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1. 发明申请

US20160256063A1 ANALYTE ASSESSMENT AND ARRHYTHMIA RISK PREDICTION USING PHYSIOLOGICAL ELECTRICAL DATA 审中-公开
标题翻译：使用生理电气数据分析评估和ARRHYTHMIA风险预测
公开(公告)号：US20160256063A1
公开(公告)日：2016-09-08
申请号：US15025158
申请日：2014-09-26
申请人： Paul A. FRIEDMAN , Kevin E. BENNET , Charles J. BRUCE , Virend K. SOMERS , Samuel J. ASIRVATHAM , Michael J. ACKERMAN , John J. DILLION , Dan SADOT , Yehu SAPIR , Amir GEVA , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： Paul A. Friedman , Kevin E. Bennet , Charles J. Bruce , Virend K. Somers , Samuel J. Asirvatham , Michael J. Ackerman , John J. Dillon , Dan Sadot , Yehu Sapir , Amir Geva
IPC分类号： A61B5/0402 , A61B5/04 , A61B5/00 , A61B5/0456 , A61B5/0472 , A61B5/145 , A61B5/0245 , A61B5/0452
CPC分类号： A61B5/0402 , A61B5/0245 , A61B5/02455 , A61B5/04011 , A61B5/04012 , A61B5/04017 , A61B5/04085 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/14546 , A61B5/6852 , A61B5/686 , A61B5/6861 , A61B5/7264 , A61B5/7275
摘要： This document describes, among other things, a computer-implemented method that includes accessing, by a computer system, electrogram data for a patient, wherein the electrogram data is obtained using one or more leads that sense physiological electrical activity of the patient. The computer system can identify one or more waveform features from the electrogram data, and one or more correlations between values of the one or more waveform features and analyte levels. One or more estimated analyte levels in the patient are determined based on 1) the one or more waveform features identified from the electrogram data and 2) the one or more correlations. The computer system can output information related to the one or more estimated analyte levels.
摘要翻译：本文件尤其描述了一种计算机实现的方法，其包括通过计算机系统访问患者的电描记图数据，其中使用感测患者的生理电活动的一个或多个引线获得电描记图数据。计算机系统可以从电描记图数据中识别一个或多个波形特征，以及一个或多个波形特征和分析物水平的值之间的一个或多个相关性。基于1）从电描记图数据识别的一个或多个波形特征和2）一个或多个相关性来确定患者中的一个或多个估计的分析物水平。计算机系统可以输出与一个或多个估计分析物水平相关的信息。

2. 发明授权

US09198683B2 Tissue capture and occlusion systems and methods 有权
标题翻译：组织捕获和闭塞系统和方法
公开(公告)号：US09198683B2
公开(公告)日：2015-12-01
申请号：US13499397
申请日：2010-09-30
申请人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Trevor A. McCaw , Elliot Y. K. Hong
发明人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Trevor A. McCaw , Elliot Y. K. Hong
IPC分类号： A61B17/00 , A61B17/29 , A61B17/12 , A61B5/0402 , A61B17/30 , A61B19/00
CPC分类号： A61B5/0538 , A61B5/0402 , A61B17/12013 , A61B17/122 , A61B17/1285 , A61B17/29 , A61B2017/00026 , A61B2017/00243 , A61B2017/2926 , A61B2017/308 , A61B2090/065
摘要： Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
摘要翻译：描述使用各种组织特征和/或技术捕获和/或捕获所选择的身体组织的系统和方法。在左心耳闭合的情况下，系统和方法可用于捕获左心耳，同时将闭合器械（缝合线，夹子，环等）放置在附件上并收紧或闭合方法（消融，低温手术，装订等），以关闭左心耳。

3. 发明授权

US08961543B2 Tissue ligation devices and methods 有权
标题翻译：组织结扎装置及方法
公开(公告)号：US08961543B2
公开(公告)日：2015-02-24
申请号：US13124950
申请日：2009-10-20
申请人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Trevor A. McCaw , Elliot Y. K. Hong
发明人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Trevor A. McCaw , Elliot Y. K. Hong
IPC分类号： A61B17/04 , A61B17/12 , A61B17/00
CPC分类号： A61B17/12013 , A61B17/0487 , A61B2017/00867 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496
摘要： Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure.
摘要翻译：用于结扎结构的装置和方法，其中连接元件的环可以暂时预紧，而不锁定环。在没有锁定的情况下，如果需要，在将环锁定在解剖结构周围之前，可以使结扎元件的环松动并重新定位。

4. 发明申请

US20120245665A1 Pacing, Sensing or Defibrillator Leads for Implantation into the Myocardium 有权
标题翻译：起搏，感觉或除颤器引导植入心肌
公开(公告)号：US20120245665A1
公开(公告)日：2012-09-27
申请号：US13393521
申请日：2010-09-02
申请人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham
发明人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham
IPC分类号： A61N1/05
CPC分类号： A61N1/0565 , A61N1/0573
摘要： An electrical lead for a cardiac device includes a body having a distal end sized for insertion through a catheter, first and second electrodes extending through the body, with each electrode terminating in a tip having proximal and distal ends and arranged to extend to an area of cardiac tissue. The tips include a fully insulated portion on the proximal and distal ends measuring in a range between 5 percent and 40 percent of the lengths of the tips, and further include an uninsulated intermediate section. The tip of the second electrode includes a helical section surrounding the first electrode and has an insulated portion on an inwardly facing portion surface facing toward the first electrode. The tip of the second electrode also includes a fully insulated portion on the proximal and distal ends measuring in the same or similar percentage range.
摘要翻译：用于心脏装置的电引线包括具有尺寸设置成用于插入穿过导管的远端的主体，延伸穿过主体的第一和第二电极，每个电极终止于具有近端和远端的尖端中，并且布置成延伸到心脏组织。尖端包括在近端和远端的完全绝缘部分，其测量范围在尖端的长度的5％至40％之间的范围内，并且还包括未绝缘的中间部分。第二电极的尖端包括围绕第一电极的螺旋部分，并且在朝向第一电极的朝内部分表面上具有绝缘部分。第二电极的尖端还包括在相同或相似百分比范围内测量的近端和远端的完全绝缘部分。

5. 发明申请

US20120220890A1 DETECTING AND TREATING NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：检测和治疗神经系统疾病
公开(公告)号：US20120220890A1
公开(公告)日：2012-08-30
申请号：US13468337
申请日：2012-05-10
申请人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
发明人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
IPC分类号： A61B5/0476 , A61M5/168 , A61N1/36
CPC分类号： A61B5/0478 , A61B5/4064 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B18/082 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B2018/00214 , A61B2018/00446 , A61B2018/00577 , A61B2018/1467 , A61N1/0529
摘要： Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
摘要翻译：映射设备的一些实施例可以能够通过脑静脉和其他脑血管空间以提供大脑的电生理映射。该装置的这些实施例还可能能够同时或分开地向目标脑组织提供消融能量或其他治疗。在这种情况下，可以使用户能够分析患者大脑的电生理图，并且可以在绘制过程之前或之后的同一时间或在短时间内分析可以使用消融能量来治疗中枢神经系统紊乱这种治疗可以在不使用侵入性手术的情况下完成，其中脑通过患者颅骨中的开口进入。

6. 发明申请

US20110224655A1 CENTRAL CORE MULTIFUNCTIONAL CARDIAC DEVICES 审中-公开
标题翻译：中心多功能心脏装置
公开(公告)号：US20110224655A1
公开(公告)日：2011-09-15
申请号：US13063374
申请日：2009-09-11
申请人： Samuel J. Asirvatham , Charles J. Bruce , Paul A. Friedman , Giovanni Speziali
发明人： Samuel J. Asirvatham , Charles J. Bruce , Paul A. Friedman , Giovanni Speziali
IPC分类号： A61B17/00
CPC分类号： A61N1/057 , A61M1/1008 , A61M1/101 , A61M1/106 , A61M1/1072 , A61M1/1074 , A61M1/1086 , A61M1/1096 , A61M1/12 , A61M1/122 , A61M1/125 , A61M25/0075 , A61M25/1011 , A61M2025/1052 , A61M2205/33 , A61M2205/3303 , A61M2230/04
摘要： Intracardiac devices that can provide a plurality of functions (e.g., pacing, defibrillation, cardiac assist, or valve replacement) via a single support member and control means.
摘要翻译：可经由单个支撑构件和控制装置提供多个功能（例如，起搏，除颤，心脏辅助或瓣膜置换）的心脏内装置。

7. 发明申请

US20110178539A1 LEFT ATRIAL APPENDAGE OCCLUSION DEVICES 审中-公开
标题翻译：左侧ATRIAL APPENDAGE OCCLUSION设备
公开(公告)号：US20110178539A1
公开(公告)日：2011-07-21
申请号：US13003707
申请日：2009-07-08
申请人： David R. Holmes, Jr. , David R. Holmes, III , Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Susan B. Johnson , Rebecca B. Fountain
发明人： David R. Holmes, Jr. , David R. Holmes, III , Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Susan B. Johnson , Rebecca B. Fountain
IPC分类号： A61F2/00
CPC分类号： A61B17/0057 , A61B17/12013 , A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00575 , A61B2017/0061 , A61B2017/00659 , A61B2017/00663 , A61M29/02
摘要： This document provides methods and materials related to minimally invasive techniques for reducing the volume of and/or occluding left atrial appendages.
摘要翻译：本文档提供了与减少左心耳和/或闭塞左心耳的微创技术相关的方法和材料。

8. 发明申请

US20160361533A1 MULTIVECTOR PATIENT CONTACT INTERFACE AND METHOD OF USE 审中-公开
标题翻译：多功能患者接触界面及使用方法
公开(公告)号：US20160361533A1
公开(公告)日：2016-12-15
申请号：US14736180
申请日：2015-06-10
申请人： Walter T. Savage , Shelley J. Savage , Douglas M. Raymond , Peter D. Gray , Paul A. Friedman , Samuel J. Asirvatham , Charles J. Bruce , Christopher V. DeSimone
发明人： Walter T. Savage , Shelley J. Savage , Douglas M. Raymond , Peter D. Gray , Paul A. Friedman , Samuel J. Asirvatham , Charles J. Bruce , Christopher V. DeSimone
IPC分类号： A61N1/04 , A61N1/36 , A61N1/39
CPC分类号： A61N1/0472 , A61N1/046 , A61N1/0476 , A61N1/36025 , A61N1/3906 , A61N1/3918
摘要： A multi-vector patient contact interface and method of use are disclosed.
摘要翻译：公开了一种多向量患者接触界面和使用方法。

9. 发明申请

US20080294229A1 Helical Electrodes for Intramyocardial Pacing and Sensing 审中-公开
标题翻译：用于心肌起搏和感觉的螺旋电极
公开(公告)号：US20080294229A1
公开(公告)日：2008-11-27
申请号：US12131756
申请日：2008-06-02
申请人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham
发明人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： The invention provides for an electrical lead, a steerable sheath and steerable catheter, a sheath and catheter that attach to cardiac tissue via an anchor screw, and a method of pacing, particularly via the atrioventricular septum.
摘要翻译：本发明提供了一种电引线，可操纵护套和可操纵导管，通过锚定螺钉附接到心脏组织的护套和导管，以及特别是通过房室隔膜起搏的方法。

10. 发明申请

US20120327204A1 ENHANCED SIGNAL NAVIGATION AND CAPTURE SYSTEMS AND METHODS 有权
标题翻译：增强信号导航和捕获系统和方法
公开(公告)号：US20120327204A1
公开(公告)日：2012-12-27
申请号：US13499431
申请日：2010-09-30
申请人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Trevor A. McCaw , Elliot Y.K. Hong
发明人： Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Trevor A. McCaw , Elliot Y.K. Hong
IPC分类号： H04N7/18
CPC分类号： A61B5/068 , A61B5/0402 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/063 , A61B5/065 , A61B5/6859 , A61B17/0057 , A61B17/12013 , A61B17/29 , A61B2017/00026 , A61B2017/00243 , A61B2017/00632 , A61B2017/2926 , A61B2017/2947 , A61B2017/308 , A61B2090/065
摘要： Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
摘要翻译：描述使用所选择的组织和/或其他组织的先天电活动导航和/或捕获选定组织的导航和组织捕获系统和方法。在左心耳闭合的情况下，系统和方法可以用于导航到左心耳并捕获/控制附肢，同时将闭合器械（缝线，夹子，环）放置在附件上并收紧或闭合关闭方法（消融，低温手术，装订等）进行闭合左心耳。用于导航装置的先天电活动的使用可以与身体的其他组织和/或区域结合使用。

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