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1. 发明授权

US4612008A Osmotic device with dual thermodynamic activity 失效
标题翻译：渗透装置具有双重热力学活性
公开(公告)号：US4612008A
公开(公告)日：1986-09-16
申请号：US685092
申请日：1984-12-21
申请人： Patrick S. L. Wong , Brian Barclay , Joseph C. Deters , Felix Theeuwes
发明人： Patrick S. L. Wong , Brian Barclay , Joseph C. Deters , Felix Theeuwes
IPC分类号： A61K9/00 , A61M7/00 , A61M31/00
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译：公开了渗透系统，其包括形成在围绕隔间的半透性材料的至少一部分中的壁。隔室含有包含有益剂的第一渗透组合物和第二和不同的渗透组合物。墙壁上的通道将第一个组合物与系统的外部连接起来。

2. 发明授权

US4751071A Composition comprising salbutamol 失效
标题翻译：组合物包含沙丁胺醇
公开(公告)号：US4751071A
公开(公告)日：1988-06-14
申请号：US1135
申请日：1987-01-07
申请人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
发明人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61K9/00 , A61M31/00 , A61J3/07
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译：公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有效试剂通过有用试剂的脉冲输送调节到使用环境。

3. 发明授权

US4851229A Composition comprising a therapeutic agent and a modulating agent 失效
标题翻译：组合物，其包含治疗剂和调节剂
公开(公告)号：US4851229A
公开(公告)日：1989-07-25
申请号：US150124
申请日：1988-01-29
申请人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
发明人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译：公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有用试剂通过有用试剂的脉冲输送调节到使用环境。

4. 发明授权

US4777049A Constant release system with pulsed release 失效
标题翻译：脉冲释放恒定释放系统
公开(公告)号：US4777049A
公开(公告)日：1988-10-11
申请号：US1599
申请日：1987-01-08
申请人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
发明人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61K9/00 , A61M31/00 , A61K9/48 , A61K9/52
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译：公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有用试剂通过有用试剂的脉冲输送调节到使用环境。

5. 发明授权

US4743248A Dosage form for delivering acid sensitive beneficial agent 失效
标题翻译：用于递送酸敏感剂的剂型
公开(公告)号：US4743248A
公开(公告)日：1988-05-10
申请号：US895551
申请日：1986-08-11
申请人： Marc L. Bartoo , Patrick S. L. Wong , Felix Theeuwes , Brian Barclay
发明人： Marc L. Bartoo , Patrick S. L. Wong , Felix Theeuwes , Brian Barclay
IPC分类号： A61K9/00 , A61K9/22 , A61K9/52 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dosage form is disclosed, which dosage form comprises an outside wall and an inside wall, which inside wall comprises means for changing its structural integrity in response to fluid having a pH greater than 5 that enters the dosage form, thereby changing the pH environment inside the dosage form and concomitantly causing the inside wall to change its structural integrity, thus causing the outside wall to collapse and be easily eliminated from a host.
摘要翻译：公开了剂型，其剂型包括外壁和内壁，其内壁包括响应于进入剂型的pH大于5的流体改变其结构完整性的装置，从而改变内部的pH环境剂型并伴随地导致内壁改变其结构完整性，从而导致外壁塌陷并容易地从主体中消除。

6. 发明授权

US4449983A Simultaneous delivery of two drugs from unit delivery device 失效
标题翻译：从单位传送装置同时递送两种药物
公开(公告)号：US4449983A
公开(公告)日：1984-05-22
申请号：US360589
申请日：1982-03-22
申请人： Richard Cortese , Brian Barclay , Felix Theeuwes
发明人： Richard Cortese , Brian Barclay , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/22 , A61K9/52 , A61M31/00
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a wall surrounding a lumen divided into a first compartment containing a drug that is separated by a hydrogel partition from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug formulation from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug formulation from the second compartment. In operation, drug formulation is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug formulation in each compartment thereby producing in each compartment a solution containing drugs, and by the expansion and swelling of the hydrogel, whereby drug formulation is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了用于将两种有益药物递送到使用环境的渗透装置。该装置包括围绕分隔成第一隔室的内壁的壁，所述第一隔室含有由水凝胶隔板与含有不同药物的第二隔室隔开的药物。通过该壁的孔与第一隔室连通，用于从第一隔室输送药物制剂，并且穿过该壁的另一个孔与第二隔室连通，用于从第二隔室输送药物制剂。在操作中，药物制剂与每个隔室分开分配，流体通过壁被吸入每个隔室，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物制剂控制，从而在每个隔室中产生隔室含有药物的溶液，以及水凝胶的膨胀和溶胀，由此药物制剂在长时间内以受控和连续的速率通过它们的孔分配。

7. 发明授权

US4455143A Osmotic device for dispensing two different medications 失效
标题翻译：渗透装置用于分配两种不同的药物
公开(公告)号：US4455143A
公开(公告)日：1984-06-19
申请号：US360396
申请日：1982-03-22
申请人： Felix Theeuwes , Brian Barclay , Richard Cortese
发明人： Felix Theeuwes , Brian Barclay , Richard Cortese
IPC分类号： A61M31/00 , A61K9/00 , A61K9/22 , A61K9/52
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了用于将两种有益药物递送到使用环境的渗透装置。该装置包括围绕分隔成包含药物的内腔的半透壁，所述第一隔室含有与含有不同药物的第二隔室分离的药物。通过该壁的孔与第一隔室连通，用于从第一隔室输送药物，另一个穿过该壁的孔与第二隔室连通，用于从第二隔室输送药物。在操作中，药物从每个隔室分开分配，流体通过壁被吸入每个隔室中，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物控制，从而在每个隔室中产生含有药物的溶液在长时间内以受控和连续的速率通过其孔口分配。

8. 发明授权

US08523797B2 Automated point-of-care fluid testing device and method of using the same 有权
标题翻译：自动化点检液体检测装置及其使用方法
公开(公告)号：US08523797B2
公开(公告)日：2013-09-03
申请号：US12435074
申请日：2009-05-04
申请人： Michael G. Lowery , Marwan A. Fathallah , John S. Ziegler , Ryan R. Brumund , Brian Barclay , Frank J. Walsworth , James D. Jacobson , Yei Feng Moy , Thomas D. Johnson
发明人： Michael G. Lowery , Marwan A. Fathallah , John S. Ziegler , Ryan R. Brumund , Brian Barclay , Frank J. Walsworth , James D. Jacobson , Yei Feng Moy , Thomas D. Johnson
IPC分类号： A61M37/00 , A61M1/30 , A61M1/00 , A61M31/00 , A61M5/00 , A61M35/00 , A61B10/00 , A61D5/00 , B65D81/00
CPC分类号： A61B5/14532 , A61B5/145 , A61B5/1486 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150389 , A61B5/150503 , A61B5/15087 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14228
摘要： A point of care fluid testing system for determining properties of a fluid comprises a patient connection, a primary fluid routing portion, a pump, a secondary fluid routing portion, and a flushing fluid connection. The patient connection connects the system to a patient. The primary fluid routing portion has a pump region, a fluid transfer region, and an in-line testing region. The pump region pumps the fluid sample from the patient to the testing portion and back to the patient. The in-line testing region evaluates a first characteristic of the fluid sample. The fluid transfer region transmits a portion of the fluid sample out of the primary fluid routing portion. The secondary fluid routing portion includes an off-line testing portion that receives the portion of the fluid sample transmitted from the fluid transfer region. The off-line testing portion evaluates a second characteristic of the fluid sample.
摘要翻译：用于确定流体性质的护理液测试系统的一个点包括患者连接，主要流体路由部分，泵，次要流体路线部分和冲洗流体连接。患者连接将系统连接到患者。主流体路线部分具有泵区域，流体转移区域和在线测试区域。泵区域将流体样品从患者泵送到测试部分并返回到患者体内。在线测试区域评估流体样品的第一特性。流体转移区域将一部分流体样品从主流体路线部分传出。次流体路线部分包括离线测试部分，其接收从流体传送区域传送的流体样本的一部分。离线测试部分评估流体样品的第二特性。

9. 发明授权

US08403908B2 Differential pressure based flow sensor assembly for medication delivery monitoring and method of using the same 有权
标题翻译：用于药物输送监测的基于差压的流量传感器组件及其使用方法
公开(公告)号：US08403908B2
公开(公告)日：2013-03-26
申请号：US12335128
申请日：2008-12-15
申请人： James D. Jacobson , Brian Barclay , Ryan Brumund , Steven T. Cho , Hrishikesh Choudhury , Marwan A. Fathallah , Tom Johnson , Patrick B. Keely , Mohammad M. Khair , Michael G. Lowery , Frank Walsworth , John S. Ziegler
发明人： James D. Jacobson , Brian Barclay , Ryan Brumund , Steven T. Cho , Hrishikesh Choudhury , Marwan A. Fathallah , Tom Johnson , Patrick B. Keely , Mohammad M. Khair , Michael G. Lowery , Frank Walsworth , John S. Ziegler
IPC分类号： A61M31/00 , G01F1/42
CPC分类号： A61M5/172 , A61M5/16804 , A61M5/16854 , A61M5/16886 , G01F1/42
摘要： A differential pressure based flow sensor assembly and method of using the same to determine the rate of fluid flow in a fluid system. The sensor assembly comprises a disposable portion, and a reusable portion. A flow restricting element is positioned along a fluid flow passage between an inlet and an outlet. The disposable portion further has an upstream fluid pressure membrane and a downstream fluid pressure membrane. The reusable portion has an upstream fluid pressure sensor and a downstream fluid pressure sensor. The upstream fluid pressure sensor senses the upstream fluid pressure at a location within the fluid flow passage between the inlet and the flow restricting element. The downstream fluid pressure sensor senses the downstream fluid pressure at a location within the fluid flow passage between the flow restricting element and the outlet. The process utilizes output of the sensors to calculate the flow rate of the fluid.
摘要翻译：一种基于压差的流量传感器组件及其使用方法来确定流体系统中的流体流速。传感器组件包括一次性部分和可重复使用的部分。流动限制元件沿着入口和出口之间的流体流动通道定位。一次性部分还具有上游流体压力膜和下游流体压力膜。可再利用部分具有上游流体压力传感器和下游流体压力传感器。上游流体压力传感器感测在入口和流动限制元件之间的流体流动通道内的位置处的上游流体压力。下游流体压力传感器感测流量限制元件和出口之间的流体流动通道内的位置处的下游流体压力。该过程利用传感器的输出来计算流体的流量。

10. 发明授权

US07819838B2 Cassette for use in a medication delivery flow sensor assembly and method of making the same 有权
标题翻译：用于药物输送流量传感器组件的盒子及其制造方法
公开(公告)号：US07819838B2
公开(公告)日：2010-10-26
申请号：US12469459
申请日：2009-05-20
申请人： John S. Ziegler , James D. Morrow , Olivier F. Currat , Jeff D. Bransky , Brian Barclay , Marwan A. Fathallah , James D. Jacobson
发明人： John S. Ziegler , James D. Morrow , Olivier F. Currat , Jeff D. Bransky , Brian Barclay , Marwan A. Fathallah , James D. Jacobson
IPC分类号： A61M31/00
CPC分类号： A61M5/16886 , A61M5/16854 , A61M2205/12 , A61M2205/3351 , A61M2205/3355
摘要： A disposable assembly for use with a sensor assembly comprises a body, a flow restricting element, and a fluid pressure membrane. The body has a lid portion and a base portion. The body defines a fluid flow passage that forms an inlet and an outlet. The flow restricting element is positioned in the fluid flow passage between the inlet and the outlet. The membrane is located between the lid and base portions along the fluid flow passage. A reinforcing structure, such as a ring or a rigid disk, is positioned between the fluid pressure membrane and the lid portion to provide increased resistance to pressure in the fluid flow passage. The ring or disk can be a separate component or formed on the membrane. The membrane thickness adjacent to sensor access openings in the lid portion can be increased for pressure resistance, too.
摘要翻译：与传感器组件一起使用的一次性组件包括主体，流动限制元件和流体压力膜。主体具有盖部分和基部部分。主体限定形成入口和出口的流体流动通道。流量限制元件位于入口和出口之间的流体流动通道中。膜沿着流体流动通道位于盖和基部之间。诸如环或刚性盘的加强结构位于流体压力膜和盖部分之间，以提供增加的流体流动通道中的压力阻力。环或盘可以是单独的部件或形成在膜上。也可以增加与盖部分中的传感器进入口相邻的膜厚度以实现耐压性。

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