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1. 发明申请

WO9523780A3 SKIN LIGHTENING COMPOSITIONS 审中-公开
标题翻译：皮肤发光组合物
公开(公告)号：WO9523780A3
公开(公告)日：1995-09-28
申请号：PCT/US9502809
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , DELONG MITCHELL ANTHONY , BRADBURY BARTON JAMES , MOTLEY CURTIS BOBBY , CARTER JOHN DAVID
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , A61K7/48
CPC分类号： A61K8/498 , A61K8/347 , A61K8/368 , A61K8/37 , A61K8/375 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/4973 , A61K8/4986 , A61K8/55 , A61Q17/04 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , Y02P20/582 , Y10S514/938 , C07C43/313
摘要： This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure (I) or (II) wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substituted alkyl, aryl, OR, OCOR, COR, CONRR, COOR, CN, SR, SOR, SO2R, SO3R and NRR, wherein X is other than hydroxy, amino and thio, if this X is attached ortho to the phenol hydroxy; (ii) m is an integer from 0 to 4; (iii) each R' and R'' is, independently, selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, aryl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; wherein halo, when it appears, is other than geminal to a hydroxy, NH2, or SH; (iv) R''' is alkyl or substituted alkyl; wherein when R''' is present, and R' is also hydrogen, R'' is other than hydrogen, hydroxy, halo, thio, cyano and amino; (v) each R is, independently, selected from the group consisting of hydrogen, alkyl, substituted alkyl and aryl; (vi) n is an integer from 1 to about 5, wherein at least one carbon in (C)n has other than alkyl or hydroxy as a substituent and (C)n adjacent to Z has other than amino, SH, CN or hydroxy as R'; (vii) Z is selected from the group consisting of O, NR, S, SO, SO2, PO2R and POR; (viii) wherein any carbon, when disubstituted, having one substituent selected from the group consisting of hydroxy, amino, cyano and thiol, has the other substituent selected from the group consisting of hydrogen, alkyl, and aryl, whether this substituent is R' or R''; and to pharmaceutically acceptable salts of these compounds, stereoisomers and enantiomers thereof free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-acceptable carrier thereof comprising a safe and effective amount of a subject skin lightening active.
摘要翻译：本发明涉及使用具有以下通式结构的活性化合物来减轻皮肤的组合物，化合物和方法：其中每个X是卤素; m为1〜4; 取代或未取代的苯基，取代或未取代的萘基，OR，OCOR，OCRROR，COR，CR（OR）OR，或者其中R'和R“独立地选自氢，卤素，C 1 -C 10烷基，取代的C 1 -C 10烷基， CONRR，COOR，CRROR，CN，SR和NRR; 每个R选自氢，C 1 -C 10烷基，取代的C 1 -C 10烷基，取代或未取代的苯基和取代或未取代的萘基; n为1至5; Z是O; 有效减轻皮肤的量; 和其药学上可接受的载体。

2. 发明专利

MX9603879A COMPOSICIONES ACLARADORAS DE LA PIEL. 未知
公开(公告)号：MX9603879A
公开(公告)日：1997-09-30
申请号：MX9603879
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , BRADBURY BARTON JAMES , CARTER JOHN DAVID , DELONG MITCHELL ANTHONY , MOTLEY CURTIS BOBBY
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , A61K07/48
摘要： Esta invencion se refiere a composiciones, compuestos y métodos para aclarar la piel, utilizando compuestos activos que tienen la estructura (I) o (II): en donde: (i) cada X se selecciona, independientemente, del grupo que consiste de halogeno, alquilo, alquilo substituido, arilo, OR, OCOR, COR, CONRR, COOR, CN, SR, SOR, SO2R, SO3R y NRR, en donde X es diferente de hidroxi, amino y tio, si esta X está unida a orto al fenol hidroxi; (ii) m es un entero de 0 a 4; (iii) cada R y cada R se selecciona, independientemente, del grupo que consiste de hidrogeno, halogeno, alquilo, alquilo substituido, arilo, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR y NRR; en donde halogeno, cuando aparece, es diferente de geminal a hidroxi, NH2, o SH; (iv) R es alquilo o alquilo substituido; en donde cuando R está presente y R también es hidrogeno, R es diferente de hidrogeno, hidroxi, halogeno, tio, ciano y amino; (v) cada R se selecciona, independientemente, del grupo que consiste de hidrogeno, alquilo, alquilo substituido y arilo; (vi) n es un entero de 1 a aproximadamente 5, en donde por lo menos un carbono en (C)n tiene un alquilo o hidroxi diferente, como substituyente y (C)n adyacente a Z tiene uno diferente a amino, SH, CN o hidroxi como R; (vii) Z se selecciona del grupo que consiste de O, NR, S, SO, SO2, PO2RR y POR; (viii) en donde cualquier carbono, cuando esté substituido, teniendo como substituyente uno seleccionado del grupo que consiste de hidroxi, amino, ciano y tiol, tiene el otro substituyente seleccionado del grupo que consiste de hidrogeno, alquilo y arilo, si este substituyente seleccionado del grupo que consiste de hidrogeno, alquilo y arilo, si este substituyente es R o R; y sales farmacéuticamente aceptables de esto compuestos, esteroisomeros y enantiomeros de los mismos, libres de o mezclados con otros enantiomeros o esteroisomeros; y tales compuestos en las composiciones con un vehículo farmacéuticamente aceptables de los mismos comprendiendo una cantidad segura y efectiva de un compuesto activo aclarador de la piel.

3. 发明专利

AU701828B2 Skin lightening compositions 未知
公开(公告)号：AU701828B2
公开(公告)日：1999-02-04
申请号：AU1939995
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , DELONG MITCHELL ANTHONY , BRADBURY BARTON JAMES , MOTLEY CURTIS BOBBY , CARTER JOHN DAVID
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , A61K7/48
摘要： This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure:wherein each X is halo; m is 1 to 4; each R' and R'' is independently selected from hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; each R is selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; n is 1 to 5; Z is O; in an amount effective to lighten skin; and a pharmaceutically-acceptable carrier therefor.

4. 发明专利

AU1939995A Skin lightening compositions 未知
公开(公告)号：AU1939995A
公开(公告)日：1995-09-18
申请号：AU1939995
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , DELONG MITCHELL ANTHONY , BRADBURY BARTON JAMES , MOTLEY CURTIS BOBBY , CARTER JOHN DAVID
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , A61K7/48
摘要： This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure:wherein each X is halo; m is 1 to 4; each R' and R'' is independently selected from hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; each R is selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; n is 1 to 5; Z is O; in an amount effective to lighten skin; and a pharmaceutically-acceptable carrier therefor.

5. 发明专利

ES2164763T3 未知
公开(公告)号：ES2164763T3
公开(公告)日：2002-03-01
申请号：ES95912061
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , DELONG MITCHELL ANTHONY , BRADBURY BARTON JAMES , MOTLEY CURTIS BOBBY , CARTER JOHN DAVID
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , A61K7/48
摘要： This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure:wherein each X is halo; m is 1 to 4; each R' and R'' is independently selected from hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; each R is selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; n is 1 to 5; Z is O; in an amount effective to lighten skin; and a pharmaceutically-acceptable carrier therefor.

6. 发明专利

AT210623T 未知
公开(公告)号：AT210623T
公开(公告)日：2001-12-15
申请号：AT95912061
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , DELONG MITCHELL ANTHONY , BRADBURY BARTON JAMES , MOTLEY CURTIS BOBBY , CARTER JOHN DAVID
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , A61K7/48
摘要： This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure:wherein each X is halo; m is 1 to 4; each R' and R'' is independently selected from hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; each R is selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; n is 1 to 5; Z is O; in an amount effective to lighten skin; and a pharmaceutically-acceptable carrier therefor.

8. 发明专利

CZ257496A3 PREPARATION FOR CLEARING THE SKIN 未知
公开(公告)号：CZ257496A3
公开(公告)日：1997-01-15
申请号：CZ257496
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , DELONG MITCHELL ANTHONY , BRADBURY BARTON JAMES , MOTLEY CURTIS BOBBY , CARTER JOHN DAVID
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , C07D305/08 , A61K7/48
摘要： This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure:wherein each X is halo; m is 1 to 4; each R' and R'' is independently selected from hydrogen, halo, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; each R is selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; n is 1 to 5; Z is O; in an amount effective to lighten skin; and a pharmaceutically-acceptable carrier therefor.

9. 发明专利

CA2184478A1 SKIN LIGHTENING COMPOSITIONS 未知
公开(公告)号：CA2184478A1
公开(公告)日：1995-09-08
申请号：CA2184478
申请日：1995-03-01
申请人： PROCTER & GAMBLE
发明人： KVALNES KALLA LYNN , DELONG MITCHELL ANTHONY , BRADBURY BARTON JAMES , MOTLEY CURTIS BOBBY , CARTER JOHN DAVID
IPC分类号： A61K8/30 , A61K8/00 , A61K8/11 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C41/48 , C07C41/54 , C07C43/315 , C07D307/20 , C07D309/10 , C07D309/12 , C07D333/32 , C07D335/02 , C07D313/04 , C07D305/08 , C07C323/12 , C07D207/12 , C07C69/16 , C07C317/18 , C07D313/18 , C07D211/40 , A61K7/48
摘要： This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure (I) or (II) wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substituted alkyl, aryl, OR, OCOR, COR, CONRR, COOR, CN, SR, SOR, SO2R, SO3R and NRR, wherein X is other than hydroxy, amino and thio, if this X is attached ortho to the phenol hydroxy; (ii) m is an integer from 0 to 4; (iii) each R' and R'' is, independently, selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, aryl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; wherein halo, when it appears, is other than geminal to a hydroxy, NH2, or SH; (iv) R''' is alkyl or substituted alkyl; wherein when R''' is present, and R' is also hydrogen, R'' is other than hydrogen, hydroxy, halo, thio, cyano and amino; (v) each R is, independently, selected from the group consisting of hydrogen, alkyl, substituted alkyl and aryl; (vi) n is an integer from 1 to about 5, wherein at least one carbon in (C)n has other than alkyl or hydroxy as a substituent and (C)n adjacent to Z has other than amino, SH, CN or hydroxy as R'; (vii) Z is selected from the group consisting of O, NR, S, SO, SO2, PO2R and POR; (viii) wherein any carbon, when disubstituted, having one substituent selected from the group consisting of hydroxy, amino, cyano and thiol, has the other substituent selected from the group consisting of hydrogen, alkyl, and aryl, whether this substituent is R' or R''; and to pharmaceutically acceptable salts of these compounds, stereoisomers and enantiomers thereof free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-acceptable carrier thereof comprising a safe and effective amount of a subject skin lightening active.

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