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1. 发明授权

US5879709A Method of treating patients with diabetes 失效
标题翻译：治疗糖尿病患者的方法
公开(公告)号：US5879709A
公开(公告)日：1999-03-09
申请号：US076339
申请日：1998-05-11
申请人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
发明人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
IPC分类号： A61K9/00 , A61K9/20 , A61K9/52 , A61K9/48 , A61K9/50 , C12N11/00
CPC分类号： A61K9/0024 , A61K9/2081 , Y10S514/866
摘要： The present invention is directed to a method of treating a patient with diabetes by implanting an improved macrocapsule containing living islet cells in the patient. The improved macrocapsules encapsulate microcapsules containing islet cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing stability of microencapsulated islet cells; enhancing cytoprotectivity by increasing diffusion distance of encapsulated islet cells from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products.
摘要翻译：本发明涉及一种通过在患者体内植入含有活体胰岛细胞的改进的大囊剂来治疗糖尿病患者的方法。改进的大囊封装含有胰岛细胞的微胶囊，通过减少微胶囊生物材料的表面积和表面粗糙度使系统更具生物相容性; 提高微囊化胰岛细胞的稳定性; 通过增加封装的胰岛细胞从体内分泌的细胞毒素的扩散距离来增强细胞保护性; 提供微囊化材料的可回收性; 并提供一种持续释放细胞产品的系统。

2. 发明授权

US5550178A Process for encapsulating biologics using crosslinkable biocompatible encapsulation system 失效
标题翻译：使用可交联生物相容性封装系统封装生物制剂的方法
公开(公告)号：US5550178A
公开(公告)日：1996-08-27
申请号：US258769
申请日：1994-06-13
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
IPC分类号： C12N11/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/39 , C08F290/00 , C08F299/02 , C08G65/332 , C08K5/06 , C08L5/00 , C08L5/04 , C08L71/00 , C08L71/02 , C12N5/00 , C12N11/04 , C08K5/15 , A61K9/14
CPC分类号： C12N11/04 , A61K9/1652 , C08G65/332 , C08L5/04 , C08L71/02 , C12N5/0012 , C08L71/00 , C12N2533/30 , C12N2533/74
摘要： Crosslinked biocompatible compositions comprising an ionically crosslinked component and a covalently crosslinked component for encapsulating biologics are disclosed. In accordance with the present invention, also disclosed are crosslinkable biocompatible mixtures comprising an ionically crosslinkable component and a covalently crosslinkable component. Methods for encapsulating biologics with the crosslinked and cross-linkable biocompatible compositions are provided. Also, retrievable macrocapsules for encapsulating microcapsules or biologics are disclosed.
摘要翻译：公开了包含离子交联组分和用于封装生物制剂的共价交联组分的交联生物相容性组合物。根据本发明，还公开了包含可离子交联组分和共价可交联组分的可交联的生物相容性混合物。提供了用交联和可交联的生物相容性组合物包封生物制剂的方法。此外，公开了用于封装微胶囊或生物制剂的可回收大囊。

3. 发明授权

US5788988A Method for making cytoprotective, biocompatible, retrievable microcapsule containment systems 失效
标题翻译：用于制备细胞保护性，生物相容性，可回收的微胶囊容纳系统的方法
公开(公告)号：US5788988A
公开(公告)日：1998-08-04
申请号：US473018
申请日：1995-06-06
申请人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
发明人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
IPC分类号： A61K9/00 , A61K9/20 , A61K9/52 , A61K9/48 , A61K9/50 , C12N11/00
CPC分类号： A61K9/0024 , A61K9/2081 , Y10S514/866
摘要： The present invention is directed to a macrocapsule for encapsulating microcapsules containing biologically active material, such as living cells or free living cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing mechanical stability of microencapsulated biological materials; enhancing cytoprotectivity by increasing diffusion distance of encapsulated biological material from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products. The method for producing such a macrocapsule containing the microcapsules is also disclosed.
摘要翻译：本发明涉及一种用于包封含有生物活性物质如活细胞或游离活细胞的微胶囊的大囊，以通过降低微囊化生物材料的表面积和表面粗糙度使系统更具生物相容性; 增加微囊化生物材料的机械稳定性; 通过增加包封的生物材料从体内分泌的细胞毒素的扩散距离来增强细胞保护性; 提供微囊化材料的可回收性; 并提供一种持续释放细胞产品的系统。还公开了含有微胶囊的这种大囊剂的制造方法。

4. 发明授权

US5545423A Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials 失效
标题翻译：用于生物活性物质的细胞保护性，生物相容性，可回收的大包囊系统
公开(公告)号：US5545423A
公开(公告)日：1996-08-13
申请号：US400442
申请日：1995-03-06
申请人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
发明人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
IPC分类号： A61K9/00 , A61K9/20 , A61K9/52 , A61K9/48 , A61K9/50 , C12N11/00
CPC分类号： A61K9/0024 , A61K9/2081 , Y10S514/866
摘要： The present invention is directed to a macrocapsule for encapsulating microcapsules containing biologically active material, such as living cells or free living cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing mechanical stability of microencapsulated biological materials; enhancing cytoprotectivity by increasing diffusion distance of encapsulated biological material from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products. The method for producing such a macrocapsule containing the microcapsules is also disclosed.
摘要翻译：本发明涉及一种用于包封含有生物活性物质如活细胞或游离活细胞的微胶囊的大囊，以通过降低微囊化生物材料的表面积和表面粗糙度使系统更具生物相容性; 增加微囊化生物材料的机械稳定性; 通过增加包封的生物材料从体内分泌的细胞毒素的扩散距离来增强细胞保护性; 提供微囊化材料的可回收性; 并提供一种持续释放细胞产品的系统。还公开了含有微胶囊的这种大囊剂的制造方法。

5. 发明授权

US5834556A Graft copolymer of polycationic species and water-soluble polymers, and uses therefor 失效
标题翻译：聚阳离子种类和水溶性聚合物的接枝共聚物，用途
公开(公告)号：US5834556A
公开(公告)日：1998-11-10
申请号：US697885
申请日：1996-08-29
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
IPC分类号： A01N1/02 , A61K9/127 , A61K9/50 , A61K35/12 , C08G81/00 , C12N5/00 , C12N5/071 , C12N5/077 , C08G63/48 , C08G63/91
CPC分类号： C12N5/0677 , A01N1/021 , A61K9/1271 , A61K9/5031 , C08G81/00 , C12N5/0006 , C12N5/0012 , A61K2035/122 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40
摘要： In accordance with the present invention, there are provided methods to render cells non-adhesive and/or non-immunogenic with respect to macromolecules typically encountered in culture media or in physiological media.
摘要翻译：根据本发明，提供了相对于通常在培养基中或生理介质中遇到的大分子使细胞不粘合和/或非免疫原性的方法。

6. 发明授权

US5334640A Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods 失效
标题翻译：离子共价交联和可交联的生物相容性封装组合物和方法
公开(公告)号：US5334640A
公开(公告)日：1994-08-02
申请号：US866038
申请日：1992-04-08
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
IPC分类号： C12N11/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/39 , C08F290/00 , C08F299/02 , C08G65/332 , C08K5/06 , C08L5/00 , C08L5/04 , C08L71/00 , C08L71/02 , C12N5/00 , C12N11/04 , C08K5/15 , A61K9/14
CPC分类号： C12N11/04 , A61K9/1652 , C08G65/332 , C08L5/04 , C08L71/02 , C12N5/0012 , C08L71/00 , C12N2533/30 , C12N2533/74
摘要： Crosslinked biocompatible compositions comprising an ionically crosslinked component and a covalently crosslinked component for encapsulating biologics are disclosed. In accordance with the present invention, also disclosed are crosslinkable biocompatible mixtures comprising an ionically crosslinkable component and a covalently crosslinkable component. Methods for encapsulating biologics with the crosslinked and crosslinkable biocompatible compositions are provided. Also, retrievable macrocapsules for encapsulating microcapsules or biologics are disclosed.
摘要翻译：公开了包含离子交联组分和用于封装生物制剂的共价交联组分的交联生物相容性组合物。根据本发明，还公开了包含可离子交联组分和共价可交联组分的可交联的生物相容性混合物。提供了用交联和可交联的生物相容组合物包封生物制剂的方法。此外，公开了用于封装微胶囊或生物制剂的可回收大囊。

7. 发明授权

US5759578A Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials 失效
公开(公告)号：US5759578A
公开(公告)日：1998-06-02
申请号：US652095
申请日：1996-05-23
申请人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
发明人： Patrick Soon-Shiong , Neil P. Desai , Roswitha E. Heintz
IPC分类号： A61K9/00 , A61K9/20 , A61K9/52 , A61K9/48 , A61K9/50 , C12N11/00
CPC分类号： A61K9/0024 , A61K9/2081 , Y10S514/866
摘要： The present invention is directed to a macrocapsule for encapsulating microcapsules containing biologically active material, such as living cells or free living cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing mechanical stability of microencapsulated biological materials; enhancing cytoprotectivity by increasing diffusion distance of encapsulated biological material from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products. The method for producing such a macrocapsule containing the microcapsules is also disclosed.

8. 发明授权

US5578442A Graft copolymers of polycationic species and water-soluble polymers, and use therefor 失效
标题翻译：聚阳离子种类和水溶性聚合物的接枝共聚物，并用于此
公开(公告)号：US5578442A
公开(公告)日：1996-11-26
申请号：US856137
申请日：1992-03-23
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
IPC分类号： A01N1/02 , A61K9/127 , A61K9/50 , A61K35/12 , C08G81/00 , C12N5/00 , C12N5/071 , C12N5/077 , C12N11/10
CPC分类号： C12N5/0677 , A01N1/021 , A61K9/1271 , A61K9/5031 , C08G81/00 , C12N5/0006 , C12N5/0012 , A61K2035/122 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40
摘要： In accordance with the present invention, there are provided methods to render cells non-adhesive and/or non-immunogenic with respect to macromolecules typically encountered in culture media or in physiological media. The invention method comprises contacting cells with an effective amount of a composition comprising a polycationic species having water-soluble polymer chains grafted thereon.
摘要翻译：根据本发明，提供了相对于通常在培养基中或生理介质中遇到的大分子使细胞不粘合和/或非免疫原性的方法。本发明方法包括使细胞与有效量的组合物接触，所述组合物包含其上接枝有水溶性聚合物链的聚阳离子种类。

9. 发明授权

US5762959A Microencapsulation of cells 失效
标题翻译：细胞的微胶囊化
公开(公告)号：US5762959A
公开(公告)日：1998-06-09
申请号：US343594
申请日：1994-11-29
申请人： Patrick Soon-Shiong , Roswitha E. Heintz , Gudmund Skjak-Braek
发明人： Patrick Soon-Shiong , Roswitha E. Heintz , Gudmund Skjak-Braek
IPC分类号： A61K9/16 , A61K9/50 , A61K35/39 , B01J13/02 , C12N11/04 , A61K9/48 , G01M3/02
CPC分类号： A61K9/1652 , A61K35/39 , A61K9/5073 , B01J13/02 , C12N11/04
摘要： In accordance with the present invention, it has been discovered that a major reason for the failure to achieve successful in vivo transplantation in large mammalian species has been flaws associated with the design of microcapsules taught in the prior art, flaws in the method of making such microcapsules, and a lack of tests to determine if a given microcapsule will be successful. In accordance with the present invention, a number of functional properties which must be met by a microcapsule in order to achieve successful in vivo transplantation in large animal models have been identified. These properties include (i) a mechanically stable capsule core, (ii) a mechanically strong capsule membrane (i.e., the membrane must be of sufficient strength to prevent capsule disruption), (iii) the absence of excess exposed positively-charged PLL (which leads to fibrosis), and (iv) an adequate level of diffusion of the entrapped biologically active material out of the capsule.
摘要翻译： PCT No.PCT / US93 / 05122 Sec。 371日期1994年12月23日第 102（e）日期1994年12月23日PCT提交1993年5月28日PCT公布。公开号WO93 / 24112 PCT 日期1993年12月9日根据本发明，已经发现，在大型哺乳动物物种中未能实现成功的体内移植的主要原因是与现有技术教导的微胶囊的设计相关的缺陷，制备这种微胶囊的方法，以及缺乏确定给定微胶囊是否成功的试验。根据本发明，已经确定了为了在大型动物模型中实现成功的体内移植而必须由微胶囊满足的许多功能特性。这些性质包括（i）机械稳定的胶囊核心，（ii）机械强力的胶囊膜（即膜必须具有足够的强度以防止胶囊破裂），（iii）不存在过量暴露的带正电荷的PLL 导致纤维化），和（iv）被捕获的生物活性物质从胶囊中的适当水平的扩散。

10. 发明授权

US09399071B2 Methods of treatment of pancreatic cancer 有权
标题翻译：胰腺癌治疗方法
公开(公告)号：US09399071B2
公开(公告)日：2016-07-26
申请号：US13701002
申请日：2011-05-20
申请人： Neil P. Desai , Patrick Soon-Shiong
发明人： Neil P. Desai , Patrick Soon-Shiong
IPC分类号： A61K9/00 , A61K47/48 , A61K9/51 , A61K31/16 , A61K31/337 , A61K31/436 , A61K31/4709 , A61K31/4745 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/69 , A61K31/7068 , A61K39/395
CPC分类号： A61K9/5169 , A61K31/16 , A61K31/337 , A61K31/436 , A61K31/4709 , A61K31/4745 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/69 , A61K31/7068 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer (e.g., gemcitabine-based therapy) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating pancreatic cancer (for example, in an individual who has been previously treated for pancreatic cancer) comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent.
摘要翻译：本发明提供了通过施用包含包含紫杉烷和白蛋白的纳米颗粒的组合物，预先治疗胰腺癌的个体（例如，吉西他滨为基础的治疗）治疗胰腺癌的方法和组合物。本发明还提供了治疗胰腺癌的联合治疗方法（例如，在先前已经用于胰腺癌的个体中），包括向个体施用有效量的包含紫杉烷和白蛋白的纳米颗粒的组合物和另一种药剂。

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