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1. 发明申请

WO2013059323A1 PEG CONJUGATES OF EXENATIDE 审中-公开
标题翻译： PEG联合使用
公开(公告)号：WO2013059323A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/060618
申请日：2012-10-17
申请人： PROLYNX LLC , SCHNEIDER, Eric, L. , SANTI, Daniel, V. , ASHLEY, Gary, W.
发明人： SCHNEIDER, Eric, L. , SANTI, Daniel, V. , ASHLEY, Gary, W.
IPC分类号： C07K16/00 , A61K38/26 , C08G59/00
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60
摘要： Slow release forms of exenatide wherein exenatide is releasably linked to polyethylene glycol carriers are disclosed.
摘要翻译：公开了艾塞那肽的缓释形式，其中艾塞那肽可释放地连接到聚乙二醇载体上。

2. 发明申请

WO2011140392A1 CONTROLLED DRUG RELEASE FROM SOLID SUPPORTS 审中-公开
标题翻译：控制药物从固体支持中释放
公开(公告)号：WO2011140392A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035422
申请日：2011-05-05
申请人： PROLYNX LLC , ASHLEY, Gary , SANTI, Daniel, V.
发明人： ASHLEY, Gary , SANTI, Daniel, V.
IPC分类号： A01N57/00
CPC分类号： A61K47/48215 , A61K47/58 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61K47/6953 , A61K47/6957 , A61K49/0043 , A61K49/0054 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/258
摘要： The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.
摘要翻译：本发明涉及用于医疗应用中的固体支持物，其提供药物如肽，核酸和小分子的受控释放。这些药物通过通过控制β消除释放药物或前药的连接共价偶联到固体支持物上。

3. 发明申请

WO2014116717A1 SEALANTS HAVING CONTROLLED DEGRADATION 审中-公开
标题翻译：具有控制降解的密封剂
公开(公告)号：WO2014116717A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/012571
申请日：2014-01-22
申请人： PROLYNX LLC , HENISE, Jeffrey, C. , ASHLEY, Gary, W. , SANTI, Daniel, V.
发明人： HENISE, Jeffrey, C. , ASHLEY, Gary, W. , SANTI, Daniel, V.
IPC分类号： A61F2/00 , C09B67/00
CPC分类号： A61L26/0019 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L24/06 , A61L24/10 , A61L26/0066 , A61L26/008 , A61L26/0085 , A61L26/009 , A61L2300/216 , A61L2300/604 , C09B11/24 , C09B57/02
摘要： The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.
摘要翻译：本发明提供了密封剂，其中任选地通过连接体为所述基团提供其中不另外包含用于结合膜或组织的蛋白质反应性基团的可生物降解的水凝胶。接头可以是可生物降解的并且可以通过消除反应生物降解。本发明还提供用于药物递送的多层凝胶，其中与药物将被递送的组织或器官接触的多孔凝胶被来自周围体液的微孔层保护。

4. 发明申请

WO2013036857A1 SULFONE LINKERS 审中-公开
公开(公告)号：WO2013036857A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054293
申请日：2012-09-07
申请人： PROLYNX LLC , ASHLEY, Gary, W. , SANTI, Daniel, V.
发明人： ASHLEY, Gary, W. , SANTI, Daniel, V.
IPC分类号： A01N41/10
CPC分类号： C07D403/12 , A61K47/60 , C07D207/46 , C07D405/12
摘要： Sulfone linkers which couple drugs to carriers of various types are described. These linkers permit the release of the drug over time in a controlled manner. The release occurs through beta-elimination, and does not require enzymatic cleavage. Products of the linkers with both drugs and macromolecules and methods of using them are described as well.
摘要翻译：描述了将药物耦合到各种载体的砜接头。这些接头允许以受控的方式随时间释放药物。释放通过β-消除发生，不需要酶切。还描述了具有药物和大分子的连接体的产物及其使用方法。

5. 发明申请

WO2013036847A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING 审中-公开
标题翻译： HYDROGELS可生物降解的交织
公开(公告)号：WO2013036847A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054278
申请日：2012-09-07
申请人： PROLYNX LLC , ASHLEY, Gary, W. , SANTI, Daniel, V. , HENISE, Jeffrey, C.
发明人： ASHLEY, Gary, W. , SANTI, Daniel, V. , HENISE, Jeffrey, C.
IPC分类号： A61K47/48
CPC分类号： A61K47/34 , A61K47/60 , A61K47/6903 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08 , C08G2650/30
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.
摘要翻译：描述了在适当的pH和温度条件下通过切割消除反应的交联化合物降解的水凝胶。水凝胶可用于递送各种试剂，例如药物。本发明提供在暴露于生理条件时以非酶过程降解成较小的可溶组分的水凝胶以及制备它们的方法。水凝胶由在生理条件下进行消除反应的交联剂制备，从而从水凝胶的骨架切割交联剂。本发明还涉及交联剂本身和形成本发明的水凝胶的中间体。根据本发明的方法制备的可生物降解的水凝胶可用于各种领域，包括生物医学工程，吸收材料和用于药物递送的载体。

6. 发明申请

WO2011140393A1 CONTROLLED RELEASE FROM MACROMOLECULAR CONJUGATES 审中-公开
标题翻译：从大分子结合物的控制释放
公开(公告)号：WO2011140393A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035423
申请日：2011-05-05
申请人： PROLYNX LLC , ASHLEY, Gary , SANTI, Daniel, V.
发明人： ASHLEY, Gary , SANTI, Daniel, V.
IPC分类号： A01N57/00
CPC分类号： A61K47/48215 , A61K9/0019 , A61K9/08 , A61K47/48023 , A61K47/54 , A61K47/60 , C07D487/04 , C07D491/22
摘要： The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and using the conjugates.
摘要翻译：本发明涉及大分子载体的缀合物和包含通过速率控制的β-消除释放药物或前药的接头的药物，以及制备和使用缀合物的方法。

7. 发明申请

WO2011140376A1 CONTROLLED DRUG RELEASE FROM DENDRIMERS 审中-公开
标题翻译：控制药物从DENDRIMERS发布
公开(公告)号：WO2011140376A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035403
申请日：2011-05-05
申请人： PROLYNX LLC , ASHLEY, Gary , SANTI, Daniel, V.
发明人： ASHLEY, Gary , SANTI, Daniel, V.
IPC分类号： A61K9/22 , A61K9/52
CPC分类号： A61K47/48315 , A61K38/2242 , A61K38/26 , A61K38/50 , A61K47/60 , A61K47/641 , A61K47/645 , C08G83/003 , C08G83/004
摘要： The invention relates to compositions that comprise dendrimers useful in medical and veterinary applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the dendrimer through a linkage that releases the drug or a prodrug through controlled beta elimination.
摘要翻译：本发明涉及包含用于医学和兽医学应用中的树枝状大分子的组合物，其提供药物（例如肽，核酸和小分子）的受控释放。这些药物通过通过对照β消除释放药物或前药的连接共价偶联到树状聚合物上。

8. 发明申请

WO2009158668A1 PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES 审中-公开
标题翻译：具有控制药物释放率的产品和药物 - 大分子药物
公开(公告)号：WO2009158668A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048943
申请日：2009-06-26
申请人： PROLYNX LLC , SANTI, Daniel, V. , ASHLEY, Gary , HEARN, Brian
发明人： SANTI, Daniel, V. , ASHLEY, Gary , HEARN, Brian
IPC分类号： A61K9/22
CPC分类号： A61K47/48023 , A61K47/54 , A61K47/60 , C08G65/329 , C08G65/33317 , C08G65/33396 , C08L2203/02
摘要： The present invention provides methods and compositions that permit controlled and prolonged drug release in vivo . The compounds are either prodrugs with tunable rates of release, or conjugates of the drug with macromolecules which exhibit tunable controlled rates of release.
摘要翻译：本发明提供允许体内可控和延长的药物释放的方法和组合物。化合物是具有可调节释放速率的前药或药物与大分子的缀合物，其表现出可调节的释放速率。

9. 发明公开

EP2222833A1 INDUSTRIAL PRODUCTION OF ORGANIC COMPOUNDS USING RECOMBINANT ORGANISMS EXPRESSING METHYL HALIDE TRANSFERASE 审中-公开
标题翻译：有机化合物的技术总值生产中使用卤代甲烷转移表达重组生物
公开(公告)号：EP2222833A1
公开(公告)日：2010-09-01
申请号：EP08857534.5
申请日：2008-11-26
申请人： The Regents of the University of California , Santi, Daniel V.
发明人： VOIGT, Christopher, A. , SANTI, Daniel, V. , BAYER, Travis, S.
IPC分类号： C12N1/00 , C12Q1/48
CPC分类号： C12N9/10 , C12P5/00 , Y02E50/16
摘要： The invention relates to a process for production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)- dependent methyl halide transferase and, optionally modified at loci that affect flux through SAM metabolic pathways or affect intracellular halide levels. In one approach the organism, halides (chlorine, bromine and/or iodine); and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non- halogenated organic molecules.
摘要翻译：本发明涉及一种用于产生使用表达S-腺苷甲硫氨酸（SAM） - 依赖性卤代甲烷转移，并且在个位点任选改性的遗传改造的生物体有机物的过程中并通过代谢途径影响通量或SAM影响细胞内卤化物水平。在一种方法中的生物体，卤化物（氯，溴和/或碘）; 和碳源在栽培介质，其中卤代甲烷产生的条件下温育。甲基卤可被收集并转换成非卤代有机分子。

10. 发明申请

WO2009073560A1 INDUSTRIAL PRODUCTION OF ORGANIC COMPOUNDS USING RECOMBINANT ORGANISMS EXPRESSING METHYL HALIDE TRANSFERASE 审中-公开
标题翻译：使用表达甲基卤化物转移酶的重组体进行工业化生产有机化合物
公开(公告)号：WO2009073560A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085019
申请日：2008-11-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SANTI, Daniel, V. , VOIGT, Christopher, A. , SANTI, Daniel, V. , BAYER, Travis, S.
发明人： VOIGT, Christopher, A. , SANTI, Daniel, V. , BAYER, Travis, S.
IPC分类号： C12N1/00 , C12Q1/48
CPC分类号： C12N9/10 , C12P5/00 , Y02E50/16
摘要： The invention relates to a process for production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)- dependent methyl halide transferase and, optionally modified at loci that affect flux through SAM metabolic pathways or affect intracellular halide levels. In one approach the organism, halides (chlorine, bromine and/or iodine); and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non- halogenated organic molecules.
摘要翻译：本发明涉及使用表达S-腺苷甲硫氨酸（SAM）依赖性甲基卤转移酶的遗传工程生物制备有机化合物的方法，并且任选地在通过SAM代谢途径影响通量或影响细胞内卤化物水平的位点上修饰。在一种方法中，生物体，卤化物（氯，溴和/或碘）; 并将碳源在培养基中在产生甲基卤的条件下培养。甲基卤化物可以被收集并转化成非卤化的有机分子。

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