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1. 发明申请

WO2010012828A3 GLUTAMINYL CYCLASE AS A DIAGNOSTIC / PROGNOSTIC INDICATOR FOR NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：谷氨酰胺环化酶作为神经退行性疾病的诊断/预测指标
公开(公告)号：WO2010012828A3
公开(公告)日：2010-05-06
申请号：PCT/EP2009059951
申请日：2009-07-31
申请人： PROBIODRUG AG , DEMUTH HANS-ULRICH , SCHILLING STEPHAN , KLEINSCHMIDT MARTIN , RAHFELD JENS-ULRICH , KEHLEN ASTRID , BORNACK MONIQUE
发明人： DEMUTH HANS-ULRICH , SCHILLING STEPHAN , KLEINSCHMIDT MARTIN , RAHFELD JENS-ULRICH , KEHLEN ASTRID , BORNACK MONIQUE
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , C12Q1/48 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/573 , G01N2333/4703 , G01N2333/523 , G01N2333/9108 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： The present invention relates to a method for predicting, diagnosing and prognosticating a neurodegenerative disease, such as Alzheimer's disease (AD), Mild Cognitive Impairment (MCI) and neurodegeneration in Down's syndrome (NDS) using glutaminyl cyclase (QC) as a diagnostic/prognostic indicator. The use of antibodies binding to QC and kits for performing said diagnostic method are also provided.
摘要翻译：本发明涉及使用谷氨酰胺酰基环化酶（QC）作为诊断/预后来预测，诊断和预测诸如阿尔茨海默氏病（AD），轻度认知障碍（MCI）和唐氏综合征（NDS）中的神经变性的神经变性疾病指示符。还提供了使用与QC和试剂盒结合的抗体来执行所述诊断方法。

2. 发明申请

WO2010009987A3 DIAGNOSTIC ANTIBODY ASSAY 审中-公开
标题翻译：诊断抗体测定
公开(公告)号：WO2010009987A3
公开(公告)日：2010-05-20
申请号：PCT/EP2009058803
申请日：2009-07-10
申请人： PROBIODRUG AG , DEMUTH HANS-ULRICH , SCHILLING STEPHAN , KLEINSCHMIDT MARTIN , GANS KATHRIN , REISENAUER-SCHAUPP ANITA , RAHFELD JENS-ULRICH , KAMPFER SONJA
发明人： DEMUTH HANS-ULRICH , SCHILLING STEPHAN , KLEINSCHMIDT MARTIN , GANS KATHRIN , REISENAUER-SCHAUPP ANITA , RAHFELD JENS-ULRICH , KAMPFER SONJA
IPC分类号： A61K39/00 , C07K16/18
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
摘要翻译：本发明涉及用于诊断淀粉样变性，特别是阿尔茨海默病的新型诊断测定法和相关方面。特别地，提供单克隆抗体和抗体测定。

3. 发明申请

WO2011064225A8 NOVEL DIAGNOSTIC METHOD FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE OR MILD COGNITIVE IMPAIRMENT 审中-公开
标题翻译：用于诊断ALZHEIMER的疾病或MILD认知障碍的新型诊断方法
公开(公告)号：WO2011064225A8
公开(公告)日：2012-07-12
申请号：PCT/EP2010068069
申请日：2010-11-24
申请人： PROBIODRUG AG , DEMUTH HANS-ULRICH , GOETTLICH CLAUDIA , KLEINSCHMIDT MARTIN , RAHFELD JENS-ULRICH
发明人： DEMUTH HANS-ULRICH , GOETTLICH CLAUDIA , KLEINSCHMIDT MARTIN , RAHFELD JENS-ULRICH
IPC分类号： C07K14/47 , G01N33/68
CPC分类号： G01N33/6896 , C07K14/4711 , G01N2800/2821
摘要： The invention relates to the detection and diagnosis of Alzheimer's disease with the use of the oligomeric state of fragments of amyloid ß as a biomarker and further concerns a novel method to determine the oligomeric state of fragments of amyloid ß in biological samples.
摘要翻译：本发明涉及使用淀粉样β的片段的寡聚状态作为生物标志物来检测和诊断阿尔茨海默氏病，并且还涉及确定生物样品中淀粉样蛋白β片段的寡聚状态的新方法。

4. 发明公开

KR20180030653A 항-피로글루타메이트화된 아밀로이드 베타 인간화 항체 审中-公开
标题翻译：抗焦谷氨酸化淀粉样蛋白β人源化抗体
公开(公告)号：KR20180030653A
公开(公告)日：2018-03-23
申请号：KR20187004514
申请日：2016-07-15
申请人： PROBIODRUG AG
发明人： KLEINSCHMIDT MARTIN , RAHFELD JENS ULRICH , PIECHOTTA ANKE , SCHILLING STEPHAN , GILLIES STEVEN
IPC分类号： C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： 본발명은피로글루타메이트화된아밀로이드베타펩타이드 (Aβ N3pE)의 N-말단에서의에피토프에결합하는인간화항체, 및아밀로이드펩타이드의축적및 부착과관련된질환및 병태, 예를들어아밀로이드증, 일군의피로글루타메이트화된아밀로이드펩타이드와관련된장애및 이상, 예를들어, 알츠하이머병, 다운증후군, 뇌아밀로이드혈관병증및 기타관련양상의예방적및 치료적처리에관한것이다. 보다구체적으로, 본발명은뇌 및주변부의다양한조직에서 Aβ N3pE의축적을방지하거나부착을역전시키고아밀로이드증을완화시키기위해, 혈장, 뇌및 뇌척수액중의피로글루타메이트화된아밀로이드베타펩타이드를결합시키는인간화단일클론항체의용도에관한것이다. 본발명은, 또한본 발명의인간화항체를사용하는아밀로이드증의진단을위한진단적분석에관한것이다.
摘要翻译：本发明提供了β淀粉样蛋白肽的血谷氨酸化学（Aβ的N3pE）N-的淀粉样变性的疾病和病症，例如，与累积和人源化抗体的粘附性，和淀粉样蛋白肽，其结合所述表位eseoui终端，一组血液谷氨酸化学失败和多个相关的淀粉样肽，例如，涉及阿尔茨海默氏病，唐氏综合症，脑预防剂和淀粉样血管病和其它相关方面的治疗性治疗。更具体地，本发明提供了一种人源化单克隆防止Aβ的N3pE在脑和外周的各种组织中的积累，或扭转的粘附性和缓解性淀粉样变性，结合血浆，脑和血液谷氨酸，星期二在CSF中的β-淀粉样肽使用抗体。本发明还涉及使用本发明的人源化抗体诊断淀粉样变性的诊断测定。

5. 发明申请

WO2017009459A3 ANTI-PYROGLUTAMATED AMYLOID BETA HUMANIZED ANTIBODIES 审中-公开
标题翻译：抗人胰岛素抗体人类抗体
公开(公告)号：WO2017009459A3
公开(公告)日：2017-03-16
申请号：PCT/EP2016066924
申请日：2016-07-15
申请人： PROBIODRUG AG
发明人： KLEINSCHMIDT MARTIN , RAHFLED JENS-ULRICH , PIECHOTTA ANKE , SCHILLING STEPHAN , GILLIES STEVEN
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to humanized antibodies that bind to an epitope at the N-terminus of pyroglutamated amyloid beta (Αβ N3pE) peptide and to preventive and therapeutic treatment of diseases and conditions that are related to accumulation and deposition of amyloid peptides, such as amyloidosis, a group of disorders and abnormalities associated with pyroglutamated amyloid peptide, like Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy and other related aspects. More specifically, it pertains to the use of humanized monoclonal antibodies to bind pyroglutamated amyloid beta peptide in plasma, brain, and cerebrospinal fluid to prevent accumulation or to reverse deposition of Αβ N3pE within the brain and in various tissues in the periphery, and to alleviate amyloidosis. The present invention further pertains to diagnostic assays for the diagnosis of amyloidosis using the humanized antibodies of the invention.
摘要翻译：本发明涉及结合焦谷氨酸淀粉样蛋白β（ΑβN3pE）肽的N-末端的表位的人源化抗体以及与淀粉状蛋白肽的积聚和沉积相关的疾病和病症的预防和治疗性治疗，例如淀粉样变性，与焦谷氨酰胺淀粉样肽相关的一组疾病和异常，如阿尔茨海默病，唐氏综合症，脑淀粉样血管病等相关方面。更具体地说，它涉及使用人源化单克隆抗体结合血浆，脑和脑脊液中的焦谷氨酰化淀粉样蛋白β肽，以防止Aβ和N3pE沉积在脑内和周围各种组织中的沉积，并减轻淀粉样变性。本发明还涉及使用本发明的人源化抗体诊断淀粉样变性的诊断测定法。

6. 发明专利

CA2731044C DIAGNOSTIC ANTIBODY ASSAY 未知
公开(公告)号：CA2731044C
公开(公告)日：2020-07-14
申请号：CA2731044
申请日：2009-07-10
申请人： PROBIODRUG AG
发明人： DEMUTH HANS-ULRICH , SCHILLING STEPHAN , KLEINSCHMIDT MARTIN , GANS KATHRIN , REISENAUER-SCHAUPP ANITA , RAHFELD JENS-ULRICH , KAMPFER SONJA
IPC分类号： A61K39/00 , C07K16/18
摘要： The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.

7. 发明专利

EA025107B1 СПОСОБ ДИАГНОСТИРОВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА, НЕЙРОДЕГЕНЕРАЦИИ ПРИ СИНДРОМЕ ДАУНА ИЛИ ЛЕГКОГО КОГНИТИВНОГО НАРУШЕНИЯ У СУБЪЕКТА (ВАРИАНТЫ) И НАБОР ДЛЯ ОСУЩЕСТВЛЕНИЯ СПОСОБА 未知
公开(公告)号：EA025107B1
公开(公告)日：2016-11-30
申请号：EA201100253
申请日：2009-07-31
申请人： PROBIODRUG AG
发明人： DEMUTH HANS-ULRICH , SCHILLING STEPHAN , KLEINSCHMIDT MARTIN , RAHFELD JENS-ULRICH , KEHLEN ASTRID , BORNACK MONIQUE
IPC分类号： G01N33/68
摘要： Приведеноописаниеспособовдиагностированиянейродегенеративногозаболевания, такогокакболезньАльцгеймера, легкоекогнитивноенарушениеи нейродегенерацияприсиндромеДауна, сиспользованиемглутаминилциклазыв качестведиагностического/прогностическогоиндикатора. Крометого, описаннабордляосуществленияэтихдиагностическихспособов.

8. 发明专利

BRPI0916601A2 método e kit de diagnóstico de uma doença neurodegenerativa, e uso de um anticorpo que se liga a glutaminil ciclase (qc) ou uma isoforma da mesma 未知
公开(公告)号：BRPI0916601A2
公开(公告)日：2015-11-10
申请号：BRPI0916601
申请日：2009-07-31
申请人： PROBIODRUG AG
发明人： KEHLEN ASTRID , DEMUTH HANS-ULRICH , RAHFELD JENS-ULRICH , KLEINSCHMIDT MARTIN , BORNACK MONIQUE , SCHILLING STEPHAN
IPC分类号： G01N33/68

9. 发明专利

SG10201405802UA NOVEL ASSAY FOR THE DETECTION OF AMYLOID BETA PEPTIDES 未知
公开(公告)号：SG10201405802UA
公开(公告)日：2014-11-27
申请号：SG10201405802U
申请日：2010-09-17
申请人： PROBIODRUG AG
发明人： KLEINSCHMIDT MARTIN , GOETTLICH CLAUDIA , DEMUTH HANS-ULRICH
摘要： A novel method for detection of A&bgr; peptides, in particular in plasma, and to the use of A&bgr; peptides for diagnosis of Alzheimer's disease.

10. 发明专利

SG193148A1 GLUTAMINYL CYCLASE AS A DIAGNOSTIC / PROGNOSTIC INDICATOR FOR NEURODEGENERATIVE DISEASES 未知
公开(公告)号：SG193148A1
公开(公告)日：2013-09-30
申请号：SG2013056478
申请日：2009-07-31
申请人： PROBIODRUG AG
发明人： DEMUTH HANS-ULRICH , SCHILLING STEPHAN , KLEINSCHMIDT MARTIN , RAHFELD JENS-ULRICH , KEHLEN ASTRID , BORNACK MONIQUE
摘要： GLUTAMINYL CYCLASE AS A DIAGNOSTIC / PROGNOSTIC INDICATOR FOR NEURODEGENERATIVE DISEASESThe present invention relates to a method for predicting, diagnosing and prognosticating a neurodegenerative disease, such as Alzheimer's disease (AD), Mild Cognitive Impairment (MCI) and neurodegeneration in Down's syndrome (NDS) using glutaminyl cyclase (QC) as a diagnostic/prognostic indicator. The use of antibodies binding to QC and kits for performing said diagnostic method are also provided.No Figure.

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