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    • 4. 发明授权
    • Method and system of multivariate analysis on normalized volume-wise data in the sinogram domain for improved quality in positron emission tomography studies
    • 正电子发射断层扫描研究中提高质量的正弦图域中的归一化体积数据的多变量分析方法和系统
    • US08175360B2
    • 2012-05-08
    • US12065140
    • 2006-08-31
    • Pasha RazifarMats BergstromBengt Langstrom
    • Pasha RazifarMats BergstromBengt Langstrom
    • G06K9/00
    • G06T11/005G06T5/002G06T5/10G06T2207/10088G06T2207/20132G06T2211/412
    • A method and system are provided for improving the quality in positron emission tomography (PET) images. PET input data is masked using raw dynamic PET data (sinograms) as input for primary component analysis (PCA) that generates primary components which in turn are used to create a mask. This mask can be used to allow object pixel data to be extracted from the sinograms into masked sinograms where background pixels outside the reference object are set to zero. A volume-wise approach to PCA uses masked sinograms as input data. Pixel-wise noise pre-normalization may then be performed generating pre-normalized sinograms from the masked PET input data. PCA is then performed on the pre-normalized sinograms resulting in PCA sinograms recreated into PCA-modified sinograms by adding background pixel values of zero. These PCA-modified sinograms may optionally be scaled and may then be reconstructed into dynamic PET images with improved image quality.
    • 提供了一种提高正电子发射断层摄影(PET)图像质量的方法和系统。 PET输入数据使用原始动态PET数据(正弦图)作为主要成分分析(PCA)的输入进行掩蔽,主成分分析(PCA)产生主要成分,而主成分又用于创建掩模。 该掩模可以用于允许将对象像素数据从正弦图提取到被引用对象外部的背景像素设置为零的掩蔽的正弦图。 PCA使用屏蔽的正弦图作为输入数据。 然后可以从掩蔽的PET输入数据生成预标准化的正弦图像素像噪声预归一化。 然后在预标准化的正弦图上进行PCA,通过添加零的背景像素值,将PCA正弦图重新创建成PCA修正的正弦图。 这些PCA修改的正弦图可以可选地被缩放,然后可以被重建成具有改善的图像质量的动态PET图像。
    • 7. 发明申请
    • Method and System of Multivariate Analysis on Normalized Volume-Wise Data in the Sinogram Domain For Improved Quality in Positron Emission Tomography Studies
    • 方法与系统的多因素分析正常化体积数据在Sinogram领域提高质量正电子发射断层扫描研究
    • US20080310697A1
    • 2008-12-18
    • US12065140
    • 2006-08-31
    • Pasha RazifarMats BergstromBengt Langstrom
    • Pasha RazifarMats BergstromBengt Langstrom
    • G06K9/00
    • G06T11/005G06T5/002G06T5/10G06T2207/10088G06T2207/20132G06T2211/412
    • A method and system are provided for improving the quality in positron emission tomography (PET) images. PET input data is masked using raw dynamic PET data (sinograms) as input for primary component analysis (PCA) that generates primary components which in turn are used to create a mask. This mask can be used to allow object pixel data to be extracted from the sinograms into masked sinograms where background pixels outside the reference object are set to zero. A volume-wise approach to PCA uses masked sinograms as input data. Pixel-wise noise pre-normalization may then be performed generating pre-normalized sinograms from the masked PET input data. PCA is then performed on the pre-normalized sinograms resulting in PCA sinograms recreated into PCA-modified sinograms by adding background pixel values of zero. These PCA-modified sinograms may optionally be scaled and may then be reconstructed into dynamic PET images with improved image quality.
    • 提供了一种提高正电子发射断层摄影(PET)图像质量的方法和系统。 PET输入数据使用原始动态PET数据(正弦图)作为主要成分分析(PCA)的输入进行掩蔽,主成分分析(PCA)产生主要成分,而主成分又用于创建掩模。 该掩模可以用于允许将对象像素数据从正弦图提取到被引用对象外部的背景像素设置为零的掩蔽的正弦图。 PCA使用屏蔽的正弦图作为输入数据。 然后可以从掩蔽的PET输入数据生成预标准化的正弦图像素像噪声预归一化。 然后在预标准化的正弦图上进行PCA,通过添加零的背景像素值,将PCA正弦图重新创建成PCA修正的正弦图。 这些PCA修改的正弦图可以可选地被缩放,然后可以被重建成具有改善的图像质量的动态PET图像。
    • 10. 发明申请
    • METHOD AND SYSTEM FOR OUTLINING A REGION IN POSITRON EMISSION TOMOGRAPHY STUDIES
    • 用于排除位置排列测量研究中的一个地区的方法和系统
    • US20100135556A1
    • 2010-06-03
    • US12447270
    • 2007-10-25
    • Pasha RazifarAnna RingheimBengt LongstromHenry EnglerAnders Wall
    • Pasha RazifarAnna RingheimBengt LongstromHenry EnglerAnders Wall
    • G06K9/48G06T7/00
    • G06T7/12G06T2207/10104
    • In a method and system for outlining a region of interest in a Positron Emission Tomography (PET) scan study, a processor may, based on application of Masked Volume Wise Principal Component Analysis (MVW-PCA) to a plurality of scan images, generate a PC2 image showing kinetic behavior of a particular part of a subject, in particular, the grey matter of the cerebellar cortex of the subject, and may outline, in the PC2 image, a region of the PC2 image having highest pixel intensity values of the PC2 image or of a portion thereof as a region of interest, and, in particular, as a reference region. The processor may generate a PC3 image showing kinetic behavior of a different part of the subject, in particular, blood vessels of the subject, import the outline into the PC3 image to determine the correctness of the outline, and modify the outline if it is incorrect.
    • 在用于概括正电子发射断层扫描(PET)扫描研究中的感兴趣区域的方法和系统中,处理器可以基于对多个扫描图像应用蒙版卷智慧主成分分析(MVW-PCA),生成 显示受试者的特定部位,特别是受试者的小脑皮质的灰质的动力学行为的PC2图像,并且可以在PC2图像中概括具有PC2的最高像素强度值的PC2图像的区域 图像或其一部分作为感兴趣区域,特别是作为参考区域。 处理器可以产生显示受试者的不同部分(特别是受试者的血管)的动力学行为的PC3图像,将轮廓导入PC3图像以确定轮廓的正确性,并且如果轮廓不正确则修改轮廓 。