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1. 发明授权

US07486395B2 System and method for a chemical imaging threat assessor with a probe 有权
标题翻译：具有探针的化学成像威胁评估者的系统和方法
公开(公告)号：US07486395B2
公开(公告)日：2009-02-03
申请号：US11544648
申请日：2006-10-10
申请人： Patrick J. Treado , Thomas C. Voigt , Wesley H. Hutchison
发明人： Patrick J. Treado , Thomas C. Voigt , Wesley H. Hutchison
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0227 , G01J3/0256 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0286 , G01J3/0289 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/2803 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J3/447 , G01N2021/656 , G01N2201/0846
摘要： The disclosure relates to a portable and/or handheld bioagent detector and methodology described herein that is based in part on advanced Raman Chemical Imaging (“RCI”) technology. According to one embodiment of the present disclosure, the detection system may include a fiber array spectral translator (“FAST”) and may also include a probe which may include a complementary metal oxide semiconductor (CMOS) camera. The probe alleviates the need to place the main instrument close to an unconfined release of a potentially hazardous material and facilitates analysis of a sample that is situated in a hard-to-reach location while minimizing contamination of the detector and operator.
摘要翻译：本公开涉及部分基于先进的拉曼化学成像（“RCI”）技术的本文描述的便携式和/或手持式生物代谢检测器和方法。根据本公开的一个实施例，检测系统可以包括光纤阵列光谱转换器（“FAST”），并且还可以包括可以包括互补金属氧化物半导体（CMOS）照相机的探针。探头减轻了将主仪器置于非限制性释放潜在危险物质的需要，并有助于分析位于难以到达的位置的样品，同时最大限度地减少检测器和操作者的污染。

2. 外观设计

USD500257S1 Handheld biothreat detector 失效
标题翻译：手持式生物探测器
公开(公告)号：USD500257S1
公开(公告)日：2004-12-28
申请号：US29186577
申请日：2003-07-18
申请人： Wesley H. Hutchison , Robert M. Stern , Patrick J. Treado
设计人： Wesley H. Hutchison , Robert M. Stern , Patrick J. Treado

3. 发明授权

US07283241B2 Method and apparatus for a microscope image selector 有权
标题翻译：显微镜图像选择器的方法和装置
公开(公告)号：US07283241B2
公开(公告)日：2007-10-16
申请号：US11045080
申请日：2005-01-31
申请人： Xinghua Wang , Thomas C. Voigt , David Tuschel , Chenhui Wang , Patrick J. Treado
发明人： Xinghua Wang , Thomas C. Voigt , David Tuschel , Chenhui Wang , Patrick J. Treado
IPC分类号： G01N21/25
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

4. 发明授权

US07564546B2 Dynamic imaging of biological cells and other subjects 有权
标题翻译：生物细胞和其他科目的动态成像
公开(公告)号：US07564546B2
公开(公告)日：2009-07-21
申请号：US10556038
申请日：2005-06-30
申请人： John S. Maier , Patrick J. Treado , David Tuschel , Thomas C. Voigt
发明人： John S. Maier , Patrick J. Treado , David Tuschel , Thomas C. Voigt
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像方法，包括细胞成像方法。该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

5. 发明申请

US20120154792A1 Portable system for detecting hazardous agents using SWIR and method for use thereof 审中-公开
标题翻译：使用SWIR检测危险品的便携式系统及其使用方法
公开(公告)号：US20120154792A1
公开(公告)日：2012-06-21
申请号：US13068542
申请日：2011-05-12
申请人： Patrick J. Treado , Matthew Nelson , Charles W. Gardner, JR. , Thomas Voigt , Jeffrey Beckstead
发明人： Patrick J. Treado , Matthew Nelson , Charles W. Gardner, JR. , Thomas Voigt , Jeffrey Beckstead
IPC分类号： G01J3/00
CPC分类号： G01J3/0208 , G01J3/0224 , G01J3/0248 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0289 , G01J3/0291 , G01J3/1256 , G01J3/26 , G01J3/2823
摘要： The disclosure provides for a portable device for detecting hazardous agents, including explosives using SWIR hyperspectral imaging. The device may comprise a collection optics, a SWIR multi-conjugate filter, a SWIR camera, and a display. The device may also comprise an RGB camera. The disclosure also provides for a method of using said portable device wherein interacted photons are collected and passed through a SWIR multi-conjugate filter. The interacted photons are detected to generate at least one SWIR hyperspectral image. The SWIR hyperspectral image may be analyzed to determine the presence or absence of a hazardous agent on a target. An RGB image of a target may also be generated and analyzed to survey a sample scene.
摘要翻译：本公开提供了用于检测危险剂的便携式装置，包括使用SWIR高光谱成像的爆炸物。该装置可以包括收集光学器件，SWIR多共轭滤光器，SWIR相机和显示器。该设备还可以包括RGB相机。本公开还提供了使用所述便携式设备的方法，其中相互作用的光子被收集并通过SWIR多重共轭滤波器。检测相互作用的光子以产生至少一个SWIR高光谱图像。可以分析SWIR高光谱图像以确定目标上是否存在危险剂。还可以生成和分析目标的RGB图像以对样本场景进行调查。

6. 发明授权

US07999928B2 Method and system for combined Raman and LIBS detection 有权
标题翻译：用于组合拉曼和LIBS检测的方法和系统
公开(公告)号：US07999928B2
公开(公告)日：2011-08-16
申请号：US11656393
申请日：2007-01-23
申请人： Jeffrey Beckstead , Patrick J. Treado , Matthew Nelson
发明人： Jeffrey Beckstead , Patrick J. Treado , Matthew Nelson
IPC分类号： G01N21/00
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/28 , G01J3/443 , G01N21/65 , G01N21/718 , G01N2201/0221
摘要： In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second illumination pattern to obtain a plurality of second sample photons; processing the plurality of first sample photons to obtain a characteristic atomic emission of the first region and processing the plurality of second sample photons to obtain a Raman spectrum; and identifying the sample through at least one of the characteristic atomic emission of the first region or the Raman spectrum of the second region of the sample.
摘要翻译：在一个实施例中，本公开涉及一种用于询问样本的方法，其中：用第一照明图案照射样品的第一区域以获得多个第一样品光子; 用第二照明图案照射样品的第二区域以获得多个第二样品光子; 处理多个第一样品光子以获得第一区域的特征原子发射并处理多个第二样品光子以获得拉曼光谱; 以及通过样品的第二区域的第一区域的特征性原子发射或拉曼光谱中的至少一个来识别样品。

7. 发明授权

US07764371B2 System and method for super resolution of a sample in a fiber array spectral translator system 有权
标题翻译：用于光纤阵列光谱转换器系统中样品超分辨率的系统和方法
公开(公告)号：US07764371B2
公开(公告)日：2010-07-27
申请号：US11675155
申请日：2007-02-15
申请人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
发明人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
IPC分类号： G01J3/00
CPC分类号： G01T1/20
摘要： The disclosure relates generally to methods and apparatus for obtaining a super resolution image of a sample using a fiber array spectral translator system. In one embodiment includes collecting photons from a sample at a first end of a fiber array spectral translator; delivering the photons from a second end of the fiber array spectral translator into a multiple detector rows of a photon detector; interpolating between the multiple detector rows to thereby form interpolated rows; and arranging an output of the multiple detector rows and the interpolated rows so as to obtain a super resolution image of the sample.
摘要翻译：本公开一般涉及使用光纤阵列频谱转换器系统获得样本的超分辨率图像的方法和装置。在一个实施例中，包括在光纤阵列光谱转换器的第一端收集来自样品的光子; 将光子从光纤阵列频谱转换器的第二端传送到光子检测器的多个检测器行中; 在多个检测器行之间内插，从而形成内插行; 并且布置多个检测器行和内插行的输出，以便获得样本的超分辨率图像。

8. 发明授权

US07738095B2 Method and apparatus for compact spectrometer for detecting hazardous agents 有权
标题翻译：用于检测危险物质的紧凑型光谱仪的方法和装置
公开(公告)号：US07738095B2
公开(公告)日：2010-06-15
申请号：US11366532
申请日：2006-03-03
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2201/0221
摘要： The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

9. 发明申请

US20090147242A1 SYSTEM AND METHOD FOR THE COINCIDENT DEPOSITION, DETECTION AND IDENTIFICATION OF THREAT AGENTS 有权
标题翻译：联合沉积物的系统和方法，威胁剂的检测和鉴定
公开(公告)号：US20090147242A1
公开(公告)日：2009-06-11
申请号：US11351286
申请日：2006-02-09
申请人： Patrick J. Treado , Charles W. Gardner, JR. , John S. Maier
发明人： Patrick J. Treado , Charles W. Gardner, JR. , John S. Maier
IPC分类号： G01J3/44 , G01N21/00 , G01N21/65
CPC分类号： G01J3/44 , G01N21/65
摘要： A system and method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is identified substantially coincident in time with the depositing of the sample of the threat agent onto the substrate.
摘要翻译：将用于沉积威胁剂的样品的系统和方法沉积在基底上。识别威胁剂与威胁剂样品沉积在基材上基本一致。

10. 发明申请

US20090128802A1 Time and Space Resolved Standoff Hyperspectral IED Explosives LIDAR Detector 有权
标题翻译：时间和空间解决了高分辨率高分辨率IED爆炸物激光雷达探测器
公开(公告)号：US20090128802A1
公开(公告)日：2009-05-21
申请号：US12199145
申请日：2008-08-27
申请人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
发明人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

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