专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008151289A1 MODULATING AIRWAY INFLAMMATION 审中-公开
标题翻译：调节空中交通工具
公开(公告)号：WO2008151289A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065951
申请日：2008-06-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MCKEON, Frank , MOU, Hongmei , YANG, Annie
发明人： MCKEON, Frank , MOU, Hongmei , YANG, Annie
IPC分类号： C12N5/00 , C12N5/02 , C40B30/06
CPC分类号： A61K48/005 , A61K38/55
摘要： Increasing the p73/DCP1β pathway activity in airway cells of the subject can be used in a method of inhibiting airway inflammation in a subject. The p73/DCP1β pathway activity can be increased in a variety of ways, such as reducing p73 degradation, increasing p73 levels or activity, and increasing DCP1β activity.
摘要翻译：在受试者的气道细胞中增加p73 /DCP1β途径活性可用于抑制受试者气道炎症的方法。可以以各种方式增加p73 /DCP1β途径活性，例如降低p73降解，增加p73水平或活性，以及增加DCP1β活性。

2. 发明申请

WO2002086450A2 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF PROTEIN INTERACTIONS IN VERTEBRATE CELLS 审中-公开
标题翻译：用于鉴定VERTEBRATE细胞中蛋白质相互作用的组合物和方法
公开(公告)号：WO2002086450A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/013008
申请日：2002-04-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MCKEON, Frank , YANG, Annie
发明人： MCKEON, Frank , YANG, Annie
IPC分类号： G01N
CPC分类号： G01N33/5035 , G01N33/5008 , G01N33/5041 , G01N33/5076 , G01N33/542 , G01N33/6803 , G01N2500/02
摘要： The present invention relates to a two-hybrid system for studying protein-protein interactions in mammalian host cells. The invention provides methods, reagents and kits for carrying out the two-hybrid screen. Accordingly the invention provides a bait construct that is capable of targeting a bait protein to a specific subcellular locale within the host cell. The invention also provides a prey construct that contains a detection sequence fused to a prey protein. The bait and prey constructs are introduced into a host cell under conditions that promote expression of the bait and prey constructs. A positive bait/prey interaction can be detected by comparing the subcellular localization of the prey construct in relation to the bait construct. The invention also provides methods for screening for compounds capable of disrupting protein-protein interaction and methods for detecting interactions between proteins and small molecule compounds.
摘要翻译：本发明涉及用于研究哺乳动物宿主细胞中的蛋白质 - 蛋白质相互作用的双杂交系统。本发明提供用于进行双杂交筛选的方法，试剂和试剂盒。因此，本发明提供了能够将诱饵蛋白靶向宿主细胞内的特定亚细胞区域的诱饵构建体。本发明还提供了含有与猎物蛋白融合的检测序列的猎物构建体。诱饵和猎物构建体在促进诱饵和猎物构建体的条件下被引入宿主细胞。通过比较猎物构建体相对于诱饵构建体的亚细胞定位，可以检测到正的诱饵/猎物相互作用。本发明还提供了筛选能够破坏蛋白质 - 蛋白质相互作用的化合物的方法以及检测蛋白质与小分子化合物之间相互作用的方法。

3. 发明申请

WO2012044992A9 METHODS AND REAGENTS FOR DETECTION AND TREATMENT OF ESOPHAGEAL METAPLASIA 审中-公开
公开(公告)号：WO2012044992A9
公开(公告)日：2012-04-05
申请号：PCT/US2011/054323
申请日：2011-09-30
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) , MULTICLONAL THERAPEUTICS, INC , BRIGHAM AND WOMEN'S HOSPITAL , NATIONAL UNIVERSITY OF SINGAPORE , HARVARD UNIVERSITY , XIAN, Wa , MCKEON, Frank , VINCENT, Matthew , CRUM, Christopher , HO, Khek, Yu
发明人： XIAN, Wa , MCKEON, Frank , VINCENT, Matthew , CRUM, Christopher , HO, Khek, Yu
IPC分类号： G01N33/50 , G01N33/574 , C12N5/09
摘要： The invention described herein relates to the treatment, detection, and diagnosis of various cancers, including esophageal or gastric adenocarcinoma and related metaplasias. The invention also includes a clonal population of Barrett's esophagus progenitor cells and methods of using them for the treatment, detection, and diagnosis of Barrett's esophagus.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式