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1. 发明申请

WO2005051459A3 BRACHYTHERAPY METHOD AND APPLICATOR FOR TREATMENT OF METASTATIC LESIONS IN A LOAD BEARING REGION 审中-公开
标题翻译：用于处理负荷轴承区域中的分层淋巴结的穿孔方法和应用
公开(公告)号：WO2005051459A3
公开(公告)日：2005-10-27
申请号：PCT/US2004039338
申请日：2004-11-22
申请人： PROXIMA THERAPEUTICS INC , PATRICK TIMOTHY J , STUBBS JAMES B
发明人： PATRICK TIMOTHY J , STUBBS JAMES B
IPC分类号： A61M36/12 , A61N5/10
CPC分类号： A61N5/1027 , A61N5/1014 , A61N2005/1011
摘要： A brachytherapy applicator for treatment of metastic lesions in a load bearing region is provided. The applicator comprises an elongate tube body having a proximal and a distal end and defining an open internal area. A fixation element located on an outer portion of the tube allows the applicator to be fixed in position in relation to a target region while delivering a dose of therapeutic radiation. The fixation element can fix the applicator to tissue and/or a stabilization element implanted within a patient. A source of radiation positioned within the elongate body, before, during, or after implantation of the applicator, provides the therapeutic radiation.
摘要翻译：本发明提供一种用于治疗负重区域中的甲状腺病变的近距离放射治疗仪。涂抹器包括具有近端和远端并限定开放内部区域的细长管体。位于管的外部的固定元件允许施用器相对于目标区域固定就位，同时递送一定剂量的治疗辐射。固定元件可以将施用器固定到植入在患者体内的组织和/或稳定元件。定位在细长体内，在施用器植入之前，之中或之后的辐射源提供治疗辐射。

2. 发明申请

WO2005046791A2 TISSUE POSITIONING SYSTEMS AND METHODS FOR USE WITH RADIATION THERAPY 审中-公开
标题翻译：组织定位系统和使用辐射治疗的方法
公开(公告)号：WO2005046791A2
公开(公告)日：2005-05-26
申请号：PCT/US2004037202
申请日：2004-11-05
申请人： PROXIMA THERAPEUTICS INC , PATRICK TIMOTHY J , STUBBS JAMES B
发明人： PATRICK TIMOTHY J , STUBBS JAMES B
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1015 , A61N5/1049
摘要： A system for treating tissue surrounding a resected cavity that is subject to a proliferative tissue disorder is provided. The system includes a tissue fixation device including a catheter body member having a proximal end, a distal end, an inner lumen, and an expandable surface element disposed proximate to the distal end of the body member, the expandable surface element sized and configured to reproducibly position tissue surrounding a resected tissue cavity in a predetermined geometry upon expansion. After expansion of the expandable surface element within a resected tissue cavity, an external radiation device positioned outside the resected cavity delivers a dose of radiation to the tissue surrounding the expandable surface element.
摘要翻译：提供了一种用于治疗受到增殖性组织病症的切除腔周围的组织的系统。所述系统包括组织固定装置，所述组织固定装置包括具有近端，远端，内腔和靠近所述主体构件的远端设置的可扩张表面元件的导管本体构件，所述可扩张表面元件的尺寸和构造可再现在扩张时以预定几何形状围绕切除的组织腔的位置组织。在可切除的组织腔内的可膨胀表面元件膨胀之后，位于被切除的腔外部的外部辐射装置向可扩张表面元件周围的组织递送剂量的辐射。

3. 发明专利

JP2006026443A Double wall balloon catheter for treating proliferative tissue 有权
标题翻译：用于治疗增生组织的双壁气囊导管
公开(公告)号：JP2006026443A
公开(公告)日：2006-02-02
申请号：JP2005297129
申请日：2005-10-12
申请人： Proxima Therapeutics Inc , プロクシマセラピューティックス、インコーポレイテッド
发明人： WILLIAMS JEFFERY A , PORTER CHRISTOPHER H , WILLIAMSON JEFFREY F , DEMPSEY JAMES F , PATRICK TIMOTHY J , STUBBS JAMES B
IPC分类号： A61M25/00 , A61N5/10 , A61M36/04
CPC分类号： A61N5/1015 , A61N2005/1021
摘要： PROBLEM TO BE SOLVED: To provide an instrument which can be used for delivering a radiation ray to a target tissue in the human body from a radiation source at a desired intensity and at a given distance from the radiation source without irradiating the body's tissues between the radiation source and a target too much. SOLUTION: The instrument 10 to use for Brachy-therapy has the concentric arrangement of inner and outer distensible spherical chambers 30, 34 arranged near the proximal end of a catheter body 12. A radiation absorption substance is put in one of the chambers 30, 34. A radiation absorption material is put in the other of the chambers 30, 34. The apparatus 10 serves to bring a more uniform absorption dose profile to a tissue which surrounds a cavity made by the removal of a tumor. An alternative embodiment form includes an inner chamber and an outer chamber in a nonspherical form where each walls are spaced equidistant over the entire surface. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种可以用于从放射源以期望的强度和给定距离从辐射源将放射线递送到人体中的靶组织的器械，而不照射身体的辐射源和目标之间的组织太多了。解决方案：用于近距离治疗的器械10具有布置在导管主体12的近端附近的内部和外部可扩张球形腔30,34的同心布置。放射线吸收物质放置在其中一个腔室放射线吸收材料放置在腔室30,34中的另一个中。装置10用于对包围通过去除肿瘤制成的空腔的组织产生更均匀的吸收剂量分布。替代实施例形式包括内室和非球形形式的外室，其中每个壁在整个表面上间隔开等间隔。版权所有（C）2006，JPO＆NCIPI

4. 发明申请

WO2006071275A3 TISSUE POSITIONING SYSTEMS FOR USE WITH RADIATION THERAPY 审中-公开
标题翻译：用于辐射治疗的组织定位系统
公开(公告)号：WO2006071275A3
公开(公告)日：2007-05-18
申请号：PCT/US2005025247
申请日：2005-07-18
申请人： CYTYC CORP , STUBBS JAMES B , WINKLER RANCE A
发明人： STUBBS JAMES B , WINKLER RANCE A
IPC分类号： A61M37/00 , A61B17/00 , A61B19/00 , A61N5/10
CPC分类号： A61N5/1027 , A61B90/04 , A61B2017/00867 , A61B2090/0427 , A61M37/0069 , A61N2005/1094
摘要： A brachytherapy device including a spacing member is disclosed herein. The spacing member is useful in that the instrument is effective to limit the amount of radiation that comes into contact with the sensitive tissue, and thereby protect sensitive tissue from overheating or hotspots, and/or protect against radiation exposure outside of the patient's body which may affect healthcare providers or others who might come close to the patient. In particular, the spacing apparatus is effective to control the proximity off a brachytherapy device to the outer surface of the sensitive tissue proximate to a surgical excision site.
摘要翻译：本文公开了包括间隔构件的近距离放射治疗装置。间隔构件是有用的，因为该仪器有效地限制与敏感组织接触的辐射量，从而保护敏感组织免于过热或热点，和/或防止辐射暴露在患者体外，可能影响医疗保健提供者或可能接近患者的其他人。特别地，间隔装置有效地控制近距离放射治疗装置到靠近外科切除部位的敏感组织的外表面。

5. 发明申请

WO2006014654A3 TISSUE POSITIONING SYSTEMS FOR USE WITH RADIATION THERAPY 审中-公开
标题翻译：用于放射治疗的组织定位系统
公开(公告)号：WO2006014654A3
公开(公告)日：2006-04-27
申请号：PCT/US2005025603
申请日：2005-07-19
申请人： CYTYC CORP , STUBBS JAMES B , WINKLER RANCE A
发明人： STUBBS JAMES B , WINKLER RANCE A
IPC分类号： A61B17/00 , A61B19/00 , A61N5/10
CPC分类号： A61M37/0069 , A61B90/04 , A61B2017/00867 , A61B2090/0427 , A61N5/1027 , A61N2005/1094
摘要： A brachytherapy device including a spacing member is disclosed herein. The spacing member is useful in that the instrument is effective to limit the amount of radiation that comes into contact with the sensitive tissue, and thereby protect sensitive tissue from overheating or hotspots, and/or protect against radiation exposure outside of the patient's body which may affect healthcare provider or others who might come close to the patient. In particular, the spacing apparatus is effective to control the proximity of a brachytherapy device to the outer surface of the sensitive tissue proximate to a surgical excision site.
摘要翻译：本文公开了包括间隔构件的近距离放射治疗装置。间隔构件是有用的，因为该仪器有效地限制与敏感组织接触的辐射量，从而保护敏感组织免于过热或热点，和/或防止辐射暴露在患者体外，可能影响医护人员或其他可能接近病人的人。特别地，间隔装置有效地控制近距离放射治疗装置邻近手术切除部位的敏感组织的外表面。

6. 发明专利

CA2296430C DOUBLE-WALL BALLOON CATHETER FOR TREATMENT OF PROLIFERATIVE TISSUE 未知
公开(公告)号：CA2296430C
公开(公告)日：2004-06-15
申请号：CA2296430
申请日：1998-06-22
申请人： PROXIMA THERAPEUTICS INC
发明人： STUBBS JAMES B , PATRICK TIMOTHY J , DEMPSEY JAMES F , WILLIAMS JEFFERY A , PORTER CHRISTOPHER H , WILLIAMSON JEFFREY F
IPC分类号： A61M25/00 , A61M36/04 , A61N5/10 , A61N5/00
摘要： An instrument (10) for use in brachy-therapy comprises a concentric arrangement of inner and outer distensible, spherical chambers (30, 34) disposed near the proximal end of a catheter body (12) where one of the chambers (30, 34) is made to contain a radioactive material with the other chamber (30, 34) containing a radiation absorptive material, the apparatus (10) functioning to provide a more uniform absorbed dose profile in tissue surrounding a cavity created by the removal of a tumo r. An alternative embodiment includes non-spherical inner and outer chambers whose respective walls are spaced equidistant over the entire surfaces thereof.

7. 发明专利

AU8159398A Double-wall balloon catheter for treatment of proliferative tissue 未知
公开(公告)号：AU8159398A
公开(公告)日：1999-02-16
申请号：AU8159398
申请日：1998-06-22
申请人： PROXIMA THERAPEUTICS INC
发明人： WILLIAMS JEFFERY A , PORTER CHRISTOPHER H , WILLIAMSON JEFFREY F , DEMPSEY JAMES F , PATRICK TIMOTHY J , STUBBS JAMES B
IPC分类号： A61M25/00 , A61M36/04 , A61N5/10 , A61N5/00
摘要： An interstitial brachytherapy apparatus for delivering radioactive emissions to an internal body location includes a catheter body member having a proximal end and distal end, an inner spatial volume disposed proximate to the distal end of the catheter body member, an outer spatial volume defined by an expandable surface element disposed proximate to the distal end of the body member in a surrounding relation to the inner spatial volume, and a radiation source disposed in the inner spatial volume.

8. 发明专利

CA2296430A1 DOUBLE-WALL BALLOON CATHETER FOR TREATMENT OF PROLIFERATIVE TISSUE 未知
公开(公告)号：CA2296430A1
公开(公告)日：1999-02-04
申请号：CA2296430
申请日：1998-06-22
申请人： PROXIMA THERAPEUTICS INC
发明人： PATRICK TIMOTHY J , STUBBS JAMES B , PORTER CHRISTOPHER H , DEMPSEY JAMES F , WILLIAMSON JEFFREY F , WILLIAMS JEFFERY A
IPC分类号： A61M25/00 , A61M36/04 , A61N5/10 , A61N5/00
摘要： An instrument (10) for use in brachy-therapy comprises a concentric arrangement of inner and outer distensible, spherical chambers (30, 34) disposed near the proximal end of a catheter body (12) where one of the chambers (30, 34) is made to contain a radioactive material with the other chamber (30, 34) containing a radiation absorptive material, the apparatus (10) functioning to provide a more uniform absorbed dose profile in tissue surrounding a cavity created by the removal of a tumor. An alternative embodiment includes non-spherical inner and outer chambers whose respective walls are spaced equidistant over the entire surfaces thereof.

9. 发明专利

AU2004288687A1 Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods 未知
公开(公告)号：AU2004288687A1
公开(公告)日：2005-05-26
申请号：AU2004288687
申请日：2004-11-05
申请人： PROXIMA THERAPEUTICS INC
发明人： STUBBS JAMES B
IPC分类号： A61N5/10
摘要： An interstitial brachytherapy apparatus and method for delivering and monitoring radioactive emissions delivered to tissue surrounding a resected tissue cavity. The brachytherapy device including a catheter body member having a proximal end, a distal end, and an outer spatial volume disposed proximate to the distal end of the body member. A radiation source is disposed in the outer spatial volume and a treatment feedback sensor is provided on the device. In use, the treatment feedback sensor can measure the radiation dose delivered from the radiation source.

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