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1. 发明授权

US06808518B2 Methods and devices for treating diseased blood vessels 有权
标题翻译：用于治疗患病血管的方法和装置
公开(公告)号：US06808518B2
公开(公告)日：2004-10-26
申请号：US09965949
申请日：2001-09-28
申请人： Parris S. Wellman , Kevin S. Weadock
发明人： Parris S. Wellman , Kevin S. Weadock
IPC分类号： A61M3100
CPC分类号： A61M37/0015 , A61M25/1011 , A61M29/02 , A61M37/00 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2037/003
摘要： The present invention provides a mechanism by which the physical properties of diseased blood vessel walls can be manipulated to achieve an effective vessel lumen diameter for a prolonged period of time. The methods and devices of the present invention selectively isolate and treat the medial or adventitial layers of these diseased blood vessels. The invention is based on the delivery of proteolytic enzymes and crosslinking agents via specialized delivery devices to a select layer of the diseased blood vessel wall. By isolating and treating these layers of the artery, collagen degrading and collagen crosslinking agents can be delivered so as to affect the diameter of the blood vessels and control blood flow therein.
摘要翻译：本发明提供了一种机制，通过该机制可以操纵患病血管壁的物理性能以在更长的时间内实现有效的血管腔直径。本发明的方法和装置选择性地分离和治疗这些患病血管的内侧或外膜层。本发明基于通过专门的递送装置将蛋白水解酶和交联剂递送到患病血管壁的选择层。通过分离和处理这些动脉层，可以递送胶原蛋白降解和胶原交联剂，以便影响血管的直径并控制其中的血流。

2. 发明授权

US06616661B2 Surgical device for clamping, ligating, and severing tissue 失效
公开(公告)号：US06616661B2
公开(公告)日：2003-09-09
申请号：US09967204
申请日：2001-09-28
申请人： Parris S. Wellman , Kevin S. Weadock , Robert Nering
发明人： Parris S. Wellman , Kevin S. Weadock , Robert Nering
IPC分类号： A61B1732
CPC分类号： A61B18/1482 , A61B17/00008 , A61B18/1442 , A61B2018/00404 , A61B2018/00595 , A61B2018/00601 , A61B2018/1412 , A61B2018/1455
摘要： A surgical device for severing tissue, the surgical device comprising; a first shaft having a first internal lumen and a first slot disposed at a distal end; a clamp slidingly disposed in the first slot between open and closed positions to capture tissue in the first slot, the clamp having a clamping surface disposed at a distal end; at least one electrode for applying RF energy to the tissue captured in the first slot; a cutting blade slidingly disposed in the first slot between open and closed positions, the cutting blade having a cutting edge to sever the tissue; first actuation means for actuating the clamp between the open and closed positions; and second actuation means for actuating the cutting blade between the open and closed positions.

3. 发明授权

US07611484B2 Methods and devices for treating diseased blood vessels 有权
标题翻译：用于治疗患病血管的方法和装置
公开(公告)号：US07611484B2
公开(公告)日：2009-11-03
申请号：US10833614
申请日：2004-04-28
申请人： Parris S. Wellman , Kevin S. Weadock
发明人： Parris S. Wellman , Kevin S. Weadock
IPC分类号： A61M29/00
CPC分类号： A61M37/0015 , A61M25/1011 , A61M29/02 , A61M37/00 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2037/003
摘要： The present invention provides a mechanism by which the physical properties of diseased blood vessel walls can be manipulated to achieve an effective vessel lumen diameter for a prolonged period of time. The methods and devices of the present invention selectively isolate and treat the medial or adventitial layers of these diseased blood vessels. The invention is based on the delivery of proteolytic enzymes and crosslinking agents via specialized delivery devices to a select layer of the diseased blood vessel wall. By isolating and treating these layers of the artery, collagen degrading and collagen crosslinking agents can be delivered so as to affect the diameter of the blood vessels and control blood flow therein.
摘要翻译：本发明提供了一种机制，通过该机制可以操纵患病血管壁的物理性能以在更长的时间内实现有效的血管腔直径。本发明的方法和装置选择性地分离和治疗这些患病血管的内侧或外膜层。本发明基于通过专门的递送装置将蛋白水解酶和交联剂递送到患病血管壁的选择层。通过分离和处理这些动脉层，可以递送胶原蛋白降解和胶原交联剂，以便影响血管的直径并控制其中的血流。

4. 发明授权

US07288075B2 Methods and devices utilizing rheological materials 失效
标题翻译：使用流变材料的方法和装置
公开(公告)号：US07288075B2
公开(公告)日：2007-10-30
申请号：US10183072
申请日：2002-06-27
申请人： Shailendra K. Parihar , Thomas P. Ryan , Timothy Dietz , Parris S. Wellman , Kevin S. Weadock , T. Anh Le , Peter Douglas , Simon Cohn , Daniel Gordon , Rajesh Pendekanti , Raghuveer Basude , Robert S. Casar , Howard A. Stone
发明人： Shailendra K. Parihar , Thomas P. Ryan , Timothy Dietz , Parris S. Wellman , Kevin S. Weadock , T. Anh Le , Peter Douglas , Simon Cohn , Daniel Gordon , Rajesh Pendekanti , Raghuveer Basude , Robert S. Casar , Howard A. Stone
IPC分类号： A61B5/103 , A61B5/117 , A61B5/00 , A61C19/00 , A61C9/00 , A61C5/04 , A61C19/04
CPC分类号： A61B17/29 , A43B3/0005 , A43B7/146 , A43B7/28 , A61B17/02 , A61B17/32053 , A61B17/62 , A61B18/1492 , A61B2017/003 , A61B2017/00398 , A61B2017/0243 , A61B2017/2905 , A61B2017/2939 , A61C9/00 , A61C9/0013 , F16F13/30 , H04R25/558 , H04R25/652 , H04R25/658
摘要： Impression devices are provided for making an impression of a desired feature. The impression devices include: a flexible bladder having a cavity formed therein, the flexible bladder being capable of conforming to the details of the desired feature; a rheological material, such as a magnetorheological fluid, disposed in the cavity of the flexible bladder; and an activator for applying an external stimulus to the rheological material to change the state of the rheological material and thereby capture an impression of the desired feature.
摘要翻译：提供了印象设备，用于产生所需功能的印象。压印装置包括：柔性气囊，其中形成有空腔，柔性气囊能够符合所需特征的细节; 设置在柔性气囊的空腔中的流变材料，例如磁流变流体; 以及用于将外部刺激施加到流变材料以改变流变材料的状态并由此捕获所需特征的印象的激活剂。

5. 发明授权

US06527771B1 Surgical device for endoscopic vein harvesting 失效
标题翻译：用于内窥镜静脉采集的手术装置
公开(公告)号：US06527771B1
公开(公告)日：2003-03-04
申请号：US09967185
申请日：2001-09-28
申请人： Kevin S. Weadock , Parris S. Wellman
发明人： Kevin S. Weadock , Parris S. Wellman
IPC分类号： A61B1732
CPC分类号： A61B17/00008 , A61B18/1442 , A61B2018/00345 , A61B2018/00404 , A61B2018/00601 , A61B2018/00607
摘要： A surgical device including: a first shaft having a first projection radially offset from an axial direction of the first shaft, the first projection having a first clamping surface; a second shaft slidably disposed relative to the first shaft, the second shaft having a second projection radially offset from the axial direction, the second projection having a second clamping surface; a dissector for dissecting tissue from a blood vessel to be harvested; a first actuator for sliding the second projection relative to the first projection to capture a side branch of the vessel between the first and second clamping surfaces; at least one electrode for applying cauterizing energy to cauterize the captured side branch; a cutting blade movably disposed on one of the first or second projections; and a second actuator for moving the cutting blade to sever the side branch captured between the first and second projections.
摘要翻译：一种手术装置，包括：第一轴，其具有从所述第一轴的轴向方向径向偏移的第一突起，所述第一突起具有第一夹紧表面; 相对于第一轴可滑动地设置的第二轴，第二轴具有径向偏离轴向的第二突起，第二突起具有第二夹紧表面; 用于从要收获的血管解剖组织的解剖器; 第一致动器，用于相对于第一突起滑动第二突起，以捕获容器在第一和第二夹紧表面之间的侧分支; 至少一个电极，用于施加烧灼能量以灼烧所捕获的侧分支; 可移动地设置在所述第一或第二突起之一上的切割刀片; 以及用于移动切割刀片以切断在第一和第二突起之间捕获的侧分支的第二致动器。

6. 发明授权

US09877862B2 Tongue suspension system with hyoid-extender for treating obstructive sleep apnea 有权
公开(公告)号：US09877862B2
公开(公告)日：2018-01-30
申请号：US12608168
申请日：2009-10-29
申请人： Kevin S. Weadock , Robert A. Rousseau , David C. Lindh, Sr.
发明人： Kevin S. Weadock , Robert A. Rousseau , David C. Lindh, Sr.
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A system for treating obstructive sleep apnea includes a first element implantable in a tongue and a second element implantable between muscle planes of an inframandibular region. The second element has a first end coupled with the first element and a second end coupled with a hyoid bone for preventing the base of the tongue from collapsing against an opposing pharyngeal wall during sleep. The first and second implantable elements have outer surfaces that are substantially impermeable to tissue in-growth to allow for post-surgical adjustment or removal, if necessary. The first implantable element is elongated and includes a first end, a second end, and a center section located between the first and second ends. The center section is implantable in the tongue, and the first and second ends of the first implantable element are advanceable beneath the tongue for being coupled with the anterior end of the second implantable element.

7. 发明申请

US20140305443A1 MAGNETIC IMPLANTS AND METHODS FOR TREATING AN OROPHARYNGEAL CONDITION 审中-公开
标题翻译：磁性植入物和治疗恶性病症的方法
公开(公告)号：US20140305443A1
公开(公告)日：2014-10-16
申请号：US14303722
申请日：2014-06-13
申请人： Robert A. Rousseau , Kevin S. Weadock , An-Min Jason Sung
发明人： Robert A. Rousseau , Kevin S. Weadock , An-Min Jason Sung
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , A61F2210/009 , A61N2/06
摘要： Magnetic devices and implantation methods are provided for use in the treatment of obstructive sleep apnea. The devices include a sheet-like element having ferromagnetic qualities. The device may also include a permanent magnet attached to the sheet-like element by magnetic forces. The devices are implanted in soft tissue surrounding the airway and in tissue space beneath the pharyngeal wall to exert forces on and/or change the shape of the soft tissue. The magnetic devices may also include a bladder containing a magnetorheological fluid that stiffens soft tissue when exposed to a magnetic field.
摘要翻译：提供磁性装置和植入方法用于治疗阻塞性睡眠呼吸暂停。这些装置包括具有铁磁性质的片状元件。该装置还可以包括通过磁力附着到片状元件的永磁体。将装置植入围绕气道的软组织和咽壁下方的组织空间中以施加力和/或改变软组织的形状。磁性装置还可以包括含有磁流变流体的气囊，当暴露于磁场时，磁流体流体会软化软组织。

8. 发明授权

US08783258B2 Implant systems and methods for treating obstructive sleep apnea 有权
标题翻译：植入系统和治疗阻塞性睡眠呼吸暂停的方法
公开(公告)号：US08783258B2
公开(公告)日：2014-07-22
申请号：US12325350
申请日：2008-12-01
申请人： John Jacobs , Kevin S. Weadock , Robert A. Rousseau , David Lindh, Sr.
发明人： John Jacobs , Kevin S. Weadock , Robert A. Rousseau , David Lindh, Sr.
IPC分类号： A61F5/37 , A61F13/00 , A61C5/14 , A61B19/00 , A61B17/56 , A61F5/04 , A61B17/58 , A61F2/30 , A61B17/70 , A61F2/20 , A61F2/02 , A61F2/08
CPC分类号： A61F5/566
摘要： A system for treating obstructive sleep apnea includes an anchoring element having scar tissue located in an inframandibular region, and a tongue implant having at least one arm extending therefrom, whereby the tongue implant is implantable in a tongue with the at least one arm being connectable with the anchoring element for coupling the tongue implant with the anchoring element. In one embodiment, the anchoring element includes a first implant part such as a flexible layer implantable in the inframandibular region and the scar tissue is formed on, in, and/or around the first implant part. The tongue implant is coupled with the anchoring element and/or the scar tissue through the at least one arm. The length of the at least one arm may be adjusted for shifting the tongue anteriorly.
摘要翻译：用于治疗阻塞性睡眠呼吸暂停的系统包括具有位于下颌区域中的瘢痕组织的锚定元件和具有从其延伸的至少一个臂的舌植入物，由此所述舌植入物可植入舌头中，所述至少一个臂可与用于将舌植入物与锚定元件联接的锚固元件。在一个实施例中，锚定元件包括第一植入部分，例如可植入在下颌下区域中的柔性层，并且瘢痕组织形成在第一植入部分上，内和/或周围。舌植入物通过至少一个臂与锚定元件和/或瘢痕组织联接。可以调节至少一个臂的长度以使舌头向前移动。

9. 发明授权

US08413661B2 Methods and devices for treatment of obstructive sleep apnea 有权
公开(公告)号：US08413661B2
公开(公告)日：2013-04-09
申请号：US12228681
申请日：2008-08-14
申请人： Robert A. Rousseau , Kevin S. Weadock
发明人： Robert A. Rousseau , Kevin S. Weadock
IPC分类号： A61F5/56 , A61F2/20 , A61N1/00
CPC分类号： A61F5/56 , A61F5/566
摘要： A pharyngeal retractor device and implantation methods are provided for use in the treatment of obstructive sleep apnea. The device includes a retracting element and a tissue engaging element that promotes tissue ingrowth around or onto the retracting element. The device is implanted in tissue space beneath the pharyngeal wall to alter the shape of the wall. The device may be implanted through the oral cavity alone or by using a trocar or a hand-held delivery system to deliver the device through the pharyngeal wall. Alternatively, the device may be implanted using an open, direct visualization approach from the side of a patient's neck.

10. 发明授权

US08894683B2 Device for attaching, relocating and reinforcing tissue and methods of using same 有权
标题翻译：用于附着，重新定位和加强组织的装置及其使用方法
公开(公告)号：US08894683B2
公开(公告)日：2014-11-25
申请号：US12151235
申请日：2008-05-05
申请人： Kevin S. Weadock , Parris Wellman , Martin Weisberg , Philip Prentice , Earl Adamy
发明人： Kevin S. Weadock , Parris Wellman , Martin Weisberg , Philip Prentice , Earl Adamy
IPC分类号： A61B17/08 , A61B17/00 , A61B17/04 , A61F2/00
CPC分类号： A61B17/0401 , A61B2017/00004 , A61B2017/00743 , A61B2017/00778 , A61B2017/00805 , A61B2017/0412 , A61B2017/0427 , A61B2017/0454 , A61B2017/0458 , A61B2017/0462 , A61B2017/0464 , A61F2/0045
摘要： A device for attaching, relocating or reinforcing tissue includes a first tissue anchoring portion having a support plate and a plurality of barbs extending from the support plate for engaging tissue at a first location, a second tissue anchoring portion having a support plate and a plurality of barbs extending from the support plate for engaging tissue at a second location which is different from the first location, and a connection element, such as a suture or a mesh structure, interposed between and interconnecting the first tissue anchoring portion and the second tissue anchoring portion. The support plate of at least one of the first tissue anchoring portion and the second tissue anchoring portion may have longitudinally axially formed therethrough a bore for receiving the connecting element so that the surgeon may pull on the end of the connecting element to adjust the distance between the first tissue anchoring portion and the second tissue anchoring portion.
摘要翻译：用于附接，重新定位或加强组织的装置包括具有支撑板的第一组织锚固部分和从支撑板延伸的多个倒钩，用于在第一位置处接合组织，第二组织锚定部分具有支撑板和多个从支撑板延伸的倒钩，用于在不同于第一位置的第二位置处接合组织;以及连接元件，例如缝合线或网状结构，插入在第一组织锚固部分和第二组织锚定部分之间并将其互连。第一组织锚固部分和第二组织锚固部分中的至少一个的支撑板可以纵向轴向地形成在其中，用于接收连接元件的孔，使得外科医生可以在连接元件的端部上拉动以调节第一组织锚定部分和第二组织锚定部分。

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