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1. 发明申请

US20070178452A1 Method for analyzing a nucleic acid 审中-公开
标题翻译：分析核酸的方法
公开(公告)号：US20070178452A1
公开(公告)日：2007-08-02
申请号：US10277951
申请日：2002-10-21
申请人： Pascal Bouffard , John Herrmann , Chunli Huang , Michael Jeffers , Jingfang Ju , Luca Rastelli , Juliette Shimkets , Jan Simons , Bruce Taillon
发明人： Pascal Bouffard , John Herrmann , Chunli Huang , Michael Jeffers , Jingfang Ju , Luca Rastelli , Juliette Shimkets , Jan Simons , Bruce Taillon
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12N15/1096 , C12Q2600/158 , G16B30/00
摘要： Disclosed is a method in which DNA sequences derived from microsome-associated mRNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification. Another embodiment of the invention uses information on the presence or absence of carefully chosen target subsequences in a single sequence clone together with DNA sequence databases to determine the clone sequence. Computer implemented methods are provided to analyze the experimental results and to determine the sample sequences in question and to carefully choose target subsequences in order that experiments yield a maximum amount of information
摘要翻译：公开了可以确定和分类来自混合样品或排列单序列克隆中的微粒体相关mRNA序列的DNA序列而不进行测序的方法。这些方法利用关于精确选择的目标子序列的存在的信息，通常长度为4至8个碱基对，优选样品DNA序列中目标子序列之间的长度以及含有可能存在的序列的DNA序列数据库在样品中确定样品序列。优选的方法是使用限制性核酸内切酶识别目标子序列并切割样品序列。然后仔细选择识别部分连接到切割片段，扩增片段，并进行实验观察。聚合酶链反应（PCR）是优选的扩增方法。本发明的另一个实施方案使用关于在单个序列克隆中与DNA序列数据库一起存在或不存在仔细选择的目标子序列的信息来确定克隆序列。提供计算机实现的方法来分析实验结果并确定所讨论的样本序列，并仔细选择目标子序列，以便实验产生最大量的信息

2. 发明授权

US08846873B2 Antibodies directed to GPNMB and uses thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US08846873B2
公开(公告)日：2014-09-30
申请号：US13355366
申请日：2012-01-20
申请人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： C07K16/30 , C07K19/00 , C07K16/28 , A61K47/48 , A61K39/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

3. 发明申请

US20130022597A1 Antibodies Directed To GPNMB And Uses Thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US20130022597A1
公开(公告)日：2013-01-24
申请号：US13355366
申请日：2012-01-20
申请人： Meina Liang , Orit Foord , Scott Klakamp , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： A61K39/395 , C12N15/13 , C40B30/04 , C12N15/63 , C12N1/21 , C12N5/10 , C07K16/18 , A61P35/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

4. 发明申请

US20060094647A1 Treatment of inflammatory bowel disease using growth factors 审中-公开
标题翻译：用生长因子治疗炎症性肠病
公开(公告)号：US20060094647A1
公开(公告)日：2006-05-04
申请号：US09992840
申请日：2001-11-06
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
IPC分类号： A61K38/17
CPC分类号： A61K38/1825 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译：本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。

5. 发明申请

US20050063971A1 Antibodies to fibroblast growth factor and their methods of use 审中-公开
标题翻译：成纤维细胞生长因子的抗体及其使用方法
公开(公告)号：US20050063971A1
公开(公告)日：2005-03-24
申请号：US10948588
申请日：2004-09-23
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John Herrmann , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John Herrmann , William LaRochelle , Henri Lichenstein
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P7/06 , A61P9/00 , A61P17/02 , A61P17/14 , A61P35/00 , A61P43/00 , C07K14/50 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07K16/28
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译：本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或抗体。本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

6. 发明申请

US20130080900A1 TECHNIQUES FOR MANAGING AND VIEWING FOLLOWED CONTENT 审中-公开
标题翻译：管理和查看以下内容的技术
公开(公告)号：US20130080900A1
公开(公告)日：2013-03-28
申请号：US13247000
申请日：2011-09-28
申请人： Benjamin Wilde , Donna Shaw , Michael Jeffers , Matthew Anderson
发明人： Benjamin Wilde , Donna Shaw , Michael Jeffers , Matthew Anderson
IPC分类号： G06F15/177
CPC分类号： G06F16/972 , G06F17/2205 , G06F17/24
摘要： Techniques to view and manage followed content are described. A technique may include receiving a selection to follow a content item. A reference to a content item selected for following may be stored for a user. The references for the user may be displayed in a centralized location in a user interface. The display may include contextual information about each followed content item with its reference. Additional information and functions for a followed content item may be displayed in response to a received selection for additional information. Other embodiments are described and claimed.
摘要翻译：描述了查看和管理跟踪内容的技术。技术可以包括接收跟随内容项目的选择。可以为用户存储对于为了跟随而选择的内容项目的引用。用户的参考可以显示在用户界面中的集中位置。显示器可以包括关于每个跟随的内容项目及其参考的上下文信息。可以响应于接收到的附加信息的选择来显示跟随内容项的附加信息和功能。描述和要求保护其他实施例。

7. 发明申请

US20050256042A1 Methods of preventing and treating alimentary mucositis 审中-公开
标题翻译：预防和治疗消化性粘膜炎的方法
公开(公告)号：US20050256042A1
公开(公告)日：2005-11-17
申请号：US10980459
申请日：2004-11-03
申请人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
发明人： Michael Jeffers , Zachary Yim , Pascal Valax , Pradyumna Namdev , Rajeev Chillakuru , William LaRochelle , Henri Lichenstein , Enrique Alvarez , William Hahne
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/50 , C12N1/21 , C12N15/74 , C12P21/06
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to compositions and methods for preventing and treating alimentary mucositis. More particularly, the present invention provides methods for preventing and/or treating alimetary mucositis by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译：本发明涉及预防和治疗消化性粘膜炎的组合物和方法。更具体地，本发明提供了通过使用包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物来预防和/或治疗哺乳动物粘膜炎的方法。

8. 发明申请

US20130156784A1 Compositions Using Antibodies Directed To GPNMB And Uses Thereof 审中-公开
标题翻译：使用针对GPNMB的抗体的组合及其用途
公开(公告)号：US20130156784A1
公开(公告)日：2013-06-20
申请号：US13544526
申请日：2012-07-09
申请人： Michael Jeffers , William LaRochelle
发明人： Michael Jeffers , William LaRochelle
IPC分类号： A61K39/395 , A61K31/426 , A61K31/5025 , A61K31/4439 , A61K33/20 , A61K31/4706 , A61K31/35 , A61K45/06 , A61K31/506
CPC分类号： A61K39/39558 , A61K31/35 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/4706 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/54 , A61K33/20 , A61K45/06 , A61K47/6803 , A61K47/6851 , C07K16/30 , C07K2317/21 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies, including fully human monoclonal antibodies, with specificity to GPNMB, and uses of such antibodies. The present invention further provides compositions that increase expression of GPNMB on the surface of tumor cells, and methods of using such compositions to increase the anti-cancer activity or other therapeutic efficacy of the antibodies and immunoconjugates provided herein.
摘要翻译：本发明涉及对GPNMB具有特异性的抗体，包括完全人单克隆抗体，以及此类抗体的用途。本发明还提供增加GPNMB在肿瘤细胞表面的表达的组合物，以及使用这些组合物增加本文提供的抗体和免疫缀合物的抗癌活性或其它治疗功效的方法。

9. 发明授权

US07056885B1 Fibroblast growth factor and nucleic acids encoding same 失效
标题翻译：成纤维细胞生长因子和核酸编码相同
公开(公告)号：US07056885B1
公开(公告)日：2006-06-06
申请号：US09609543
申请日：2000-07-03
申请人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
IPC分类号： A61K38/18 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX polypeptides and polynucleotides, and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods of use for the FGF-CX polypeptide, polynucleotide and antibody.
摘要翻译：本发明提供FGF-CX多肽和多核苷酸，以及免疫特异性结合FGF-CX或FGF-CX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。本发明另外提供了用于FGF-CX多肽，多核苷酸和抗体的方法。

10. 发明授权

US06982250B2 Methods of prevention and treatment of inflammatory bowel disease 失效
标题翻译：预防和治疗炎症性肠病的方法
公开(公告)号：US06982250B2
公开(公告)日：2006-01-03
申请号：US10011364
申请日：2001-11-16
申请人： Henry Lichenstein , Michael Jeffers
发明人： Henry Lichenstein , Michael Jeffers
IPC分类号： A61K38/00 , C07K17/00
CPC分类号： C07K14/50 , A61K38/00 , C07K14/49 , C07K14/51 , C07K14/52
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. The invention includes methods of reducing the morality rate or delaying mortality in a subject suffering from an inflammatory pathology. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译：本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。本发明包括降低患有炎性病理学的受试者的道德率或延缓死亡率的方法。在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。

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