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    • 6. 发明专利
    • STORAGE-STABLE TRANSDERMAL PATCH
    • CA2002298C
    • 1996-02-20
    • CA2002298
    • 1989-11-06
    • PROCTER & GAMBLE
    • BENECKE ARNOLD GEORGEKINNE DANIEL JAMESWNUK ANDREW JULIAN
    • A61F13/02A61K9/70A61M37/00
    • A shelf-stable device for transdermally administering an active pharmaceutical to a patient. The device includes a drug reservoir that contains the drug formulation. In one preferred embodiment of the present invention, the drug reservoir is sandwiched between an upper and a lower solvent barrier film that are made from a material such as a polyester that will not absorb the drug and/or skin permeating enhancing solvent, if any, contained within the reservoir. The drug reservoir and solvent barrier films are encapsulated within a hermetically-sealed compartment that protects the drug formulation from common environmental factors such as water vapor, oxygen, and light which can adversely affect the stability and efficacy of the drug formulation. The hermetically-sealed compartment also prevents the drug formulation from coming into contact with and possibly dissolving the adhesive used to secure the device to the patient's skin. In another particularly preferred embodiment of the present invention, the device's drug reservoir is encapsulated within a hermetically-sealed compartment that is made from solvent/environment barrier films that serve the dual functions of preventing the device's components from absorbing the drug/solvent formulation from the reservoir, and protecting the drug/solvent formulation from common environmental factors.
    • 8. 发明专利
    • IMPROVED TEAR-AWAY CANISTER LID
    • CA2170590C
    • 1999-03-16
    • CA2170590
    • 1994-08-24
    • PROCTER & GAMBLE
    • KINNE DANIEL JAMES
    • B65D17/40B65D43/02B65D43/06B65D43/04B65D55/08
    • The present invention pertains to improved closure arrangements which are durable in construction, yet easy to open and reclose, and which provide an initial hermetic seal with tamper evidency, all utilizing a one-piece lid design. In two embodiments according to the present invention, unique combinations of a mechanical interlocking closure system (17, 26), heat-sealing or bonding (25), and a weakened failure zone (24) are employed in the vicinity of the lid/container juncture to achieve these desirable characteristics. In a third embodiment of the present invention, a mechanical interlocking and sealing arrangement is utilized to achieve hermetic sealing of the container without the need for a heat seal or bonded region, and a weakened failure zone is located just inward of the mechanical interlocking connection. With all embodiments according to the present invention, upon tearing the lid open the lid forms a recloseable plug-fit closure to reclose the container, while the rim of the lid once remains attached to the container in its initial position. The resulting container is extraordinarily simple in construction, rendering it easy and cost effective to produce, yet providing superior performance both in maintaining the initial freshness of the product and in providing ease of consumer operation.