专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06919321B2 Ophthalmic lubricating solution adapted for use in lasik surgery 失效
标题翻译：适用于拉米克手术的眼科润肤溶液
公开(公告)号：US06919321B2
公开(公告)日：2005-07-19
申请号：US10432274
申请日：2001-11-29
申请人： Pao-Li Wang , Uday Doshi , Masoud R. Jafari , Kerry L. Markwardt , Emerson Maddox
发明人： Pao-Li Wang , Uday Doshi , Masoud R. Jafari , Kerry L. Markwardt , Emerson Maddox
IPC分类号： A61K9/00 , A61K31/716 , A61K31/728 , A61K31/736 , A61K31/737 , A61K38/39
CPC分类号： A61K31/716 , A61K9/0048 , A61K31/728 , A61K31/736 , A61K31/737 , A61K38/39
摘要： Ocular lubricant solutions are described. The solutions are adapted to facilitate the formation of a corneal flap during LASIK surgery. The solutions contain one or more viscosity enhancing agents (e.g., chondroitin sulfate) in a substantially salt-free, ophthalmically acceptable vehicle. Methods of lubricating the cornea to facilitate flap formation are also described.
摘要翻译：描述了眼部润滑剂溶液。该解决方案适用于在LASIK手术期间促进角膜瓣的形成。该溶液含有一种或多种基本上不含盐的眼科可接受载体中的粘度增强剂（例如硫酸软骨素）。还描述了润滑角膜以促进瓣形成的方法。

2. 发明授权

US06878694B2 Ophthalmic irrigating solution adapted for use in lasik surgery 失效
标题翻译：适用于拉米克手术的眼科冲洗液
公开(公告)号：US06878694B2
公开(公告)日：2005-04-12
申请号：US10432273
申请日：2001-11-29
申请人： Uday Doshi , Kerry L. Markwardt , Pao-Li Wang , Emerson Maddox
发明人： Uday Doshi , Kerry L. Markwardt , Pao-Li Wang , Emerson Maddox
IPC分类号： A61K9/00 , A61K31/728 , A61K31/736 , A61K31/737 , A61K31/74 , A61K31/70
CPC分类号： A61K31/728 , A61K9/0048 , A61K31/736 , A61K31/737 , A61K31/74
摘要： Compositions and methods for facilitating the formulation and closure of a corneal flap during LASIK surgery are described. The compositions and methods are based on the use of one or more viscosity-enhancing agents (e.g., chondroitin sulfate) to provide an ophthalmic irrigating solution with improved coating properties and prolonged dwelling time on the cornea, thereby providing lubrication for the microkeratome used to form the corneal flap, reduce corneal epithelial abrasions, and help to produce smooth and consistent cuts with the microkeratome blade.
摘要翻译：描述了在LASIK手术期间促进角膜瓣的配制和闭合的组合物和方法。组合物和方法基于使用一种或多种粘度增强剂（例如，硫酸软骨素）来提供具有改善的涂层性能和在角膜上延长的住院时间的眼用冲洗溶液，由此为用于形成的微型角膜刀提供润滑角膜瓣，减少角膜上皮擦伤，并有助于使用微型角膜刀刀片产生平滑和一致的切口。

3. 发明授权

US07820194B2 Combinations of viscoelastics for use during surgery 有权
标题翻译：手术中使用的粘弹胶组合
公开(公告)号：US07820194B2
公开(公告)日：2010-10-26
申请号：US10955084
申请日：2004-09-30
申请人： Masoud R. Jafari , Kerry L. Markwardt , Uday Doshi
发明人： Masoud R. Jafari , Kerry L. Markwardt , Uday Doshi
IPC分类号： A61F2/00 , A61F13/00 , A61K31/795
CPC分类号： A61K9/0048 , A61K31/716 , A61K31/728 , A61K31/737 , A61L24/001 , A61L24/043 , A61L26/0052 , A61L2430/16 , C08L5/08 , A61L31/041 , A61K2300/00
摘要： An improved viscoelastic composition useful in the performance of ophthalmic surgical procedures and especially cataract procedures is disclosed. The embodiments of the composition comprise combinations of sodium hyaluronate and chondroitin sulfate and exhibit an improved rheological profile.
摘要翻译：公开了一种用于执行眼科外科手术，特别是白内障手术的改进的粘弹性组合物。该组合物的实施方案包括透明质酸钠和硫酸软骨素的组合，并表现出改善的流变学特性。

4. 发明授权

US08529938B2 Combinations of viscoelastics for use during surgery 有权
标题翻译：手术中使用的粘弹胶组合
公开(公告)号：US08529938B2
公开(公告)日：2013-09-10
申请号：US12887017
申请日：2010-09-21
申请人： Masoud R. Jafari , Kerry L. Markwardt , Uday Doshi
发明人： Masoud R. Jafari , Kerry L. Markwardt , Uday Doshi
IPC分类号： A61F2/00 , A61F13/00 , A61K31/795
CPC分类号： A61K9/0048 , A61K31/716 , A61K31/728 , A61K31/737 , A61L24/001 , A61L24/043 , A61L26/0052 , A61L2430/16 , C08L5/08 , A61L31/041 , A61K2300/00
摘要： An improved viscoelastic composition useful in the performance of ophthalmic surgical procedures and especially cataract procedures is disclosed. The embodiments of the composition comprise combinations of sodium hyaluronate and chondroitin sulfate and exhibit an improved rheological profile.
摘要翻译：公开了一种用于执行眼科外科手术，特别是白内障手术的改进的粘弹性组合物。该组合物的实施方案包括透明质酸钠和硫酸软骨素的组合，并表现出改善的流变学特性。

5. 发明申请

US20110015151A1 COMBINATION OF VISCOELASTICS FOR USE DURING SURGERY 有权
标题翻译：手术期间使用粘弹性的组合
公开(公告)号：US20110015151A1
公开(公告)日：2011-01-20
申请号：US12887017
申请日：2010-09-21
申请人： Masoud R. Jafari , Kerry L. Markwardt , Uday Doshi
发明人： Masoud R. Jafari , Kerry L. Markwardt , Uday Doshi
IPC分类号： A61K31/737 , A61P41/00
CPC分类号： A61K9/0048 , A61K31/716 , A61K31/728 , A61K31/737 , A61L24/001 , A61L24/043 , A61L26/0052 , A61L2430/16 , C08L5/08 , A61L31/041 , A61K2300/00
摘要： An improved viscoelastic composition useful in the performance of ophthalmic surgical procedures and especially cataract procedures is disclosed. The embodiments of the composition comprise combinations of sodium hyaluronate and chondroitin sulfate and exhibit an improved rheological profile.
摘要翻译：公开了一种用于执行眼科外科手术，特别是白内障手术的改进的粘弹性组合物。该组合物的实施方案包括透明质酸钠和硫酸软骨素的组合，并表现出改善的流变学特性。

6. 发明申请

US20090258955A1 INTRAOCULAR IRRIGATING SOLUTION HAVING IMPROVED FLOW CHARACTERISTICS 审中-公开
标题翻译：具有改进流动特性的内部灌溉解决方案
公开(公告)号：US20090258955A1
公开(公告)日：2009-10-15
申请号：US12423727
申请日：2009-04-14
申请人： Mandar V. Shah , Mikhail Boukhny , William H. Garner , Kerry L. Markwardt , Uday Doshi
发明人： Mandar V. Shah , Mikhail Boukhny , William H. Garner , Kerry L. Markwardt , Uday Doshi
IPC分类号： A61K47/38 , A61K47/02
CPC分类号： A61K9/0048 , A61K38/14 , A61K38/39
摘要： Improved intraocular irrigating solutions are described comprising a cellulose derivative such as hydroxypropylmethylcellulose. In addition, certain solutions of the present invention comprise glutathione and dextrose. The solutions have enhanced viscosities that reduce the risk of damage to intraocular tissues during intraocular surgical procedures by reducing the turbulence of the solutions and dampening the movement of tissue fragments and air bubbles. The solutions preferably also have modified surface tensions that more closely resemble the surface tension of the aqueous humor.
摘要翻译：描述了改进的眼内冲洗溶液，其包含纤维素衍生物如羟丙基甲基纤维素。此外，本发明的某些溶液包含谷胱甘肽和葡萄糖。该溶液具有增强的粘度，通过减少溶液的湍流并抑制组织碎片和气泡的运动，减少眼内手术过程中损伤眼内组织的风险。溶液优选还具有更接近于房水表面张力的改性表面张力。

7. 发明授权

US07084130B2 Intraocular irrigating solution having improved flow characteristics 有权
标题翻译：具有改善流动特性的眼内注射溶液
公开(公告)号：US07084130B2
公开(公告)日：2006-08-01
申请号：US10240449
申请日：2001-12-11
申请人： Mandar V. Shah , Mikhail Boukhny , William H. Garner , Kerry L. Markwardt , Uday Doshi
发明人： Mandar V. Shah , Mikhail Boukhny , William H. Garner , Kerry L. Markwardt , Uday Doshi
IPC分类号： A61K31/765 , A61K31/717 , A61K31/715
CPC分类号： A61K38/39 , A61K9/0048 , A61K38/14
摘要： Improved intraocular irrigating solutions are described. The solutions have enhanced viscosities that reduce the risk of damage to intraocular surgical procedures by reducing the turbulence of the solutions and dampening the movement of tissue fragments and air bubbles. The solutions preferably also have modified surface tensions that more closely resemble the surface tension of the aqueous humor.
摘要翻译：描述改进的眼内灌洗溶液。该溶液具有增强的粘度，通过减少溶液的湍流并抑制组织碎片和气泡的运动来降低眼内手术程序的损伤风险。溶液优选还具有更接近于房水表面张力的改性表面张力。

8. 发明授权

US07169755B2 Solution for removing cataracts via liquefracture 有权
$Solution for removing cataracts via liquefracture$
标题翻译：通过液压清除白内障的解决方案
公开(公告)号：US07169755B2
公开(公告)日：2007-01-30
申请号：US10433166
申请日：2001-12-11
申请人： Mandar V. Shah , Glenn Sussman , Donald M Cohen , Uday Doshi , Kerry L. Markwardt
发明人： Mandar V. Shah , Glenn Sussman , Donald M Cohen , Uday Doshi , Kerry L. Markwardt
IPC分类号： A61K38/16 , A61M37/00
CPC分类号： A61K9/0048 , A61F9/00736
摘要： An improved solution for use in the removal of cataractous lenses via liquefracture is described. The liquefracture solution contains a viscosity-enhancing agent to increase the residence time of the solution in the heating chamber of the liquefracture handpiece, thereby increasing the expulsion force of the solution from the handpiece (i.e., “pulse force”). An agent that releases gas when the liquefracture solution is heated in the handpiece may also be included in the solution, thereby also enhancing the pulse force of the solution upon expulsion from the handpiece. The solution preferably also contains a partially water-soluble agent that forms a temporarily insoluble precipitate when heated in a liquefracture handpiece. The precipitate acts as an abrasive agent when expelled with the liquefracture solution from the handpiece, thereby facilitating the cutting and disintegration of the cataractous lens material.
摘要翻译：描述了用于通过液压除去白内障透镜的改进的解决方案。液化溶液含有粘度增强剂，以增加溶液在液化机构的加热室中的停留时间，从而增加溶液从手持件的排出力（即“脉冲力”）。当液体溶液在手持件中被加热时释放气体的试剂也可以包含在溶液中，从而也可以在从手持件排出时增强溶液的脉冲力。溶液优选还含有部分水溶性试剂，其在液化手机中加热时形成暂时不溶的沉淀。当用液体溶液从手持件排出时，沉淀物用作研磨剂，从而有助于白内障镜片材料的切割和分解。

9. 发明申请

US20110207809A1 METHOD OF ACCELERATING CORNEAL WOUND HEALING 审中-公开
标题翻译：加速角膜愈合的方法
公开(公告)号：US20110207809A1
公开(公告)日：2011-08-25
申请号：US13034889
申请日：2011-02-25
申请人： Eric C. Carlson , Daniel A. Gamache , Mark R. Hellberg , Peter G. Klimko , Kerry L. Markwardt , John M. Yanni
发明人： Eric C. Carlson , Daniel A. Gamache , Mark R. Hellberg , Peter G. Klimko , Kerry L. Markwardt , John M. Yanni
IPC分类号： A61K31/366 , A61K31/16 , A61K31/191 , A61K31/22 , A61P27/02
CPC分类号： C07D309/30 , A61K9/0048 , A61K31/047 , A61K31/16 , A61K31/191 , A61K31/22 , A61K31/366 , C07C59/105 , C07C69/675 , C07C235/06
摘要： The topical ophthalmic use of 5,6,7-trihydroxyheptanoic acid and analogs for the acceleration of corneal wound healing in humans, is disclosed.
摘要翻译：公开了5,6,7-三羟基庚酸及其类似物在人体中加速角膜伤口愈合的局部眼用。

10. 发明授权

US06486138B1 Ophthalmic compositions containing galactomannan polymers and borate 有权
公开(公告)号：US06486138B1
公开(公告)日：2002-11-26
申请号：US09447146
申请日：1999-11-23
申请人： Bahram Asgharian , Gerald Cagle , Mandar V. Shah , Kerry L. Markwardt
发明人： Bahram Asgharian , Gerald Cagle , Mandar V. Shah , Kerry L. Markwardt
IPC分类号： A61K31715
CPC分类号： A61K31/74 , A61K9/0048 , A61K33/22 , A61K45/06 , A61K47/02 , A61K47/36 , Y10S514/839 , Y10S514/912 , Y10S514/944 , A61K2300/00
摘要： The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions to the eye.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式