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1. 发明申请

US20180028228A1 IMPLANTABLE FLUID DELIVERY DEVICES, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：US20180028228A1
公开(公告)日：2018-02-01
申请号：US15727766
申请日：2017-10-09
申请人： PALO ALTO RESEARCH CENTER INCORPORATED
发明人： David Mathew Johnson , Scott A. Uhland , Ramkumar Abhishek , Robert Thomas Krivacic , Martin Sheridan
IPC分类号： A61B17/43 , A61D7/00 , A61M31/00 , A61B17/435
CPC分类号： A61B17/43 , A61B17/435 , A61D7/00 , A61M31/002
摘要： Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.

2. 发明申请

US20160139280A1 Neutron Detector With Interblended Liquid Scintillator 有权
标题翻译：中子检测器与混合液体闪烁体
公开(公告)号：US20160139280A1
公开(公告)日：2016-05-19
申请号：US14547092
申请日：2014-11-18
申请人： Palo Alto Research Center Incorporated
发明人： Saroj Kumar Sahu , Craig Eldershaw , Martin Sheridan
IPC分类号： G01T3/06
CPC分类号： G01T3/06
摘要： A neutron detector that utilizes cells in which a liquid scintillator is contained in elongated detector tubes, with photo-detectors disposed at each end of the tube to measure scintillation light generated by incident neutrons. The liquid scintillator is an interblended mixture including an ionic liquid blended with a scintillation enhancer and/or a moderator and/or a controlled optical attenuator. A longitudinal position of an incident neutron is determined by the magnitudes of the scintillation light portions arriving at each photo-detector, which are proportional to the distances between the neutron interaction point and the photo-detectors. The cells are arranged in a closely-spaced parallel planar array to facilitate determining incident neutron location in two dimensions. A detector system utilizes a first detector array to detect fast neutrons, a thermalizer (e.g., polyethylene) to convert fast incident neutrons to thermal neutrons, and a second detector array to detect the thermal neutrons.
摘要翻译：中子探测器利用细长的检测器管中包含液体闪烁体的细胞，其中光探测器设置在管的每一端以测量由入射中子产生的闪烁光。液体闪烁体是包含与闪烁增强剂和/或调节剂和/或受控光衰减剂混合的离子液体的混合混合物。入射中子的纵向位置由到达每个光电检测器的闪烁光部分的大小确定，其与中子相互作用点和光电检测器之间的距离成比例。电池被布置在紧密间隔的平行平面阵列中以便于确定二维中的入射中子位置。检测器系统利用第一检测器阵列来检测快中子，将快速入射的中子转换成热中子的热化器（例如，聚乙烯），以及用于检测热中子的第二检测器阵列。

3. 发明申请

US20160030010A1 IMPLANTABLE ESTRUS DETECTION DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译：可植入式检测装置，系统和方法
公开(公告)号：US20160030010A1
公开(公告)日：2016-02-04
申请号：US14448074
申请日：2014-07-31
申请人： PALO ALTO RESEARCH CENTER INCORPORATED
发明人： David Mathew Johnson , Scott A. Uhland , Ramkumar Abhishek , Robert Thomas Krivacic , Martin Sheridan
IPC分类号： A61B10/00 , A61D19/04 , A61B5/1459 , A61B5/1455 , A61M31/00 , A61B5/11 , A61B5/03 , A61B5/07 , A61B5/00 , A61D19/02 , A61B5/0205
CPC分类号： A61B10/0012 , A61B5/02055 , A61B5/02416 , A61B5/035 , A61B5/076 , A61B5/1032 , A61B5/1118 , A61B5/14551 , A61B5/14552 , A61B5/1459 , A61B5/4839 , A61B2010/0016 , A61B2010/0019 , A61B2503/40 , A61D17/002 , A61D19/027 , A61D19/04
摘要： Devices, systems, and methods for detecting estrus in subjects are provided. Devices include a housing configured for intravaginal/intrauterine deployment and retention and a sensor disposed in or on the housing, and are configured to use condition information sensed by the sensor to determine an estrus condition of the subject. Methods include deploying a device in the subject, sensing the condition information, and determining an estrus condition using the condition information. Systems include a device configured to communicate with a base station and/or with other implanted devices, which are located within a reception radius thereof, regarding the determined estrus condition.
摘要翻译：提供了用于检测受试者发情的装置，系统和方法。设备包括被配置用于阴道内/子宫内展开和保持的壳体和设置在壳体中或壳体上的传感器，并且被配置为使用由传感器感测的状态信息来确定受试者的发情状况。方法包括在受检者中部署装置，感测状况信息，以及使用条件信息确定发情状况。系统包括被配置为关于所确定的发情状况与位于其接收半径内的基站和/或与其他植入设备通信的设备。

4. 发明申请

US20150177119A1 FLOW CYTOMETER 有权
标题翻译：流量计
公开(公告)号：US20150177119A1
公开(公告)日：2015-06-25
申请号：US14139246
申请日：2013-12-23
申请人： Palo Alto Research Center Incorporated
发明人： Joerg Martini , Noble M. Johnson , Michael I. Recht , David M. Johnson , Tim Curley , Peter Kiesel , Martin Sheridan
IPC分类号： G01N15/14 , G01N21/62
CPC分类号： G01N15/1459 , G01N15/1436 , G01N2015/1447
摘要： Embodiments are directed to a host structure that includes a waveguide configured to deliver measurement light to a compartment at least partially within the host structure. The compartment is configured to reversibly engage a fluidic optical cartridge. The host structure also includes a detector configured to receive and process output light emanating from the fluidic optical cartridge as well as electronics to process signals from the detector.
摘要翻译：实施例涉及一种主机结构，其包括被配置为将测量光至少部分地在主机结构内传送到隔间的波导。隔室被配置成可逆地接合流体光学盒。主机结构还包括检测器，其被配置为接收和处理从流体光学存储器发出的输出光以及处理来自检测器的信号的电子装置。

5. 发明申请

US20140200553A1 DEVICES AND METHODS FOR INTRALUMINAL RETENTION AND DRUG DELIVERY 有权
标题翻译：用于内皮保留和药物递送的装置和方法
公开(公告)号：US20140200553A1
公开(公告)日：2014-07-17
申请号：US13742203
申请日：2013-01-15
申请人： PALO ALTO RESEARCH CENTER INCORPORATED
发明人： David Mathew Johnson , Martin Sheridan , Scott A. Uhland , Ramkumar Abhishek , Eric Peeters , Timothy J. Curley , Felicia Linn , Philipp H. Schmaelzle
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61D7/00 , A61M5/1452 , A61M2210/1433 , A61M2210/1475
摘要： Retention devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and at least one reservoir contained within the housing. The at least one reservoir may have an actuation end and a release end and contain at least one drug formulation. A plug may be contained within the at least one reservoir and be moveable from the actuation end toward the release end. The device may also include an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir. The device may also include at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject.
摘要翻译：提供了用于药物递送的保留装置和方法。该装置可以包括被配置用于腔内部署到人或动物受试者中的壳体和容纳在壳体内的至少一个储存器。至少一个储存器可以具有致动端和释放端，并且包含至少一种药物制剂。塞子可以容纳在至少一个储存器内并且可以从致动端朝向释放端移动。该装置还可以包括可操作地连接到至少一个储存器的致动端并被构造成从贮存器驱动至少一种药物制剂的致动系统。该装置还可以包括固定到壳体上的至少一个保持构件，并可在非应力位置，展开位置和保持位置之间移动，用于将装置保持在受试者的腔内位置。

6. 发明授权

US11547447B2 Implantable fluid delivery devices, systems, and methods 有权
公开(公告)号：US11547447B2
公开(公告)日：2023-01-10
申请号：US17181539
申请日：2021-02-22
申请人： Palo Alto Research Center Incorporated
发明人： David Mathew Johnson , Scott A. Uhland , Robert Thomas Krivacic , Ramkumar Abhishek , Martin Sheridan
IPC分类号： A61B17/43 , A61M31/00 , A61D7/00 , A61B17/435
摘要： Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.

7. 发明申请

US20210169525A1 IMPLANTABLE FLUID DELIVERY DEVICES, SYSTEMS, AND METHODS 有权
公开(公告)号：US20210169525A1
公开(公告)日：2021-06-10
申请号：US17181539
申请日：2021-02-22
申请人： Palo Alto Research Center Incorporated
发明人： David Mathew Johnson , Scott A. Uhland , Ramukumar Abhishek , Robert Thomas Krivacic , Martin Sheridan
IPC分类号： A61B17/43 , A61M31/00 , A61D7/00
摘要： Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.

8. 发明授权

US10925644B2 Implantable fluid delivery devices, systems, and methods 有权
公开(公告)号：US10925644B2
公开(公告)日：2021-02-23
申请号：US15727766
申请日：2017-10-09
申请人： PALO ALTO RESEARCH CENTER INCORPORATED
发明人： David Mathew Johnson , Scott A. Uhland , Ramkumar Abhishek , Robert Thomas Krivacic , Martin Sheridan
IPC分类号： A61B17/43 , A61M31/00 , A61D7/00 , A61B17/435
摘要： Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.

9. 发明申请

US20150177118A1 FLUIDIC OPTICAL CARTRIDGE 审中-公开
标题翻译：流体光学盒
公开(公告)号：US20150177118A1
公开(公告)日：2015-06-25
申请号：US14139317
申请日：2013-12-23
申请人： Palo Alto Research Center Incorporated
发明人： David M. Johnson , Noble M. Johnson , Michael I. Recht , Joerg Martini , Tim Curley , Peter Kiesel , Martin Sheridan
IPC分类号： G01N15/14 , G01N21/59 , G01N21/47 , G01N21/64
CPC分类号： G01N15/1459 , G01N15/1436 , G01N2015/145
摘要： Embodiments are directed to an apparatus that includes a fluidic structure and optical components. The fluidic structure includes a transparent channel through which objects in an analyte fluid can travel along respective paths during operation of the apparatus. The optical components are configured to provide measurement light to the objects traveling through the transparent channel. The fluidic structure is configured to reversibly engage with a host structure. The host structure includes a source of the measurement light and electronics to receive and process output light emanating from the objects traveling in the channel. The fluidic structure makes an air-tight seal when engaged with the host structure.
摘要翻译：实施例涉及一种包括流体结构和光学部件的装置。流体结构包括透明通道，通过该透明通道，分析物流体中的物体可以在装置的操作期间沿相应的路径行进。光学部件被配置为向穿过透明通道的物体提供测量光。流体结构被配置为与主机结构可逆地接合。主机结构包括测量光和电子设备的源，用于接收和处理从在通道中行进的物体发出的输出光。当与主机结构接合时，流体结构形成气密密封。

10. 发明授权

US10324020B2 Fluidic optical cartridge 有权
公开(公告)号：US10324020B2
公开(公告)日：2019-06-18
申请号：US14139317
申请日：2013-12-23
申请人： Palo Alto Research Center Incorporated
发明人： David M. Johnson , Noble M. Johnson , Michael I. Recht , Joerg Martini , Tim Curley , Peter Kiesel , Martin Sheridan
IPC分类号： G01N15/14 , B01L3/00
摘要： Embodiments are directed to an apparatus that includes a fluidic structure and optical components. The fluidic structure includes a transparent channel through which objects in an analyte fluid can travel along respective paths during operation of the apparatus. The optical components are configured to provide measurement light to the objects traveling through the transparent channel. The fluidic structure is configured to reversibly engage with a host structure. The host structure includes a source of the measurement light and electronics to receive and process output light emanating from the objects traveling in the channel. The fluidic structure makes an air-tight seal when engaged with the host structure.

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