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1. 发明授权

US08501193B1 Stabilized Tat antigen and the use thereof for anti-HIV vaccination 失效
标题翻译：稳定的Tat抗原及其用于抗HIV疫苗接种的用途
公开(公告)号：US08501193B1
公开(公告)日：2013-08-06
申请号：US10599448
申请日：2005-04-01
申请人： Pascal Drevet , Evelyne Lajeunesse , Alain Lecoq , Michel Leonetti , André Menez , Gervaise Moine , Robert Thai
发明人： Pascal Drevet , Evelyne Lajeunesse , Alain Lecoq , Michel Leonetti , André Menez , Gervaise Moine , Robert Thai
IPC分类号： A61K39/21 , C09F7/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16322
摘要： The invention relates to a vaccine composition comprising at least one type of anti-HIV vaccine composition containing at least one type of stabilized Tat antigen and to the use thereof for preventing and/or treating a human HIV infection.
摘要翻译：本发明涉及一种疫苗组合物，其包含至少一种含有至少一种稳定的Tat抗原的抗HIV疫苗组合物及其用于预防和/或治疗人类HIV感染的用途。

2. 发明申请

US20110117017A1 PEPTIDES WITH PROPERTIES OF AN ALLOSTERIC ANTAGONIST SELECTIVE FOR THE ALPHA 1A ADRENERGIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译：具有ALPHA 1A ADRENERGIC受体选择性的ANOSTERIC ANTAGONIST的性质的肽及其用途
公开(公告)号：US20110117017A1
公开(公告)日：2011-05-19
申请号：US12279250
申请日：2007-02-23
申请人： Nicolas Gilles , André Menez , Renée Menez , Christopher Menez , Cécile Berlioz
发明人： Nicolas Gilles , André Menez , Renée Menez , Christopher Menez , Cécile Berlioz
IPC分类号： A61K38/17 , C07K14/46 , C07K14/72 , C07H21/04 , A61P13/02 , A61P15/10 , A61P35/00 , A61P9/12 , C40B30/04 , G01N33/566 , C12N15/63 , C12N5/10 , C12N1/00 , A61K49/00
CPC分类号： C07K14/70571 , C07K14/4703
摘要： Peptides characterized by: a) a sequence selected from the group consisting of the sequence SEQ ID NO: 2, and the derived variants having at least 70% identity or 80% similarity with the entire sequence SEQ ID NO: 2, b) a three-finger structure including eight cysteine residues linked by four disulfide bridges, respectively between the first and the third cysteine, the second and the fourth cysteine, the fifth and the sixth cysteine, and the seventh and the eighth cysteine, and c) an activity of an allosteric antagonist selective for the alpha 1a adrenergic receptor, and therapeutic and pharmacological uses thereof.
摘要翻译：其特征在于：a）选自序列SEQ ID NO：2的序列和与整个序列SEQ ID NO：2具有至少70％同一性或80％相似性的衍生变体，b）三分别在第一和第三半胱氨酸，第二和第四半胱氨酸，第五和第六半胱氨酸以及第七和第八半胱氨酸之间通过四个二硫键连接的八个半胱氨酸残基的指甲结构，和c）对α1a肾上腺素能受体选择性的变构拮抗剂及其治疗和药理学用途。

3. 发明授权

US07541157B2 Method of screening groups of radioactive molecules and applications thereof 失效
标题翻译：筛选放射性分子组的方法及其应用
公开(公告)号：US07541157B2
公开(公告)日：2009-06-02
申请号：US10514562
申请日：2003-05-28
申请人： Vincent Dive , André Menez , Reto Stocklin , Bertrand Tavitian , Fabrice Beau , Bertrand Czarny , Joël Cotton
发明人： Vincent Dive , André Menez , Reto Stocklin , Bertrand Tavitian , Fabrice Beau , Bertrand Czarny , Joël Cotton
IPC分类号： G01N33/53 , C40B50/06
CPC分类号： C07K5/1027 , G01N33/5082
摘要： The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.
摘要翻译：本发明涉及筛选放射性分子组的无扩增方法，该方法至少包括以下步骤：（1）向至少一种动物施用分子组; （2）屠宰至少一只动物，并在体内分析给予的分子的放射性的组织分布; （3）选择检测放射性信号的组织或器官的部分; （4）使用合适的技术如色谱和/或提取技术分离来自组织或器官切片的放射性级分; 和（5）来自步骤4中获得的放射性级分的分子使用合适的分析技术如色谱和/或质谱鉴定。

4. 发明授权

US06649166B1 Peptides and proteins for desensitizing subjects allergic to bee venom and compositions containing same 失效
标题翻译：用于使对蜂毒过敏的受试者的脱敏剂和含有它们的组合物的肽和蛋白质
公开(公告)号：US06649166B1
公开(公告)日：2003-11-18
申请号：US09890065
申请日：2002-03-28
申请人： Bernard Maillere , Sandra Pouvelle , Catherine Texier , André Menez
发明人： Bernard Maillere , Sandra Pouvelle , Catherine Texier , André Menez
IPC分类号： A61K3804
CPC分类号： A61K39/35 , C12N9/20
摘要： The invention concerns peptides and proteins for desensitizing specifically the vast majority of subjects allergic to bee venom and compositions containing said peptides or proteins. The peptides are selected in the group consisting of: the fragment (1) corresponding to positions P85-97 of the major bee venom allergen, the fragment (2) corresponding to positions P81-93 of the major bee venom allergen, the fragment (3) corresponding to positions P94-106 of the major bee venom allergen, the fragment (4) corresponding to positions P76-88 of the major bee venom allergen, the fragment (5) corresponding to positions P77-94 of the major bee venom allergen, and the fragment (6) corresponding to positions P122-134 of the major bee venom allergen, fragments (I) and (2) forming group (1); fragment (3) forming group (II); fragments (4) and (4) forming group (III) and fragment (6) forming group IV and the mutated fragments of said fragments (1) to (6) which have a binding activity with MHC class (II) molecules identical or higher than those of said fragments (1) to (6). The invention also concerns compositions containing said peptides or proteins.
摘要翻译：本发明涉及用于特异性脱敏大部分对蜂毒过敏的受试者和含有所述肽或蛋白质的组合物的肽和蛋白质。所述肽选自：对应于主要蜂毒变应原的位置P85-97的片段（1），对应于主要蜂毒变应原的位置P81-93的片段（2），片段（3 ）对应于主要蜂毒变应原的位置P94-106，对应于主要蜂毒变应原的位置P76-88的片段（4），对应于主要蜂毒变应原的位置P77-94的片段（5）和对应于主要蜂毒变应原的位置P122-134的片段（6），形成组（1）的片段（I）和（2）; 片段（3）形成基团（II）; 形成IV族的片段（4）和（4）和形成组IV的片段（6）和与MHC类（II）分子相同或更高的结合活性的所述片段（1）至（6）的突变片段（1）〜（6）的片段。本发明还涉及含有所述肽或蛋白质的组合物。

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