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1. 发明申请

WO2011133670A2 BIOMEDICAL AND CHEMICAL SENSING WITH NANOBEAM PHOTONIC CRYSTAL CAVITIES USING OPTICAL BISTABILITY 审中-公开
标题翻译：使用光学稳定性的纳米级光子晶体生物医学和化学传感
公开(公告)号：WO2011133670A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033251
申请日：2011-04-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , QUAN, Qimin , VOLLMER, Frank , LONCAR, Marko
发明人： QUAN, Qimin , VOLLMER, Frank , LONCAR, Marko
IPC分类号： G01N33/483 , B82B3/00 , G01N21/27
CPC分类号： G01N21/63 , G01N21/77 , G01N2021/7789
摘要： A miniature optical biosensor and biosensor array where high sensitivity for detection of biomolecular interaction does not require a fluorescent label. Non-linear frequency- shifts of optical resonators ('nanobeams') provide a digital all-or-nothing response to equilibrium binding of a biomarker to surface-immobilized bio-recognition elements, a signal suitable to identify active components in genetic and proteomic circuits, as well as toxic substances. The threshold level for the digital response is adjustable to accommodate for varying receptor affinities. A bistable cavity sensing (BCS) method can be used to track the shift of the resonance induced by the analyte more precisely than the conventional cavity sensing method, where the resolution is limited by the cavity linewidth. BCS method can be used to quantitate the concentration of the analyte, and their binding kinetics, affinities and etc.
摘要翻译：用于检测生物分子相互作用的高灵敏度的微型光学生物传感器和生物传感器阵列不需要荧光标记。光学谐振器（“nanobeams”）的非线性频移为生物标志物与表面固定的生物识别元件的平衡结合提供了数字全无反应，适合于鉴定遗传和蛋白质组学电路中的有效成分的信号，以及有毒物质。数字响应的阈值水平是可调节的，以适应不同的受体亲和力。可以使用双稳态腔感测（BCS）方法跟传统腔感测方法更精确地跟踪由分析物引起的共振的偏移，其中分辨率受空腔线宽的限制。 BCS法可用于定量分析物的浓度及其结合动力学，亲和力等。

2. 发明申请

WO2007134177A2 METHODS, MATERIALS AND DEVICES FOR LIGHT MANIPULATION WITH ORIENTED MOLECULAR ASSEMBLIES IN MICRONSCALE PHOTONIC CIRCUIT ELEMENTS WITH HIGH-Q OR SLOW LIGHT 审中-公开
标题翻译：用于在具有高Q或慢光的微型光电元件中用于具有定向分子组装的光学操作的方法，材料和装置
公开(公告)号：WO2007134177A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068683
申请日：2007-05-10
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VOLLMER, Frank , TOPOLANCIK, Juraj
发明人： VOLLMER, Frank , TOPOLANCIK, Juraj
IPC分类号： B31D1/02
CPC分类号： G02B6/1225 , G02F1/0126 , G02F1/3511 , G02F2202/32 , G02F2203/15
摘要： An optical device that comprises an input waveguide, an output waveguide, a high-Q resonant or photonic structure that generate slow light connected to the input waveguide and the output waveguide, and an interface, surface or mode volume modified with at least one material formed from a single molecule, an ordered aggregate of molecules or nanostructures. The optical device may include more than one input waveguide, output waveguide, high-Q resonant or photonic structure and interface, surface or mode volume. The high-Q resonant or photonic structure may comprise at least one selected from the group of: microspherical cavities, microtoroidal cavities, microring-cavities, photonic crystal defect cavities, fabry-perot cavities, photonic crystal waveguides. The ordered aggregate of molecules or nanostructures comprises at least one selected from the group of: organic or biological monolayers, biological complexes, cell membranes, bacterial membranes, virus assemblies, nanowire or nanotube assemblies, quantum-dot assemblies, one or more assemblies containing one ore more rhodopsins, green fluorescence proteins, diarylethers, lipid bilayers, chloroplasts or components, mitochondria or components, cellular or bacterial organelles or components, bacterial S-layers, photochromic molecules. Further, the molecular aggregate may exhibit a photoinduced response.
摘要翻译：一种包括输入波导，输出波导，产生连接到输入波导和输出波导的慢光的高Q谐振或光子结构的光学装置，以及形成有至少一种材料的界面，表面或模式体积来自单个分子，分子或纳米结构的有序聚集体。光学器件可以包括多于一个的输入波导，输出波导，高Q谐振或光子结构以及界面，表面或模式体积。高Q谐振或光子结构可以包括选自以下的组中的至少一个：微球腔，微孔腔，微环腔，光子晶体缺陷腔，fabry-perot腔，光子晶体波导。分子或纳米结构的有序聚集体包括选自以下组中的至少一种：有机或生物单层，生物复合物，细胞膜，细菌膜，病毒组件，纳米线或纳米管组件，量子点组件，一个或多个包含一个更多的视紫红质，绿色荧光蛋白，二芳基醚，脂质双层，叶绿体或组分，线粒体或组分，细胞或细菌细胞器或组分，细菌S层，光致变色分子。此外，分子聚集体可以表现出光诱导的反应。

3. 发明申请

WO2008151224A1 SYSTEM AND METHOD FOR STRONG PHOTON LOCALIZATION BY DISORDERED PHOTONIC CRYSTAL STRUCTURES (QUASICRYSTALS) 审中-公开
标题翻译：通过异常光子晶体结构（QUASICRYSTALS）的强光子定位的系统和方法
公开(公告)号：WO2008151224A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065745
申请日：2008-06-04
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , TOPOLANCIK, juraj , VOLLMER, Frank
发明人： TOPOLANCIK, juraj , VOLLMER, Frank
IPC分类号： G01B9/02
CPC分类号： G02B6/305 , G01N21/774 , G01N21/7743 , G02B6/1225 , G02B2006/12164
摘要： Periodic high-index-contrast photonic crystal (PhC) structures such as two- dimensional arrays of air holes in dielectric slabs inhibit light propagation in bands of frequencies and confine light in dislocations where the lattice periodicity is broken. The present invention is a conceptually different approach to photon localization in PhC structures. The disclosed design concept introduces structural perturbations uniformly throughout the fabricated crystal by deliberately changing the shape or orientations of elements that form the lattice. Optimized introduction of such random structural perturbations produces optical nanocavities with ultra-small modal volumes and high quality (Q) factors of over 250,000. Applications of such disordered photonic crystal structures are disclosed for optical sensing systems and random nano-lasers.
摘要翻译：定期的高折射率对比光子晶体（PhC）结构如电介质平板中的空气孔的二维阵列抑制频率带中的光传播，并将光限制在晶格周期性破坏的位错中。本发明是在PhC结构中的光子定位的概念上不同的方法。所公开的设计概念通过有意地改变形成晶格的元件的形状或方向，在整个制造的晶体中均匀地引入结构扰动。这种随机结构扰动的优化引入产生具有超小型模量和超过25万的高质量（Q）因子的光学纳米结构。公开了这种无序光子晶体结构的应用，用于光学传感系统和随机纳米激光器。

4. 发明申请

WO2008034118A2 METHODS AND DEVICES FOR MEASUREMENTS USING PUMP-PROBE SPECTROSCOPY IN HIGH-Q MICROCAVITIES 审中-公开
标题翻译：使用PUMP-PROBE光谱测量在高Q微观尺度下的测量方法和设备
公开(公告)号：WO2008034118A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078586
申请日：2007-09-15
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VOLLMER, Frank , TOPOLANCIK, Juraj
发明人： VOLLMER, Frank , TOPOLANCIK, Juraj
IPC分类号： C12M3/00
CPC分类号： G01N21/77 , G01N2021/7789 , G02B6/29343
摘要： The use of optical micro cavities, high-Q resonators and slow-light structures as tools for detecting molecules and probing conformations and measuring polarizability and anisotropy of molecules and molecular assemblies using a pump-probe approach is described. Resonances are excited simultaneously or sequentially with pump and probe beams coupled to the same microcavity, so that a pump beam wavelength can be chosen to interact with molecules adsorbed to the microcavity surface, whereas a probe beam wavelength can be chosen to non-invasively measure pump-induced perturbations. The induced perturbations are manifest due to changes of resonance conditions and measured from changes in transfer characteristics or from changes of the scattering spectra of a micocavity-waveguide system. The perturbations induced by the pump beam may be due to polarizability changes, changes in molecular conformation, breakage or formation of chemical bonds, triggering of excited states, and formation of new chemical species. Furthermore, heat may be generated due to absorption of the pump beam. Furthermore, the use resonant modes with different states of polarization allows for measurements of polarizability and its anisotropy in samples interacting with the optical device.
摘要翻译：描述了使用光学微腔，高Q谐振器和慢光结构作为用于检测分子和探测构型的工具，并使用泵 - 探针方法测量分子和分子组件的极化率和各向异性。同时或顺序地激发谐振与耦合到相同微腔的泵浦和探针光束，使得可以选择泵浦波长以与吸附到微腔表面的分子相互作用，而可以选择探测波束波长以非侵入性地测量泵引起的扰动。由于谐振条件的变化以及由传导特性的变化或由微腔波导系统的散射光谱的变化所测量，引起的扰动是显而易见的。泵浦光束引起的扰动可能是由于极化率变化，分子构象变化，化学键断裂或形成，触发激发态以及形成新的化学物质。此外，由于泵浦光束的吸收，可能产生热量。此外，具有不同偏振态的使用谐振模式允许测量与光学器件相互作用的样品中的极化率及其各向异性。

5. 发明申请

WO2011091037A2 RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD 审中-公开
标题翻译：快速病原体诊断装置和方法
公开(公告)号：WO2011091037A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/021718
申请日：2011-01-19
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , YUNG, Chong Wing , INGBER, Donald E. , COOPER, Ryan Mcomber , VOLLMER, Frank , DOMANSKY, Karel , LESLIE, Daniel Christopher , SUPER, Michael
发明人： YUNG, Chong Wing , INGBER, Donald E. , COOPER, Ryan Mcomber , VOLLMER, Frank , DOMANSKY, Karel , LESLIE, Daniel Christopher , SUPER, Michael
IPC分类号： G01N35/08 , G01N33/48 , G01N33/52 , G01N33/58 , G01N1/38
CPC分类号： C12Q1/04 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2400/043 , G01N33/54306 , G01N33/54333 , G01N33/54366 , G01N35/0098
摘要： A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or elecrto-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples.
摘要翻译：诊断和检测系统的微流体装置包括通过一个或多个微通道连接到出口端口的入口端口，并且包括连接到至少一个微通道的捕获和可视化腔室（CVC）。待分析的流体可以与具有亲和力的磁性微珠混合，以与目标组分（例如流体中的病原体）结合。包括磁性结合的目标组分的流体可以通过微流体装置注入。诸如由永久磁体或电磁体提供的磁场梯度可以施加到流体和流过微流体装置的磁性结合的目标组分，以使磁性结合的目标组分迁移到（CVC）中并与流体。可以使用各种技术来分析和测试磁性结合的目标组分，以检测特定有机和无机材料（例如生物流体中的病原体和液体食物源（例如水）中的污染）的存在。该装置和方法提供了用于快速检测相对较小的流体样品中的病原体和污染物的系统。

6. 发明申请

WO2006108096A2 METHOD AND APPARATUS FOR MEASURING AND MONITORING DISTANCES, PHYSICAL PROPERTIES, AND PHASE CHANGES OF LIGHT REFLECTED FROM A SURFACE BASED ON A RING-RESONATOR 审中-公开
标题翻译：用于测量和监测基于环形谐振器的表面反射的光的距离，物理特性和相位变化的方法和装置
公开(公告)号：WO2006108096A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/012805
申请日：2006-04-06
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VOLLMER, Frank , FISCHER, Peer
发明人： VOLLMER, Frank , FISCHER, Peer
IPC分类号： G01B9/02
CPC分类号： G01N21/553 , G01N21/05 , G01N21/23 , G01N21/39 , G01N21/45 , G01N21/7746 , G01N2021/0346 , G01N2021/432 , G01N2021/7789 , G02B2006/1213
摘要： A method and apparatus for performing refractive index, birefringence and optical activity measurements of a material such as a solid, liquid, gas or thin film is disclosed. The method and apparatus can also be used to measure the properties of a reflecting surface. The disclosed apparatus has an optical ring-resonator in the form of a fiber-loop resonator, or a race-track resonator, or any waveguide-ring or other structure with a closed optical path that constitutes a cavity. A sample is introduced into the optical path of the resonator such that the light in the resonator is transmitted through the sample and relative and/or absolute shifts of the resonance frequencies or changes of the characteristics of the transmission spectrum are observed. A change in the transfer characteristics of the resonant ring, such as a shift of the resonance frequency, is related to a sample's refractive index (refractive indices) and/or change thereof. In the case of birefringence measurements, rings that have modes with two (quasi)-orthogonal (linear or circular) polarization states are used to observe the relative shifts of the resonance frequencies. A reflecting surface may be introduced in a ring resonator. The reflecting surface can be raster-scanned for the purpose of height-profiling surface features. A surface plasmon resonance may be excited and phase changes of resonant light due to binding of analytes to the reflecting surface can be determined in the frequency domain.
摘要翻译：公开了一种用于对诸如固体，液体，气体或薄膜的材料进行折射率，双折射和光学活性测量的方法和装置。该方法和装置也可用于测量反射表面的性质。所公开的装置具有光纤环路谐振器或赛道轨道谐振器形式的光环形谐振器，或具有构成空腔的闭合光路的任何波导环或其它结构。将样品引入谐振器的光路中，使得谐振器中的光透射通过样品，并且观察到谐振频率的相对和/或绝对偏移或透射光谱的特性的变化。谐振环的传递特性的变化，例如共振频率的偏移，与样品的折射率（折射率）和/或其变化有关。在双折射测量的情况下，使用具有两个（准） - 正交（线性或圆形）偏振态的模式的环观察共振频率的相对移动。可以在环形谐振器中引入反射表面。为了高度分布表面特征的目的，可以对反射表面进行光栅扫描。可以激发表面等离子体共振，并且可以在频域中确定由于分析物与反射表面的结合而引起的共振光的相变。

7. 发明申请

WO2015042025A1 CENTRIFUGAL FORCE QUARTZ CRYSTAL MICROBALANCE 审中-公开
标题翻译：离心力晶体晶体微结构
公开(公告)号：WO2015042025A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/055806
申请日：2014-09-16
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： WEBSTER, Aaron , VOLLMER, Frank , SATO, Yuki
IPC分类号： G01N33/48 , G01N11/14 , H03H9/19
CPC分类号： G01N5/00 , G01N2011/0026 , G01N2203/0094
摘要： A system and method include applying a sample to a sensing surface, causing the sensing surface to oscillate, applying force normal t the sensing surface, and measuring oscillation of the sensing surface while applying the force. The system includes a sensing platform having a sensing surface configured to couple with a sample and oscillate in a shear mode.
摘要翻译：系统和方法包括将样品施加到感测表面，使感测表面振荡，施加力垂直于感测表面，并在施加力时测量感测表面的振动。该系统包括感测平台，其具有被配置为与样品耦合并且以剪切模式振荡的感测表面。

8. 发明公开

EP2526427A2 RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD 审中-公开
标题翻译：装置和方法病原体进行快速诊断
公开(公告)号：EP2526427A2
公开(公告)日：2012-11-28
申请号：EP11735111.4
申请日：2011-01-19
申请人： President and Fellows of Harvard College
发明人： YUNG, Chong Wing , INGBER, Donald E. , COOPER, Ryan Mcomber , VOLLMER, Frank , DOMANSKY, Karel , LESLIE, Daniel Christopher , SUPER, Michael
IPC分类号： G01N35/08 , G01N33/48 , G01N33/52 , G01N33/58 , G01N1/38
CPC分类号： C12Q1/04 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2400/043 , G01N33/54306 , G01N33/54333 , G01N33/54366 , G01N35/0098
摘要： A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or electro-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples.

9. 发明申请

WO2012146352A1 ANTRIEBSVORRICHTUNG FÜR EIN FRONT-, HECK- ODER ALLRADGETRIEBENES KRAFTFAHRZEUG 审中-公开
标题翻译：驱动装置的前置，后轮上或者驱动的机动车辆
公开(公告)号：WO2012146352A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/001643
申请日：2012-04-16
申请人： AUDI AG , MÄRKL, Johann , VOLLMER, Frank
发明人： MÄRKL, Johann , VOLLMER, Frank
IPC分类号： B60K5/02 , B60K17/16
CPC分类号： B60K17/165 , B60K5/02 , F16H2200/0008 , F16H2200/0013 , F16H2200/0017
摘要： Die Erfindung betrifft eine Antriebsvorrichtung für ein front-, heck- oder allradgetriebenes Kraftfahrzeug, mit einem in Fahrlängsrichtung angeordneten Antriebsaggregat, das über eine Kraftabgabewelle und eine nachgeschaltete Drehmomentübertragungseinrichtung auf die Eingangswelle eines Geschwindigkeits-Wechselgetriebes abtreibt und bei dem einerseits der Kraftabgabewelle bzw. Getriebeeingangswelle ein Achsdifferenzial angeordnet ist, dessen Eingangselement über die Abtriebswelle des Wechselgetriebes angetrieben ist und dessen in Querrichtung verlaufende Abtriebs-Halbwellen als Abtriebselemente über Gelenkwellen trieblich mit den angetriebenen Rädern des Kraftfahrzeuges verbunden sind, wobei die eine Halbwelle die Drehmomentübertragungseinrichtung unterhalb dessen Drehachse kreuzt. Eine baulich und räumlich günstige Antriebsvorrichtung mit torque vectoring Funktion wird dadurch erzielt, dass dem Achsdifferenzial (24; 24') seitlich gegenüberliegend ein Überlagerungsgetriebe (30) mit einem Zusatzantrieb (32) zur veränderlichen Drehmomentverteilung auf die Räder angeordnet ist und dass zumindest das eine Ausgangselement (62, 34; 48; 78) des Überlagerungsgetriebes (30) die Drehmomentübertragungseinrichtung (14) ebenfalls kreuzend mit dem gegenüberliegenden Abtriebselement (28) des Achsdifferenziales (24; 24') trieblich verbunden ist.
摘要翻译：本发明涉及一种用于前一个驱动装置，后部或具有设置在所述驱动单元，其经由动力输出轴和上的变化速变速箱的输入轴的下游扭矩传递装置，并且其中，一方面，所述动力输出轴或变速器输入轴车桥差速器驱除的前后驱动方向的四轮驱动机动车布置，所述输入构件被所述齿轮箱的输出轴和其在横向方向上驱动输出半轴被连接为经由铰链轴输出元件驱动到机动车辆，其中，所述一个半波越过旋转轴线下方的转矩传递装置的从动车轮行驶驱动。在结构上和有利的驱动用扭矩矢量功能装置是实现在车桥差速器;上侧（24 24”），其具有用于改变扭矩分配到车轮的辅助驱动器（32），和一个叠加齿轮（30）相对的在其至少一个输出元件叠加传动装置（30）的扭矩传递装置（14）还渡Achsdifferenziales的相对输出构件（28）的（78 62，34; 48）（24; 24“）被驱动地连接。

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