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1. 发明申请

US20110270532A1 Systems And Methods For Identifying Exon Junctions From Single Reads 审中-公开
标题翻译：用于从单次读取中识别外显子结的系统和方法
公开(公告)号：US20110270532A1
公开(公告)日：2011-11-03
申请号：US13097328
申请日：2011-04-29
申请人： Paolo VATTA , Onur Sakarya , Heinz Breu , Liviu Popescu , Asim Siddiqui , Fiona Hyland
发明人： Paolo VATTA , Onur Sakarya , Heinz Breu , Liviu Popescu , Asim Siddiqui , Fiona Hyland
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G16B30/00
摘要： Systems and methods are used to identify an exon junction from a single read of a transcript. A transcript sample is interrogated and a read sequence is produced using a nucleic acid sequencer. A first exon sequence and a second exon sequence are obtained using the processor. The first exon sequence is mapped to a prefix of the read sequence using the processor. The second exon sequence is mapped to a suffix of the read sequence using the processor. A sum of a number of sequence elements of the first exon sequence that overlap the prefix of the read sequence, of a number of sequence elements of the second exon sequence that overlap the suffix of the read sequence, and of a constant is calculated using the processor. If the sum equals a length of the read sequence, a junction is identified in the read using the processor.
摘要翻译：系统和方法用于从单次阅读誊本中鉴定出外显子连接。询问转录物样品，并使用核酸测序仪产生读序列。使用处理器获得第一外显子序列和第二外显子序列。使用处理器将第一个外显子序列映射到读取序列的前缀。第二个外显子序列使用处理器映射到读序列的后缀。与第一外显子序列的序列元素的数量重叠，读取序列的前缀，与重写序列的后缀重叠的第二外显子序列的多个序列元件的数目和一个常数的序列元素的总和是使用处理器。如果总和等于读取序列的长度，则使用处理器在读取中识别结。

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