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1. 发明授权

US4237885A Delivery system with mated members for storing and releasing a plurality of beneficial agents 失效
标题翻译：具有用于存储和释放多个有益试剂的配合构件的输送系统
公开(公告)号：US4237885A
公开(公告)日：1980-12-09
申请号：US953480
申请日：1978-10-23
申请人： Patrick S. L. Wong , Bruce B. Pharriss
发明人： Patrick S. L. Wong , Bruce B. Pharriss
IPC分类号： A61F6/08 , A61K9/00 , A61M31/00 , A61M7/00
CPC分类号： A61F6/08 , A61K9/0036 , A61M31/002
摘要： A delivery system is disclosed. The system is useful for the preprogrammed, unattended delivery of at least one beneficial agent to a pre-selected environment of use. The system comprises (I), a beneficial agent (II), a delivery module comprising, (a) a closed tubular member twined about itself to form a multiplicity of continuous, entwined, mated members, the members having, (b) an internal reservoir for storing agent in an amount for execution of the program, (c) a rate controller which maintains the rate of agent delivered in an effective amount from the members throughout the life of the system, (d) an energy source for transferring agent from the reservoir to the environment, and, (e) a portal for releasing agent from the members to the environment, (III), a platform which integrates the module into a unit sized, shaped and adapted for insertion and retention in the environment, and, (IV) a program which provides for the controlled release of agent to produce the desired beneficial effect over a prolonged period of time.
摘要翻译：公开了传送系统。该系统对于预先选择的使用环境中的至少一种有益试剂的预编程的，无人值守的递送是有用的。所述系统包括（I），有益剂（II），递送模块，其包括：（a）围绕其自身缠绕的密封管状构件，以形成多个连续的，缠结的配合构件，所述构件具有（b）内部用于存储执行程序的存储器的存储器，（c）速率控制器，其在系统的整个寿命期间保持从成员有效量传递的代理程序的速率，（d）转移代理从（e）用于将成员从成员释放到环境的门户，（III），将模块整合成尺寸，形状并适于插入和保持在环境中的单元的平台，以及，（IV）一个程序，其规定了药剂的控制释放以在长时间内产生期望的有益效果。

2. 发明授权

US06929803B2 Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings 失效
标题翻译：液体填充的明胶胶囊通过多个涂层转化为控制释放系统
公开(公告)号：US06929803B2
公开(公告)日：2005-08-16
申请号：US10117359
申请日：2002-04-04
申请人： Patrick S. L. Wong , Liang C. Dong , Jiansheng Wan
发明人： Patrick S. L. Wong , Liang C. Dong , Jiansheng Wan
IPC分类号： A61K9/66 , A61K9/00 , A61K9/52 , A61K9/64 , A61K47/42 , A61K9/48
CPC分类号： A61K9/0004
摘要： A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, an expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.
摘要翻译：一种剂型，其包含形成有复合壁并且含有液体活性剂制剂的明胶胶囊，其中所述壁包含形成在所述明胶胶囊的外表面上的阻挡层，形成在阻挡层上的可膨胀层和形成的半透膜描述在可膨胀层之上。剂型和方法提供将标准明胶，液体制剂胶囊转化成受控释放剂型，其允许活性剂随时间的控制释放到使用环境中。

3. 发明授权

US06572582B1 Mixing system for an active agent delivery device 失效
标题翻译：用于活性剂递送装置的混合系统
公开(公告)号：US06572582B1
公开(公告)日：2003-06-03
申请号：US09447655
申请日：1999-11-23
申请人： Patrick S. L. Wong , Stephen S. Hwang , Vincent J. Ferrari
发明人： Patrick S. L. Wong , Stephen S. Hwang , Vincent J. Ferrari
IPC分类号： A61M3700
CPC分类号： A61J1/2093 , A61J7/0038
摘要： The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.
摘要翻译：本发明涉及一种用于活性剂输送装置的混合系统。该装置包括具有第一端和第二端的细长管状构件和混合系统。混合系统使整个剂量的活性剂被夹带在液体中。在使用中，液体被吸入装置的第一端，混合系统将液体和活性剂混合在装置内，并且夹带在液体中的活性剂从该构件的第二端引出并进入患者的口中。

4. 发明授权

US06440457B1 Method of administering antidepressant dosage form 失效
标题翻译：抗抑郁药剂型的施用方法
公开(公告)号：US06440457B1
公开(公告)日：2002-08-27
申请号：US08068480
申请日：1993-05-27
申请人： David Emil Edgren , Gurdish Kaur Bhatti , Zahedeh Hatamkhani , Patrick S. L. Wong
发明人： David Emil Edgren , Gurdish Kaur Bhatti , Zahedeh Hatamkhani , Patrick S. L. Wong
IPC分类号： A61K922
CPC分类号： A61K31/135 , A61K9/0004 , Y10S514/96 , Y10S514/964
摘要： The invention pertains to a dosage form 10 and to administering an antidepressant medicament 16 for an extended period of time in a rate-known dose.
摘要翻译：本发明涉及一种剂型10，并以剂量已知的剂量给予抗抑郁药物16延长一段时间。

5. 发明授权

US06174547B1 Dosage form comprising liquid formulation 有权
公开(公告)号：US06174547B1
公开(公告)日：2001-01-16
申请号：US09353702
申请日：1999-07-14
申请人： Liang-Chang Dong , Steven Espinal , Patrick S. L. Wong
发明人： Liang-Chang Dong , Steven Espinal , Patrick S. L. Wong
IPC分类号： A61K948
CPC分类号： A61K9/4858 , A61K9/0004 , A61K9/1075 , A61K9/4866
摘要： A dosage form is disclosed comprising a drug formulation that self-emulsifies in said dosage form.

6. 发明授权

US6120803A Prolonged release active agent dosage form adapted for gastric retention 有权
公开(公告)号：US6120803A
公开(公告)日：2000-09-19
申请号：US131923
申请日：1998-08-10
申请人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
发明人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
IPC分类号： A61K47/22 , A61K9/00 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/341 , A61K31/522 , A61K45/00 , A61P31/12
CPC分类号： A61K9/0065 , A61K9/2072
摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

7. 发明授权

US6096339A Dosage form, process of making and using same 失效
标题翻译：剂型，制作及使用过程
公开(公告)号：US6096339A
公开(公告)日：2000-08-01
申请号：US826642
申请日：1997-04-04
申请人： Atul D. Ayer , Andrew Lam , Judy A. Magruder , Lawrence G. Hamel , Patrick S. L. Wong
发明人： Atul D. Ayer , Andrew Lam , Judy A. Magruder , Lawrence G. Hamel , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22 , A61K9/24
CPC分类号： A61K9/0004
摘要： The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.
摘要翻译：所公开的本发明涉及包含药物制剂的剂型，其包含具有协调粒径的药物和药物载体以及用于从剂型分配药剂制剂的装置。

8. 发明授权

US5512299A Method of treating oral inflammatory disease 失效
标题翻译：治疗口腔炎症的方法
公开(公告)号：US5512299A
公开(公告)日：1996-04-30
申请号：US092024
申请日：1993-07-14
申请人： Virgil A. Place , Myriam T. Encarnacion , Patrick S. L. Wong , Juan M. E. Harrison
发明人： Virgil A. Place , Myriam T. Encarnacion , Patrick S. L. Wong , Juan M. E. Harrison
IPC分类号： A61K9/00 , A61K9/22 , A61K9/20
CPC分类号： A61K31/573 , A61K9/0004 , A61K9/006
摘要： A method of treating inflammatory disease of the mouth by locally delivering beclomethasone dipropionate and related compounds to the oral cavity of a patient over an extended period of time is disclosed. In one embodiment, beclomethasone dipropionate is delivered by an osmotic device (10), in another embodiment, it is delivered by an erosion controlled device (110) and in yet another embodiment, it is delivered by a diffusion controlled device (310).
摘要翻译：公开了一种通过在长时间内将二丙酸倍氯米松和相关化合物局部递送到患者的口腔来治疗口腔炎症的方法。在一个实施方案中，二丙酸倍氯米松通过渗透装置（10）递送，在另一个实施方案中，其由侵蚀受控装置（110）递送，并且在另一个实施方案中，其由扩散控制装置（310）递送。

9. 发明授权

US5348746A Method for administering drug 失效
标题翻译：给药方法
公开(公告)号：US5348746A
公开(公告)日：1994-09-20
申请号：US964538
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

10. 发明授权

US5324280A Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效
标题翻译：用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
申请人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
发明人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译：公开了用于将有益剂制剂递送到使用环境的渗透系统。渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。

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