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1. 发明授权

US07470810B2 Alkyl and aryl-thiotrifluoroacetates and process 有权
标题翻译：烷基和芳基 - 三油酰氯酸盐和方法
公开(公告)号：US07470810B2
公开(公告)日：2008-12-30
申请号：US11032734
申请日：2005-01-11
申请人： Padam N. Sharma , Edward J. Gublo , Susan D. Boettger , Saibaba Racha , John Usher
发明人： Padam N. Sharma , Edward J. Gublo , Susan D. Boettger , Saibaba Racha , John Usher
IPC分类号： C07C321/04
CPC分类号： C07C327/22 , C07C231/02 , C07C2603/74 , Y02P20/55 , C07C233/48
摘要： Novel C3-C19 alkyl- and aryl-thiotrifluoroacetates are provided which have the structure wherein Q is C9-C19 alkyl or aryl, and are useful protecting agents for the amino or hydroxy functional groups of amines, amino acids or primary or secondary alcohols or amino alcohols to enable formation of amide bonds in peptides or proteins which are useful as screening agents, pharmaceuticals and cosmetics. A process for preparing C3-C19 alkyl- and aryl-thiotrifluoroacetates is also provided wherein a C3-C19 alkylthiol or arylthiol is treated with trifluoroacetic anhydride (TFAA) in the presence of organic base such as pyridine, a solvent such as dichloromethane (DCM) and dimethylaminopyridine (DMAP) as a catalyst to form the desired C3-C19 alkyl- or aryl-thiotrifluoroacetate.In addition, a process for protecting a primary or secondary amino group or a primary or secondary hydroxyl group or an amino alcohol with a trifluoroacetyl protecting group is provided wherein a primary or secondary amine, amino acid, a primary or secondary alcohol or an amino alcohol is treated with a C3 to C19 alkyl- or aryl-thiotrifluoroacetate in basic aqueous solution.
摘要翻译：提供新的C3-C19烷基 - 和芳基 - 三油酸乙酯，其具有其中Q是C9-C19烷基或芳基的结构，并且是胺，氨基酸或伯或仲醇或氨基的氨基或羟基官能团的有用的保护剂醇，以在肽或蛋白质中形成酰胺键，其可用作筛选剂，药物和化妆品。还提供了制备C 3 -C 19烷基 - 和芳基 - 三硫代三氟乙酸盐的方法，其中在有机碱如吡啶，溶剂如二氯甲烷（DCM））存在下，用三氟乙酸酐（TFAA）处理C 3 -C 19烷基硫醇或芳基硫醇，和二甲基氨基吡啶（DMAP）作为催化剂形成所需的C 3 -C 19烷基 - 或芳基 - 三硫代三氟乙酸盐。另外，提供了用三氟乙酰基保护基保护伯或仲氨基或伯或仲羟基或氨基醇的方法，其中伯胺或仲胺，氨基酸，伯或仲醇或氨基醇在碱性水溶液中用C3至C19烷基 - 或芳基 - 三硫代三氟乙酸盐处理。

2. 发明申请

US20050159612A1 Novel alkyl- and aryl-thiotrifluoroacetates and process 有权
标题翻译：新型烷基 - 和芳基 - 三硫代三氟乙酸盐和方法
公开(公告)号：US20050159612A1
公开(公告)日：2005-07-21
申请号：US11032734
申请日：2005-01-11
申请人： Padam Sharma , Edward Gublo , Susan Boettger , Saibaba Racha , John Usher
发明人： Padam Sharma , Edward Gublo , Susan Boettger , Saibaba Racha , John Usher
IPC分类号： C07C231/02 , C07C233/48 , C07C323/22 , C07C327/22 , C07C333/02 , C07C233/58
CPC分类号： C07C327/22 , C07C231/02 , C07C2603/74 , Y02P20/55 , C07C233/48
摘要： Novel C3-C19 alkyl- and aryl-thiotrifluoroacetates are provided which have the structure wherein Q is C9-C19 alkyl or aryl, and are useful protecting agents for the amino or hydroxy functional groups of amines, amino acids or primary or secondary alcohols or amino alcohols to enable formation of amide bonds in peptides or proteins which are useful as screening agents, pharmaceuticals and cosmetics. A process for preparing C3-C19 alkyl- and aryl-thiotrifluoroacetates is also provided wherein a C3-C19 alkylthiol or arylthiol is treated with trifluoroacetic anhydride (TFAA) in the presence of organic base such as pyridine, a solvent such as dichloromethane (DCM) and dimethylaminopyridine (DMAP) as a catalyst to form the desired C3-C19 alkyl- or aryl-thiotrifluoroacetate. In addition, a process for protecting a primary or secondary amino group or a primary or secondary hydroxyl group or an amino alcohol with a trifluoroacetyl protecting group is provided wherein a primary or secondary amine, amino acid, a primary or secondary alcohol or an amino alcohol is treated with a C3 to C19 alkyl- or aryl-thiotrifluoroacetate in basic aqueous solution.
摘要翻译：提供新的C 3 -C 20烷基 - 和芳基 - 三油酸乙酯，其具有其中Q为C 9 -C 19的结构并且是用于胺，氨基酸或伯或仲醇或氨基醇的氨基或羟基官能团的有用的保护剂，以使肽或蛋白质中的酰胺键能够形成，其可用作筛选剂，药品和化妆品。还提供了制备C 3 -C 20 - 烷基 - 和芳基 - 三硫代三氟乙酸盐的方法，其中C 3 -C 19 - 在有机碱如吡啶，溶剂如二氯甲烷（DCM）和二甲基氨基吡啶（DMAP）等催化剂存在下，用三氟乙酸酐（TFAA）处理烷基硫醇或芳基硫醇，形成所需的C 3 烷基 - 或芳基 - 三硫代三氟乙酸盐。另外，提供了用三氟乙酰基保护基保护伯或仲氨基或伯或仲羟基或氨基醇的方法，其中伯胺或仲胺，氨基酸，伯或仲醇或氨基醇在碱性水溶液中用C 3〜C 19烷基 - 或芳基 - 三硫代三氟乙酸酯处理。

3. 发明授权

US09234426B2 Mine operation monitoring system 有权
标题翻译：矿井作业监测系统
公开(公告)号：US09234426B2
公开(公告)日：2016-01-12
申请号：US13500778
申请日：2010-10-08
申请人： Mark Morrison , John Usher , Chris Green
发明人： Mark Morrison , John Usher , Chris Green
IPC分类号： G09G5/00 , E21F17/00 , G05B19/418
CPC分类号： E21F17/00 , G05B19/41885 , G05B2219/31466 , Y02P90/26
摘要： A method of monitoring a mine operation is disclosed. The method comprises collecting map data associated with a mine operation, the map data being indicative of at least one map representation associated with the mine operation, collecting mine equipment location data indicative of the location of at least one item of mine equipment relative to the mine operation, and facilitating selection and display of a map representation associated with a mine operation. When a map representation associated with a mine operation is displayed, a representation of at least one item of mine equipment on the map representation at a representative location relative to the mine operation.
摘要翻译：公开了一种监视矿井作业的方法。该方法包括收集与矿井操作相关联的地图数据，地图数据表示与矿井操作相关联的至少一个地图表示，收集指示矿井设备相对于矿山至少一个矿物位置的矿井设备位置数据操作，并且便于选择和显示与矿井操作相关联的地图表示。当显示与矿场作业相关联的地图表示时，在相对于矿井操作的代表位置处的地图表示上的至少一个矿物设备项目的表示。

4. 发明申请

US20150131814A1 METHOD AND SYSTEM FOR CONTACT SENSING USING COHERENCE ANALYSIS 有权
标题翻译：使用相关分析的接触感知方法和系统
公开(公告)号：US20150131814A1
公开(公告)日：2015-05-14
申请号：US14079506
申请日：2013-11-13
申请人： John Usher , Steve Goldstein , Jason McIntosh
发明人： John Usher , Steve Goldstein , Jason McIntosh
IPC分类号： H04R29/00 , H04R1/08
CPC分类号： H04R1/1041 , G06F3/017 , G06F3/02 , H03K17/94 , H03K2217/94005 , H04R1/2853 , H04R3/005 , H04R25/43 , H04R2430/01 , H04R2430/03 , H04R2499/11
摘要： Herein provided is a method for acoustical switching suitable for use with a microphone enabled electronic device. The method includes capturing a first microphone signal from a first microphone on a device, analyzing the first microphone signal for a contact event versus a non-contact event, and directing the electronic device to switch a processing state responsive to detection of either the contact event or non-contact event. In another configuration, additional microphone can be added for performing coherence analysis between at least two microphone signals mounted on or in the device. At least one parameter settings of the device can be changed in response to at least one detected physical contact on the device. Other embodiments are disclosed.
摘要翻译：这里提供了适用于与麦克风启用的电子设备一起使用的声学切换的方法。该方法包括从设备上的第一麦克风捕获第一麦克风信号，分析第一麦克风信号以获得接触事件与非接触事件，以及响应于接触事件的检测而引导电子设备切换处理状态或非接触事件。在另一种配置中，可以添加额外的麦克风，用于在安装在设备上或设备中的至少两个麦克风信号之间进行相干性分析。响应于设备上的至少一个检测到的物理接触，可以改变设备的至少一个参数设置。公开了其他实施例。

5. 发明授权

US08917880B2 Earhealth monitoring system and method I 有权
标题翻译：耳风监测系统及方法I
公开(公告)号：US08917880B2
公开(公告)日：2014-12-23
申请号：US13425743
申请日：2012-03-21
申请人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
发明人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
IPC分类号： G01C3/08 , H04R29/00 , A61F11/06 , A61B5/00 , A61B5/12 , G01H3/14
CPC分类号： A61B5/6817 , A61B5/121 , G01H3/14
摘要： Methods of operating an audio device are provided. A method includes calculating estimated sound pressure levels (SPLs) for drive signals directed to an ear canal receiver (ECR) during a time increment Δt; calculating an estimated SPL_Dose during the time increment Δt using the estimated sound pressure levels; and calculating a total SPL_Dose at a time t of the audio device using the estimated SPL_Dose.
摘要翻译：提供操作音频设备的方法。一种方法包括在时间增量＆Dgr; t期间计算针对耳道接收器（ECR）的驱动信号的估计声压级（SPL）; 使用估计的声压级在时间增量＆Dgr; t期间计算估计的SPL_Dose; 以及使用估计的SPL_Dose在音频设备的时间t计算总SPL_Dose。

6. 发明授权

US08855343B2 Method and device to maintain audio content level reproduction 有权
标题翻译：保持音频内容等级再现的方法和设备
公开(公告)号：US08855343B2
公开(公告)日：2014-10-07
申请号：US12323505
申请日：2008-11-26
申请人： John Usher , Steven Goldstein
发明人： John Usher , Steven Goldstein
IPC分类号： H04R25/00 , H03G9/18 , H03G3/32 , H03G9/00
CPC分类号： H03G3/32 , H03G9/005 , H03G9/18
摘要： An earpiece and method to control a level of audio reproduction within an occluded ear canal are provided. The method includes the steps of measuring an ambient sound level from an Ambient Sound Microphone (ASM) at an entrance to an occluded ear canal, measuring a residual background noise level within an occluded ear canal from an Ear Canal Microphone (ECM), measuring a level of audio content delivered to the occluded ear canal, and adjusting a gain of the audio content so as to maintain reproduction of the audio content within a predetermined level range.
摘要翻译：提供了一种用于控制闭塞耳道内的音频再现水平的听筒和方法。该方法包括以下步骤：在耳塞入口处测量来自环境声音麦克风（ASM）的环境声级，测量来自耳道麦克风（ECM）的闭塞耳道内的残留背景噪声水平，测量传送到闭塞的耳道的音频内容的级别，以及调整音频内容的增益，以便将音频内容的再现保持在预定的电平范围内。

7. 发明申请

US20140081644A1 Method and Device for Voice Operated Control 审中-公开
标题翻译：语音控制方法和设备
公开(公告)号：US20140081644A1
公开(公告)日：2014-03-20
申请号：US14087056
申请日：2013-11-22
申请人： John Usher , Steve Goldstein , Marc Boillot
发明人： John Usher , Steve Goldstein , Marc Boillot
IPC分类号： H04R1/10 , G10L19/00 , H04R3/00
CPC分类号： H04R1/08 , G10L15/20 , G10L19/00 , G10L25/78 , H04R1/1041 , H04R3/005 , H04R25/50
摘要： At least one exemplary embodiment is directed to a method and device for voice operated control. The method can include measuring a first sound received from a first microphone, measuring a second sound received from a second microphone, detecting a spoken voice based on an analysis of measurements taken at the first and second microphone, mixing the first sound and the second sound to produce a mixed signal, and controlling the production of the mixed signal based on one or more aspects of the spoken voice.
摘要翻译：至少一个示例性实施例涉及用于语音操作控制的方法和装置。该方法可以包括测量从第一麦克风接收的第一声音，测量从第二麦克风接收的第二声音，基于在第一麦克风和第二麦克风进行的测量分析来检测口语声音，混合第一声音和第二声音以产生混合信号，并且基于口语的一个或多个方面控制混合信号的产生。

8. 发明授权

US08611560B2 Method and device for voice operated control 有权
标题翻译：语音操作控制方法和装置
公开(公告)号：US08611560B2
公开(公告)日：2013-12-17
申请号：US12102555
申请日：2008-04-14
申请人： Steven Wayne Goldstein , John Usher , Marc Andre Boillot
发明人： Steven Wayne Goldstein , John Usher , Marc Andre Boillot
IPC分类号： H04R3/00
CPC分类号： H04R1/08 , G10L15/20 , G10L19/00 , G10L25/78 , H04R1/1041 , H04R3/005 , H04R25/50
摘要： Methods and devices for voice operated control are provided. The method can include measuring an ambient sound received from at least one Ambient Sound Microphone, measuring an internal sound received from at least one Ear Canal Microphone, detecting a spoken voice from a wearer of the earpiece based on an analysis of the ambient sound and the internal sound, and controlling at least one voice operation of the earpiece if the presence of spoken voice is detected. The analysis can be a sound pressure level (SPL) difference, a correlation, a coherence, or a spectral difference.
摘要翻译：提供语音操作控制的方法和设备。该方法可以包括测量从至少一个环境声音麦克风接收的环境声音，测量从至少一个耳道麦克风接收的内部声音，基于对环境声音的分析来检测来自耳机佩戴者的口语声音，以及内部声音，并且如果检测到语音的存在，则控制耳机的至少一个语音操作。分析可以是声压级（SPL）差异，相关性，相干性或光谱差异。

9. 发明授权

US08208644B2 Earhealth monitoring system and method III 有权
标题翻译：耳风监测系统及方法三
公开(公告)号：US08208644B2
公开(公告)日：2012-06-26
申请号：US11930938
申请日：2007-10-31
申请人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
发明人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
IPC分类号： H04R29/00 , H04R25/02 , G06F17/00
CPC分类号： G01H3/14
摘要： A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal receiver (ECR) for producing audio signals as a function of ambient sound received at the ambient sound microphone and a sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECR and calculates a total SPL_Dose experienced by the ear for periods Δt. The logic circuit may select an action parameter in response to the Total SPL_Dose.
摘要翻译：用于监测耳朵声压级的系统包括用于接收环境声音的环境声麦克风（ASM）和用于产生作为环境声麦克风接收的环境声音的函数的音频信号的耳道接收器（ECR），以及声音信号从相关联的个人音频设备接收。逻辑电路与ASM和ECR可操作地相关联，并计算耳朵对于周期＆Dgr; t所经历的总SPL_Dose。逻辑电路可以响应于总SPL_Dose来选择动作参数。

10. 发明授权

US08194865B2 Method and device for sound detection and audio control 有权
标题翻译：用于声音检测和音频控制的方法和装置
公开(公告)号：US08194865B2
公开(公告)日：2012-06-05
申请号：US12035873
申请日：2008-02-22
申请人： Steven W. Goldstein , John Usher , Dmitry N. Zotkin
发明人： Steven W. Goldstein , John Usher , Dmitry N. Zotkin
IPC分类号： H04R29/00
CPC分类号： H04R1/1091 , H04R1/1083 , H04R3/00 , H04R3/007 , H04R2430/01 , H04R2430/03 , H04R2460/07 , H04R2460/15
摘要： Methods and devices for sound detection and audio control are provided. A listening device (100) can include a receiver (102) and a sound director for directing a sound produced by the receiver into an ear of the user, a microphone (104) and a mount for mounting the microphone so as to receive the sound in an environment, a detector for detecting an auditory signal in the sound received by the microphone, and an alerting device for alerting the user to the presence of the auditory signal. The user's personal safety is enhanced due to the user being alerted to the presence of the auditory signal, which otherwise may be unnoticed by the user due to a loud sound level created at the ear of the user by the receiver.
摘要翻译：提供了声音检测和音频控制的方法和设备。聆听装置（100）可以包括用于将由接收器产生的声音引导到用户的耳朵中的接收器（102）和声音引导器，用于安装麦克风以便接收声音的麦克风（104）和安装座在环境中，用于检测由麦克风接收的声音中的听觉信号的检测器，以及用于向用户通知听觉信号的存在的警报装置。由于用户被警告听觉信号的存在而增强了用户的个人安全性，否则由于接收机在用户耳朵处产生的大声声级，用户可能不会注意到该信号。

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