发明人： Paul A. Lovoi , Steve Axelrod
IPC分类号： G01T1/02
CPC分类号： G01T1/00 , G01T1/026
摘要： A radiation sensor array is carried on a flexible sheet of film, for placement on the skin of a patient adjacent to a brachytherapy location beneath the skin. With the array approximately centered on a position where radiation source to skin distance is estimated to be minimum, the array of sensors is used to monitor radiation dose received at the skin. With a controller connected to the array and preferably also to the radiation source in the applicator, the radiation dose received at all skin points of interest can be monitored, a point of maximum dose and a projected approach to limit dose can be calculated, and in response the system can warn the operator or control a brachytherapy procedure so as to discontinue radiation or control the radiation level or source position in real time. The system can also include percutaneous sensors.
摘要翻译：辐射传感器阵列承载在柔性薄膜片上，用于放置在与皮肤附近的近距离放射治疗位置相邻的患者的皮肤上。以阵列为中心，辐射源至皮肤距离估计为最小的位置，传感器阵列用于监测皮肤接收的辐射剂量。通过将控制器连接到阵列并且优选地也连接到施用器中的辐射源，可以监测在所有皮肤感兴趣点处接收的辐射剂量，可以计算最大剂量点和限制剂量的预计接近点，并且在响应系统可以警告操作者或控制近距离放射治疗程序，以便实时中止辐射或控制辐射水平或源位置。该系统还可以包括经皮传感器。

6. 发明授权

US07686755B2 Radiation therapy apparatus with selective shielding capability 有权
标题翻译：具有选择性屏蔽能力的放射治疗仪
公开(公告)号：US07686755B2
公开(公告)日：2010-03-30
申请号：US11471277
申请日：2006-06-19
申请人： Peter C. Smith , Michael Klein , Heike Hausen , Paul A. Lovoi
发明人： Peter C. Smith , Michael Klein , Heike Hausen , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22051 , A61B2090/0481 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.
摘要翻译：近程放射治疗仪包括各种形式的选择性屏蔽装置，用于控制指向患者组织的辐射的方向和强度。在一些形式中，施用器包括可伸缩护套，在一些可伸缩的手指中。在其他形式中，具有可膨胀气囊的施用器具有可从邻近气囊的位置缩回或从球囊缩回的护罩，或者屏蔽件本身可以与气囊分开地或与气囊一起充气。

7. 发明申请

US20100074407A1 Treatment of lesions or imperfections in skin, near-skin or in other anatomic tissues, including under direct visualization 审中-公开
标题翻译：治疗皮肤，近皮肤或其他解剖组织中的损伤或缺陷，包括直接观察
公开(公告)号：US20100074407A1
公开(公告)日：2010-03-25
申请号：US12284289
申请日：2008-09-19
申请人： Steve Axelrod , Thomas W. Rusch , Paul A. Lovoi , Anuradha Walawalkar , Sara Z. Yao
发明人： Steve Axelrod , Thomas W. Rusch , Paul A. Lovoi , Anuradha Walawalkar , Sara Z. Yao
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1001 , A61N2005/1091 , A61N2005/1094 , A61N2005/1095
摘要： An apparatus and method for treatment of lesions or imperfections in or near exposed anatomic surfaces using low-level ionizing radiation includes a substantially transparent applicator to administer radiation from an energy source to a surface area with the lesion. The applicator is positioned over the lesion to be treated, a treatment plan is created to achieve the desired therapeutic effect to the lesion, and execution of the treatment plan is executed by the energy source. Verification of the treatment to plan and safety methods are disclosed.
摘要翻译：用于使用低级电离辐射治疗暴露的解剖表面内或附近的损伤或缺陷的装置和方法包括基本上透明的施用器，以将能量源的辐射施加到具有损伤的表面区域。施用器位于要治疗的病变上，创建治疗计划以实现对病变的期望的治疗效果，并且由能量源执行治疗计划的执行。公开了对计划和安全方法的处理的验证。

8. 发明申请

US20090209802A1 BALLOON BRACHYTHERAPY APPLICATOR AND METHOD 有权
标题翻译：气球加速器和方法
公开(公告)号：US20090209802A1
公开(公告)日：2009-08-20
申请号：US11871116
申请日：2007-10-11
申请人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
发明人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.
摘要翻译：公开了用于近距离放射治疗患者，特别是切除腔中的腔周围的组织的方法和施用装置。在需要在连续辐射治疗之间恢复时间的治疗方案中，本发明的施用器保留在皮肤下，允许皮肤至少部分愈合，并且稍后重新进行一次或多次随后的治疗。为了减少患者的不适，麻醉剂可以通过施用器输注到患者组织，用于插入，球囊充气或去除涂抹器。

9. 发明申请

US20080009658A1 Radiation therapy apparatus with selective shielding capability 审中-公开
公开(公告)号：US20080009658A1
公开(公告)日：2008-01-10
申请号：US11471013
申请日：2006-06-19
申请人： Peter C. Smith , Michael Klein , Heike Hausen , Paul A. Lovoi
发明人： Peter C. Smith , Michael Klein , Heike Hausen , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22051 , A61B2090/0481 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.

10. 发明授权

US07127033B2 Miniature x-ray tube cooling system 有权
标题翻译：微型X射线管冷却系统
公开(公告)号：US07127033B2
公开(公告)日：2006-10-24
申请号：US10789653
申请日：2004-02-28
申请人： Paul A. Lovoi , John Rieke , Alex Lim , Peter C. Smith , Thomas W. Rusch
发明人： Paul A. Lovoi , John Rieke , Alex Lim , Peter C. Smith , Thomas W. Rusch
IPC分类号： H01J35/32
CPC分类号： A61N5/1002 , A61M25/003 , A61M25/10 , A61M2025/0004 , A61M2025/0034 , A61M2025/0036 , A61M2025/0039 , A61N2005/005 , A61N2005/1022 , H01J35/32 , H01J2235/1216 , H01J2235/122 , H01J2235/1262 , H05G1/025
摘要： A miniature x-ray tube is cooled using a catheter preferably having multiple small lumens for inflow and outflow of coolant. Inflow may be through an outer lumen(s) in a concentric-extrusion catheter, the liquid turning back at the distal end of the catheter to a proximal flow over the anode end of the x-ray tube and through an inner lumen within which the x-ray tube is positioned. A coolant distribution head may engage with the anode end of the x-ray tube, with small orifices so as to distribute coolant essentially evenly over the anode surface. Temperature and flow rate of the inflowing coolant liquid are balanced so as to optimize heat transfer while efficiently carrying coolant through small lumens without the need for high pressures. Some embodiments use the inflation liquid in an applicator balloon as the coolant, with the liquid actively flowing or, in a simplified system, with the liquid static.
摘要翻译：使用优选具有用于冷却剂的流入和流出的多个小流明的导管来冷却微型X射线管。流入可以穿过同心挤出导管中的外腔，液体在导管的远端处返回到X射线管的阳极端上的近端流动并且穿过内腔，在内腔内 x射线管被定位。冷却剂分配头可以与X射线管的阳极端接合，具有小孔，以便将冷却剂基本均匀地分布在阳极表面上。流入的冷却剂液体的温度和流速是平衡的，以便优化热传递，同时有效地将冷却剂携带在小流明中，而不需要高压。一些实施例使用施用器气囊中的充气液体作为冷却剂，其中液体主动地流动，或者在简化的系统中使液体静止。

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