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    • 9. 发明申请
    • VIRAL TREATMENT
    • 病毒治疗
    • WO0057870A3
    • 2001-03-08
    • PCT/US0008419
    • 2000-03-29
    • PROCTER & GAMBLE
    • CAMDEN JAMES BERGERGARDNER JOSEPH HERMANSTANTON DAVID THOMAS
    • C07D471/04A61K9/08A61K9/107A61K9/127A61K9/20A61K9/46A61K31/437A61K38/55A61K47/26A61K47/36A61K47/40A61K47/42A61P31/10A61P31/12A61P31/14A61P31/18A61P31/20A61P31/22A61P43/00
    • A61K31/437
    • A pharmaceutical composition that inhibits or slows the growth of viruses is disclosed. This same composition can be used to treat viral infections, particularly HIV and hepatitis as well as fungal infections of the genus cryptococcus neoformans or curvularai lunata. The composition comprises from about 10 mg to about 6000 mg of a 2-thienyl-imidazolo[4,5]pyridine of formula (I), wherein n is from 1 to 4, R is selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, hydroxy, sulfhydryl, alkoxy having the formula: -O(CH2)yCH3, wherein y is from 1 to 6, the prodrugs thereof, and the pharmaceutically acceptable salts thereof. The preferred anti-viral compound is (a) and its hydrochloride salt. Mixtures of the 2-thienyl-imidazolo[4,5]pyridines with other antiviral agents or potentiators (AZT, 3-TC(lamivudine) or protease inhibitors for example) can also be used to treat viral infections.
    • 公开了抑制或减缓病毒生长的药物组合物。 这种相同的组合物可以用于治疗病毒感染,特别是艾滋病毒和肝炎,以及新隐型隐球菌属或曲霉菌属的真菌感染。 组合物包含约10mg至约6000mg式(I)的2-噻吩基 - 咪唑并[4,5]吡啶,其中n为1至4,R选自氢,具有 1至7个碳原子,氯,溴或氟,氧氯,羟基,巯基,具有下式的-O(CH 2)y CH 3的烷氧基,其中y为1至6,其前药及其药学上可接受的盐。 优选的抗病毒化合物是(a)及其盐酸盐。 2-噻吩基 - 咪唑并[4,5]吡啶与其它抗病毒剂或增效剂(例如AZT,3-TC(拉米夫定)或蛋白酶抑制剂)的混合物也可用于治疗病毒感染。