专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080085886A1 Aza-benzofuranyl compounds and methods of use 审中-公开
标题翻译：氮杂 - 苯并呋喃基化合物及其使用方法
公开(公告)号：US20080085886A1
公开(公告)日：2008-04-10
申请号：US11894506
申请日：2007-08-20
申请人： Pascal Savy , Stephen Price , Hazel Dyke , John Montana , Karen Williams , Mark Stanley , Liang Bao
发明人： Pascal Savy , Stephen Price , Hazel Dyke , John Montana , Karen Williams , Mark Stanley , Liang Bao
IPC分类号： A61K31/44 , A61K31/00 , A61K31/535 , A61P43/00 , C07D413/00 , C07D471/02
CPC分类号： C07D491/048
摘要： The invention relates to azabenzofuranyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的式I的氮杂苯并呋喃基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并呋喃基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

2. 发明申请

US20080081821A1 AZA-benzothiophenyl compounds and methods of use 有权
标题翻译： AZA-苯并噻吩基化合物及其使用方法
公开(公告)号：US20080081821A1
公开(公告)日：2008-04-03
申请号：US11894345
申请日：2007-08-20
申请人： Pascal Savy , Stephen Price , Hazel Dyke , John Montana , Karen Williams , Mark Stanley , Liang Bao
发明人： Pascal Savy , Stephen Price , Hazel Dyke , John Montana , Karen Williams , Mark Stanley , Liang Bao
IPC分类号： A61K31/44 , A61P43/00 , C07D471/02
CPC分类号： C07D495/04
摘要： The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的式I的氮杂苯并噻吩基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并噻吩基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

3. 发明授权

US08669248B1 Adenine inhibitors of HSP90 有权
标题翻译：腺苷抑制剂HSP90
公开(公告)号：US08669248B1
公开(公告)日：2014-03-11
申请号：US13249914
申请日：2011-09-30
申请人： John Montana , Janusz Kulagowski , Hazel Hunt , Yukari Perrella
发明人： John Montana , Janusz Kulagowski , Hazel Hunt , Yukari Perrella
IPC分类号： C07D413/06 , A61K31/538
CPC分类号： C07D519/00 , C07D473/34
摘要： In general, the present invention relates to small molecule inhibitors of the heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention. The invention further relates to the medical use of these compounds and compositions for the treatment of neurodegenerative diseases.
摘要翻译：通常，本发明涉及伴侣蛋白的热休克蛋白90家族的小分子抑制剂。本发明还包括药物组合物和试剂盒，其包括本发明的化合物和组合物。本发明还涉及这些化合物和组合物用于治疗神经变性疾病的医学用途。

4. 发明申请

US20060052344A1 Heterocyclic silicon compounds and their use in the treatment of diseases or conditions associated with gnrh (gonadotropin-releasing hormone) 审中-公开
标题翻译：杂环硅化合物及其在治疗与gnrh（促性腺激素释放激素）相关的疾病或病症中的应用
公开(公告)号：US20060052344A1
公开(公告)日：2006-03-09
申请号：US10531333
申请日：2003-11-19
申请人： John Montana , Ian Fleming , Reinhold Tacke , Jurgen Daiss
发明人： John Montana , Ian Fleming , Reinhold Tacke , Jurgen Daiss
IPC分类号： A61K31/695 , C07F7/08
CPC分类号： C07F7/0812
摘要： A compound of formula (I) wherein one of X and Y is silicon, and the other is carbon or silicon; Z is oxygen, sulphur or —N(R)—, wherein R is hydrogen or alkyl; R1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy or cycloalkyl; and R2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -alkyl-cycloalkyl, -alkyl-heterocycloalkyl, -alkyl-aryl or -alkyl-heteroaryl; or a pharmaceutically acceptable salt thereof. The compounds are used in the manufacture of a medicament for the treatment or prevention of a disease or condition associated with GnRH (gonadotropin-releasing hormone), e.g. for the treatment or prevention of progression of cancer (e.g. leukaemia therapy), of a fertility disorder, of HIV infection or AIDS, of Alzheimer's disease of fibrosis, of endometriosis, of uterine fibroids or of uterine leiomyoma.
摘要翻译：式（I）的化合物，其中X和Y中的一个是硅，另一个是碳或硅; Z是氧，硫或-N（R） - ，其中R是氢或烷基; R 1是氢，卤素，烷基，烯基，炔基，烷氧基或环烷基; 和R 2是烷基，烯基，炔基，环烷基，杂环烷基，芳基，杂芳基， - 烷基 - 环烷基 - - 烷基 - 杂环烷基， - 烷基 - 芳基或 - 烷基 - 杂芳基; 或其药学上可接受的盐。所述化合物用于制备用于治疗或预防与GnRH（促性腺激素释放激素）相关的疾病或病症的药物，例如，用于治疗或预防艾滋病的纤维化，子宫内膜异位症，子宫肌瘤或子宫肌瘤的癌症（例如白血病治疗），生殖障碍，艾滋病毒感染或艾滋病的进展

5. 发明授权

US06169090A Heterocyclic compounds and their therapeutic use 失效
标题翻译：杂环化合物及其治疗用途
公开(公告)号：US06169090A
公开(公告)日：2001-01-02
申请号：US09328182
申请日：1999-06-08
申请人： Hazel Joan Dyke , Verity Margaret Sabin , Andrew Sharpe , Alan Findlay Haughan , Christopher Lowe , George Buckley , John Montana
发明人： Hazel Joan Dyke , Verity Margaret Sabin , Andrew Sharpe , Alan Findlay Haughan , Christopher Lowe , George Buckley , John Montana
IPC分类号： C07D491048
CPC分类号： C07D491/04
摘要： The compound, according to formula (i) wherein X and Y are independently CH, N or N-oxide, provided that X and Y do not both represent CH; Z is CO or CS; R1 is alkyl, optionally substituted with one or more halogens; and R2, R3, R4 and R5 are each various organic groups. Such compounds have therapeutic utility, via inhibition of phosphodiesterase IV.
摘要翻译：根据式（ⅰ）的化合物，其中X和Y独立地是CH，N或N-氧化物，条件是X和Y不都表示CH; Z是CO或CS; R1是烷基，任选被一个或多个卤素 R2，R3，R4和R5分别是各种有机基团。这些化合物通过抑制磷酸二酯酶IV具有治疗效用。

6. 发明授权

US5853623A Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases 失效
标题翻译：肽基化合物及其作为金属蛋白酶抑制剂的治疗用途
公开(公告)号：US5853623A
公开(公告)日：1998-12-29
申请号：US644383
申请日：1996-05-10
申请人： John Montana , David Alan Owen , Jonathan Dickens , Andrew Douglas Baxter
发明人： John Montana , David Alan Owen , Jonathan Dickens , Andrew Douglas Baxter
IPC分类号： A61K8/00 , A61K8/64 , A61K38/00 , A61P1/02 , A61P1/14 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P25/00 , A61P29/00 , A61P31/00 , A61P33/02 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , A61Q11/00 , C07K5/06 , C07K5/062 , C07K5/065 , A61K38/55
CPC分类号： C07K5/0606 , C07K5/06043 , A61K38/00 , Y10S530/868
摘要： The present invention concerns novel mercaptoalkylpeptidyl compounds of formula (I) which are useful inhibitors of matrix metalloproteinase and/or TNF-mediated diseases including degenerative diseases and certain cancers. The invention also concerns methods of treating patients suffering from disorders or diseases which can be attributed to or are associated with matrix metalloproteinase or TNF activity.
摘要翻译：本发明涉及式（I）的新型巯基烷基肽基化合物，它们是有用的基质金属蛋白酶抑制剂和/或TNF介导的疾病，包括退行性疾病和某些癌症。本发明还涉及治疗可归因于或与基质金属蛋白酶或TNF活性相关的疾病或疾病的患者的方法。

7. 发明授权

US5736549A Hypoxanthine and guanine compounds 失效
标题翻译：次黄嘌呤和鸟嘌呤化合物
公开(公告)号：US5736549A
公开(公告)日：1998-04-07
申请号：US539568
申请日：1995-10-05
申请人： Steven Colin Beasley , Alan Findlay Haughan , John Montana , Robert John Watson
发明人： Steven Colin Beasley , Alan Findlay Haughan , John Montana , Robert John Watson
IPC分类号： A61K31/52 , A61K31/522 , A61P3/08 , A61P17/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , C07D473/00 , C07D473/18 , C07D473/30
CPC分类号： C07D473/00 , C07D473/18
摘要： Compounds of formula I ##STR1## where n=0-2; R.sup.1 is H, NH.sub.2 or a halogen; R.sup.2 is H or NH.sub.2 ; R.sup.3 is any of the four groups ##STR2## where m=0 or 1; and X is O, NR.sup.5, or S(O).sub.0-2 and, in group (b), the X's may be the same or different. Compounds of the invention have utility as inhibitors of purine nucleoside phosphyorylase (PNP).
摘要翻译：式I的化合物其中n = 0-2; R1是H，NH2或卤素; R2是H或NH2; R3是四个组中的任何一个，其中m = 0或1; 并且X是O，NR 5或S（O）0-2，并且在组（b）中，X可以相同或不同。本发明化合物可用作嘌呤核苷磷酰化酶（PNP）的抑制剂。

8. 发明申请

US20120088763A1 TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE 失效
标题翻译：三唑吡啶衍生物及其治疗用途
公开(公告)号：US20120088763A1
公开(公告)日：2012-04-12
申请号：US13201716
申请日：2010-02-16
申请人： Harry Finch , John Montana , Monique Bodil Van Niel , Chi-Kit Woo , Jamie Knight , Bohdan Waszkowycz
发明人： Harry Finch , John Montana , Monique Bodil Van Niel , Chi-Kit Woo , Jamie Knight , Bohdan Waszkowycz
IPC分类号： A61K31/5377 , A61P11/00 , A61P11/06 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; R1 is C1-C6 alkyl, C3-C6 cycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and R3 and R4 are independently H or C1-C6 alkyl, or R3 and R4 taken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is —O— or —S(O)p— wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C3-C6 divalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R2NHC(═O)W—; W is a bond, —NH— or —C(RA)(RB), wherein RA and RB are independently H, methyl, ethyl, amino, hydroxyl or halo; and R2 is a radical as defined in the claims.
摘要翻译：式（I）化合物是p38MAP激酶的抑制剂，其可用作治疗特别是呼吸道疾病的抗炎剂，其中： R 1是C 1 -C 6烷基，C 3 -C 6环烷基，任选取代的苯基，任选被取代的5-或6-元单环杂芳基，或其中n是1或2的式（II）基团，R 3和R 4是独立地是H或C 1 -C 6烷基，或者R 3和R 4与它们所连接的氮一起形成任选含有另外选自N和O的杂原子的6元杂环; Y是-O-或-S（O）p - ，其中p是0,1或2; A是任选取代的二价亚芳基，或单环或双环亚杂芳基或具有5或6个环原子的C 3 -C 6二价亚环烷基或哌啶子基，其中环氮连接至R 2 NHC（= O）W - ; W是键，-NH-或-C（RA）（RB），其中RA和RB独立地是H，甲基，乙基，氨基，羟基或卤素; 并且R 2是如权利要求中所定义的基团。

9. 发明授权

US06180611B2 Peptidyl compounds 失效
标题翻译：肽基化合物
公开(公告)号：US06180611B2
公开(公告)日：2001-01-30
申请号：US09315279
申请日：1999-05-20
申请人： John Montana , Andrew Douglas Baxter , David Alan Owen , Robert John Watson , Neil Phillipson
发明人： John Montana , Andrew Douglas Baxter , David Alan Owen , Robert John Watson , Neil Phillipson
IPC分类号： A61K3800
CPC分类号： C07K5/06052 , A61K38/00 , C07K5/06034 , C07K5/06043 , C07K5/0606 , Y10S530/868
摘要： Compounds of general formula (I): have utility as inhibitors of matrix metalloproteinases and TNF.
摘要翻译：通式（I）的化合物：可用作基质金属蛋白酶和TNF的抑制剂

10. 发明授权

US5994312A Peptidyl compounds 失效
标题翻译：肽基化合物
公开(公告)号：US5994312A
公开(公告)日：1999-11-30
申请号：US124877
申请日：1998-07-30
申请人： John Montana , Andrew Douglas Baxter , David Alan Owen , Robert John Watson , Neil Phillipson
发明人： John Montana , Andrew Douglas Baxter , David Alan Owen , Robert John Watson , Neil Phillipson
IPC分类号： A61K38/46 , A61K31/40 , A61K38/00 , A61K38/05 , A61P1/02 , A61P9/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07D209/48 , C07K5/023 , C07K5/06 , C07K5/062
CPC分类号： C07K5/06052 , C07K5/06034 , C07K5/06043 , C07K5/0606 , A61K38/00 , Y10S530/868
摘要： Compounds of general formula (I): ##STR1## have utility as inhibitors of matrix metalloproteinases and TNF.
摘要翻译：通式（I）的化合物：可用作基质金属蛋白酶和TNF的抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式