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1. 发明申请

WO0118181A3 ENZYME INHIBITORS 审中-公开
标题翻译：酶抑制剂
公开(公告)号：WO0118181A3
公开(公告)日：2001-12-13
申请号：PCT/US0024713
申请日：2000-09-08
申请人： PROCTER & GAMBLE , UNDERINER TODD LAURENCE , OSBORNE SCOTT EDWARD , BATES TIMOTHY , GARRETT GARRY STEVEN , FOSSUM RENAE DIANNA
发明人： UNDERINER TODD LAURENCE , OSBORNE SCOTT EDWARD , BATES TIMOTHY , GARRETT GARRY STEVEN , FOSSUM RENAE DIANNA
IPC分类号： C12N9/99 , A61K31/787 , A61K47/48 , A61P17/00 , A61P43/00 , C07K5/023 , C08G65/333 , C08G65/334 , C08G73/04
CPC分类号： A61K47/60
摘要： The present invention relates to polymer conjugates which inhibit protease or lipase enzyme, said polymer conjugates comprising a polymer component bonded to an enzyme inhibitor component having an acyl unit capable of inhibiting the activity of more than one protease or lipase enzymes, wherein said inhibitor component is directly bonded to said polymer component or is bonded by a linking unit, said linking unit capable of modulating the interaction of a target enzyme and said inhibitor component wherein said polymer component remains bonded to said inhibitor component after said acyl unit interacts with said target enzyme.
摘要翻译：本发明涉及抑制蛋白酶或脂肪酶的聚合物缀合物，所述聚合物缀合物包含与具有能够抑制超过一种蛋白酶或脂肪酶活性的酰基单元的酶抑制剂组分结合的聚合物组分，其中所述抑制剂组分是所述连接单元能够调节目标酶和所述抑制剂组分的相互作用，其中所述聚合物组分在所述酰基单元与所述目标酶相互作用后保持与所述抑制剂组分结合。

2. 发明申请

WO9946316A3 ENZYME INHIBITORS 审中-公开
标题翻译：酶抑制剂
公开(公告)号：WO9946316A3
公开(公告)日：2000-03-23
申请号：PCT/US9905314
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： MCIVER JOHN MCMILLAN , UNDERINER TODD LAURENCE , BATES TIMOTHY
IPC分类号： A61K8/30 , A61K20060101 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/505 , A61K31/77 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , A61Q17/00 , C07C257/14 , C07C257/18 , C07C277/08 , C07C279/18 , C07D233/04 , C07D239/06 , C08G20060101 , C08G65/329 , C08G65/48 , C12N20060101
CPC分类号： C08G65/333 , A61K8/0208 , A61K8/0216 , A61K8/86 , A61K31/155 , A61K31/77 , A61K2800/92 , A61Q19/00 , C07C257/14 , C07C257/18 , C07C279/18 , C08G65/3326 , Y10S514/844 , Y10S514/846
摘要： The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having structure (1): and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L1, L2, L3, L4, Z, X, B1 and B2 are defined herein.
摘要翻译：本发明涉及可用于预防和治疗不良健康，皮肤，头发和口腔状况的化合物，组合物和方法。化合物，组合物和方法也广泛适用于健康，皮肤，头发，口腔，美容和个人护理应用。特别地，本发明涉及具有结构（1）的化合物及其互变异构体，可接受的盐和生物可水解的酰胺，酯和酰亚胺，其中A，Q，n，P，L1，L2，L3，L4，Z ，X，B1和B2在本文中定义。

3. 发明专利

HU0102516A2 ENZYME INHIBITORS 未知
公开(公告)号：HU0102516A2
公开(公告)日：2001-11-28
申请号：HU0102516
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： BATES TIMOTHY , MCIVER JOHN MCMILLAN , UNDERINER TODD LAURENCE
IPC分类号： A61K8/30 , A61K20060101 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/505 , A61K31/77 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , A61Q17/00 , C07C257/14 , C07C257/18 , C07C277/08 , C07C279/18 , C07D233/04 , C07D239/06 , C08G20060101 , C08G65/329 , C08G65/48 , C12N20060101
摘要： The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having the structure: and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L1, L2, L3, L4, Z, X, B1, and B2 are defined herein.

4. 发明专利

CO5080778A1 INHIBIDORES DE ENZIMAS 未知
公开(公告)号：CO5080778A1
公开(公告)日：2001-09-25
申请号：CO99015434
申请日：1999-03-12
申请人： PROCTER & GAMBLE
发明人： MCMILLAN MCIVER JOHN , UNERINER TODD LAURENCE , BATES TIMOTHY
IPC分类号： A61K8/30 , A61K20060101 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/505 , A61K31/74 , A61K31/77 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , A61Q17/00 , C07C257/14 , C07C257/18 , C07C277/08 , C07C279/18 , C07D233/04 , C07D239/06 , C08G20060101 , C08G65/329 , C08G65/48 , C12N20060101
摘要： La presente invención se relaciona con un compuesto que tiene la estructura: Y los tautómeros, sales aceptables y amidas biohidrolizables, ésteres e imidas de los mismos, en donde:a) B1 se selecciona del grupo que consta de hidrógeno, metilo, etilo, propilo, un grupo metileno conectado a B1 y B2 formen un anillo de cinco miembros, y un grupo metileno conectado a B2 a través de un enlace simple de manera que B1 y B2 formen un anillo de cinco miembros, y un grupo metileno conectado a B2 a través de otro grupo metileno tal que B1 y B2 formen un anillo de seis miembros;b) B2 se selecciona del grupo que consta de hidrógeno, metilo, etilo, propilo, un grupo metileno conectado a B1 a través de un enlace simple de manera que B1 y B2 formen un anillo de cinco miembros, y un grupo metileno conectado a B1 a través de otro grupo metileno tal que B1 y B2 formen un anillo de seis miembros;c) X se selecciona del grupo que consta de cero, -CH2 -, y-NH-;d) Z es un anillo carboxílico aromático, o no sustituido, monocíclico o policíclico, o anillo heterocíclico;e) L1, L2 , L3 se seleccionan, cada uno, independientemente del grupo que consta de cero, -NH-, -O-, -S-, -C(O)-, -CF2-, alquilo, alquenilo, cicloalquilo, arilo, arilalquilo, arilalquenilo, -C(O)NH-, -NH-SO2-R1-, -C(O)-R2-, -C(O)R3-O-, -C(O)R4-S-, -C(O)R5-NH-, NH-R6-, -O-R7-, -C(O)O-R8-, C(O)NH-R9-, NHC(O)-R10-, -OC(O)-R11-y-C(O)-CH(R12)-N(R13 )-Y-, en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 y R11 se seleccionan, independientemente del grupo que consta de alquilo, alquenilo, cicloalquilo, arilo, arilalquilo, arilalquenilo, alquilamino, alquilamino protegido, arilamino, arilamino protegido, arilalquilamino, arilalquilamino protegido, en donde R12 se selecciona del grupo que consta de hidrógeno, alquilo, alquenilo, cicloalquilo, arilo arilalquilo, arilalquenilo, alquilamino protegido, arilamino, arilamino protegido, arilalquilamino, arilalquilamino protegido, y -AA en donde -AA es una cadena lateral de aminoácido, y R13 es hidrógeno, o R12 y R13 juntos forman un anillo heterocíclico monocíclico o policíclico que incluye el nitrógeno al cual se enlaza R13 , y en donde Y es cero o -C(O)-CH(R14)-N(R15)-en donde R14 se selecciona del grupo que consta de hidrógeno, alquilo, alquenilo, cicloalquilo, arilo, arilalquenilo, alquilamino, alquilamino protegido, arilamino, arilamino protegido, arilalquilamino, arilalquilamino protegido, y -AA en donde -AA es una cadena lateral de aminoácido, y R15 es hidrógeno, ...

5. 发明专利

SK13652000A3 ENZYME INHIBITORS 未知
公开(公告)号：SK13652000A3
公开(公告)日：2001-04-09
申请号：SK13652000
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： MCIVER JOHN MCMILLAN , UNDERINER TODD LAURENCE , BATES TIMOTHY
IPC分类号： A61K8/30 , A61K20060101 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/505 , A61K31/77 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , A61Q17/00 , C07C257/14 , C07C257/18 , C07C277/08 , C07C279/18 , C07D233/04 , C07D239/06 , C08G20060101 , C08G65/329 , C08G65/48 , C12N20060101
摘要： The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having the structure: and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L1, L2, L3, L4, Z, X, B1, and B2 are defined herein.

6. 发明专利

CZ20003316A3 Compounds and preparations inhibiting enzymes 未知
公开(公告)号：CZ20003316A3
公开(公告)日：2001-03-14
申请号：CZ20003316
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： MCIVER JOHN , UNDERINER TODD LAURENCE , BATES TIMOTHY
IPC分类号： A61K31/155 , A61K31/77 , C07C257/14 , C07C257/18 , C07C279/18 , C08G65/48

7. 发明专利

TR200002602T2 未知
公开(公告)号：TR200002602T2
公开(公告)日：2001-02-21
申请号：TR200002602
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： ROURKE FRANCIS JAMES , OSBORNE SCOTT EDWARD , ROE DONALD CARROLL , UNDERINER TODD LAURENCE , MCIVER JOHN MCMILLAN , BATES TIMOTHY
IPC分类号： A61F13/49 , A61F5/44 , A61F13/15 , A61F13/472 , A61K31/44 , A61K31/606 , A61K36/48 , A61K38/55 , A61K45/00 , A61L15/44 , A61P17/00

8. 发明专利

AU3079799A Protease inhibitors in absorbent articles 未知
公开(公告)号：AU3079799A
公开(公告)日：1999-09-27
申请号：AU3079799
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： ROURKE FRANCIS JAMES , OSBORNE SCOTT EDWARD , ROE DONALD CARROLL , UNDERINER TODD LAURENCE , MCIVER JOHN MCMILLAN , BATES TIMOTHY
IPC分类号： A61F13/49 , A61F5/44 , A61F13/15 , A61F13/472 , A61K31/44 , A61K31/606 , A61K36/48 , A61K38/55 , A61K45/00 , A61L15/44 , A61P17/00

9. 发明专利

CA2322502A1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES 未知
公开(公告)号：CA2322502A1
公开(公告)日：1999-09-16
申请号：CA2322502
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： UNDERINER TODD LAURENCE , MCIVER JOHN MCMILLAN , BATES TIMOTHY , ROE DONALD CARROLL , OSBORNE SCOTT EDWARD , ROURKE FRANCIS JAMES
IPC分类号： A61F13/49 , A61F5/44 , A61F13/15 , A61F13/472 , A61K31/44 , A61K31/606 , A61K36/48 , A61K38/55 , A61K45/00 , A61L15/44 , A61P17/00
摘要： The invention provides an absorbent article, at least a portion of which has a protease inhibitor incorporated therein to decrease the activity of fecal proteases that may otherwise initiate or contribute to inflammation of the skin of a wearer of the article resulting in diaper rash or diaper dermatitis. Preferably the article further comprises a delivery system for releasably containing and delivering the protease inhibitor to at least a portion of the skin of the wearer. More preferably, the delivery system comprises a skin care composition and at least a portion of the composition, including the protease inhibitor, is automatically transferred from the article to the wearer's skin without manual intervention during normal usage of the article to form a defense against fecal proteases at the skin-feces interface. Most preferably, repeated application of similarly treated articles to the wearer's skin provides an available source from which the protease inhibitor continuously transfers onto the skin over time and accumulatesto provide a proactive defense against fecal proteases for the reduction or prevention of diaper dermatitis due to proteolytic enzymes.

10. 发明专利

BR9909248A 未知
公开(公告)号：BR9909248A
公开(公告)日：2001-10-09
申请号：BR9909248
申请日：1999-03-11
申请人： PROCTER & GAMBLE
发明人： MCIVER JOHN MCMILLAN , UNDERINER TODD LAURENCE , BATES TIMOTHY
IPC分类号： A61K8/30 , A61K20060101 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/505 , A61K31/77 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , A61Q17/00 , C07C257/14 , C07C257/18 , C07C277/08 , C07C279/18 , C07D233/04 , C07D239/06 , C08G20060101 , C08G65/329 , C08G65/48 , C12N20060101
摘要： The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having the structure: and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L1, L2, L3, L4, Z, X, B1, and B2 are defined herein.

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