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1. 发明授权

US4761430A Arylbenzenesulfonamide containing pharmaceutical compositions 失效
标题翻译：含有芳基苯磺酰胺的药物组合物
公开(公告)号：US4761430A
公开(公告)日：1988-08-02
申请号：US910738
申请日：1986-09-23
申请人： Patrick Choay , Pierre Roger , Dominique Olliero
发明人： Patrick Choay , Pierre Roger , Dominique Olliero
IPC分类号： C07D213/71 , C07D295/185 , C07D333/34 , A61K31/19 , A61K31/215
CPC分类号： C07D295/185 , C07D213/71 , C07D333/34
摘要： The invention relates to new medicaments having lipid regulating propertiesnd processes for their preparation.The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the arylsulfonamide type corresponding to the formula: ##STR1## in which: Ar prepresents an aromatic ring which may if necessary be substituted;n+m+1 is comprised from 3 to 11, being preferably equal to 3, 5 or 10;R.sub.5 and R.sub.6 represent independently of one another, particularly an alkyl radical;R.sub.4 represents the hydroxy group, the radical OR.sub.7 in which R.sub.7 is particularly an alkyl group, the radical NR.sub.8 R.sub.9 in which R.sub.8 and R.sub.9 are identical or different, and represent in particular a hydrogen atom, and form with the nitrogen a nitrogenous heterocyclic ring with 5 or 6 links.
摘要翻译：本发明涉及具有脂质调节性质的新药物及其制备方法。根据本发明的药物含有至少一种对应于下式的至少一种芳基磺酰胺类型的化合物（或其相应的光学异构体）：其中：Ar表示可以根据需要被取代的芳环; n + m + 1为3〜11，优选为3,5或10; R5和R6彼此独立地表示，特别是烷基; R 4表示羟基，其中R 7特别为烷基的基团OR 7，其中R 8和R 9相同或不同的基团NR 8 R 9，特别表示氢原子，并与氮形成含氮杂环，具有5 或6个链接。

2. 发明授权

US4613618A Method for treating disorders of lipid metabolism using benzene sulfonamides 失效
标题翻译：使用苯磺酰胺治疗脂质代谢紊乱的方法
公开(公告)号：US4613618A
公开(公告)日：1986-09-23
申请号：US388964
申请日：1982-06-16
申请人： Patrick Choay , Pierre Roger , Dominique Olliero
发明人： Patrick Choay , Pierre Roger , Dominique Olliero
IPC分类号： C07D213/71 , C07D295/185 , C07D333/34 , A61K31/19 , A61K31/20 , A61K31/215
CPC分类号： C07D295/185 , C07D213/71 , C07D333/34
摘要： The invention relates to new medicaments having lipid regulating properties and processes for their preparation.The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the arylsulfonamide type corresponding to the formula: ##STR1## in which: Ar represents an aromatic ring which may if necessary be substituted;n+m+1 is comprised from 3 to 11, being preferably equal to 3,5 or 10, or is comprised from 1 to 11 when Ar represents an aryl group in which at least one of the R.sub.1,R.sub.2 and R.sub.3 radicals is a CF.sub.3 group;R.sub.5 and R.sub.6 represent independently of one another particularly an alkyl radical;R.sub.4 represents the hydroxy group, the radical OR.sub.7 in which R.sub.7 is particularly an alkyl group, the radical NR.sub.8 R.sub.9 in which R.sub.8 and R.sub.9 are identical or different, and represent in particular a hydrogen atom, and form with the nitrogen a nitrogenous heterocyclic ring with 5 or 6 links.
摘要翻译：本发明涉及具有脂质调节性质的新药物及其制备方法。根据本发明的药物含有至少一种对应于下式的至少一种芳基磺酰胺类型的化合物（或其相应的光学异构体）：其中：Ar表示可以根据需要被取代的芳环; n + m + 1由3至11组成，优选等于3,5或10，或当Ar表示其中至少一个R 1，R 2和R 3基团为 CF3组; R5和R6彼此独立地表示烷基; R 4表示羟基，其中R 7特别为烷基的基团OR 7，其中R 8和R 9相同或不同的基团NR 8 R 9，特别表示氢原子，并与氮形成含氮杂环，具有5 或6个链接。

3. 发明授权

US4760062A Pharmaceutical compositions of N-heterocyclic benzenesulfonamides and their use 失效
标题翻译： N-杂环苯磺酰胺的药物组合物及其用途
公开(公告)号：US4760062A
公开(公告)日：1988-07-26
申请号：US662178
申请日：1984-10-18
申请人： Pierre Roger , Patrick Choay , Jean-Paul Fournier
发明人： Pierre Roger , Patrick Choay , Jean-Paul Fournier
IPC分类号： A61K31/395 , A61K31/443 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P25/20 , C07D243/00 , C07D243/08 , C07D295/22 , C07D295/26 , C07D307/68 , C07D405/06
CPC分类号： C07D295/26 , C07C309/00 , C07D243/08 , C07D405/06
摘要： The invention relates to new N-cyclic benzenesulfonamides, their process of preparation and their use as active substance of pharmaceutical compositions. The new benzenesulfonamides according to the invention correspond to the following general formula (I): ##STR1## in which: V represents, for example, hydrogen,W represents, for example CF.sub.3,X represents, for example, hydrogen,Y represents, for example, hydrogen,n is 2 or 3,Z represents, for example, the group NR.sub.4, in which R.sub.4 represents, for example, hydrogen.These compounds are useful in pharmaceutical compositions for the treatment of nervous disorders with anxiety.
摘要翻译：本发明涉及新的N-环苯磺酰胺，其制备方法及其作为药物组合物的活性物质的用途。根据本发明的新型苯磺酰胺对应于以下通式（I）：其中：V表示例如氢，W表示例如CF 3，X表示例如氢，Y 表示例如氢，n为2或3，Z表示例如NR4基团，其中R4表示例如氢。这些化合物可用于用焦虑治疗神经障碍的药物组合物中。

4. 发明授权

US4902791A Nitrosourea derivatives, process for their preparation and medicaments containing them 失效
标题翻译：亚硝基脲衍生物，其制备方法和含有它们的药物
公开(公告)号：US4902791A
公开(公告)日：1990-02-20
申请号：US181760
申请日：1988-04-14
申请人： Pierre Roger , Patrick Choay , Claude Monneret , Jean-Paul Fournier , Alain Martin
发明人： Pierre Roger , Patrick Choay , Claude Monneret , Jean-Paul Fournier , Alain Martin
IPC分类号： C07C271/06 , C07H13/12
CPC分类号： C07H13/12 , C07C271/06 , Y10S514/908
摘要： The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them.The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an --NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an --NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R" can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R" represents hydrogen, and R' and R" cannot be simultaneously hydrogen atoms.These compounds present an antitumor activity. No drawing.
摘要翻译：本发明涉及亚硝基脲衍生物，其制备方法和含有它们的药物组合物。本发明的亚硝基脲衍生物对应于下式（I）：其中：R可以表示氢原子或1〜30个碳原子的烷基，X表示羟基或-NR1R2基，Y表示表示氢原子，羟基或-NR'1R'2基团，其中R1和/或R'1各自表示氢原子或基团，Hal表示卤素，R2和/或R' 2可以各自表示氢原子或含有1至6个碳原子的烷基，R'和R“可以表示氢或OH，条件是至少X表示，其中R1表示或Y表示< IMAGE>，其中R'1表示，并且条件是R'表示氢或R“表示氢，并且R'和R”不能同时为氢原子。这些化合物具有抗肿瘤活性。没画

5. 发明授权

US4871843A Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions 失效
标题翻译：环状苯磺酰胺，其制备方法及其作为药物组合物的活性物质的用途
公开(公告)号：US4871843A
公开(公告)日：1989-10-03
申请号：US224549
申请日：1985-07-26
申请人： Pierre Roger , Patrick Choay , Jean-Paul Fournier
发明人： Pierre Roger , Patrick Choay , Jean-Paul Fournier
IPC分类号： C07D243/08 , C07D295/22 , C07D295/26 , C07D405/06
CPC分类号： C07D295/26 , C07C309/00 , C07D243/08 , C07D405/06
摘要： The invention relates to new N-cyclic benzenesulfonamides, their process of preparation and their use as active substance of pharmaceutical compositions. The new benzenesulfonamides according to the invention correspond to the following general formula (I): ##STR1## in which: V represents, for example, hydrogen,W represents, for example CF.sub.3,X represents, for example, hydrogen,Y represents, for example, hydrogen,n is 2 or 3,Z represents, for example, the group NR.sub.4, in which R.sub.4 represents, for example, hydrogen.These compounds are useful in pharmaceutical compositions for the treatment of nervous disorders with anxiety.
摘要翻译：本发明涉及新的N-环苯磺酰胺，其制备方法及其作为药物组合物的活性物质的用途。根据本发明的新型苯磺酰胺对应于以下通式（I）：其中：V表示例如氢，W表示例如CF 3，X表示例如氢，Y 表示例如氢，n为2或3，Z表示例如NR4基团，其中R4表示例如氢。这些化合物可用于用焦虑治疗神经障碍的药物组合物中。

6. 发明授权

US4585769A Benzenesulfonyl-lactams and their use as active substances of pharmaceutical compositions 失效
标题翻译：苯磺酰基内酰胺及其作为药物组合物的活性物质的用途
公开(公告)号：US4585769A
公开(公告)日：1986-04-29
申请号：US662187
申请日：1984-10-18
申请人： Pierre Roger , Patrick Choay , Jean-Paul Fournier
发明人： Pierre Roger , Patrick Choay , Jean-Paul Fournier
IPC分类号： A61K31/40 , A61P25/00 , C07D207/48 , C07D211/96 , C07D223/10 , A61K31/55 , C07D209/32 , C07D211/40
CPC分类号： C07D223/10 , C07D207/48 , C07D211/96
摘要： The invention relates to new benzenesulfonyl-lactams, process for their preparation and their use as active substance in pharmaceutical compositions.Compounds according to the invention correspond to the general formula (I): ##STR1## in which: X can represent hydrogen,Y can represent the CF.sub.3 group,Z can represent chlorine,W can represent hydrogen,n is 1, 2 or 3,R.sub.1 can represent hydrogen,R.sub.2 can represent the OH group, provided that when n is 2 or 3, X or Z represents an alkoxy group from 1 to 4 carbon atoms or that Y represents the CF.sub.3 or NO.sub.2 group, and when n is 1, Y or W represents the CF.sub.3 group.These new compounds may be introduced as active substances, particularly in the treatment of disorders of the memory.
摘要翻译：本发明涉及新的苯磺酰基内酰胺，其制备方法及其作为药物组合物中活性物质的用途。根据本发明的化合物对应于通式（I）：其中：X可以表示氢，Y可以表示CF 3基团，Z可以表示氯，W可以表示氢，n是1,2 或3，R 1可以表示氢，R 2可以表示OH基团，条件是当n为2或3时，X或Z表示1至4个碳原子的烷氧基或Y表示CF 3或NO 2基团，并且当n 是1，Y或W表示CF 3基团。这些新化合物可以作为活性物质引入，特别是用于治疗记忆障碍。

7. 发明授权

US4983726A Process for preparing nitrosourea derivatives 失效
标题翻译：亚硝基脲衍生物的制备方法
公开(公告)号：US4983726A
公开(公告)日：1991-01-08
申请号：US440905
申请日：1989-11-24
申请人： Pierre Roger , Patrick Choay , Claude Monneret , Jean-Paul Fournier
发明人： Pierre Roger , Patrick Choay , Claude Monneret , Jean-Paul Fournier
IPC分类号： C07C271/06 , C07H13/12
CPC分类号： C07H13/12 , C07C271/06 , Y10S514/908
摘要： The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them.The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R" can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R" represents hydrogen, and R' and R" cannot be simultaneously hydrogen atoms.These compounds present an antitumor activity.

8. 发明授权

US07951821B2 N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy 失效
标题翻译： N- [苯基（哌啶-2-基）甲基]苯甲酰胺衍生物，其制备及其在治疗中的用途
公开(公告)号：US07951821B2
公开(公告)日：2011-05-31
申请号：US11680782
申请日：2007-03-01
申请人： Gihad Dargazanli , Genevieve Estenne-Bouhtou , Benoit Marabout , Pierre Roger , Mireille Sevrin
发明人： Gihad Dargazanli , Genevieve Estenne-Bouhtou , Benoit Marabout , Pierre Roger , Mireille Sevrin
IPC分类号： A61K31/445
CPC分类号： C07D211/26
摘要： This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.
摘要翻译：本发明公开了一种通式（I）的化合物，其中R 1表示氢原子或任选取代的烷基，或环烷基烷基，或任选取代的苯基烷基或烯基，X表示氢原子或一个或多个选自卤素原子和三氟甲基，烷基和烷氧基的取代基，R 2表示一个或多个选自卤素原子，任选取代的烷氧基和任选取代的氨基的取代基。本发明的化合物表现出治疗效用。

9. 发明授权

US07205319B2 N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives, preparation thereof, and use thereof in therapy 失效
标题翻译： N- [苯基（哌啶-2-基）甲基]苯甲酰胺衍生物，其制备及其在治疗中的用途
公开(公告)号：US07205319B2
公开(公告)日：2007-04-17
申请号：US11045247
申请日：2005-01-28
申请人： Gihad Dargazanli , Geneviève Estenne-Bouhtou , Benoît Marabout , Pierre Roger , Mireille Sevrin
发明人： Gihad Dargazanli , Geneviève Estenne-Bouhtou , Benoît Marabout , Pierre Roger , Mireille Sevrin
IPC分类号： A61K31/445 , C07D413/02
CPC分类号： C07D211/26
摘要： This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.
摘要翻译：本发明公开并要求通式（I）的化合物，

10. 发明申请

US20050159450A1 Derivative of n-[phenyl(piperidin-2-yl)methyl]benzamide, the preparation method thereof and application of same in therapeutics 失效
标题翻译： n- [苯基（哌啶-2-基）甲基]苯甲酰胺的衍生物及其制备方法及其在治疗中的应用
公开(公告)号：US20050159450A1
公开(公告)日：2005-07-21
申请号：US10511886
申请日：2003-04-17
申请人： Gihad Dargazanli , Genevieve Estenne-Bouhtou , Pascale Magat , Benoit Marabout , Florence Medaisko , Pierre Roger , Mireille Sevrin , Corinne Veronique
发明人： Gihad Dargazanli , Genevieve Estenne-Bouhtou , Pascale Magat , Benoit Marabout , Florence Medaisko , Pierre Roger , Mireille Sevrin , Corinne Veronique
IPC分类号： A61K20060101 , A61K31/445 , A61K31/4458 , A61K31/452 , A61P20060101 , A61P1/00 , A61P11/16 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P29/00 , A61P43/00 , C07D20060101 , C07D211/26 , C07D211/32 , C07D211/94
CPC分类号： C07D211/26
摘要： Compound of general formula (I) in which A represents either a group of formula N—R1 in which R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a phenylalkyl group, an alkenyl group or an alkynyl group, or a group of formula N+(O−)R1 in which R1 is as defined above, or alternatively a group of formula N+(R′)R1 in which R′ represents an alkyl group and R1 is as defined above, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents a hydrogen atom, one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, amino groups of formula NR3R4 in which R3 and R4 each represent a hydrogen atom or an alkyl group, or form with the nitrogen atom carrying them a pyrrolidine, piperidine or morpholine ring, or an optionally substituted phenyl group. Application in therapy.
摘要翻译：通式（I）的化合物，其中A表示式NR 1的基团，其中R 1表示氢原子，烷基，环烷基，苯基烷基，烯基或炔基，或其中R 1为低级烷基的基团，其中R 1为N（O） > 1 如上所定义，或者可选地，其中R'表示烷基的式N +，（R'）R 1' 如上定义，X表示氢原子或一个或多个选自卤素原子和三氟甲基，烷基和烷氧基的取代基，R 2表示氢原子，一个或多个选自卤素原子和三氟甲基，烷基和烷氧基的更多取代基，式NR 3 R 4的氨基，其中R 3和R“ 或者分别代表氢原子或烷基，或与氮原子一起带有吡咯烷，哌啶或吗啉环的形式，或 n任选取代的苯基。应用于治疗。

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