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1. 发明申请

WO2006050385A2 CARDIAC MOTION CHARACTERIZATION BY STRAIN MEASUREMENT 审中-公开
标题翻译：通过应变测量的心脏运动特征
公开(公告)号：WO2006050385A2
公开(公告)日：2006-05-11
申请号：PCT/US2005039535
申请日：2005-10-31
申请人： PROTEUS BIOMEDICAL INC , JENSON MARC , THOMPSON TODD , COLLIOU OLIVIER , SAVAGE GEORGE M , ZDEBLICK MARK , FRANK JEREMY , ARNS LAWRENCE , WHITE ROBERT
发明人： JENSON MARC , THOMPSON TODD , COLLIOU OLIVIER , SAVAGE GEORGE M , ZDEBLICK MARK , FRANK JEREMY , ARNS LAWRENCE , WHITE ROBERT
IPC分类号： H01L21/44 , H01L21/48
CPC分类号： A61N1/056 , A61B5/1107 , A61B5/6851 , A61B5/6857 , A61B5/6858 , A61B5/686 , A61B2562/0266 , A61N1/08 , A61N1/3627
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了用于评估心脏组织位置例如心脏壁的运动的方法。在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

2. 发明申请

WO2006042039A3 CONTINUOUS FIELD TOMOGRAPHY 审中-公开
标题翻译：连续现场测量
公开(公告)号：WO2006042039A3
公开(公告)日：2007-07-05
申请号：PCT/US2005036035
申请日：2005-10-06
申请人： PROTEUS BIOMEDICAL INC , SAVAGE GEORGE M , ZDEBLICK MARK , COSTELLO BENEDICT , THOMPSON TODD , COLLIOU OLIVIER , ROBERTSON TIMOTHY
发明人： SAVAGE GEORGE M , ZDEBLICK MARK , COSTELLO BENEDICT , THOMPSON TODD , COLLIOU OLIVIER , ROBERTSON TIMOTHY
IPC分类号： A61B8/02
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

3. 发明专利

JP2012011237A Implantable addressable segmented electrode 审中-公开
标题翻译：可植入地线的电极
公开(公告)号：JP2012011237A
公开(公告)日：2012-01-19
申请号：JP2011227945
申请日：2011-10-17
申请人： Proteus Biomedical Inc , プロテウスバイオメディカルインコーポレイテッド
发明人： JENSEN MARC , COSTELLO BENEDICT J , THOMPSON TODD , ZDEBLICK MARK , FRANK JEREMY , LEI DINO , ADDIS BRUCE , COLLIOU OLIVIER , SAVAGE GEORGE M
IPC分类号： A61N1/05 , A61N1/08 , A61N1/372
CPC分类号： A61N1/05 , A61N1/375
摘要： PROBLEM TO BE SOLVED: To provide implantable addressable segmented electrode devices.SOLUTION: There are provided implantable addressable segmented electrode devices, as well as methods for making and using the same. The subject devices include segmented electrode structures made up of an integrated circuit electrically coupled to two or more electrodes, where each electrode can be individually activated. In addition, implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures, are provided.
摘要翻译：要解决的问题：提供可植入可寻址分段电极装置。解决方案：提供可植入可寻址分段电极装置，以及制造和使用它们的方法。主题装置包括由电耦合到两个或更多个电极的集成电路组成的分段电极结构，其中每个电极可以被单独激活。此外，提供了可植入装置和系统，以及包含这种装置和系统或其组件的套件，其包括分段电极结构。版权所有（C）2012，JPO＆INPIT

4. 发明申请

WO2004052182A3 MONITORING AND TREATING HEMODYNAMIC PARAMETERS 审中-公开
标题翻译：监测和治疗HEMODYNAMIC参数
公开(公告)号：WO2004052182A3
公开(公告)日：2005-07-14
申请号：PCT/US0339524
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL INC
发明人： ZDEBLICK MARK , SAVAGE GEORGE M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/03 , A61B5/042 , A61B5/05 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/22 , A61N1/00 , A61N1/05
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier (100) provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors (106). The carrier (100) includes a body (102) and at least two electrical conductors (104) coupled with at least two effectors (106). Effectors (106) may be any combination of sensors (206), actuators (206) or both. Sensors (206) may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators (206) may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors (106) residing on parallel conductors in the patient, including addressing a first addressable sensor (106) in the network to obtain data and addressing a second addressable sensor (106) in the network to obtain data.
摘要翻译：复用的医疗载体（100）提供用于感测一个或多个患者参数和/或通过单独识别的效应器（106）递送能量。载体（100）包括主体（102）和与至少两个效应器（106）耦合的至少两个电导体（104）。效应器（106）可以是传感器（206），致动器（206）或两者的任何组合。传感器（206）可以测量诸如压力，氧含量，体积，电导率，流体流速或任何其它化学或物理参数的参数。致动器（206）可用于例如调节心脏，刺激肌肉或神经组织，广播超声波能量，发光，加热或其他形式的辐射，或递送任何形式的能量或物质。一种用于从患者收集医学数据的方法包括询问驻留在患者中的并行导体上的复用传感器（106）的网络，包括寻址网络中的第一可寻址传感器（106）以获得数据并寻址第二可寻址传感器（106 ）在网络中获取数据。

5. 发明专利

AU2003296956A1 METHOD AND SYSTEM FOR MONITORING AND TREATING HEMODYNAMIC PARAMETERS 未知
公开(公告)号：AU2003296956A1
公开(公告)日：2004-06-30
申请号：AU2003296956
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL INC
发明人： SAVAGE GEORGE M , ZDEBLICK MARK
IPC分类号： A61B20060101 , A61B5/00 , A61B5/03 , A61B5/296 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/22 , A61N1/00 , A61N1/05
摘要： A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. The carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a second addressable sensor in the network to obtain data.

6. 发明专利

CA2650920C PATIENT CUSTOMIZED THERAPEUTIC REGIMENS 未知
公开(公告)号：CA2650920C
公开(公告)日：2016-10-18
申请号：CA2650920
申请日：2007-05-02
申请人： PROTEUS BIOMEDICAL INC
发明人： ZDEBLICK MARK J , THOMPSON ANDREW , SAVAGE GEORGE M
IPC分类号： A61G99/00 , G06Q10/00 , G16H10/60
摘要： Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.

7. 发明专利

AU2003296956A8 Monitoring and treating hemodynamic parameters 未知
公开(公告)号：AU2003296956A8
公开(公告)日：2004-06-30
申请号：AU2003296956
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL INC
发明人： SAVAGE GEORGE M , ZDEBLICK MARK
IPC分类号： A61B20060101 , A61B5/00 , A61B5/03 , A61B5/296 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/22 , A61N1/00 , A61N1/05
摘要： A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. The carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a second addressable sensor in the network to obtain data.

8. 发明专利

CA2508800A1 METHOD AND SYSTEM FOR MONITORING AND TREATING HEMODYNAMIC PARAMETERS 未知
公开(公告)号：CA2508800A1
公开(公告)日：2004-06-24
申请号：CA2508800
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL INC
发明人： ZDEBLICK MARK , SAVAGE GEORGE M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/03 , A61B5/296 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/22 , A61N1/00 , A61N1/05 , A61B5/05
摘要： A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. T he carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volum e, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecti ng medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a seco nd addressable sensor in the network to obtain data.

9. 发明公开

EP1581102A4 METHOD AND SYSTEM FOR MONITORING AND TREATING HEMODYNAMIC PARAMETERS 审中-公开
标题翻译：方法和系统的监测和治疗血液动力学参数
公开(公告)号：EP1581102A4
公开(公告)日：2006-12-20
申请号：EP03812966
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL INC
发明人： ZDEBLICK MARK , SAVAGE GEORGE M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/03 , A61B5/042 , A61B5/05 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/22 , A61N1/00 , A61N1/05
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier (100) provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors (106). The carrier (100) includes a body (102) and at least two electrical conductors (104) coupled with at least two effectors (106). Effectors (106) may be any combination of sensors (206), actuators (206) or both. Sensors (206) may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators (206) may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors (106) residing on parallel conductors in the patient, including addressing a first addressable sensor (106) in the network to obtain data and addressing a second addressable sensor (106) in the network to obtain data.

10. 发明公开

EP1799113A4 CONTINUOUS FIELD TOMOGRAPHY 审中-公开
标题翻译：连续场断层摄影
公开(公告)号：EP1799113A4
公开(公告)日：2010-07-07
申请号：EP05811836
申请日：2005-10-06
申请人： PROTEUS BIOMEDICAL INC
发明人： SAVAGE GEORGE M , ZDEBLICK MARK , COSTELLO BENEDICT , THOMPSON TODD , COLLIOU OLIVIER , ROBERTSON TIMOTHY
IPC分类号： A61B8/02 , A61B5/00
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365

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