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1. 发明申请

US20070142391A1 Piperazine-2-carboxamide derivatives 失效
标题翻译：哌嗪-2-甲酰胺衍生物
公开(公告)号：US20070142391A1
公开(公告)日：2007-06-21
申请号：US10545296
申请日：2004-02-06
申请人： Patrick Page , Catherine Jorand-Lebrun , Russell Thomas , Matthias Schwarz
发明人： Patrick Page , Catherine Jorand-Lebrun , Russell Thomas , Matthias Schwarz
IPC分类号： A61K31/496 , C07D403/14 , C07D405/14
CPC分类号： C07D231/12 , A61K31/16 , A61K31/495 , C07D233/56 , C07D241/04 , C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention is related to piperazine-2-carboxamide derivatives of formula (I) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery. Wherein A, X, Y, R1 and R2 are as defined in the description.
摘要翻译：本发明涉及式（I）的哌嗪-2-甲酰胺衍生物，其用于治疗和/或预防早产，早产，痛经和用于在剖宫产分娩前停止劳动。其中A，X，Y，R 1和R 2如说明书中所定义。

2. 发明申请

US20050215605A1 Thiazolidine carboxamide derivatives as modulators of the prostaglandin f receptor 审中-公开
公开(公告)号：US20050215605A1
公开(公告)日：2005-09-29
申请号：US10508014
申请日：2003-03-27
申请人： Patrick Page , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin
发明人： Patrick Page , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/55 , A61P15/00 , A61P15/06 , A61P43/00 , C07D277/06 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , C07D277/06 , C07D417/14 , Y02P20/582
摘要： The present invention is related to thiazolidine carboxamide derivatives of formula (II) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery. G is selected from the group consisting of C1-C6-alkyl aryl, C1-C6-alkyl heteroaryl, C1-C6 Alkyl cycloalkyl, C1-C6-alkyl heteroaryl, aryl, heteroaryl, C3-C8-cycloalkyl or -heterocycloalkyl, said cycloalkyl or aryl or hetetoaryl groups may be fused with cycloalkyl or aryl or heteroaryl groups. R1 is selected from the group consisting of aryl, heteroaryl, C3-C8-cycloalkyl or -heterocyclo-alkyl, said (hetero)cycloalkyl or aryl or heteroaryl groups may be fused with (hetero)cycloalkyl or aryl or heteroaryl groups. R2 is selected from the group consisting of H, carboxy, acyl, alkoxycarbonyl, aminocarbonyl, C1-C5-alkyl carboxy, C1-C5-alkyl acyl, C1-C5-alkyl alkoxycarbonyl, C1-C5-alkyl aminocarbonyl, C1-C5-alkyl acyloxy, C1-C5-alkyl acylamino, C1-C5-alkyl ureido, C1-C5alkyl amino, C1-C5-alkyl alkoxy, C1-C5-alkyl sulfanyl, C1-C5-alkyl sulfinyl, C1-C5-alkyl sulfonyl, C1-C5-alkyl sulfonylamino, C1-C5-alkyl sulfonyloxy, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, aryl, heteroaryl, C3-C8-cycloalkyl, heterocycloalkyl, C1-C6-alkyl aryl, C2-C6-alkyl heteroaryl, C1-C6-alkyl cycloalkyl, C1-C6-alkyl heterocycloalkyl, C2-C6-alkenyl aryl, C2-C6-alkenyl heteroaryl, C2-C6-alkynyl aryl, or C2-C6-alkynyl heteroaryl.

3. 发明授权

US08404690B2 Piperazine-2-carboxamide derivatives 失效
标题翻译：哌嗪-2-甲酰胺衍生物
公开(公告)号：US08404690B2
公开(公告)日：2013-03-26
申请号：US10545296
申请日：2004-02-06
申请人： Patrick Page , Catherine Jorand-Lebrun , Russell J. Thomas , Matthias Schwarz
发明人： Patrick Page , Catherine Jorand-Lebrun , Russell J. Thomas , Matthias Schwarz
IPC分类号： A61K31/497 , C07D401/00
CPC分类号： C07D231/12 , A61K31/16 , A61K31/495 , C07D233/56 , C07D241/04 , C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention is related to piperazine-2-carboxamide derivatives of formula (I) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery. Wherein A, X, Y, R1 and R2 are as defined in the description.
摘要翻译：本发明涉及式（I）的哌嗪-2-甲酰胺衍生物，其用于治疗和/或预防早产，早产，痛经和用于在剖宫产分娩前停止劳动。其中A，X，Y，R 1和R 2如说明书中所定义。

4. 发明授权

US08415480B2 Thiazolidine carboxamide derivatives as modulators of the prostaglandin F receptor 有权
标题翻译：噻唑烷羧酰胺衍生物作为前列腺素F受体的调节剂
公开(公告)号：US08415480B2
公开(公告)日：2013-04-09
申请号：US12140682
申请日：2008-06-17
申请人： Patrick Naxos Page , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
发明人： Patrick Naxos Page , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
IPC分类号： A61K31/4402 , A61K31/426 , C07D417/12 , C07D277/46
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , C07D277/06 , C07D417/14 , Y02P20/582
摘要： The present invention is related to thiazolidine carboxamide derivatives of formula (II) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery.
摘要翻译：本发明涉及式（II）的噻唑烷羧酰胺衍生物，其用于治疗和/或预防早产，早产，痛经和用于在剖宫产分娩前停止劳动。

5. 发明申请

US20080255094A1 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR 有权
标题翻译：作为PROSTAGLANDIN F受体的调节剂的噻唑烷羧酰胺衍生物
公开(公告)号：US20080255094A1
公开(公告)日：2008-10-16
申请号：US12140682
申请日：2008-06-17
申请人： Patrick Naxos PAGE , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
发明人： Patrick Naxos PAGE , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
IPC分类号： A61K31/55 , C07D277/06 , A61K31/426 , A61P15/06 , A61P15/04 , C07D417/12
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , C07D277/06 , C07D417/14 , Y02P20/582
摘要： The present invention is related to thiazolidine carboxamide derivatives of formula (II) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery.
摘要翻译：本发明涉及式（II）的噻唑烷羧酰胺衍生物，其用于治疗和/或预防早产，早产，痛经和用于在剖宫产分娩前停止劳动。

6. 发明授权

US07115754B2 Pyrrolidine derivatives as oxytocin antagonists 有权
标题翻译：吡咯烷衍生物作为催产素拮抗剂
公开(公告)号：US07115754B2
公开(公告)日：2006-10-03
申请号：US10518543
申请日：2003-07-04
申请人： Catherine Jorand-Lebrun , Jerome Dorbais , Anna Quattropani , Matthias Schwarz , Delphine Valognes
发明人： Catherine Jorand-Lebrun , Jerome Dorbais , Anna Quattropani , Matthias Schwarz , Delphine Valognes
IPC分类号： C07D207/09 , C07D207/18 , A01N43/36
CPC分类号： C07D231/12 , C07D207/22 , C07D233/56 , C07D249/08 , C07D403/06
摘要： The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1 is selected from the group comprising or consisting of H and C1–C6-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea
摘要翻译：本发明涉及式（I）的新型吡咯烷衍生物，其几何异构体，其作为对映异构体的光学活性形式，非对映异构体，这些及其外消旋体形式的混合物，及其盐，其中R 1〜 >选自由H和C 1 -C 6 - 烷基组成或组成的组，用于预防和/或治疗早产，早产或痛经

7. 发明申请

US20060004020A1 Pyrrolidine derivatives as oxytocin antagonists 有权
标题翻译：吡咯烷衍生物作为催产素拮抗剂
公开(公告)号：US20060004020A1
公开(公告)日：2006-01-05
申请号：US10518543
申请日：2003-07-04
申请人： Catherine Jorand-Lebrun , Jerome Dorbais , Anna Quattropani , Matthias Schwarz , Delphine Valognes
发明人： Catherine Jorand-Lebrun , Jerome Dorbais , Anna Quattropani , Matthias Schwarz , Delphine Valognes
IPC分类号： A61K31/496 , A61K31/4025 , A61K31/416 , A61K31/401 , C07D43/02 , C07D27/18
CPC分类号： C07D231/12 , C07D207/22 , C07D233/56 , C07D249/08 , C07D403/06
摘要： The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1 is selected from the group comprising or consisting of H and C1-C6-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea.
摘要翻译：本发明涉及式（I）的新型吡咯烷衍生物，其几何异构体，其作为对映异构体的光学活性形式，非对映体，这些及其外消旋体形式的混合物，及其盐，其中R 1〜选自由H和C 1 -C 6 - 烷基组成或由H和C 1 -C 6 - 烷基组成的组，用于预防和/或治疗早产，早产或痛经。

8. 发明申请

US20090215749A9 THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR 有权
标题翻译：作为PROSTAGLANDIN F受体的调节剂的噻唑烷羧酰胺衍生物
公开(公告)号：US20090215749A9
公开(公告)日：2009-08-27
申请号：US12140682
申请日：2008-06-17
申请人： Patrick Naxos PAGE , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
发明人： Patrick Naxos PAGE , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel , Matthias Schwarz , Estelle Hamelin , Russell J. Thomas
IPC分类号： A61K31/55 , C07D277/06 , A61K31/426 , A61P15/06 , A61P15/04 , C07D417/12
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , C07D277/06 , C07D417/14 , Y02P20/582
摘要： The present invention is related to thiazolidine carboxamide derivatives of formula (II) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery.
摘要翻译：本发明涉及式（II）的噻唑烷羧酰胺衍生物，其用于治疗和/或预防早产，早产，痛经和用于在剖宫产分娩前停止劳动。

9. 发明授权

US07557136B2 Pyrrolidine derivatives as oxytocin antagonists 失效
标题翻译：吡咯烷衍生物作为催产素拮抗剂
公开(公告)号：US07557136B2
公开(公告)日：2009-07-07
申请号：US10547032
申请日：2004-02-16
申请人： Matthias Schwarz , Catherine Jorand-Lebrun , Delphine Valognes
发明人： Matthias Schwarz , Catherine Jorand-Lebrun , Delphine Valognes
IPC分类号： A61K31/40 , A61K31/4245 , A61K31/4184 , C07D207/14 , C07D271/06 , C07D403/06
CPC分类号： C07D413/06 , C07D207/22
摘要： The present invention relates to novel pyrrolidine derivatives of Formula (I), its geometrical isomers, its optically active forms as enantiomers, diastercomers, mixtures of these and its racemate forms, as well as salts thereof, wherein: R1is selected from the group comprising or consisting of H and C1-C6-alkyl; R2 is selected from the group comprising or consisting of hydrogen, C1-C6-alkyl, C1-C6 alkyl aryl, heteroaryl, C1-C6 alkyl heteroaryl, C2-C6-alkenyl, C2-C6-alkenyl aryl, C2-C6 alkenyl heteroaryl, C2-C6-alkynyl, C2-C6-alkynyl aryl, C2C6-alkynyl heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, CI-C6-alkyl cycloallcyl, CI-C6-alkyl heterocycloalkyl, CIC6 alkyl carboxy, acyl, C1-C6-alkyl acyl, C1-C6-alkyl acyloxy, C1-C6-alkyl alkoxy, alkoxycarbonyl, C1-C6-alkyl alkoxycarbonyl, aminocarbonyl, C1-C6-alkyl aminocarbonyl, C1-C6-alkyl acylarnino, C1-C6-alkyl ureido, amino, C1-C6-alkyl amino, sulfonyloxy, C1-C6 alkyl sulfonyloxy, sulfonyl, C1-C6-alkyl sulfonyl, sulfinyl, C1-C6-alkyl sulfinyl, C1-C6alkyl sulfanyl, C1-C6-alkyl sulfonylamino.
摘要翻译：本发明涉及式（I）的新型吡咯烷衍生物，其几何异构体，其作为对映异构体的光学活性形式，diastercomers，它们的混合物及其外消旋体形式及其盐，其中：R 1选自包括或由H和C 1 -C 6 - 烷基组成; R 2选自氢，C 1 -C 6 - 烷基，C 1 -C 6烷基芳基，杂芳基，C 1 -C 6烷基杂芳基，C 2 -C 6 - 烯基，C 2 -C 6烯基芳基，C 2 -C 6烯基杂芳基，C 2 -C 6 - 炔基芳基，C 2 -C 6炔基杂芳基，C 3 -C 8环烷基，杂环烷基，C 1 -C 6烷基环烷基，C 1 -C 6烷基杂环烷基，CIC 6烷基羧基，酰基，C 1 -C 6 - 烷基酰基，C 1 -C 6烷基酰氧基，C 1 -C 6烷基烷氧基，烷氧基羰基，C 1 -C 6烷基烷氧基羰基，氨基羰基，C 1 -C 6烷基氨基羰基，C 1 -C 6烷基酰基氨基，C 1 -C 6烷基脲基，氨基，C 1 -C 6烷基氨基，磺酰氧基，C 1 -C 6烷基磺酰氧基，磺酰基，C 1 -C 6烷基磺酰基，亚磺酰基，C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基硫烷基，C 1 -C 6烷基磺酰基氨基。

10. 发明申请

US20070037806A1 Pyrrolidine derivatives as oxytocin antagonists 失效
公开(公告)号：US20070037806A1
公开(公告)日：2007-02-15
申请号：US10547032
申请日：2004-02-16
申请人： Matthias Schwarz , Catherine Jorand-Lebrun , Delphine Valognes
发明人： Matthias Schwarz , Catherine Jorand-Lebrun , Delphine Valognes
IPC分类号： A61K31/5377 , A61K31/4245 , A61K31/401 , A61K31/4184 , C07D413/02 , C07D403/02
CPC分类号： C07D413/06 , C07D207/22
摘要： The present invention relates to novel pyrrolidine derivatives of Formula (I), its geometrical isomers, its optically active forms as enantiomers, diastercomers, mixtures of these and its racemate forms, as well as salts thereof, wherein: Rlis selected from the group comprising or consisting of H and C1-C6-alkyl; R2 is selected from the group comprising or consisting of hydrogen, C1-C6-alkyl, C1-C6 alkyl aryl, heteroaryl, C1-C6 alkyl heteroaryl, C2-C6-alkenyl, C2-C6-alkenyl aryl, C2-C6 alkenyl heteroaryl, C2-C6-alkynyl, C2-C6-alkynyl aryl, C2C6-alkynyl heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, C1-C6-alkyl cycloallcyl, C1-C6-alkyl heterocycloalkyl, C1C6 alkyl carboxy, acyl, C1-C6-alkyl acyl, C1-C6-alkyl acyloxy, C1-C6-alkyl alkoxy, alkoxycarbonyl, C1-C6-alkyl alkoxycarbonyl, aminocarbonyl, C1-C6-alkyl aminocarbonyl, C1-C6-alkyl acylarnino, C1-C6-alkyl ureido, amino, C1-C6-alkyl amino, sulfonyloxy, C1-C6 alkyl sulfonyloxy, sulfonyl, C1-C6-alkyl sulfonyl, sulfinyl, C1-C6-alkyl sulfinyl, C1-C6alkyl sulfanyl, C1-C6-alkyl sulfonylamino;

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