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1. 发明申请

WO2006035237A2 METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE 审中-公开
标题翻译：有关阿尔茨海默病的方法和组合物
公开(公告)号：WO2006035237A2
公开(公告)日：2006-04-06
申请号：PCT/GB2005003756
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING S COLLEGE LONDON , WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEVEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
发明人： WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEVEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译：提供了与阿尔茨海默病有关的方法和组合物。具体而言，提供了相对于其在正常状态中的表达而在阿尔茨海默病状态中差异表达的蛋白质。确定并描述与阿尔茨海默病有关的蛋白质。还提供了使用差异表达蛋白诊断阿尔茨海默病的方法，以及用于预防和治疗阿尔茨海默病的化合物的鉴定和治疗用途的方法。

2. 发明专利

CA2580532A1 METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE 未知
公开(公告)号：CA2580532A1
公开(公告)日：2006-04-06
申请号：CA2580532
申请日：2005-09-29
申请人： KING S COLLEGE LONDON , PROTEOME SCIENCES PLC
发明人： BAUMANN CHRISTIAN , KUHN KARSTEN , LOVESTONE SIMON , JOUBERT RICHARD , HYE ABDUL , PREFOT PETRA , KIENLE STEFAN , WESTBROOK JULES , LYNHAM STEPHEN , WARD MALCOLM , PRINZ THORSTEN , SCHAEFER JUERGEN , BYERS HELEN
IPC分类号： G01N33/68 , A61P25/28
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

3. 发明专利

AU2011253636B2 Methods and compositions relating to alzheimer's disease 未知
公开(公告)号：AU2011253636B2
公开(公告)日：2014-01-09
申请号：AU2011253636
申请日：2011-11-23
申请人： KING S COLLEGE LONDON , PROTEOME SCIENCES PLC
发明人： WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEPHEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
IPC分类号： A61P25/28 , A61K38/17 , G01N33/68
摘要： Abstract Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

4. 发明专利

DK2354795T3 Fremgangsmåder og sammensætninger i forbindelse med Alzheimers sygdom 未知
公开(公告)号：DK2354795T3
公开(公告)日：2015-02-16
申请号：DK10010288
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING S COLLEGE LONDON
发明人： WESTBROOK JULES , BYERS HELEN , WARD MALCOM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEPHEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIELNE STEFAN
IPC分类号： G01N33/68 , A61P25/28

5. 发明专利

DE602005025897D1 VERFAHREN UND ZUSAMMENSETZUNGEN IN VERBINDUNG MIT MORBUS ALZHEIMER 未知
公开(公告)号：DE602005025897D1
公开(公告)日：2011-02-24
申请号：DE602005025897
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING S COLLEGE LONDON
发明人： WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEPHEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
IPC分类号： G01N33/68

6. 发明专利

CA2580532C METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE 未知
公开(公告)号：CA2580532C
公开(公告)日：2019-06-25
申请号：CA2580532
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING S COLLEGE LONDON
发明人： WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEPHEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
IPC分类号： G01N33/68 , A61P25/28
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

7. 发明专利

AT495445T 未知
公开(公告)号：AT495445T
公开(公告)日：2011-01-15
申请号：AT05788728
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING S COLLEGE LONDON
发明人： WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEPHEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
IPC分类号： G01N33/68
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

8. 发明专利

AU2005288689A1 Methods and compositions relating to Alzheimer's disease 未知
公开(公告)号：AU2005288689A1
公开(公告)日：2006-04-06
申请号：AU2005288689
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING S COLLEGE LONDON
发明人： LYNHAM STEPHEN , BAUMANN CHRISTIAN , KIENLE STEFAN , JOUBERT RICHARD , WARD MALCOLM , BYERS HELEN , SCHAEFER JUERGEN , PRINZ THORSTEN , PREFOT PETRA , WESTBROOK JULES , HYE ABDUL , LOVESTONE SIMON , KUHN KARSTEN
IPC分类号： G01N33/68
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

9. 发明申请

WO2007068985A2 DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER 审中-公开
标题翻译：大肠癌的诊断和预后
公开(公告)号：WO2007068985A2
公开(公告)日：2007-06-21
申请号：PCT/GB2006050460
申请日：2006-12-15
申请人： ELECTROPHORETICS LTD , JOUBERT RICHARD , PREFOT PETRA , BOEHM GITTE , ARNHOLD JUERGEN , HOEHLE CLAUDIA , NEUKUM ERHARD , SCHAEFER JURGEN
发明人： JOUBERT RICHARD , PREFOT PETRA , BOEHM GITTE , ARNHOLD JUERGEN , HOEHLE CLAUDIA , NEUKUM ERHARD , SCHAEFER JURGEN
CPC分类号： A61K38/17 , G01N33/57419
摘要： The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth factor-beta induced protein IG-H3 (SwissProt Acc. No. Q15582); suppressor of G2 allele of SKP1 homolog (isoform 2) (SwissProt Acc. No. Q9Y2Z0-2); hypothetical protein (part of URG4) (SwissProt Acc. No. Q9NWR7); calponin-2 (SwissProt Acc. No. Q99439); heat shock protein HSP90-beta (SwissProt Acc. No. P08238); phosphoglycerate mutase 1 (SwissProt Acc. No. P18669); serpin C1 protein (SwissProt Acc. No. P01008); or haptoglobin precursor (SwissProt Acc. No. P00738); or a decreased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being serotransferrin (SwissProt Acc. No. P02787); 26S proteasome subunit p40.5 (Swiss Prot Acc. No. Q9UNM7); aldo-keto reductase family 1 member B10 (SwissProt Acc. No. O60218); fructosamine-3-kinase (SwissProt Acc. No. Q9H479); peripherin (SwissProt Acc. No. P41219); alpha-2-macroglobulin (SwissProt Acc. No. P01023); serpin C1 protein (SwissProt Acc. No. P01008); or apolipoprotein A IV (SwissProt Acc. No. P06727). The same proteins can be used for prognosis by detecting changes in their concentration in the course of treatment for colorectal cancer.
摘要翻译：本发明涉及一种诊断取自人受试者的有效身体组织的诊断样品中的结直肠癌的方法，其包括检测诊断样品中蛋白质浓度与对照，正常人样品，蛋白质是：转化生长因子-β诱导的蛋白质IG-H3（SwissProt Acc.No.Q15582）; SKP1同系物（亚型2）（SwissProt Acc.No.Q9Y2Z0-2）的G2等位基因抑制子; 假想蛋白质（URG4的一部分）（SwissProt Acc.No.Q9NWR7）; calponin-2（SwissProt登录号Q99439）; 热休克蛋白HSP90-β（SwissProt Acc.No.P08238）; 磷酸甘油酸变位酶1（SwissProt Acc.No.P18669）; 丝氨酸蛋白酶抑制剂C1蛋白（SwissProt Acc.No.P01008）; 或触珠蛋白前体（SwissProt Acc.No.P00738）; 或与正常人样品相比，诊断样品中蛋白质浓度降低，所述蛋白质是血清转铁蛋白（SwissProt Acc.No.P02787）; 26S蛋白酶体亚基p40.5（Swiss Prot Acc.No.Q9UNM7）; 醛酮还原酶家族1成员B10（SwissProt Acc.No.O60218）; 果糖胺-3-激酶（SwissProt Acc.No.Q9H479）; 外周蛋白（SwissProt Acc.No.P41219）; α-2-巨球蛋白（SwissProt Acc.No.P01023）; 丝氨酸蛋白酶抑制剂C1蛋白（SwissProt Acc.No.P01008）; 或载脂蛋白A IV（SwissProt Acc.No.P06727）。通过检测结肠直肠癌治疗过程中其浓度的变化，可以将相同的蛋白质用于预后。

10. 发明专利

JP2014209132A アルツハイマー病に関する方法及び組成物审中-公开
标题翻译：与阿尔茨海默病相关的方法和组合
公开(公告)号：JP2014209132A
公开(公告)日：2014-11-06
申请号：JP2014159434
申请日：2014-08-05
申请人：プロティオーム・サイエンシィズ・ピーエルシー , Proteome Sciences Plc , キングスカレッジロンドンKings Collegelondon , King's College London , キングスカレッジロンドンKings College London
发明人： WESTBROOK JULES , BYERS HELEN , MARCOLM WARD , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEPHEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
IPC分类号： G01N33/68 , G01N27/447 , G01N27/62 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要：【課題】アルツハイマー病に関する方法及び組成物を提供する。とくに、健常状態における発現と比較して、アルツハイマー病状態で差異的に発現するタンパク質を提供する。アルツハイマー病に関連するタンパク質を同定し、且つそれを記載する。また、差異的に発現するタンパク質を用いたアルツハイマー病の診断方法を提供し、アルツハイマー病の予防及び治療のための化合物の同定方法、及びそれらの治療上の使用方法を提供する。【解決手段】例えば本発明は、被験者におけるアルツハイマー病の診断方法を提供する。この方法は、前記被験者からの組織サンプルまたは体液サンプルにおいて、ここに記載する方法により同定された1つ以上の差異的に発現するタンパク質を検出することを含む。【選択図】なし
摘要翻译：要解决的问题：提供与阿尔茨海默氏病相关的方法和组合物，特别是与正常状态下的表达相比，在阿尔茨海默病状态下差异表达的蛋白质，鉴定和描述与阿尔茨海默氏病相关的蛋白质，并提供使用差异表达的蛋白质的阿尔茨海默氏病的诊断方法，以及用于鉴定化合物的方法，用于预防和治疗阿尔茨海默氏病。以及该化合物的治疗用途的方法。解决方案：本发明中的阿尔茨海默氏病的诊断方法包括：通过本文所述的方法鉴定的一种或多种差异表达的蛋白质，在来自受试者的组织样品或体液样品中。

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