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1. 发明申请

US20060240541A1 Lateral flow assay systems and methods 有权
公开(公告)号：US20060240541A1
公开(公告)日：2006-10-26
申请号：US11112807
申请日：2005-04-22
申请人： Patrick Petruno , John Petrilla , Michael Brosnan , Rong Zhou , Daniel Roitman
发明人： Patrick Petruno , John Petrilla , Michael Brosnan , Rong Zhou , Daniel Roitman
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N33/54386 , G01N21/17 , G01N21/274 , G01N21/6428 , G01N21/8483 , G01N33/558 , G01N2021/6439 , G01N2201/062 , G01N2201/067 , Y10S435/805 , Y10S435/823 , Y10S436/807 , Y10S436/809 , Y10S436/81 , Y10S436/823 , Y10T436/25125
摘要： In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

2. 发明申请

US20060122782A1 Read-write assay system 有权
标题翻译：读写测定系统
公开(公告)号：US20060122782A1
公开(公告)日：2006-06-08
申请号：US11004390
申请日：2004-12-03
申请人： John Petrilla , Patrick Petruno , Daniel Roitman , Rong Zhou , Michael Brosnan
发明人： John Petrilla , Patrick Petruno , Daniel Roitman , Rong Zhou , Michael Brosnan
IPC分类号： G06F19/00
CPC分类号： G01N35/00732
摘要： A read-write assay system includes providing an assay device; and writing assay device information to the assay device for subsequent reading of the assay device information from the assay device; or performing an assay with the assay device and subsequent writing of the assay related information to the assay device or reading of assay related information from the assay device.
摘要翻译：读写测定系统包括提供测定装置; 以及将测定装置信息写入测定装置，以便随后从测定装置读取测定装置信息; 或使用测定装置进行测定，然后将测定相关信息写入测定装置或从测定装置读取测定相关信息。

3. 发明申请

US20060240568A1 Assay test strips and reading same 有权
公开(公告)号：US20060240568A1
公开(公告)日：2006-10-26
申请号：US11280640
申请日：2005-11-16
申请人： Patrick Petruno , John Petrilla , Michael Brosnan , Rong Zhou , Daniel Roitman , Bo Curry
发明人： Patrick Petruno , John Petrilla , Michael Brosnan , Rong Zhou , Daniel Roitman , Bo Curry
IPC分类号： G01N33/558
CPC分类号： G01N33/54386 , G01N21/17 , G01N21/274 , G01N21/6428 , G01N21/8483 , G01N33/558 , G01N2021/6439 , G01N2201/062 , G01N2201/067 , Y10S435/805 , Y10S435/823 , Y10S436/807 , Y10S436/809 , Y10S436/81 , Y10S436/823 , Y10T436/25125
摘要： An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

4. 发明申请

US20070231922A1 Assay test strips with multiple labels and reading same 有权
标题翻译：测试带有多个标签并读取相同的测试条
公开(公告)号：US20070231922A1
公开(公告)日：2007-10-04
申请号：US11236152
申请日：2005-09-26
申请人： Patrick Petruno , John Petrilla , Michael Brosnan , Rong Zhou , Daniel Roitman
发明人： Patrick Petruno , John Petrilla , Michael Brosnan , Rong Zhou , Daniel Roitman
IPC分类号： G01N33/558
CPC分类号： G01N21/8483 , G01N33/558 , G01N2021/6441 , Y10S435/805 , Y10S435/823 , Y10S436/807 , Y10S436/823 , Y10T436/25125
摘要： In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.
摘要翻译：在一个方面，分析测试条包括特异性结合目标分析物的测试标签和对目标分析物没有任何特异性结合亲和力并且具有与测试标记不同的光学特性的对照标记。在另一方面，测定试片包括特异性结合目标分析物和至少一种对目标分析物没有任何特异性结合亲和力的非特异性结合标记的测试标记。还描述了读取测定条带的系统和方法。

5. 发明申请

US20060128034A1 Diagnostic test using gated measurement of fluorescence from quantum dots 审中-公开
标题翻译：使用量子点荧光的门控测量进行诊断测试
公开(公告)号：US20060128034A1
公开(公告)日：2006-06-15
申请号：US11008912
申请日：2004-12-10
申请人： Patrick Petruno , Daniel Roitman , Rong Zhou , John Petrilla , Marcel Bruchez , Andrew Watson
发明人： Patrick Petruno , Daniel Roitman , Rong Zhou , John Petrilla , Marcel Bruchez , Andrew Watson
IPC分类号： G01N33/551 , C12M1/34
CPC分类号： G01N21/6428 , G01N21/8483
摘要： A rapid diagnostic test system or process uses a gated measurement of the fluorescent light from quantum dots after shutting off an illuminating light source. A delay between shutting off the illumination and measuring allows background fluorescence from substances other than the quantum dots to drop significantly when compared to the intensity of the fluorescence from the quantum dots. Using quantum dots permits high measurement repetition rates and good extinction of background fluorescence.
摘要翻译：快速诊断测试系统或过程在关闭照明光源之后使用来自量子点的荧光的门控测量。关闭照明和测量之间的延迟允许来自量子点以外的物质的背景荧光与来自量子点的荧光强度相比显着下降。使用量子点允许高测量重复率和背景荧光的良好消光。

6. 发明申请

US20070116595A1 Assaying test strips having different capture reagents 有权
标题翻译：测试具有不同捕获试剂的试纸
公开(公告)号：US20070116595A1
公开(公告)日：2007-05-24
申请号：US11285413
申请日：2005-11-22
申请人： John Petrilla , Daniel Roitman
发明人： John Petrilla , Daniel Roitman
IPC分类号： G01N31/22
CPC分类号： G01N21/8483 , G01N21/253 , G01N33/54366 , G01N33/54386 , Y10T403/18 , Y10T436/110833
摘要： In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.
摘要翻译：一方面，诊断测试系统包括插座，光学检测器和逻辑电路。每个光学检测器在插座中具有对应的视图，并且响应于来自相应视图的光而在相应的检测器输出处产生电信号。逻辑电路包括分别耦合到检测器输出并且产生对应于在逻辑输入处接收的信号的逻辑组合的输出逻辑信号的逻辑输入。在另一方面，响应于从测试条的多个视图的相应视图接收的光产生相应的检测信号，并且产生与检测信号的相应逻辑组合对应的至少一个输出逻辑信号。

7. 发明申请

US20060275920A1 Apparatus and method for discriminating among lateral flow assay test indicators 审中-公开
标题翻译：用于区分侧流测定测试指标的装置和方法
公开(公告)号：US20060275920A1
公开(公告)日：2006-12-07
申请号：US11140978
申请日：2005-06-01
申请人： John Petrilla , Annette Grot
发明人： John Petrilla , Annette Grot
IPC分类号： G01N33/558 , G01J3/42
CPC分类号： G01N33/558 , G01N21/8483 , G01N27/3271 , G01N2021/6441
摘要： An apparatus for analyzing a lateral flow test strip having a plurality of types of markers for binding to analytes corresponding, respectively, to the types of markers. The apparatus includes a plurality of emitters corresponding, respectively, to the plurality types of markers on the lateral flow test strip. Each emitter emits light in a predetermined range near an optimum absorption wavelength for the corresponding type of marker to excite the marker.
摘要翻译：一种用于分析横向流动测试条的装置，其具有多个类型的标记，用于结合分别对应于标记类型的分析物。该装置包括分别对应于横向流动测试条上的多种类型的标记的多个发射器。每个发射器在相应类型的标记物的最佳吸收波长附近的预定范围内发射光以激发标记。

8. 发明申请

US20060281193A1 Non-optical reading of test zones 审中-公开
标题翻译：测试区域的非光学读取
公开(公告)号：US20060281193A1
公开(公告)日：2006-12-14
申请号：US11148623
申请日：2005-06-09
申请人： John Petrilla , Carol Schembri , Peter Robrish
发明人： John Petrilla , Carol Schembri , Peter Robrish
IPC分类号： C12M1/34 , G01N33/558
CPC分类号： G01N33/558
摘要： A test zone is read. Conjugate material is exposed to a sample. The conjugate material, when conjugated with at least one analyte in the sample, forms either electrically detectable conjugated material or magnetically detectable conjugated material. Conjugated material in the sample is captured in a test zone. A test is performed on the conjugated material captured in the test zone in order to detect analyte in the sample. The test is an electrical measurement, or a magnetic measurement.
摘要翻译：读取测试区。共轭材料暴露于样品。当共轭材料与样品中的至少一种分析物共轭时，形成电可检测的共轭材料或磁性可检测的共轭材料。样品中的共轭材料被捕获在测试区域中。对在测试区中捕获的共轭材料进行测试，以便检测样品中的分析物。测试是电测量或磁测量。

9. 发明申请

US20060132765A1 Integrated optoelectronic system for measuring fluorescence or luminescence emission decay 有权
标题翻译：用于测量荧光或发光衰减的集成光电子系统
公开(公告)号：US20060132765A1
公开(公告)日：2006-06-22
申请号：US11017748
申请日：2004-12-22
申请人： Julie Fouquet , Ian Hardcastle , Rene Helbing , Annette Grot , John Petrilla
发明人： Julie Fouquet , Ian Hardcastle , Rene Helbing , Annette Grot , John Petrilla
IPC分类号： G01N21/64
CPC分类号： G01N21/6408
摘要： An optoelectronic system for measuring fluorescence or luminescence emission decay, including (a) a light source being a light emitting diode, a semiconductor laser or a flash tube; (b) a first integrated circuit comprising at least one circuit causing the light source to emit light pulses towards a sample which causes a fluorescence or luminescence emission from the sample; (c) a photodiode detecting the emission; (d) a second integrated circuit comprising a detection analysis system determining information about the sample by analyzing decay of the detected emission; and (e) an enclosure enclosing the light source, the first integrated circuit, the second integrated circuit and the photodiode.
摘要翻译：一种用于测量荧光或发光衰减的光电子系统，包括（a）作为发光二极管的光源，半导体激光器或闪光管; （b）第一集成电路，包括至少一个电路，使得所述光源向所述样品发射光脉冲，从而导致来自所述样品的荧光或发光发射; （c）检测发光的光电二极管; （d）第二集成电路，包括检测分析系统，通过分析检测到的发射的衰减来确定关于样品的信息; 和（e）包围光源的外壳，第一集成电路，第二集成电路和光电二极管。

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