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    • 2. 发明授权
    • Method and apparatus for monitoring physiologic parameters conjunction with a treatment
    • 用于监测与治疗结合的生理参数的方法和装置
    • US06438407B1
    • 2002-08-20
    • US09528627
    • 2000-03-20
    • Kevin T. OusdigianKaren A. StoneVasant Padmanabhan
    • Kevin T. OusdigianKaren A. StoneVasant Padmanabhan
    • A61B504
    • A61N1/37247
    • A system including an implantable medical device and an associated external device, in which the implantable device is adapted to monitor a physiologic parameter and includes a telemetry system for transmitting information to and receiving information from the external device, including information regarding the measured physiological parameter and in which wherein the external device includes a telemetry system for receiving information from the implanted device and for transmitting information to the implanted device and is provided with a mechanism for receiving information indicative of occurrences of significant therapeutic events and is further provided with a display system which combines information received from the implantable device related to the monitored physiologic parameter with the information of therapeutic significance and for displays the combined information in a time-scaled display in which the measured physiologic parameter is displayed along a common time scale with indications of occurrences of the significant therapy related events. The implantable device may also include a mechanism for delivering a therapy; and the mechanism in the external device for receiving information indicative of occurrences of significant therapeutic events may receive information regarding changes in the therapy delivered by the implantable device. The mechanism in the external device for receiving information indicative of occurrences of significant therapeutic events may also or in addition receive information indicative of changes in the therapy delivered by a physician, e.g. changes in a drug therapy.
    • 一种包括可植入医疗装置和相关联的外部装置的系统,其中所述可植入装置适于监测生理参数,并且包括用于向所述外部装置发送信息并从外部装置接收信息的遥测系统,所述遥测系统包括关于所测量的生理参数的信息, 其中所述外部设备包括用于从所述植入设备接收信息并用于向所述植入设备发送信息的遥测系统,并且设置有用于接收指示重要治疗事件发生的信息的机构,并且还具有显示系统,所述显示系统 将从与所监视的生理参数相关的可植入装置接收的信息与具有治疗意义的信息组合,并且以按照公共时间尺度显示测量的生理参数的时间尺度显示中的组合信息显示 有明显的治疗相关事件的发生。 可植入装置还可以包括用于递送治疗的机构; 并且用于接收指示重大治疗事件发生的信息的外部设备中的机制可以接收关于由可植入装置递送的治疗变化的信息。 用于接收指示重大治疗事件发生的信息的外部设备中的机制还可以或另外接收指示由医师传递的治疗变化的信息,例如, 药物治疗的变化。
    • 3. 发明授权
    • Method and apparatus for monitoring heart rate
    • 监测心率的方法和装置
    • US06714811B1
    • 2004-03-30
    • US09452659
    • 1999-12-01
    • Vasant PadmanabhanKaren A. StoneWalter H. OlsonKevin T. Ousdigian
    • Vasant PadmanabhanKaren A. StoneWalter H. OlsonKevin T. Ousdigian
    • A61B504
    • A61B5/0031A61B5/0205A61B5/024A61B5/11A61B2560/0431
    • A monitoring device for implant in a patient's body. The device is provided with a physiologic sensor generating output signals, which signals are stored as numerical values. The device defines first monitoring periods limited to time periods during successive nights during which the patient is likely to be asleep, stores the numerical values generated during the first monitoring periods in a memory and calculates values reflecting general levels of the numerical values during the first monitoring periods. The device may also or alternatively define second monitoring periods limited to time periods during successive daytime and store numerical values generated during the second monitoring periods. The physiologic sensor may be an electrogram amplifier or other sensor indicative of metabolic demand for oxygenated blood, such as an activity sensor. The calculated values reflecting general levels of the numerical values generated during the monitoring periods may be average values, such as mean values or over-all total values, depending upon the sensor employed.
    • 一种用于植入患者体内的监测装置。 该装置设置有生成输出信号的生理传感器,该信号被存储为数值。 该装置定义了限制在患者可能睡着的连续夜晚的时间段的第一监测时段,将在第一监测周期期间产生的数值存储在存储器中,并且计算反映在第一监测期间的数值的一般水平的值 时期。 设备还可以或者替代地定义限制在连续白天期间的时间段的第二监视周期,并且存储在第二监视周期期间生成的数值。 生理传感器可以是电描记放大器或指示氧合血液的代谢需求的其它传感器,例如活性传感器。 反映在监测期间产生的数值的一般水平的计算值可以是平均值,例如平均值或全部总值,这取决于所使用的传感器。
    • 7. 发明授权
    • Method and apparatus for monitoring pacemaker intervals
    • 用于监测起搏器间隔的方法和装置
    • US5372607A
    • 1994-12-13
    • US081721
    • 1993-06-23
    • Karen A. StoneRichard M. PowellMichael R. TollingerGary Berg
    • Karen A. StoneRichard M. PowellMichael R. TollingerGary Berg
    • A61N1/365A61N1/368A61N1/37
    • A61N1/36514A61N1/368A61N1/37
    • A method and apparatus for optimizing the performance of a rate-responsive cardiac pacemaker. A pacemaker is provided which is capable of obtaining and storing information about a patient's cardiac function and about a pacemaker's operation during a brief exercise interval. The data collected includes information about the number of cardiac events during each two-second interval of the exercise, as well as the percentage of paced events during each two-second interval. Data reflecting the output of the pacemaker's activity sensor output is also collected for each two second interval of the test. In addition, AV interval data for each cardiac cycle during the test is collected, this data being distinguished according to whether it reflects atrial-pace-to-ventricular-sense or atrial-sense-to-ventricular-sense AV intervals. The disclosed pacemaker is operable in conjunction with an external programming/processing unit, which receives the stored data after the exercise test is concluded. The data is processed and presented on the programmer screen in a manner which enables the clinician to readily assimilate it and observe the effects of hypothetical changes in rate-response programming in the pacemaker. Additionally, the clinician is able to observe the programmed AV rate adaption profiles in conjunction with the patient's actual AV performance, and compare this data with an AV profile from a typical healthy heart.
    • 一种用于优化速率响应心脏起搏器的性能的方法和装置。 提供了起搏器,其能够获得和存储关于患者的心脏功能的信息以及在短暂的运动间隔期间关于起搏器的操作。 收集的数据包括关于运动的每两秒间隔期间的心脏事件的数量以及每两秒间隔期间的起搏事件的百分比的信息。 也可以每两个测试间隔收集反映起搏器活动传感器输出信号的数据。 此外,收集测试期间每个心动周期的AV间隔数据,根据它是否反映心房心室感觉或心房感觉到心室感觉AV间隔来区分该数据。 所公开的起搏器可与外部编程/处理单元结合操作,外部编程/处理单元在运动测试结束之后接收存储的数据。 数据在编程器屏幕上被处理和呈现,使得临床医生能够容易地吸收它并且观察起搏器中速率响应编程中假设变化的影响。 此外,临床医生能够结合患者的实际AV性能观察编程的AV速率适应曲线,并将该数据与来自典型健康心脏的AV图像进行比较。