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1. 发明申请

WO2008104580A1 NEW USE OF GLUTAMINYL CYCLASE INHIBITORS 审中-公开
标题翻译：谷氨酰胺环化酶抑制剂的新用途
公开(公告)号：WO2008104580A1
公开(公告)日：2008-09-04
申请号：PCT/EP2008/052411
申请日：2008-02-28
申请人： PROBIODRUG AG , SCHILLING, Stephan , CYNIS, Holger , HOFFMANN, Torsten , DEMUTH, Hans-Ulrich
发明人： SCHILLING, Stephan , CYNIS, Holger , HOFFMANN, Torsten , DEMUTH, Hans-Ulrich
IPC分类号： A61K31/4164 , C07D233/54 , C07D235/06 , C07D403/12 , C07D405/12 , C07D417/12 , A61P25/28
CPC分类号： A61K31/4164 , C07D233/54 , C07D233/61 , C07D235/06 , C07D403/06 , C07D417/12
摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase, and use thereof for the treatment and/or prevention of a disease or disorder selected from the group consisting of inflammatory diseases selected from a. neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, Familial Danish Dementia, multiple sclerosis, b. chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis, c. fibrosis, e.g. lung fibrosis, liver fibrosis, renal fibrosis, d. cancer, e.g. cancer/hemangioendothelioma proliferation, gastric carcinomas, e. metabolic diseases, e.g. hypertension, f. and other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis. Further, the invention relates to a respective diagnostic method, assay and kit.
摘要翻译：本发明一般涉及谷氨酰胺肽环转移酶的抑制剂及其用于治疗和/或预防选自以下的炎性疾病的疾病或病症的用途。神经变性疾病，例如轻度认知障碍（MCI），阿尔茨海默病，唐氏综合征神经变性，家族性英国痴呆，家族性丹麦痴呆，多发性硬化，b。慢性和急性炎症，例如类风湿关节炎，动脉粥样硬化，再狭窄，胰腺炎，c。纤维化，例如肺纤维化，肝纤维化，肾纤维化，d。癌症，例如癌症/血管内皮瘤增生，胃癌，e。代谢疾病，例如高血压，f。和其它炎性疾病，例如神经性疼痛，移植排斥/移植物衰竭/移植物血管病变，HIV感染/艾滋病，睾丸炎，结节性硬化症。此外，本发明涉及相应的诊断方法，测定和试剂盒。

2. 发明申请

WO2013024043A2 IN VIVO SCREENING MODELS FOR TREATMENT OF QC-RELATED DISORDERS 审中-公开
标题翻译：模型体内筛选相关的疾病治疗QC
公开(公告)号：WO2013024043A2
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065724
申请日：2012-08-10
申请人： PROBIODRUG AG , GRAUBNER, Sigrid , JAGLA, Wolfgang , SCHILLING, Stephan , CYNIS, Holger , HOFFMANN, Torsten , WERMANN, Michael , SCHULZ, Katrin , BAEUSCHER, Christoph , KOHLMANN, Stefanie , DEMUTH, Hans-Ulrich
发明人： GRAUBNER, Sigrid , JAGLA, Wolfgang , SCHILLING, Stephan , CYNIS, Holger , HOFFMANN, Torsten , WERMANN, Michael , SCHULZ, Katrin , BAEUSCHER, Christoph , KOHLMANN, Stefanie , DEMUTH, Hans-Ulrich
IPC分类号： C07K14/47 , C12N9/10 , A01K67/027
CPC分类号： A01K67/0278 , A01K2217/052 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0312 , C07K14/4711 , C12N9/104
摘要： The present invention provides a double transgenic non-human animal, in particular a transgenic mouse encoding Qpct proteins, which have been implicated in Qpct-related diseases, and Amyloid Precursor Protein (APP). The present invention additionally provides cells and cell lines comprising transgenes encoding for Qpct and APP. The present invention further provides methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.
摘要翻译：本发明涉及一种双转基因非人动物，特别是编码蛋白质的转基因小鼠QPCT已在与QPCT相关的疾病有牵连，和淀粉样前体蛋白（APP）。本发明还涉及细胞和细胞系，其包含编码QPCT和APP转基因。本发明还涉及一种用于评估影响QPCT对于用于组合物用于治疗与QPCT相关的疾病的治疗剂的方法和组合物。

3. 发明申请

WO2008087197A1 IN VIVO SCREENING MODELS FOR TREATMENT OF ALZHEIMER'S DISEASE AND OTHER QPCT-RELATED DISORDERS 审中-公开
标题翻译：用于治疗阿尔茨海默病和其他与QPCT有关的疾病的生殖器筛查模型
公开(公告)号：WO2008087197A1
公开(公告)日：2008-07-24
申请号：PCT/EP2008/050532
申请日：2008-01-18
申请人： PROBIODRUG AG , SCHILLING, Stephan , CYNIS, Holger , HOFFMANN, Torsten , DEMUTH, Hans-Ulrich , WERMANN, Michael , SCHULZ, Katrin
发明人： SCHILLING, Stephan , CYNIS, Holger , HOFFMANN, Torsten , DEMUTH, Hans-Ulrich , WERMANN, Michael , SCHULZ, Katrin
IPC分类号： C12N15/85
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/052 , A01K2267/0312 , A01K2267/0318 , C12N9/104
摘要： The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding Qpct proteins, which have been implicated in Qpct-related diseases. The present invention additionally provides cells and cell lines comprising transgenes encoding for Qpct. The present invention further provides methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.
摘要翻译：本发明提供了转基因非人动物，特别是编码Qpct蛋白的转基因小鼠，其涉及Qpct相关疾病。本发明另外提供了包含编码Qpct的转基因的细胞和细胞系。本发明还提供了用于评估影响Qpct的药剂的方法和组合物，用于治疗Qpct相关疾病的组合物。

4. 发明申请

WO2010026209A1 Use of isoQC inhibitors 审中-公开
标题翻译：使用isoQC抑制剂
公开(公告)号：WO2010026209A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/061440
申请日：2009-09-04
申请人： PROBIODRUG AG , DEMUTH, Hans-Ulrich , CYNIS, Holger , GANS, Kathrin , HOFFMANN, Torsten , KEHLEN, Astrid , RAHFELD, Jens-Ulrich , SCHILLING, Stephan , HEISER, Ulrich , WERMANN, Michael , FRIEDRICH, Daniel , GAERTNER, Ulf-Torsten , HAMANN, Antje , SOMMER, Robert , ALMSTETTER, Michael , TREML, Andreas , THORMANN, Michael
发明人： DEMUTH, Hans-Ulrich , CYNIS, Holger , GANS, Kathrin , HOFFMANN, Torsten , KEHLEN, Astrid , RAHFELD, Jens-Ulrich , SCHILLING, Stephan , HEISER, Ulrich , WERMANN, Michael , FRIEDRICH, Daniel , GAERTNER, Ulf-Torsten , HAMANN, Antje , SOMMER, Robert , ALMSTETTER, Michael , TREML, Andreas , THORMANN, Michael
IPC分类号： A61K31/4178 , A61K31/4184 , A61K31/433 , A61K31/437 , A61P29/00
CPC分类号： A61K31/4178 , A61K31/4184 , A61K31/433 , A61K31/437 , A61K45/06 , A61K2300/00
摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorderselected from the group consisting of a.chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis, b.other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barr syndrome, chronic inflammatory demyelinising polyradiculoneuropathy and multiple sclerosis, c.neuroinflammation, and d.neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.
摘要翻译：本发明一般涉及谷氨酰胺肽转氨酶样蛋白（QPCTL）的抑制剂及其用于治疗和/或预防由慢性和急性炎症组成的组中选择的炎性疾病或病症的用途，例如类风湿性关节炎，动脉粥样硬化，再狭窄，胰腺炎等。神经性疼痛，移植物排斥反应/移植物衰竭/移植物血管病变，HIV感染/艾滋病，睾丸炎，结节性硬化症，吉兰巴尔综合征，慢性炎症性脱髓鞘性多发性神经病和多发性硬化，神经炎症和神经退行性疾病。轻度认知障碍（MCI），阿尔茨海默氏症，唐氏综合征神经变性，家族性英国痴呆和家族性丹麦痴呆，可能由神经炎症引起。

5. 发明申请

WO2010133620A2 MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE QPCTL-GENE 审中-公开
标题翻译：携带QPCTL基因的锁定突变的小鼠模型
公开(公告)号：WO2010133620A2
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056862
申请日：2010-05-19
申请人： PROBIODRUG AG , SCHILLING, Stephan , GRAUBNER, Sigrid , SEDLMEIER, Reinhard , KOCH, Birgit , CYNIS, Holger , STEPHAN, Anett , DEMUTH, Hans-Ulrich
发明人： SCHILLING, Stephan , GRAUBNER, Sigrid , SEDLMEIER, Reinhard , KOCH, Birgit , CYNIS, Holger , STEPHAN, Anett , DEMUTH, Hans-Ulrich
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/03 , A01K2227/105 , A01K2267/0356 , A01K2267/0368
摘要： The present invention provides a knock- out non-human animal, in particular a mouse carrying a QPCTL knock- out mutation. The present invention additionally provides the respective cells and cell lines and methods and compositions for evaluating agents that affect QPCTL, for use in compositions for the treatment of QPCTL- related diseases.
摘要翻译：本发明提供了敲除非人动物，特别是携带QPCTL敲除突变的小鼠。本发明另外提供各自的细胞和细胞系以及用于评估影响QPCTL的试剂的方法和组合物，用于治疗与QPCTL相关的疾病的组合物。

6. 发明申请

WO2012028706A1 IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS 审中-公开
标题翻译：用于治疗等质量相关疾病的生殖器筛查模型
公开(公告)号：WO2012028706A1
公开(公告)日：2012-03-08
申请号：PCT/EP2011/065173
申请日：2011-09-02
申请人： PROBIODRUG AG , CYNIS, Holger , SCHILLING, Stephan , GRAUBNER, Sigrid , SEDLMEIER, Reinhard , BECKER, Andreas , DEMUTH, Hans-Ulrich
发明人： CYNIS, Holger , SCHILLING, Stephan , GRAUBNER, Sigrid , SEDLMEIER, Reinhard , BECKER, Andreas , DEMUTH, Hans-Ulrich
IPC分类号： C12N9/10 , C12N15/85 , A01K67/027 , G01N33/50
CPC分类号： A01K67/0278 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , C12N9/104 , C12N15/8509 , C12Y203/02005 , G01N33/5088 , G01N2333/9108 , G01N2500/10
摘要： The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding isoQC, which has been implicated in isoQC-related diseases. The present invention additionally provides cells and cell lines comprising transgenes encoding for isoQC. The present invention further provides methods and compositions for evaluating agents that affect isoQC, for use in compositions for the treatment of isoQC-related diseases.
摘要翻译：本发明提供了转基因非人动物，特别是编码isoQC的转基因小鼠，其已经涉及isoQC相关疾病。本发明另外提供了包含编码isoQC的转基因的细胞和细胞系。本发明还提供了用于评估影响isoQC的试剂的方法和组合物，用于治疗等QC相关疾病的组合物。

7. 发明申请

WO2009034158A2 TRANSGENIC MICE 审中-公开
标题翻译：转基因小鼠
公开(公告)号：WO2009034158A2
公开(公告)日：2009-03-19
申请号：PCT/EP2008/062117
申请日：2008-09-12
申请人： PROBIODRUG AG , SCHILLING, Stephan , CYNIS, Holger , DEMUTH, Hans-Ulrich , GRAUBNER, Sigrid , JAGLA, Wolfgang
发明人： SCHILLING, Stephan , CYNIS, Holger , DEMUTH, Hans-Ulrich , GRAUBNER, Sigrid , JAGLA, Wolfgang
IPC分类号： A01K67/027 , C12N15/85 , C07K14/47 , C12N9/10
CPC分类号： C12Y203/02005 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , C07K14/4711 , C07K2319/00 , C12N9/104 , C12N15/8509 , C12N2830/008
摘要： The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding Aβ peptide proteins, which have been implicated in Aβ peptide-related diseases. The present invention additionally provides cells and cell lines comprising transgenes encoding for Aβ peptide. The present invention further provides methods and compositions for evaluating agents that affect Aβ peptide, for use in compositions for the treatment of Aβ peptide-related diseases.
摘要翻译：本发明提供了一种转基因非人动物，特别是编码Aβ肽蛋白的转基因小鼠，其已经涉及Aβ肽相关疾病。本发明另外提供了包含编码Aβ肽的转基因的细胞和细胞系。本发明还提供了用于评估影响Aβ肽的药剂的方法和组合物，用于治疗Aβ肽相关疾病的组合物中。

8. 发明申请

WO2010020669A1 ANTIBODIES DIRECTED AGAINST PYROGLUTAMATE MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1 N1PE) 审中-公开
标题翻译：抗吡虫胺单体化合物蛋白-1（MCP-N1P）的抗体
公开(公告)号：WO2010020669A1
公开(公告)日：2010-02-25
申请号：PCT/EP2009/060757
申请日：2009-08-20
申请人： PROBIODRUG AG , CYNIS, Holger , DEMUTH, Hans-Ulrich , GANS, Kathrin , KAMPFER, Sonja , RAHFELD, Jens-Ulrich , SCHILLING, Stephan
发明人： CYNIS, Holger , DEMUTH, Hans-Ulrich , GANS, Kathrin , KAMPFER, Sonja , RAHFELD, Jens-Ulrich , SCHILLING, Stephan
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , G01N33/6854
摘要： Monoclonal antibodies which bind specifically to the proinflammatory cytokine pyroglutamate MCP-1 (MCP-1 N1pE) are described.
摘要翻译：描述了特异性结合促炎细胞因子焦谷氨酸MCP-1（MCP-1 N1pE）的单克隆抗体。

9. 发明申请

WO2008034891A2 NOVEL GENES RELATED TO GLUTAMINYL CYCLASE 审中-公开
标题翻译：与谷氨酰胺环化酶有关的新基因
公开(公告)号：WO2008034891A2
公开(公告)日：2008-03-27
申请号：PCT/EP2007/060013
申请日：2007-09-21
申请人： PROBIODRUG AG , SCHILLING, Stephan , CYNIS, Holger , RAHFELD, Jens-Ulrich , DEMUTH, Hans-Ulrich
发明人： SCHILLING, Stephan , CYNIS, Holger , RAHFELD, Jens-Ulrich , DEMUTH, Hans-Ulrich
IPC分类号： C12N15/54 , C12N9/10 , A61K31/4164 , C07D233/54 , C07D235/06 , C07D403/12 , C07D405/12 , C07D417/12
CPC分类号： C12N9/104 , C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.
摘要翻译：本发明涉及谷氨酰胺酰环化酶（QC，EC 2.3.2.5）的同工酶的新型谷氨酰胺酰 - 肽环转移酶样蛋白（QPCTL），以及编码这些同工酶的分离的核酸，所有这些都可用于发现新的治疗剂，用于测定环化酶活性，以及测定化合物对这些谷氨酰胺酰基环化酶同工酶的抑制活性。

10. 发明申请

WO2005039548A2 USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES 审中-公开
标题翻译：使用谷氨酰胺和谷氨酸周期的影响
公开(公告)号：WO2005039548A2
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011630
申请日：2004-10-15
申请人： PROBIODRUG AG , SCHILLING, Stephan , HOFFMANN, Torsten , NIESTROJ, André, Johannes , DEMUTH, Hans-Ulrich , HEISER, Ulrich
发明人： SCHILLING, Stephan , HOFFMANN, Torsten , NIESTROJ, André, Johannes , DEMUTH, Hans-Ulrich , HEISER, Ulrich
IPC分类号： A61K31/00
CPC分类号： A61K31/00 , A61K31/13 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K38/06 , A61K38/07 , A61K38/08
摘要： The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of diseases that can be treated by modulation of QC-activity, e.g. diseases selected from the group consisting of duodenal cancer with or w/o Heliobacter pylori infections, colorectal cancer, Zolliger-Ellison syndrome, Familial British Dementia and Familial Danish Dementia.
摘要翻译：本发明提供了哺乳动物谷氨酰胺酰化环化酶（QC，EC 2.3.2.5）的新生理底物，QC的新效应物以及包含这些效应物的这些效应物和药物组合物的用途，用于治疗可以通过调节QC- 活动，例如选自由具有或不具有幽门螺旋杆菌感染的十二指肠癌，结肠直肠癌，佐立格 - 埃利森综合征，家族性英国痴呆和家族性丹麦痴呆组成的组的疾病。

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