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1. 发明专利

JP2005181312A Coordinate conversion method from scanner image coordinates of rare cell into microscope coordinates using reticle mark on sample medium 审中-公开
标题翻译：使用样品标记在样品介质上的稀有细胞扫描仪图像坐标转换为微观坐标的坐标转换方法
公开(公告)号：JP2005181312A
公开(公告)日：2005-07-07
申请号：JP2004358696
申请日：2004-12-10
申请人： Palo Alto Research Center Inc , Scripps Res Inst:The , ザスクリップスリサーチインスティテュート , パロアルトリサーチセンターインコーポレイテッド
发明人： CURRY DOUGLAS N , BRUCE RICHARD H , KRIVACIC ROBERT T , HSIEH HUANGPIN B , LERNER RICHARD A
IPC分类号： G01B11/00 , G01N15/00 , G01N15/14 , G01N21/27 , G01N21/64 , G06T1/00 , G06T7/00
CPC分类号： G01N15/1475 , G01N15/1468 , G01N2015/0065 , G06K9/00134 , G06K9/32 , G06T7/73 , G06T2207/30024
摘要： PROBLEM TO BE SOLVED: To provide a method of acquiring an objective position, with respect to image formation technology. SOLUTION: A first coordinates space of an image forming system is determined, and the coordinates in the first coordinates space are specified. A second coordinates space of a second image forming system is determined, and the coordinates in the second coordinates space are specified. Coordinate conversion parameter, are calculated by using the coordinates specified by the first coordinates space. Then, the coordinates of at least one object are specified in the first coordinates space, and the coordinates of the first coordinates space of this object are conversed into the specific coordinates in the second coordinates space. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供关于图像形成技术的获取目标位置的方法。解决方案：确定图像形成系统的第一坐标空间，并且指定第一坐标空间中的坐标。确定第二图像形成系统的第二坐标空间，并且指定第二坐标空间中的坐标。坐标转换参数，通过使用由第一个坐标空间指定的坐标进行计算。然后，在第一坐标空间中指定至少一个对象的坐标，并且将该对象的第一坐标空间的坐标转换为第二坐标空间中的特定坐标。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2007192819A Novel immunocytostaining method for enhanced dye ratio discrimination in rare event sensing 有权
标题翻译：用于在罕见事件感测中增强染色体比例的新型免疫测定方法
公开(公告)号：JP2007192819A
公开(公告)日：2007-08-02
申请号：JP2007002559
申请日：2007-01-10
申请人： Palo Alto Research Center Inc , パロアルトリサーチセンターインコーポレイテッド
发明人： HSIEH H BEN , LAZARUS NICOLE HANSON , KRIVACIC ROBERT T , CURRY DOUGLAS N , BRUCE RICHARD H
IPC分类号： G01N33/53 , G01N21/64 , G01N21/78
CPC分类号： G01N1/30 , G01N15/1468 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N33/56966 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： PROBLEM TO BE SOLVED: To carry out low- and high-density cell sensing and discrimination in a blood smear assay and the like.
SOLUTION: A method of preparing a sample containing cells comprises steps of: placing a first material containing the cells on a slide; adding a first type of antibody; adding a second type of antibody; associating a first marker with one of the first type of antibody and the second type of antibody; and associating a second marker with one of the first type of antibody and the second type of antibody, wherein the prepared sample is configured to emit signals having a spectral resolution sufficient to permit filtering to differentiate and eliminate most false positives from true positive imaging event, and furthermore a confirmation is carried out by a higher resolution sensing method to determine whether they are truly the cells of interest.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：在血液涂片测定等中进行低密度和高密度细胞感测和鉴别。解决方案：制备含有细胞的样品的方法包括以下步骤：将含有细胞的第一材料放置在载玻片上; 加入第一类抗体; 添加第二类抗体; 将第一标记与第一类型的抗体和第二类型抗体之一缔合; 以及将第二标记物与所述第一类型抗体和所述第二类型抗体中的一种缔合，其中所述制备的样品被配置为发射具有足以允许过滤的光谱分辨率的信号以区分并消除来自真阳性成像事件的大多数假阳性，此外，通过更高分辨率的感测方法进行确认，以确定它们是否真正是感兴趣的细胞。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2008151784A System and method for removing auto-fluorescence through use of multiple detection channels 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：JP2008151784A
公开(公告)日：2008-07-03
申请号：JP2007319724
申请日：2007-12-11
申请人： Palo Alto Research Center Inc , パロアルトリサーチセンターインコーポレイテッド
发明人： KRIVACIC ROBERT T , HSIEH H BEN , CURRY DOUGLAS N , BRUCE RICHARD H
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： PROBLEM TO BE SOLVED: To exclude such false substances as to occur due to auto-fluorescent events only through the use of a single laser and a single dye.
SOLUTION: A single probe is adhered to a sample. The sample is excited by a light source of a single wavelength. By emitting a light a distance from the light source, auto-fluorescence can be separated from signals in a system and a method. The light is split, and the split beams of light are collected in two separate channels or more. A first channel among the separate channels is positioned closer to the light source than the second channel is, and the second channel is closer to a discharge frequency of the single probe than the first channel is. The light collected in the first channel and the light collected in the second channel are examined to generate output signals on the basis of the examination.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：仅通过使用单个激光和单个染料来排除由于自发荧光事件而发生的这种假物质。
解决方案：将单个探针粘附到样品上。样品被单个波长的光源激发。通过从光源发射一段距离的光，自动荧光可以与系统和方法中的信号分离。光被分裂，分束光束被收集在两个独立的通道或更多的通道中。分离通道中的第一通道位于比第二通道更靠近光源，并且第二通道比第一通道更靠近单个探针的放电频率。在第一通道中收集的光和在第二通道中收集的光被检查以基于检查产生输出信号。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2006177955A Improved scanning and condensing method for rare-cell detector 审中-公开
标题翻译：改进的稀释检测器的扫描和浓缩方法
公开(公告)号：JP2006177955A
公开(公告)日：2006-07-06
申请号：JP2005364417
申请日：2005-12-19
申请人： Palo Alto Research Center Inc , パロ・アルト・リサーチ・センター・インコーポレーテッドPalo Alto Research Center Incorporated
发明人： CURRY DOUGLAS N , BRUCE RICHARD H , KRIVACIC ROBERT T
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N21/6428 , G01N2021/6484 , G01N2201/1085
摘要： PROBLEM TO BE SOLVED: To more accurately detect cells, while suppressing the occurrence number of false images or ghosts by enhancing the throughput, reliability (accuracy) and the scanning speed.
SOLUTION: The sweep irradiation with a radiation beam 64' is applied to a specimen 12', which is supported on the stage 20' of an imager 10', from an orthogonal direction by a scanning-type radiation source 110 so that preferably almost circular irradiation spot due to the radiation beam 64' traverses the specimen 12'. Optical paths, for example, the incident side openings 124 and 126 of branch optical fiber bundles 120 and 122 orthogonally face and are arranged with respect to the specimen 12' so as to approach the locus of the irradiation spot. The light signal, emitted by the specimen 12' corresponding to irradiation with the radiation beam 64', is transmitted to the emission side opening 52' by the optical paths to be sensed in the emission side opening 52' by a photosensor 90' and is processed by a processor 80' to form an image the specimen 12'.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：通过提高吞吐量，可靠性（精度）和扫描速度，同时抑制伪像或重影的发生次数，从而更准确地检测单元。解决方案：通过扫描型辐射源110将正向辐射束64'的扫描照射施加到由扫描型辐射源110从正交方向支撑在成像器10'的平台20'上的样本12'，使得优选地，由于辐射束64'穿过样本12'，几乎圆形的照射斑点。光路例如分支光纤束120和122的入射侧开口124和126正交地相对于样本12'布置，以便接近照射点的轨迹。由与辐射束64'照射相对应的样本12'发射的光信号通过光传感器90'在发射侧开口52'中被感测的光路传输到发射侧开口52'，并且是由处理器80'处理以形成样本12'的图像。版权所有（C）2006，JPO＆NCIPI

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